Breast Cancer - news item 1 of 133
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New Coordinating Panel Targets Federal Breast Cancer Agenda
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RESEARCH TRIANGLE PARK, N.C. - The National Institutes of Health announced Aug. 16 that a newly formed advisory committee known as the Interagency Breast Cancer and Environmental Research Coordinating Committee will develop and coordinate a federal research agenda on environmental and genetic factors related to breast cancer. Full story on...
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RSS Source: Med Worm - Breast Cancer Thu, 9 Sep 2010 6:27:36 am
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Breast Cancer - news item 2 of 133
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Patient selection is biggest challenge for phase I breast cancer trials
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Around 20% of metastatic breast cancer patients who enter phase I clinical trials show a measurable benefit after 4 months, depending on their tumor characteristics and the biological activity of the novel agents, study results show. (Source: MedWire News - Oncology)
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RSS Source: Med Worm - Breast Cancer Thu, 9 Sep 2010 5:19:09 am
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Breast Cancer - news item 3 of 133
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Time Course of Risk Factors in Cancer Etiology and Progression [REVIEW ARTICLES]
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Patients with cancer increasingly ask what they can do to change their lifestyles and improve outcomes. Risk factors for onset of cancer may differ substantially from those that modify survival with implications for counseling. This review focuses on recent data derived from population-based studies of causes of cancer and of...
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RSS Source: Med Worm - Breast Cancer Wed, 8 Sep 2010 10:00:49 pm
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Breast Cancer - news item 4 of 133
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Weight, Physical Activity, Diet, and Prognosis in Breast and Gynecologic Cancers [REVIEW ARTICLES]
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Diet, physical activity, and weight may affect prognosis among women who are diagnosed with breast or gynecologic cancer. Observational studies show associations between being overweight or obese and weight gain with several measures of reduced prognosis in women with breast cancer and some suggestion of poor prognosis in underweight women....
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RSS Source: Med Worm - Breast Cancer Wed, 8 Sep 2010 10:00:49 pm
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Breast Cancer - news item 5 of 133
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Postdoc in molecular endocrinology and cancer - Geneva, Switzerland
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Added via www.naturejobs.com The Department of Cell Biology at the University of Geneva has a vacancy for a postdoctoral researcher with a strong theoretical and practical background in molecular and cellular biology. Applicants are required to submit a short proposal for a project to investigate the factors contributing to tamoxifen...
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RSS Source: Med Worm - Breast Cancer Wed, 8 Sep 2010 12:00:00 pm
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Breast Cancer - news item 6 of 133
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Non-Hormone Treatments Can Relieve Hot Flashes In Women With Breast Cancer
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Many women enduring hot flashes experience the heat, sweat and reddened upper body as an uncomfortable inconvenience. However, hot flashes can greatly diminish a woman's quality of life, disrupting sleep at night or causing embarrassment as she goes about her daily business. Hot flashes, called flushes in medical circles, occur...
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RSS Source: Med Worm - Breast Cancer Wed, 8 Sep 2010 10:00:00 am
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Breast Cancer - news item 7 of 133
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Prophylactic Surgeries Associated With Lower Risk Of Cancer For Women With BRCA1/2 Gene Mutations
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Women at increased risk of breast and ovarian cancer because of inherited mutations of the BRCA1 or BRCA2 genes who had prophylactic mastectomy or salpingo-oophorectomy (removal of the fallopian tubes and ovaries) had an associated decreased risk of breast cancer and ovarian cancer, according to a study in the September...
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RSS Source: Med Worm - Breast Cancer Wed, 8 Sep 2010 9:00:00 am
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Breast Cancer - news item 8 of 133
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The Optimal Set-Up For Obtaining The Best Breast Scan Image With Minimal Radiation Dose To The Patient
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A mathematical tool known as a Monte Carlo analysis could help improve the way X-rays are used for mammography and reduce the number of breast cancers missed by the technique as well as avoiding false positives, according to research published this month in the International Journal of Low Radiation. Worldwide,...
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RSS Source: Med Worm - Breast Cancer Wed, 8 Sep 2010 8:00:00 am
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Breast Cancer - news item 9 of 133
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Michael Douglas chooses toxic chemotherapy, radiation to battle throat cancer
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(NaturalNews) One by one, celebrities with cancer are killed off by the cancer industry and its extremely toxic (even inhumane) treatments of chemotherapy and radiation. The next potential victim is actor Michael Douglas, who recently revealed he is suffering from stage 4 throat cancer. While Douglas has the courage to...
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RSS Source: Med Worm - Breast Cancer Wed, 8 Sep 2010 7:00:00 am
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Breast Cancer - news item 10 of 133
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Mexican origin: Breast cancer comes early
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HOUSTON, Sept. 7 (UPI) -- U.S. researchers say screening for breast cancer needs to begin sooner for women of Mexican-ancestry than for other women. Breast cancer - Cancer - Health - Breast - United States (Source: Health News - UPI.com)
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RSS Source: Med Worm - Breast Cancer Wed, 8 Sep 2010 3:47:24 am
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Breast Cancer - news item 11 of 133
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Surgical outcomes of borderline breast lesions detected by needle biopsy in a breast screening program
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Conclusions: Further research is required to determine whether characteristics of the mammographic lesion (particularly calcification patterns), the area targeted for biopsy and number of core samples retrieved, can indicate a closer correlation with eventual pathology. This study identified no findings in the diagnostic assessment that could exclude women with borderline...
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 11:00:00 pm
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Breast Cancer - news item 12 of 133
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Genomic distance entrained clustering and regression modelling highlights interacting genomic regions contributing to proliferation in breast cancer
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Conclusions: Data-mining of large-scale microarray gene expression datasets can reveal regional clusters of co-ordinate gene expression, independent of cause. By correlating these clusters with tumour proliferation we have identified a number of genomic regions that act together to promote proliferation in ER+ breast cancer. Identification of such regions should enable...
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 11:00:00 pm
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Breast Cancer - news item 13 of 133
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Health 2.0 Developer Challenge: Project HealthDesign Challenge
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Deadline: September 15, 2010 Program Area: Pioneer Purpose: In its first round, from 2006 to 2008, Project HealthDesign supported nine teams to design and build prototype applications that could be run on top of personal health data. Now, the Robert Wood Johnson Foundation's Pioneer Portfolio and California HealthCare Foundation seek...
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 11:00:00 pm
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Breast Cancer - news item 14 of 133
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Discussion on "ghostwritten" articles which overstated benefits of HRT
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Source: PLoS Medicine, BMJ Area: News Following a recent litigational case against Wyeth, PLoS Medicine has featured an article showing how industry uses "ghostwriters" to insert marketing messages into articles published in medical journals. The litigation against Wyeth involved more than 14,000 plaintiffs who brought claims related to the development...
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 11:00:00 pm
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Breast Cancer - news item 15 of 133
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ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis.
