Creutzfeldt-Jakob Disease (CJD) - news item 1 of 88
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Serum tau protein as a marker for the diagnosis of Creutzfeldt-Jakob disease
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Abstract Total tau protein (t-tau) levels in cerebrospinal fluid (CSF) (CSF-tau) are markedly elevated in patients with Creutzfeldt-Jakob disease (CJD). Some CSF-tau may leak into the blood. We evaluated t-tau levels in serum (serum-tau) as a possible marker for the differential diagnosis of CJD from Alzheimer’s disease (AD) and other...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 28 Feb 2011 4:14:23 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 2 of 88
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Potential Treatment For Prion Diseases
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Scientists who examined more than 10,000 chemical compounds during the last year in search of potential new drugs for a group of untreatable brain diseases, are reporting that one substance shows unusual promise. The early positive signs for so-called prion diseases come from research in laboratory mice and cell cultures,...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Fri, 25 Feb 2011 8:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 3 of 88
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The risk of variant Creutzfeldtâ€Jakob disease among UK patients with bleeding disorders, known to have received potentially contaminated plasma products
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Summary.  The risk of variant Creutzfeldtâ€Jakob disease (vCJD) from potentially infected plasma products remains unquantified. This risk has been assessed for 787 UK patients with an inherited bleeding disorder prospectively followedâ€up for 10†20 years through the UK Haemophilia Centre Doctors’ Organisation (UKHCDO) Surveillance Study. These patients had been treated with...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Tue, 22 Feb 2011 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 4 of 88
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Improving Understanding Of The Spread Of Infectious Prions
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Researchers at the University of California, San Diego School of Medicine have identified the motors that move non-infectious prion proteins (PrPC) - found within many mammalian cells - up and down long, neuronal transport pathways. Identifying normal movement mechanisms of PrPC may help researchers understand the spread of infectious prions...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sat, 19 Feb 2011 7:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 5 of 88
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The Creutzfeldt†Jakob disease (CJD) neurological status scale: a new tool for evaluation of disease severity and progression
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Conclusions †  The CJDâ€NS scale is sensitive to neurological signs and their progression in CJD patients. (Source: Acta Neurologica Scandinavica)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 7 Feb 2011 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 6 of 88
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Blood Test Spots Variant CJD (CME/CE)
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(MedPage Today) -- A blood test to detect the abnormal prion proteins responsible for variant Creutzfeldt-Jakob disease (vCJD) -- aka mad cow disease -- showed good sensitivity and specificity in an early-stage study, researchers said. (Source: MedPage Today Infectious Disease) MedWorm Message: Watch the new MedWorm demo and find out...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 3 Feb 2011 7:17:18 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 7 of 88
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VCJD blood test developed in UK
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UK researchers have developed the first ever reliable blood test for the human version of CJD (Source: Nursing in Practice)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 3 Feb 2011 8:47:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 8 of 88
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Prion disease diagnosis just got easier
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By Tiffany O'Callaghan Invasive biopsy is currently the only sure way to diagnose the degenerative neurological condition Creutzfeldt-Jakob Disease (CJD). [More] (Source: Scientific American - Official RSS Feed)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sun, 30 Jan 2011 10:01:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 9 of 88
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Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion
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Authors: Ryuichiro Atarashi, Katsuya Satoh, Kazunori Sano, Takayuki Fuse, Naohiro Yamaguchi, Daisuke Ishibashi, Takehiro Matsubara, Takehiro Nakagaki, Hitoki Yamanaka, Susumu Shirabe, Masahito Yamada, Hidehiro Mizusawa, Tetsuyuki Kitamoto, Genevieve Klug, Amelia McGlade, Steven J Collins & Noriyuki Nishida The development of technologies for the in vitro amplification of abnormal conformations of...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sat, 29 Jan 2011 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 10 of 88
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CJD diagnosis just got easier
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Test for Creutzfeldt†Jakob disease raises hopes of speedier diagnosis. (Source: news@nature.com)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sat, 29 Jan 2011 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 11 of 88
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An autopsied case of V180I Creutzfeldtâ€Jakob disease presenting with panencephalopathicâ€type pathology and a characteristic prion protein type
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A 73â€yearâ€old Japanese woman showed slowly progressive aphasia, apraxia and dementia. She had no family history of prion disease or dementia. One year later she showed parkinsonism and corticobasal degeneration was initially suspected. On MRI, the left temporal neocortex seemed swollen on T2â€weighted images in the initial stage, and a...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Wed, 26 Jan 2011 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 12 of 88
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Fundamentals of prions and their inactivation (Review).