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Conclusion: This study has revealed that even in the presence of vast IGF-IR overexpression, a modest increase in ErbB2 can augment tumor establishment in vivo, mediate resistance to IGF-IR downregulation and facilitate metastasis. This supports the growing evidence suggesting a possible advantage of using IGF-IR and ErbB2-directed therapies concurrently in...
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 11:00:00 pm
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Breast Cancer - news item 16 of 133
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Experimental assessment of pro-lymphangiogenic growth factors in the treatment of post-surgical lymphedema following lymphadenectomy
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Conclusions: Growth factor therapy has the potential to increase lymphatic function and reduce edema magnitude in an animal model of lymphedema. The application of this concept to lymphedema patients warrants further examination. (Source: Breast Cancer Research)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 11:00:00 pm
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Breast Cancer - news item 17 of 133
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Response: Re: Population-Based Study of Contralateral Prophylactic Mastectomy and Survival Outcomes of Breast Cancer Patients
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(Source: JNCI)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 8:02:14 pm
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Breast Cancer - news item 18 of 133
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Re: Population-Based Study of Contralateral Prophylactic Mastectomy and Survival Outcomes of Breast Cancer Patients
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(Source: JNCI)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 8:02:14 pm
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Breast Cancer - news item 19 of 133
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Early Breast Cancer: Single Dose of Radiation During Surgery Gains Support
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(Source: JNCI)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 8:02:14 pm
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Breast Cancer - news item 20 of 133
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Overexpression and Activation of the {alpha}9-Nicotinic Receptor During Tumorigenesis in Human Breast Epithelial Cells
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Conclusion The 9-nAChR is important for nicotine-induced transformation of normal human breast epithelial cells. (Source: JNCI)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 8:02:14 pm
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Breast Cancer - news item 21 of 133
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Nicotine Binding to Receptor Linked to Breast Cancer Cell Growth
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(Source: JNCI) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 8:02:13 pm
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Breast Cancer - news item 22 of 133
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From Nicotine to Breast Cancer, Implications of Cholinergic Receptor Pathway
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(Source: JNCI)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 8:02:13 pm
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Breast Cancer - news item 23 of 133
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TRACO: Breast Cancer and Epigenetics
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For more information, visit http://ccr.cancer.gov/careers/traco.aspAir date: 11/22/2010 4:00:00 PM (Source: Videocast - All Events)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 5:03:00 pm
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Breast Cancer - news item 24 of 133
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Who dares question the industrial food system over GM salmon? | Dan Kennedy
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Genetically modified salmon is deemed safe for human consumption †despite higher levels of a suspected carcinogenWith fish stocks around the world depleted by overfishing and disrupted by climate change, farm-raised salmon stands as a viable if not entirely appetising alternative.Last Friday, though, the US Food and Drug Administration (FDA)...
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 4:59:54 pm
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Breast Cancer - news item 25 of 133
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Dynamic deterministic effects propagation networks: learning signalling pathways from longitudinal protein array data
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We present a new method for reconstructing signalling networks from time course experiments after external perturbation and show an application of the method to data measuring abundance of phosphorylated proteins in a human breast cancer cell line, generated on reverse phase protein arrays. Results: Signalling dynamics is modelled using active...
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 4:38:02 pm
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Breast Cancer - news item 26 of 133
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Inferring cancer subnetwork markers using density-constrained biclustering
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Motivation: Recent genomic studies have confirmed that cancer is of utmost phenotypical complexity, varying greatly in terms of subtypes and evolutionary stages. When classifying cancer tissue samples, subnetwork marker approaches have proven to be superior over single gene marker approaches, most importantly in cross-platform evaluation schemes. However, prior subnetwork-based approaches...
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 4:38:02 pm
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Breast Cancer - news item 27 of 133
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Immutep announces final results in phase I/II chemoimmunotherapy trial in metastatic breast cancer
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Clinical research paper describes IMP321’s potency in achieving clinical benefit in 90 per cent of patients, combined with paclitaxel in first-line metastatic breast cancer Orsay, France, September 7, 2010 - Immutep S.A. announced today the... (Source: Drugs.com - Clinical Trials)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 1:09:22 pm
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Breast Cancer - news item 28 of 133
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Ghostwritten articles overstated benefits of HRT
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(Source: BMJ Online First)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 11:21:38 am
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Breast Cancer - news item 29 of 133
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Researchers Battle 'Triple Negative' Cancer
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Scientists are taking aim at an particularly devastating type of cancer known as "triple negative" breast cancer. (Source: WDSU.com - Health)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 10:31:54 am
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Breast Cancer - news item 30 of 133
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Over-expression of ST3Gal-I promotes mammary tumorigenesis
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Changes in glycosylation are common in malignancy, and as almost all surface proteins are glycosylated, this can dramatically affect the behavior of tumor cells. In breast carcinomas, the O-linked glycans are frequently truncated, often as a result of premature sialylation. The sialyltransferase ST3Gal-I adds sialic acid to the galactose residue...
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 9:48:31 am
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Breast Cancer - news item 31 of 133
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Levels of specific glycans significantly distinguish lymph node-positive from lymph node-negative breast cancer patients
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One of the most urgent requirements in breast cancer is the development of a blood-based test for early detection and prognosis. Previously published results found a significant difference between specific glycan levels in patients with advanced breast cancer and healthy controls. The aim of this investigation was to address a...
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 9:48:31 am
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Breast Cancer - news item 32 of 133
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'Genetic link' to breast cancer
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Researchers have identified a series of genetic variations which may play a role in a common breast cancer. (Source: BBC News | Health | UK Edition)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 9:30:12 am
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Breast Cancer - news item 33 of 133
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Breast cancer in the developing world: Meeting the unforeseen challenge to women, health and equity
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Harvard School of Public Health (2009) (Source: WHO Maternal, Newborn and Child Health)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 8:55:00 am
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Breast Cancer - news item 34 of 133
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Preventative mastectomies can reduce risk
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SAN ANTONIO, Sept. 7 (UPI) -- Preventative mastectomies do reduce cancer risks for some women, U.S. researchers say. Cancer - Health - Conditions and Diseases - Breast cancer - Mastectomy (Source: Health News - UPI.com)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 8:44:26 am
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Breast Cancer - news item 35 of 133
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BRCA2 mutation indicates shorter survival in men with prostate cancer
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Men with prostate cancer who carry a deleterious germline mutation in the breast cancer 2 gene do not survive as long as prostate cancer patients who are non-carriers, UK study results show. (Source: MedWire News - Oncology) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free...
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 5:19:14 am
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Breast Cancer - news item 36 of 133
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Breast Cancer Predisposition Syndromes
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A small, but important, percentage of breast cancer cases is caused by the inheritance of a single copy of a mutated gene. BRCA1 and BRCA2 are the genes most commonly associated with inherited breast cancer; however, mutations in TP53 and PTEN cause Li-Fraumeni syndrome and Cowden syndrome, respectively, both of...
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 5:10:59 am
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Breast Cancer - news item 37 of 133
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Original article: A metaâ€synthesis of women's symptoms experience and breast cancer
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DENIEFFE S. & GOONEY M. (2010) European Journal of Cancer Care (Source: European Journal of Cancer Care)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 5:09:34 am
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Breast Cancer - news item 38 of 133
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Antiproliferative Activity of N6-Isopentenyladenosine on MCF-7 Breast Cancer Cells: Cell Cycle Analysis and DNA-Binding Study
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DNA and Cell Biology , Vol. 0, No. 0. (Source: DNA and Cell Biology)
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RSS Source: Med Worm - Breast Cancer Tue, 7 Sep 2010 1:58:55 am
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Breast Cancer - news item 39 of 133
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Internal mammary lymph node recurrence: rare but characteristic metastasis site in breast cancer
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Conclusions: The risk of IMLN recurrence is low and there are certain characteristics features on CT images. ER/PR status is both a risk factor for DFI of IMLN recurrence and a prognostic factor for overall survival after IMLN recurrence. Patients with only IMLN recurrence and/or local lesion have a good...
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RSS Source: Med Worm - Breast Cancer Mon, 6 Sep 2010 11:00:00 pm
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Breast Cancer - news item 40 of 133
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Vital Signs: Prevention: Surgery Sharply Reduces Risk of 2 Cancers
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For women who carry a genetic mutation that puts them in danger of developing ovarian and breast cancer, prophylactic mastectomy and oophorectomy offer protection. (Source: NYT Health) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Breast Cancer Mon, 6 Sep 2010 6:49:39 pm
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Breast Cancer - news item 41 of 133
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The association of carbohydrate intake, glycemic load, glycemic index, and selected rice foods with breast cancer risk: a case-control study in South Korea.
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Authors: Yun SH, Kim K, Nam SJ, Kong G, Kim MK Despite carbohydrate hypothesis related to breast cancer development, the inter-relationships of carbohydrate measures with risk of breast cancer are unclear. We evaluated the association between the risk of breast cancer and total carbohydrate intake, glycemic load, and glycemic index,...
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RSS Source: Med Worm - Breast Cancer Mon, 6 Sep 2010 2:57:04 pm
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Breast Cancer - news item 42 of 133
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3 to 4 drinks per week may raise risk of breast cancer's return
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Drinking even moderate amounts of alcohol may raise the risk for breast cancer recurrence in some women, but may in fact lower the risk for dying ... (Source: USATODAY.com Health)
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RSS Source: Med Worm - Breast Cancer Mon, 6 Sep 2010 2:00:41 pm
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Breast Cancer - news item 43 of 133
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Snippets in surgical pathology
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(Source: Journal of Clinical Pathology)
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RSS Source: Med Worm - Breast Cancer Mon, 6 Sep 2010 10:33:46 am
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Breast Cancer - news item 44 of 133
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Tissue microarray construction from gross specimens: development of a novel simple technique
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Conclusion This study describes a satisfactory technique for construction of TMA from a gross tumour specimen. Such a technique is well suited to centres which handle a high number of cases of a particular type, such as breast carcinoma. Further studies on other tumour types would help in validating these...
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RSS Source: Med Worm - Breast Cancer Mon, 6 Sep 2010 10:33:45 am
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Breast Cancer - news item 45 of 133
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Comparative validation of the SP6 antibody to Ki67 in breast cancer
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Conclusions SP6 and MIB1 provide highly comparable measures of Ki67 that predict progression of advanced disease similarly. SP6 is substantially better suited than MIB1 to image analysis. (Source: Journal of Clinical Pathology) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Breast Cancer Mon, 6 Sep 2010 10:33:45 am
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Breast Cancer - news item 46 of 133
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'Basal-like' breast cancer does not originate from basal stem cells
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New research uncovers a case of mistaken identity that may have a significant impact on future breast cancer prevention and treatment strategies. The study suggests that despite their "stem cell-like" characteristics, most aggressive breast tumors are not derived from normal mammary gland stem cells. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Breast Cancer Mon, 6 Sep 2010 8:41:22 am
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Breast Cancer - news item 47 of 133
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Supporting women with intellectual disabilities to access breast cancer screening: a healthcare professional perspective
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(Source: European Journal of Cancer Care)
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RSS Source: Med Worm - Breast Cancer Mon, 6 Sep 2010 5:10:26 am
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Breast Cancer - news item 48 of 133
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Targeted breast cancer strategies needed for Mexican-American women
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Policies that target screening, education, and treatment are needed to address breast cancer disparities among Mexican-origin women in the United States, say researchers. (Source: MedWire News - Oncology)
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RSS Source: Med Worm - Breast Cancer Mon, 6 Sep 2010 12:00:00 am
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Breast Cancer - news item 49 of 133
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Regulation of breast cancer cell motility by T-cell lymphoma invasion and metastasis-inducing protein
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Conclusions: Tiam1 expression correlates with cell motility in human breast cancer cells, and is required to support the motile phenotype. Localization of endogenous Tiam1 to the Golgi, and its demonstrated role in Golgi reorientation, suggest that it may support motility through a mechanism that is discrete from its known function...
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RSS Source: Med Worm - Breast Cancer Sun, 5 Sep 2010 11:00:00 pm
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Breast Cancer - news item 50 of 133
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Control of mammary tumor differentiation by SKI-606 (bosutinib)
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Authors: L Hebbard, G Cecena, J Golas, J Sawada, L G Ellies, A Charbono, R Williams, R E Jimenez, M W.ell, K T Arndt, S Q DeJoy, R A Rollins, V Diesl, M Follettie, L Chen, E Rosfjord, R D Cardiff, M Komatsu, F Boschelli & R G Oshima (Source:...
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RSS Source: Med Worm - Breast Cancer Sun, 5 Sep 2010 11:00:00 pm
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Breast Cancer - news item 51 of 133
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Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice
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Authors: L Sevenich, F Werner, M Gajda, U Schurigt, C Sieber, S Müller, M Follo, C Peters & T Reinheckel (Source: Oncogene)
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RSS Source: Med Worm - Breast Cancer Sun, 5 Sep 2010 11:00:00 pm
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Breast Cancer - news item 52 of 133
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miR-145-dependent targeting of Junctional Adhesion Molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness
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Authors: M Götte, C Mohr, C-Y Koo, C Stock, A-K Vaske, M Viola, S A Ibrahim, S Peddibhotla, Y H-F Teng, J-Y Low, K Ebnet, L Kiesel & G W Yip (Source: Oncogene)
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RSS Source: Med Worm - Breast Cancer Sun, 5 Sep 2010 11:00:00 pm
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Breast Cancer - news item 53 of 133
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The RNA helicase p68 modulates expression and function of the Î 133 isoform(s) of p53, and is inversely associated with Î 133p53 expression in breast cancer
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The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancer Oncogene advance online publication, September 6, 2010. doi:10.1038/onc.2010.381 Authors: H C Moore, L B Jordan, S E Bray, L Baker, P R Quinlan, C A Purdie,...