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Authors: Sakudo A, Ano Y, Onodera T, Nitta K, Shintani H, Ikuta K, Tanaka Y Prion is an infectious particle composed of an abnormal isoform of the prion protein (PrPSc) and causes prion diseases such as bovine spongiform encephalopathy (BSE), Creutzfeldt-Jakob disease (CJD) and scrapie. Host cells express cellular prion...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 24 Jan 2011 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 13 of 88
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RNA integrity in postâ€mortem human vCJD and control brain tissue
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Conclusion: Reasonable quality RNA can be isolated from samples dissected from archived frozen human half brains but repeated sampling results in RNA degradation. Better quality RNA is obtained from samples placed in RNALater than from snap frozen samples. The quality and yield of RNA are not affected by age at...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Wed, 19 Jan 2011 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 14 of 88
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Creutzfeldt-Jacob disease mimics, or how to sort out the subacute encephalopathy patient.
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Authors: Murray K Sporadic Creutzfeldt-Jacob disease (CJD) is a rare untreatable neurodegenerative disease which every neurologist will occasionally encounter during their career. However, it is likely to appear on their differential diagnosis list significantly more frequently. Numerous conditions can present with subacute encephalopathy which might be sporadic CJD and this...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Wed, 19 Jan 2011 7:30:31 am
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Creutzfeldt-Jakob Disease (CJD) - news item 15 of 88
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BSE Pathogens Can Be Transmitted By Air
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Airborne prions are also infectious and can induce mad cow disease or Creutzfeldt-Jakob disorder. This is the surprising conclusion of researchers at the University of Zurich, the University Hospital Zurich and the University of Tübingen. They recommend precautionary measures for scientific labs, slaughterhouses and animal feed plants. The prion is...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 17 Jan 2011 7:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 16 of 88
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Prions That Cause Mad Cow Disease Can Spread Through Air
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Prions, the agents that cause bovine spongiform encephalopathy (BSE or mad cow disease) and Creutzfeldt-Jakob disease, can spread through the air and induce infection, according to new research led by the University of Zurich; a discovery that may come as a great surprise to many, because until now it was...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sat, 15 Jan 2011 5:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 17 of 88
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Researchers Identify Drug Target For Prion Diseases, Including "Mad Cow"
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Scientists at the University of Kentucky have discovered that plasminogen, a protein used by the body to break up blood clots, speeds up the progress of prion diseases such as mad cow disease. This finding makes plasminogen a promising new target for the development of drugs to treat prion diseases...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Tue, 11 Jan 2011 8:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 18 of 88
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Genetic prion disease with codon 196 PRNP mutation: clinical and pathological findings.
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Authors: Schelzke G, Eigenbrod S, Romero C, Varges D, Breithaupt M, Taratuto AL, Kretzschmar HA, Zerr I Ten percent to 15% of all human transmissible spongiform encephalopathy are characterized by a mutation in prion protein gene (PRNP). They are distinct with respect to clinical signs, disease onset, disease duration, and...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 10 Jan 2011 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 19 of 88
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Transmission of sporadic Creutzfeldt-Jakob disease by blood transfusion: risk factor or possible biases.