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RSS Source: Med Worm - Breast Cancer Sun, 5 Sep 2010 11:00:00 pm
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Breast Cancer - news item 54 of 133
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Involvement of C12orf32 overexpression in breast carcinogenesis.
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Authors: Kim JW, Fukukawa C, Ueda K, Nishidate T, Katagiri T, Nakamura Y Through genome-wide gene expression profile analysis of breast cancer, we identified a gene, chromosome 12 open reading frame 32 (C12orf32), to be involved in mammary carcinogenesis. Semiquantitative RT-PCR and Northern blot analysis confirmed C12orf32 overexpression in breast...
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RSS Source: Med Worm - Breast Cancer Sun, 5 Sep 2010 9:01:45 pm
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Breast Cancer - news item 55 of 133
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Using PET/CT In The Detection Of Breast Cancer Metastases
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About one-third of women diagnosed with early-stage breast cancer will have their cancer travel, or metastasize, to other parts of the body, with the bone being the most common site of initial detectable spread. Controversy continues to surround the question of whether CT and bone scans should be standard in...
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RSS Source: Med Worm - Breast Cancer Sun, 5 Sep 2010 7:00:00 am
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Breast Cancer - news item 56 of 133
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Newly Developed Prediction Tool Helps Estimate Local Recurrence In Patients With Non-Invasive Breast Cancer
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The decision regarding treatment following breast-conserving surgery for patients diagnosed with ductal carcinoma in-situ (DCIS) has long been an area of discussion and confusion for patients and physicians alike. While the mortality rates for DCIS remain low, the risk of local recurrence in the breast is high. Standard treatments following...
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RSS Source: Med Worm - Breast Cancer Sun, 5 Sep 2010 7:00:00 am
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Breast Cancer - news item 57 of 133
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First-line bevacizumab plus taxane-based chemotherapy for locally recurrent or metastatic breast cancer: safety and efficacy in an open-label study in 2251 patients.
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CONCLUSIONS: The study population in ATHENA was more representative of general oncology practice than populations enrolled into randomised trials, although there may have been some bias towards younger, fitter patients. The safety and efficacy of bevacizumab-taxane therapy in this large study were consistent with results from randomised first-line trials. PMID:...
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RSS Source: Med Worm - Breast Cancer Sat, 4 Sep 2010 11:00:00 pm
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Breast Cancer - news item 58 of 133
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Preventive Mastectomies Pay Off for Some Women
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Study shows women with BRCA1 and BRCA2 genetic mutations significantly reduce their risk of breast and ovarian cancer with preventive surgeries (Source: Disabled World)
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RSS Source: Med Worm - Breast Cancer Sat, 4 Sep 2010 4:34:21 pm
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Breast Cancer - news item 59 of 133
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New origins of breast cancer discovered
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New research has shown that scientists may have been looking in the wrong place in their search for the most aggressive forms of breast cancer (Source: Nursing in Practice) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Breast Cancer Sat, 4 Sep 2010 6:50:46 am
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Breast Cancer - news item 60 of 133
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Newer breast imaging techniques pose greater risk for cancer
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Newer breast imaging techniques such as breast-specific gamma imaging and positron emission mammography have a much greater risk for radiation-induced breast cancer than mammography, study findings indicate. (Source: MedWire News - Oncology)
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RSS Source: Med Worm - Breast Cancer Sat, 4 Sep 2010 5:19:31 am
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Breast Cancer - news item 61 of 133
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Earlier Stage at Diagnosis and Improved Survival Among Medicare HMO Patients with Breast Cancer
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Journal of Women's Health Sep 2010, Vol. 19, No. 9: 1619-1624. (Source: Journal of Women)
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RSS Source: Med Worm - Breast Cancer Sat, 4 Sep 2010 1:54:34 am
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Breast Cancer - news item 62 of 133
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Talks With Plastic Surgeon Urged Before Mastectomy
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Where woman goes for treatment may influence breast reconstruction decision, study suggests (Source: Cancercompass News: Breast Cancer)
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RSS Source: Med Worm - Breast Cancer Sat, 4 Sep 2010 12:00:00 am
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Breast Cancer - news item 63 of 133
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Free Headgear
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Chemotherapy for breast cancer can cause hair loss. If it appears that your hair will be taking a break while you're in treatment, get some headgear to top off your wardrobe. You can cover your head with free headgear - here's how to get free wigs, hats, caps, and scarves...
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 11:00:00 pm
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Breast Cancer - news item 64 of 133
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Clinical significance of high focal adhesion kinase gene copy number and overexpression in invasive breast cancer
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Abstract Increased expression and activation of focal adhesion kinase (FAK) was reported to be an unfavorable factor in various human cancers, including breast cancer. In order to study FAK gene status as a prognostic factor, we evaluated FAK gene copy number and FAK protein expression in invasive breast cancer. Tumors...
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 5:34:57 pm
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Breast Cancer - news item 65 of 133
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Distinct function of androgen receptor coactivator ARA70α and ARA70β in mammary gland development, and in breast cancer
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Abstract Steroid receptor coactivators are important in regulating the function of the receptors in endocrine organ development and in cancers, including breast. Androgen receptor (AR) coactivator ARA70, was first identified as a gene fused to the ret oncogene and later characterized as an AR coactivator. We previously reported that the...
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 5:34:50 pm
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Breast Cancer - news item 66 of 133
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The association between biological subtype and locoregional recurrence in newly diagnosed breast cancer
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Abstract We investigated the association between the risk of locoregional recurrence (LRR) and biological subtypes defined by hormonal receptors (HR) and HER-2 status in women with invasive breast cancer (BC). A total of 618 newly diagnosed BC patients were identified from a cancer registry within a single institution with standardized...
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 5:34:41 pm
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Breast Cancer - news item 67 of 133
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Family history of breast cancer in first-degree relatives and triple-negative breast cancer risk
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We examined the relationship between having a family history of breast cancer in first-degree relatives and risk of triple-negative breast cancer, and risk of two other breast cancer subtypes defined by tumor marker expression. We evaluated data collected by the Breast Cancer Surveillance Consortium from 2,599,946 mammograms on 1,054,466 women,...
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 5:34:33 pm
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Breast Cancer - news item 68 of 133
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Phase II, double-blind, randomized trial of capecitabine plus enzastaurin versus capecitabine plus placebo in patients with metastatic or recurrent breast cancer after prior anthracycline and taxane therapy
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Abstract Capecitabine is frequently used in the treatment of recurrent/progressive metastatic breast cancer (MBC) after prior anthracycline and taxane therapy. With the intention of improving the efficacy of single agent capecitabine, we initiated a randomized, double-blind, placebo-controlled Phase II study of the novel serine/threonine kinase inhibitor enzastaurin in combination with...