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CONCLUSION: This is the first case-control study showing a significant risk of transfusion occurring more than 10 years before clinical onset in sporadic CJD patients. It remains questionable whether the significance of these data is biologically plausible or the consequence of biases in the design of the study, but they...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 6 Jan 2011 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 20 of 88
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Different CSF β-amyloid processing in Alzheimer’s and Creutzfeldt†Jakob disease
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Abstract Decreased levels of β-amyloid (Aβ) 1-42 in cerebrospinal fluid (CSF) are characteristic for Alzheimer’s disease (AD) and are also evident in Creutzfeldt†Jakob disease (CJD). Aβ plaques are thought to be responsible for this decrease in AD patients, whereas such Aβ plaques are rarely seen in CJD. To investigate...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Wed, 5 Jan 2011 3:49:24 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 21 of 88
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Discovery That Prions Mutate And Adapt To Host Environment Points To Normal Prion Protein As Most Effective Therapeutic Target For "Mad Cow" Disease
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Scientists from the Florida campus of The Scripps Research Institute have shown that prions, bits of infectious protein that can cause fatal neurodegenerative disease such as bovine spongiform encephalopathy (BSE) or "mad cow disease," have the ability to adapt to survive in a new host environment. In this regard, although...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 20 Dec 2010 8:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 22 of 88
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Early Detection May Be Possible For Prion Diseases: NIH Study
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A fast test to diagnose fatal brain conditions such as mad cow disease in cattle and Creutzfeldt-Jakob disease in humans could be on the horizon, according to a new study from National Institutes of Health scientists. Researchers at NIH's National Institute of Allergy and Infectious Diseases (NIAID) have developed a...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 6 Dec 2010 7:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 23 of 88
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Actions of the Japanese Pancreas and Islet Transplantation Association Regarding Transplanted Human Islets Isolated Using Liberase HI
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Conclusions: Three years of follow-up revealed that none of the Japanese recipients of islet transplants developed CJD. Prion bioassays showed that the Liberase HI used to isolate islets for transplantation was free of infectious TSE prions. (Source: Transplantation Proceedings)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Tue, 30 Nov 2010 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 24 of 88
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Counselling people with Creutzfeldt-Jakob Disease (CJD) and their families
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This article gives an account of the counselling service for people with Creutzfeldt-Jakob Disease (CJD) at the National Prion Clinic which is based in the National Hospital for Neurology and Neurosurgery in the UK and aims to provide information, advocacy and support from diagnosis through bereavement for people with a...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sun, 28 Nov 2010 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 25 of 88
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A case of dementia with Lewy bodies that temporarily showed symptoms similar to Creutzfeldt†Jakob disease
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AbstractWe discuss a case of a 67â€yearâ€old male with dementia with Lewy bodies (DLB) that was initially suspected as Creutzfeldt†Jakob disease (CJD) or another type of encephalopathy, because he showed rapidly progressive deterioration, myoclonus, gait disturbance and a decline in activities of daily living. The present study describes a...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 25 Nov 2010 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 26 of 88
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Generalized cerebral atrophy seen on MRI in a naturally exposed animal model for Creutzfeldt-Jakob disease
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Conclusions: Our findings indicate that MRI imaging can detect diffuse cerebral atrophy in asymptomatic and symptomatic sheep infected with scrapie. Nine of these 37 positive sheep, including 2 one-year old animals, were PrPSc positive only in lymph tissues but PrPSc negative in the brain. This suggests either 1) that the...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 25 Nov 2010 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 27 of 88
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Probable variant Creutzfeldt†Jakob disease in Asia: A case report from Taiwan and review of two prior cases
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New variant Creutzfeldt†Jakob disease (vCJD) was first identified in the UK in 1996, and was causally linked to bovine spongiform encephalopathy. Herein we report the first case of vCJD in Taiwan: a 34â€yearâ€old man who had lived in the UK between 1989 and 1997. The patient presented with depression,...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 25 Nov 2010 5:04:39 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 28 of 88
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Serial diffusion-weighted MRI and SPECT findings in a Creutzfeldt†Jakob disease patient with V180I mutation
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We report serial changes of diffusion-weighted imaging (DWI) and single photon emission computed tomography (SPECT) in a patient with Creutzfeldt†Jakob disease with V180I mutation (CJD180). DWI abnormalities in our patient were more predominantly observed in the left cerebral cortex than left basal ganglia. Hemilateral abnormalities progressed over 5months to...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sun, 21 Nov 2010 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 29 of 88
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Ultrastructural Characteristics (or Evaluation) of Creutzfeldt-Jakob Disease and Other Human Transmissible Spongiform Encephalopathies or Prion Diseases.
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Authors: Liberski PP, Sikorska B, Hauw JJ, Kopp N, Streichenberger N, Giraud P, Boellaard J, Budka H, Kovacs GG, Ironside J, Brown P The authors report on a large series of human prion diseases to establish ultrastructural characteristics that may be useful for their diagnosis. For Creutzfeldt-Jakob disease (CJD and...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sat, 13 Nov 2010 5:55:22 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 30 of 88
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Brother of man with CJD fights to get his treatment reinstated
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(No abstract is available for this citation) (Source: BMJ Online First) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 4 Nov 2010 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 31 of 88
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Variably protease-sensitive prionopathy in a PRNP codon 129 heterozygous UK patient with co-existing tau, α synuclein and Aβ pathology
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Content Type Journal ArticleDOI 10.1007/s00401-010-0766-yAuthors Mark W. Head, National CJD Surveillance Unit, School of Molecular and Clinical Medicine, The University of Edinburgh, Edinburgh, UKSuzanne Lowrie, National CJD Surveillance Unit, School of Molecular and Clinical Medicine, The University of Edinburgh, Edinburgh, UKGurjit Chohan, National CJD Surveillance Unit, School of Molecular and...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Tue, 2 Nov 2010 4:19:51 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 32 of 88
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The Prion Diseases
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The prion diseases are a family of rare neurodegenerative disorders that result from the accumulation of a misfolded isoform of the prion protein (PrP), a normal constituent of the neuronal membrane. Five subtypes constitute the known human prion diseases; kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), fatal insomnia (FI), and...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 1 Nov 2010 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 33 of 88
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Size Of Protein Aggregates, Not Abundance, Drives Spread Of Prion-Based Disease
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Mad Cow disease and its human variant Creutzfeldt-Jakob disease, which are incurable and fatal, have been on a welcome hiatus from the news for years, but because mammals remain as vulnerable as ever to infectious diseases caused by enigmatic proteins called prions, scientists have taken no respite of their own....
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 1 Nov 2010 6:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 34 of 88
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Genetic Creutzfeldt†Jakob disease and fatal familial insomnia: insights into phenotypic variability and disease pathogenesis
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Abstract Human prion diseases are a group of rare neurodegenerative disorders characterized by the conversion of the constitutively expressed prion protein, PrPC, into an abnormally aggregated isoform, called PrPSc. While most people who develop a prion disease have no identifiable cause and a few acquire the disease through an identified...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Tue, 26 Oct 2010 3:45:53 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 35 of 88
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The role of cerebrospinal fluid 14-3-3 and other proteins in the diagnosis of sporadic Creutzfeldt-Jakob disease in the UK: a 10-year review
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Background It is 10 years since the detection of cerebrospinal fluid (CSF) 14-3-3 was included in the diagnostic criteria for sporadic Creutzfeldt–Jakob disease (sCJD) by the WHO. Since that time, other CSF proteins, such as S100b and tau protein, have been proposed as surrogate markers for sCJD. The authors aimed...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 21 Oct 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 36 of 88
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14-3-3 protein detection and sporadic CJD: the status quo serves well while awaiting progress
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(No abstract is available for this citation) (Source: Journal of Neurology, Neurosurgery and Psychiatry)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 21 Oct 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 37 of 88
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POD01 Misleading MRI in two recent patients with variant Creutzfeldt-Jakob disease emphasises the importance of tissue diagnosis
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As the vCJD outbreak evolves we are alert to possible changes in the clinicopathological phenotype, investigations and genetic analysis. MRI typically shows high signal in the pulvinar nucleus on T2W images and has recently been added to the CJD diagnostic criteria. Here we report MRI findings prompting a diagnosis of...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 21 Oct 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 38 of 88
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Researchers Discover Eye Test For Neurological Diseases In Livestock
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The eyes of sheep infected with scrapie - a neurological disorder similar to mad cow disease - return an intense, almost-white glow when they're hit with blue excitation light, according to a research project led by Iowa State University's Jacob Petrich. The findings suggest technologies and techniques can be developed...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 21 Oct 2010 6:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 39 of 88
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UCSF'S Prusiner Receives President's National Medal Of Science
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UCSF Nobel laureate Stanley B. Prusiner, MD, UCSF professor of neurology and director of the Institute for Neurodegenerative Diseases, has been named to receive the National Medal of Science, the nation's highest honor for science and technology. Prusiner was among 10 recipients named by President Barack Obama. In addition, three...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 18 Oct 2010 7:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 40 of 88
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Study Results Are Consistent With Earlier Estimates Of VCJD Prion Prevalence In Britain
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This study involved using immunohistochemistry to examine 9,160 anonymised tonsils for the presence of abnormal prions and found one sample showing evidence of prions associated with vCJD... (Source: Health News from Medical News Today)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 4 Oct 2010 10:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 41 of 88
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Elevated levels of tau protein in cerebrospinal fluid of patients with probable creutzfeldt-jakob disease.