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 5:34:29 pm
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Breast Cancer - news item 69 of 133
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17α-Alkynyl 3α, 17β-androstanediol non-clinical and clinical pharmacology, pharmacokinetics and metabolism
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Summary 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235, Apoptone) is an orally bioavailable synthetic analogue of 3β-androstanediol, that is active in rodent models of prostate and breast cancer, and is in Phase IIa clinical trials for the treatment of early- and late-stage prostate cancer. In preparation for clinical studies, nuclear hormone receptor and P450...
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 5:17:52 pm
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Breast Cancer - news item 70 of 133
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Comments on: Improving Breast Cancer Surgery: A Classification and Quadrant per Quadrant Atlas for Oncoplastic Surgery (Clough KB, Kaufman GJ, et al. ASO DOI 10.1245/s10434-009-0792-y)
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Content Type Journal ArticleDOI 10.1245/s10434-010-1301-zAuthors F. Santanelli, Plastic and Reconstructive Surgery Unit, Sant’Andrea Hospital, IInd School of Medicine, “Sapienza†University of Rome, Rome, ItalyG. Paolini, Plastic and Reconstructive Surgery Unit, Sant’Andrea Hospital, IInd School of Medicine, “Sapienza†University of Rome, Rome, ItalyB. Longo, Plastic and Reconstructive Surgery Unit, Sant’Andrea Hospital,...
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 4:47:05 pm
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Breast Cancer - news item 71 of 133
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Development of the Psychosocial Distress Questionnaire†Breast Cancer (PDQ-BC): a breast cancer-specific screening instrument for psychosocial problems
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Conclusion The PDQ-BC is an easy-to-complete, acceptable, non-burdensome, and short screening instrument for routine use in breast cancer patient care. This instrument facilitates a greater awareness of the concerns and needs for breast cancer patients care during treatment with chemotherapy and the follow-up. It is linked to a good referral...
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 3:19:32 pm
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Breast Cancer - news item 72 of 133
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Important Breakthrough In Origins Of Aggressive Breast Cancer
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Researchers have made a major breakthrough in finding out how aggressive cancers originate, raising hope of novel targeted therapies for future breast cancer patients, according to a study published in the peer-reviewed journal Cell Stem Cell. The scientists say this is the first study to show that the most aggressive...
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 3:00:00 pm
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Breast Cancer - news item 73 of 133
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GIPC1-MyoGEF Interaction [Signal Transduction]
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We reported previously that MyoGEF, a guanine nucleotide exchange factor, plays a role in regulating breast cancer cell polarization and invasion. Here, we identify GIPC1 as an interacting partner of MyoGEF. Both in vitro and in vivo binding assays show that the GIPC1 PDZ domain binds to the PDZ-binding motif...
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 1:38:14 pm
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Breast Cancer - news item 74 of 133
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CTCF Demarcates Response to Estrogen [Cell Biology]
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Transcription activation by estrogen receptor (ER) is rapid and dynamic. How the prompt and precise ER response is established and maintained is still not fully understood. Here, we report that two boundary elements surrounding the well defined ER target TFF1 locus are occupied by the CCCTC-binding factor (CTCF). These elements...
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 1:38:13 pm
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Breast Cancer - news item 75 of 133
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Tumor location breakthrough in breast cancer research
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Confusion over the location of breast cancers may have led to avoidable deaths and the prescribing of inappropriate treatments, according to new research. (Source: Nursing Times Breaking News)
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 10:15:00 am
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Breast Cancer - news item 76 of 133
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Women of Mexican origin at higher risk for breast cancer
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Women of Mexican origin in the U.S. are younger when diagnosed with breast (more) (Source: AuntMinnie.com Headlines)
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 7:00:00 am
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Breast Cancer - news item 77 of 133
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Fertility concerns linked to depression among young breast cancer survivors
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Concerns about fertility after breast cancer treatment contribute to long-term depressive symptoms among young breast cancer survivors, US researchers report. (Source: MedWire News - Oncology) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 5:19:57 am
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Breast Cancer - news item 78 of 133
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Microsoft Excel-based algorithm predicts cancer prognosis
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Using readily available computer programs, researchers have developed a system to identify genes that will be useful in the classification of breast cancer. The algorithm will enable researchers to quickly generate valuable gene signatures without specialized software or extensive bioinformatics training. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 3:00:00 am
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Breast Cancer - news item 79 of 133
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Dissemination of a Breast and Cervical Cancer Early Detection Program Through a Network of Community-Based Organizations
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This article describes the dissemination of ENCORE plus to 78 YWCAs in 30 states. It illustrates the application of social cognitive theory and diffusion theory to increase program adoption, implementation, and maintenance among community organizations that have not traditionally provided public health related services. The article highlights elements of the...
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RSS Source: Med Worm - Breast Cancer Fri, 3 Sep 2010 2:39:47 am
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Breast Cancer - news item 80 of 133
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Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2).
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Authors: Ni Z, Bikadi Z, Rosenberg MF, Mao Q The human breast cancer resistance protein (BCRP/ABCG2) is the second member of the G subfamily of the large ATP-binding cassette (ABC) transporter superfamily. BCRP was initially discovered in multidrug resistant breast cancer cell lines where it confers resistance to chemotherapeutic agents...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 11:00:00 pm
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Breast Cancer - news item 81 of 133
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A mesofluidic multiplex immunosensor for detection of circulating cytokeratin-positive cells in the blood of breast cancer patients.