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CONCLUSIONS:: These data suggest that Chinese patients with probable CJD have similar increased levels of tau in the CSF as in Caucasian patients. Measurement of CSF tau will be another potential technique for antemortem CJD diagnosis. PMID: 20881758 [PubMed - in process] (Source: The American Journal of the Medical Sciences)...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 30 Sep 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 42 of 88
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013 Differential diagnosis of rapidly progressive dementia
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Abstract: Dementia, as a clinical syndrome, has many potential causes. The majority of cases are due to neurodegenerative diseases and/or vascular disease with relatively gradual progressive clinical courses. However, dementia can be rapidly progressive with time courses measured in only weeks or a few months. These more rapidly progressive dementias...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Fri, 24 Sep 2010 2:41:34 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 43 of 88
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Variant CJD: where has it gone, or has it?
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Authors: Will B PMID: 20858625 [PubMed - as supplied by publisher] (Source: Practical Neurology)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 23 Sep 2010 10:57:51 am
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Creutzfeldt-Jakob Disease (CJD) - news item 44 of 88
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The fiendish complexity of general practice
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A case of CJD close to home illustrates what is often forgotten in the myopic debate over GP pay and QOF points, says Nigel Praities. (Source: Pulse Today Clinical Updates) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Wed, 22 Sep 2010 3:01:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 45 of 88
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Iatrogenic Creutzfeldt-Jakob disease in Australia: time to amend infection control measures for pituitary hormone recipients?
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Authors: Boyd A, Klug GM, Schonberger LB, McGlade A, Brandel JP, Masters CL, Collins SJ From 1967, the Australian Human Pituitary Hormone Program offered treatment for short stature and infertility using human cadaver-acquired pituitary hormones (human growth hormone [hGH] and human pituitary gonadotrophin [hPG]). The program was suspended in 1985 when...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sun, 19 Sep 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 46 of 88
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Detecting Mad Cow Disease Via The Eyes Of Cattle
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The eyes may or may not be windows to the soul, as the old adage goes, but scientists are reporting evidence that a peek into the eyes of cattle may become the basis for a long-sought test to detect infection with the agent that causes Mad Cow Disease. That test...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Fri, 10 Sep 2010 7:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 47 of 88
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Tau and 14-3-3 of genetic and sporadic Creutzfeldt†Jakob disease patients in Israel
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Abstract One of the largest clusters of genetic Creutzfeldt†Jakob disease (gCJD) is found among Jews of Libyan origin in Israel and is linked to the E200K mutation in PRNP (gCJDE200K). The aim of this study was to compare the levels of cerebrospinal fluid (CSF) biomarkers, Tau and 14-3-3 proteins,...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 9 Sep 2010 4:49:20 am
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Creutzfeldt-Jakob Disease (CJD) - news item 48 of 88
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An atypical phenotype of CJD associated with the E200K mutation in the prion protein gene
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This report confirms the heterogeneity of phenotypes in E200K mutated familial CJD with the occurrence of a new phenotype not previously described. Content Type Journal ArticleDOI 10.1007/s10072-010-0388-0Authors Carlo Masullo, Institute of Neurology, Catholic University of Sacred Heart, 00168 Rome, ItalyAlessandra Bizzarro, Institute of Neurology, Catholic University of Sacred Heart, 00168...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sat, 21 Aug 2010 4:46:20 am
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Creutzfeldt-Jakob Disease (CJD) - news item 49 of 88
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Pruritus in familial Creutzfeldt†Jakob disease: a common symptom associated with central nervous system pathology
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Abstract Pruritus, a common feature of animal prion diseases such as scrapie, is rarely reported in humans with Creutzfeldt†Jakob disease (CJD), and its anatomical background is not well defined. The present study was undertaken to carry out a methodical prospective search for the prevalence of pruritus in CJD patients...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Fri, 20 Aug 2010 4:47:06 am
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Creutzfeldt-Jakob Disease (CJD) - news item 50 of 88
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New Sporadic Prion Protein Disease Identified By CWRU