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Authors: Breton F, Bennetau B, Lidereau R, Thomas L, Regnier G, Ehrhart JC, Tauc P, Tran PL We have recently reported the analytical performance of an immunosensor comprising one mm-scale parallel plate laminar flow chamber and applied to capture MCF7 breast cancer cells (Ehrhart et al., Biosens. Bioelectr. 24, 467,...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 11:00:00 pm
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Breast Cancer - news item 82 of 133
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Biologic profiling of lymph node negative breast cancers by means of microRNA expression
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Authors: Emiel A M Janssen, Aida Slewa, Einar Gudlaugsson, Kristin Jonsdottir, Ivar Skaland, Håvard Søiland & Jan P A Baak (Source: Modern Pathology AOP)
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 11:00:00 pm
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Breast Cancer - news item 83 of 133
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[Correspondence] The International Study of Insulin and Cancer
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Studies have suggested the possibility of an association between use of insulin glargine and cancer, with conflicting results. Among other issues under debate is the role of insulin itself in cancer development and the contribution of confounding factors or analytical methods to observations. The International Study of Insulin and Cancer (...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 11:00:00 pm
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Breast Cancer - news item 84 of 133
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Large-scale proteomic identification of S100 proteins in breast cancer tissues
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Conclusions: This article reports for the first time the comparative proteomic screening of several S100 protein members among a large group of breast cancer patients. The results obtained strongly support the hypothesis that a significant deregulation of multiple S100 protein members is associated with breast cancer progression, and suggest that...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 11:00:00 pm
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Breast Cancer - news item 85 of 133
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Molecular and Functional Imaging of Breast Cancer
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Molecular and functional imaging of the breast could alter clinical practice in diagnosing and staging primary breast cancer and assessing response to therapy. Cancer Control: Journal of the Moffitt Cancer Center (Source: Medscape Radiology Headlines)
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 8:07:43 pm
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Breast Cancer - news item 86 of 133
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Knowledge of Breast Cancer and Screening Practices Among Iranian Immigrant Women in Toronto
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Abstract Breast cancer is a leading cause of mortality and morbidity in Canada. Secondary prevention through screening may enable early identification and treatment, but this is suboptimal among all Canadian women, particularly minority immigrant women. This cross-sectional exploratory study assessed breast health knowledge and practices among Iranian immigrant women residing...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 3:00:56 pm
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Breast Cancer - news item 87 of 133
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Doctor who cut rugby player's lip is free to practise after warning
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(Source: BMJ Online First)
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 2:46:17 pm
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Breast Cancer - news item 88 of 133
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'Major advance' in tackling aggressive breast cancer
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A breakthrough in understanding how a particularly aggressive form of breast cancer develops could lead to the creation of new drugs which would stop tumours ever developing, scientists hope. (Source: Telegraph Health)
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 1:56:23 pm
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Breast Cancer - news item 89 of 133
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Study: Preemptive Surgery May Help Prevent Cancer For Some Women
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A study published in the Journal of the American Medical Association suggests that women with a gene mutation linked to breast and ovarian cancer face lower risks of developing such cancer after receiving mastectomies or having their ovaries removed, The Wall Street Journal reports. The study, which involved 2,482 women, "...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 12:00:00 pm
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Breast Cancer - news item 90 of 133
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Buscan a voluntarios para caminata a favor de Breast Cancer Research
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AURORA. El equipo 129 del Distrito Escolar West Aurora, del mismo número, solicita caminantes para la recaudación de fondos a favor de Breast Cancer Research. El Equipo 129 está en busca de miembros adicionales para el evento que se llevará a cabo el 17... (Source: OrlandoSentinel: Medical Research) MedWorm Message:...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 11:21:28 am
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Breast Cancer - news item 91 of 133
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Breast Cancer Prognosis Prediction Tool: Microsoft Excel-Based Algorithm
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Using readily available computer programs, researchers have developed a system to identify genes that will be useful in the classification of breast cancer. The algorithm, described in BioMed Central's open access Journal of Experimental & Clinical Cancer Research will enable researchers to quickly generate valuable gene signatures without specialized software...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 11:00:00 am
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Breast Cancer - news item 92 of 133
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The anxious wait: assessing the impact of patient accessible EHRs for breast cancer patients
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Source: Wiljer D et al, BMC Medical Informatics and Decision Making, 10(1) Content: Background Personal health records (PHRs) provide patients with access to personal health information (PHI) and targeted education. The use of PHRs has the potential to improve a wide range of outcomes, including empowering patients to be more...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 10:07:05 am
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Breast Cancer - news item 93 of 133
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Gene-expression profiling in breast cancer: bespoke cancer therapy or more fiction than science?
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Content Type Journal ArticleDOI 10.1007/s11845-010-0565-4Authors M. Barry, Eccles Breast Screening Unit, Mater Misericordiae University Hospital, Eccles St, Dublin 7, IrelandM. R. Kell, Eccles Breast Screening Unit, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland Journal Irish Journal of Medical ScienceOnline ISSN 1863-4362Print ISSN 0021-1265 (Source: Irish Journal of Medical...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 8:48:37 am
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Breast Cancer - news item 94 of 133
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The Import of Trust in Regular Providers to Trust in Cancer Physicians among White, African American, and Hispanic Breast Cancer Patients
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CONCLUSIONS Our results suggest that patients are very trusting of their breast cancer providers. This is an important finding given that research with other populations has shown an association between trust and patient satisfaction and treatment adherence. Our findings also suggest that a trusting relationship with a regular provider facilitates...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 8:46:52 am
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Breast Cancer - news item 95 of 133
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Erratum to: Longitudinal Patterns in Survival, Comorbidity, Healthcare Utilization and Quality of Care among Older Women Following Breast Cancer Diagnosis
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Content Type Journal ArticleDOI 10.1007/s11606-010-1493-8Authors Amresh D. Hanchate, Center for Organization, Leadership and Management Research (COLMR), VA Boston Healthcare System, Boston, MA USAKerri M. Clough-Gorr, Section of Geriatrics, Boston University School of Medicine, Boston, MA USAArlene S. Ash, Health Care Research Unit, Section of General Internal Medicine, Boston University School...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 8:46:52 am
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Breast Cancer - news item 96 of 133
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Development of High-Throughput Quantitative Assays for Glucose Uptake in Cancer Cell Lines
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Conclusions These studies indicate that 2-NBDG can be used to aid in the high-throughput analysis of the influence of chemotherapeutics on glucose uptake in cancer cells. Content Type Journal ArticleDOI 10.1007/s11307-010-0399-5Authors Mohamed Hassanein, Vanderbilt Integrative Cancer Biology Center, Vanderbilt University Medical Center, 2220 Pierce Avenue, 771 Preston Research Building, Nashville,...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 8:42:24 am
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Breast Cancer - news item 97 of 133
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BRCA1 and BRCA2 families and the risk of skin cancer
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Abstract BRCA1 and BRCA2 mutation carriers have elevated risks of breast and ovarian cancers. The risks for cancers at other sites remain unclear. Melanoma has been associated with BRCA2 mutations in some studies, however, few surveys have included non-melanoma skin cancer. We followed 2729 women with a BRCA1 or BRCA2...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 8:40:37 am
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Breast Cancer - news item 98 of 133
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Novel BRCA1/2 mutations in Serbian breast and breast†ovarian cancer patients with hereditary predisposition
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Abstract: Mutations in breast cancer susceptibility (BRCA) genes lead to defects in DNA repair processes resulting in elevated genome instability and predisposing to breast and ovarian cancer. The study was designed to detect mutational spectra of BRCA1/2 genes in a Serbian population. Using automated DNA sequencing, we tested individuals for...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 8:28:01 am
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Breast Cancer - news item 99 of 133
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Amplification of the RARA gene in acute myeloid leukemia: significant finding or coincidental observation?
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We present a unique case of a 59-year-old female with a history of breast cancer, now presenting with pancytopenia and bilateral infiltration with effusion in nodules of the right upper lobe of the lung. She was diagnosed with AML-M5. Chromosome analysis demonstrated a hypodiploid clone with complex numerical/structural abnormalities including...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 8:28:01 am
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Breast Cancer - news item 100 of 133
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Intraoperative assessment of sentinel lymph nodes in breast cancer
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Abstract (Source: British Journal of Surgery) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 8:03:44 am
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Breast Cancer - news item 101 of 133
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Surgeons Impact Whether A Woman Gets Breast Reconstruction
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When breast cancer surgeons regularly confer with plastic surgeons prior to surgery, their patients are more likely to have reconstruction, according to a new study led by researchers at the University of Michigan Comprehensive Cancer Center. Where a woman goes for breast cancer treatment can vary widely - ranging from...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 8:00:00 am
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Breast Cancer - news item 102 of 133
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The ASCO Post Publishes Multiple Perspectives On Outcome Of ODAC Meeting Regarding Bevacizumab In Advanced Breast Cancer
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The ASCO Post captured initial reactions to the Oncologic Drugs Advisory Committee (ODAC) recommendation that the breast cancer indication for bevacizumab (Avastin) be revoked in interviews with ODAC voting members, breast cancer specialists, oncologists in private practice, third-party payers, and a patient advocate.... (Source: Health News from Medical News Today)
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 8:00:00 am
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Breast Cancer - news item 103 of 133
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Pharmacological interventions for fertility preservation during chemotherapy
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Content Type Journal ArticleDOI 10.1007/s10549-010-1134-2Authors Zeev Blumenfeld, Reproductive Endocrinology, Department of Obstetrics and Gynecology, Faculty of Medicine, Rappaport Institute, Technion-Israel Institute of Technology, Rambam Health Care Campus, Bath-Galim, 31096 Haifa, Israel Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment)
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 6:55:03 am
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Breast Cancer - news item 104 of 133
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Association of diagnostic work-up with subsequent attendance in a breast cancer screening program for false-positive cases
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In conclusion, in comparison to women with normal or benign findings on index mammograms, false-positive cases warranting additional imaging evaluation, clinical and imaging follow-up, or biopsy had uniformly decreased odds of attending subsequent routine screening rounds. Content Type Journal ArticleDOI 10.1007/s10549-010-1118-2Authors Arnaud Seigneurin, Registre du Cancer de l’Isère, Centre Hospitalier...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 6:55:02 am
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Breast Cancer - news item 105 of 133
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Comprehensive CYP2D6 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy
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Abstract The association between CYP2D6 genotype and outcome in breast cancer patients treated with adjuvant tamoxifen remains controversial. We assessed the influence of comprehensive versus limited CYP2D6 genotype in the context of tamoxifen adherence and co-medication in a large cohort of 618 patients. Genotyping of 33 CYP2D6 alleles used two...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 6:55:01 am
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Breast Cancer - news item 106 of 133
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Fertility drugs and the risk of breast cancer: a meta-analysis and review
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Abstract The risk of breast cancer has been associated with reproductive history. The purpose of this study was to determine the relationship between fertility drugs used in assisted reproductive procedures and the risk of breast cancer. We performed a literature search using the MEDLINE, the COCHRANE Library, and Scopus to...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 6:54:57 am
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Breast Cancer - news item 107 of 133
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Glutathione S-transferase P1 Ile105Val polymorphism and breast cancer risk: convergence and divergence of the two recent meta-analyses
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Content Type Journal ArticleDOI 10.1007/s10549-010-1143-1Authors Konstantinos P. Economopoulos, School of Medicine, National University of Athens, Athens, GreeceTheodoros N. Sergentanis, School of Medicine, National University of Athens, Athens, Greece Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment)
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 6:54:57 am
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Breast Cancer - news item 108 of 133
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Oral fluoropyrimidine may augment the efficacy of aromatase inhibitor via the down-regulation of estrogen receptor in estrogen-responsive breast cancer xenografts
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Abstract The present preclinical study was designed to evaluate a new combination therapy comprised of the aromatase inhibitor anastrozole (ANA) and the oral fluoropyrimidines, UFT and S-1 against the estrogen receptor (ER)-positive human breast cancer cell line MCF-7/Arom 14, which was stably transfected with the cDNA of human aromatase. MCF-7/Arom...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 6:54:56 am
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Breast Cancer - news item 109 of 133
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Association between mitogen-activated protein kinase kinase kinase 1 rs889312 polymorphism and breast cancer risk: evidence from 59,977 subjects
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In conclusion, this meta-analysis suggests that the MAP3K1 rs889312 C allele is a low-penetrant risk factor for developing breast cancer, and there is limited evidence to indicate that MAP3K1 rs889312 polymorphism is associated with increased risk of breast cancer in BRCA1 mutation carriers. Content Type Journal ArticleDOI 10.1007/s10549-010-1151-1Authors Pei-Hua Lu,...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 6:54:55 am
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Breast Cancer - news item 110 of 133
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Value of PET-FDG in primary breast cancer based on histopathological and immunohistochemical prognostic factors
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Conclusion SUV, a preoperative and noninvasive metabolic parameter, correlates with other known prognostic factors in breast cancer. This study provides valuable insight into the usefulness of FDG-PET/CT for preoperative staging of patients with triple-negative and poorly differentiated breast tumors but not for evaluating axillary lymph nodes and lobular carcinomas. Content...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 6:36:22 am
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Breast Cancer - news item 111 of 133
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Surgical Decision-making in Immediate Breast Reconstruction
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Conclusions The most common reason for not offering immediate breast reconstruction is the need for postmastectomy radiotherapy and surgeons are able to predict this accurately. The addition of invasive and expensive staging investigations premastectomy does not appear to assist this decision-making process. Despite careful patient selection, a high rate of...
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RSS Source: Med Worm - Breast Cancer Thu, 2 Sep 2010 6:20:59 am
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Breast Cancer - news item 112 of 133
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Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells.
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Authors: Oh SJ, Kim O, Lee JS, Kim JA, Kim MR, Choi HS, Shim JH, Kang KW, Kim YC Acquired resistance to tamoxifen (TAM) is a serious therapeutic problem among breast cancer patients. Previously, we have reported that TAM-resistant MCF-7 cells (TAMR-MCF-7 cells) showed increased angiogenic intensity through Pin1-dependent vascular...
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 11:00:00 pm
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Breast Cancer - news item 113 of 133
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PTEN, PIK3CA, p-AKT, and p-p70S6K Status. Association with Trastuzumab Response and Survival in Patients with HER2-Positive Metastatic Breast Cancer.
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In conclusion, PI3K pathway activation plays a pivotal role in trastuzumab resistance. Our findings may facilitate the evaluation of tumor response to trastuzumab-based and targeted therapies. PMID: 20813970 [PubMed - as supplied by publisher] (Source: The American Journal of Pathology)
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 11:00:00 pm
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Breast Cancer - news item 114 of 133
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The Potential for Enhancing the Power of Genetic Association Studies in African Americans through the Reuse of Existing Genotype Data
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Author Summary This paper discusses and provides unique insight into an important problem raised by the current state of genetic studies into disease susceptibility, namely whether we can reuse genetic data from participants genotyped as controls in one study when cases (people with a disease of interest) are obtained from...
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 11:00:00 pm
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Breast Cancer - news item 115 of 133
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Surprise breast cancer source
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Some breast cancers may not originate from stem cells as previously believed (Source: The Scientist)
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 11:00:00 pm
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Breast Cancer - news item 116 of 133
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Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
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Conclusions: These results should help to improve our understanding of the biologic heterogeneity of breast cancer and provide tools for the further evaluation of the unique biology of claudin-low tumors and cell lines. (Source: Breast Cancer Research)
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 11:00:00 pm
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Breast Cancer - news item 117 of 133
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An algorithm to discover gene signatures with predictive potential
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Conclusions: We confirmed the capacity of our algorithm to generate gene signatures with bona fide predictive ability. The simplicity of our algorithm will enable biological researchers to quickly generate valuable gene signatures without specialized software or extensive bioinformatics training. (Source: Journal of Experimental and Clinical Cancer Research) MedWorm Message: Register...
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 11:00:00 pm
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Breast Cancer - news item 118 of 133
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Two young sisters both have double mastectomy after breast cancer claims mother, gran and great aunts
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Two young sisters in perfect health have had their breasts removed to cheat the deadly disease that has claimed the lives of both their mother and grandmother. (Source: the Mail online | Health) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 8:46:44 pm
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Breast Cancer - news item 119 of 133
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Alcohol May Increase Risk for Breast Cancer Recurrence
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Drinking 3 or 4 alcoholic beverages a week might increase the risk for recurrence and death in breast cancer patients; the effect is greatest in postmenopausal and overweight/obese women. Medscape Medical News (Source: Medscape Today Headlines)
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 8:26:53 pm
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Breast Cancer - news item 120 of 133
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SIU med school gets federal grant to study breast cancer
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Research scientist Sophia Ran at Southern Illinois University School of Medicine in Springfield won a five-year, more than $1.5 million grant from the National Cancer Institute to study ways to prevent or reduce metastasis in breast cancer. (Source: bizjournals.com Health Care:Biotechnology headlines)
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 7:48:04 pm
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Breast Cancer - news item 121 of 133
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New Breast Cancer Imaging Poses Much Greater Radiation Risk Than Mammography
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Compared with mammography, new techniques that use radioisotopes increase radiation risk more than 20-fold and should not be used for screening. Medscape Medical News (Source: Medscape Today Headlines)
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 7:24:35 pm
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Breast Cancer - news item 122 of 133
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Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment
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Recent medical advances have improved the understanding, diagnosis, and treatment of paraneoplastic syndromes. These disorders arise from tumor secretion of hormones, peptides, or cytokines or from immune cross-reactivity between malignant and normal tissues. Paraneoplastic syndromes may affect diverse organ systems, most notably the endocrine, neurologic, dermatologic, rheumatologic, and hematologic systems....
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 5:01:47 pm
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Breast Cancer - news item 123 of 133
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Mayo Clinic and UNF Host Sixth Annual Upbeat Pink:
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October is National Breast Cancer Awareness Month and Mayo Clinic and the University of North Florida are honoring the occasion by hosting the sixth annual "Upbeat Pink: A Musical Tribute to Breast Cancer Survivorship" concert on Friday, Oct. 15, at 8 p.m. at the UNF Lazzara Hall in Jacksonville. (Source:...
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 2:45:54 pm
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Breast Cancer - news item 124 of 133
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Video: Preventative Surgeries
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Dr. Jennifer Ashton discussed a new study that found a new preventative breast cancer surgery that may greatly decrease cancer risk. (Source: Health News: CBSNews.com) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 2:12:01 pm
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Breast Cancer - news item 125 of 133
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Bisulfite Patch PCR enables multiplexed sequencing of promoter methylation across cancer samples [METHOD]
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Aberrant DNA methylation frequently occurs at gene promoters during cancer progression. It is important to identify these loci because they are often misregulated and drive tumorigenesis. Bisulfite sequencing is the most direct and highest resolution assay for identifying aberrant promoter methylation. Recently, genomic capture methods have been combined with next-generation...
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 2:02:24 pm
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Breast Cancer - news item 126 of 133
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Eisai Announces Extension Of FDA Review Of Drug Application For Investigational Agent Eribulin Mesylate
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Eisai Inc. announced today that it has received notification from the U.S. Food and Drug Administration (FDA) that the agency expects to complete priority review of the eribulin mesylate New Drug Application (NDA) for locally advanced or metastatic breast cancer on or before December 30, 2010, which is a three...
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 1:00:00 pm
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Breast Cancer - news item 127 of 133
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High-fat diet during puberty linked to breast cancer
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Girls eating a high-fat diet during puberty, even those who do not become overweight or obese, appears to be at a greater risk of developing breast cancer during the later part of life, as per Michigan State University researchers. The implications - that a high-fat diet may have detrimental effects...
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 12:36:37 pm
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Breast Cancer - news item 128 of 133
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Link Between High-Fat Diet During Puberty And Breast Cancer Risk Later In Life
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Girls eating a high-fat diet during puberty, even those who do not become overweight or obese, may be at a greater risk of developing breast cancer later in life, according to Michigan State University researchers. The implications - that a high-fat diet may have detrimental effects independent of its effect...
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 12:00:00 pm
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Breast Cancer - news item 129 of 133
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JECCR: Microsoft Excel-based algorithm predicts cancer prognosis
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Using readily available computer programs such as Microsoft Excel, researchers can quickly generate valuable gene signatures for predicting breast cancer without specialized software or extensive bioinformatics training, according to an article published online Sept. 1 in Journal of Experimental & Clinical Cancer Research. (Source: Cardiovascular Business News)
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 10:58:25 am
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Breast Cancer - news item 130 of 133
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Swiss Breast Cancer Patient Becomes First In World To Receive Treatment Using Gated RapidArc From Varian Medical Systems
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A 51-year-old breast cancer patient from Switzerland has become the first person in the world to be treated using Gated RapidArc®, which makes it possible to monitor patient breathing and compensate for tumor motion while quickly delivering radiotherapy during a continuous rotation around the patient. This development from Varian Medical...
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 10:00:00 am
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Breast Cancer - news item 131 of 133
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Assessing the Prioritization of Primary Care Referrals for Polysomnograms
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Conclusion: In a public hospital, primary care patients were less likely to be referred for PSG compared to mammogram and endoscopy. Uninsured patients were more likely to be referred for PSG than those with private insurance. Further studies are needed to address the low PSG referral rates in high-risk populations....
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 9:38:01 am
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Breast Cancer - news item 132 of 133
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High-fat diet during puberty linked to breast cancer risk later in life
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Girls eating a high-fat diet during puberty, even those who do not become overweight or obese, may be at a greater risk of developing breast cancer later in life, according to researchers. The implications -- that a high-fat diet may have detrimental effects independent of its effect to cause obesity...
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 8:44:24 am
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Breast Cancer - news item 133 of 133
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Preventive Surgeries Linked To Lower Risk Of Breast And Ovarian Cancer
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Women with the inherited mutations of the BRCA1 or BRCA2 genes who had preventive (prophylactic) breast removal (mastectomy) or the removal of the fallopian tubes and ovaries (salpingo-oophorectomy) were found to have a significantly lower risk of developing ovarian and breast cancers, says a study published in JAMA (Journal of...
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RSS Source: Med Worm - Breast Cancer Wed, 1 Sep 2010 8:00:00 am
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