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A new sporadic prion protein disease has been discovered. Variably protease-sensitive prionopathy (VPSPr), as it has been named, is the second type of complete sporadic disease to be identified since Creutzfeldt-Jakob disease (CJD) was reported in the 1920s. The landmark finding from the National Prion Disease Pathology Surveillance Center at...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sat, 14 Aug 2010 7:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 51 of 88
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Heterozygosity at Polymorphic Codon 219 in Variant Creutzfeldt-Jakob Disease [Observation]
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Conclusions The E219K polymorphism is neutral or may even confer susceptibility to vCJD. The observations are interpretable in the context of the conformational selection model of prion replication. A barrier to prion disease transmission depends on the degree to which permitted pathologic conformations of the prion protein overlap between the...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 9 Aug 2010 6:50:57 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 52 of 88
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Establishment of a standard 14-3-3 protein assay of cerebrospinal fluid as a diagnostic tool for Creutzfeldt†Jakob disease
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Establishment of a standard 14-3-3 protein assay of cerebrospinal fluid as a diagnostic tool for Creutzfeldt–Jakob disease Laboratory Investigation advance online publication, August 9, 2010. doi:10.1038/labinvest.2009.68 Authors: Katsuya Satoh, Minoru Tobiume, Yuki Matsui, Kazuo Mutsukura, Noriyuki Nishida, Yusei Shiga, Katsumi Eguhchi, Susumu Shirabe & Testutaro Sata (Source: Laboratory Investigation AOP)...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sun, 8 Aug 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 53 of 88
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New research: sporadic type of Creutzfeldt-Jakob disease (mad cow) results from surgery
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(NaturalNews) There is probably no more horrific and frightening incurable disease than Creutzfeldt-Jakob disease (CJD). Also known as the human form of mad cow disease, this degenerative, always fatal brain disorder strikes about one person in every million worldwide each year, according to the National Institute of Neurological Disorders and...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Wed, 4 Aug 2010 6:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 54 of 88
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Cloned milk
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The British public may have been subjected to an inadvertent experimentAge: Unclear. But keep refrigerated and drink within four days.Appearance: Like milk, but sinister.Cloned milk? Cloned milk? Do you mean milk that has been made from genetically identical milk? How is that possible? Are there little milk pods in the...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 2 Aug 2010 6:00:58 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 55 of 88
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Brain disease-causing prions can form spontaneously on contact with metal
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Prions, which cause a range of brain wasting conditions including Creutzfeldt–Jakob disease (CJD), can form spontaneously when healthy brain tissue comes into contact with metal. (Source: Medical Research Council Press Releases)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Tue, 27 Jul 2010 11:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 56 of 88
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Perils of the “Unstandard†and the habitual hygiene of hydrogels
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The Fusarium crisis and, later, the Acanthamoeba outbreak, shook the contact lens field after a period in which the regulatory sector was already charged by concerns over mad cow disease. Regulations imposed in Britain and France to contain a spread of mad cow disease, officially Creutzfeldt-Jacob Disease (CJD), threatened to...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sat, 24 Jul 2010 5:22:04 am
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Creutzfeldt-Jakob Disease (CJD) - news item 57 of 88
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Brain biopsy in dementia: clinical indications and diagnostic approach
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Abstract Brain biopsy may be performed to make a definitive diagnosis in patients with rapidly progressive dementia. To assess the value of this procedure, we previously studied 90 consecutive cerebral biopsies performed in the tertiary referral centre of the National Hospital for Neurology and Neurosurgery, Queen Square between 1989 and...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sat, 17 Jul 2010 8:10:16 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 58 of 88
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Surgery Linked To Creutzfeldt-Jakob Disease
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A new study spearheaded by Spanish scientists demonstrates a causal relationship between the onset of Creutzfeldt-Jakob disease (CJD), caused by a protein called a prion, and general surgery. CJD manifests itself in hereditary acquired; and sporadic forms, or for unknown reasons, which accounts for the majority of cases... (Source: Health...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Fri, 9 Jul 2010 8:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 59 of 88
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Surgery linked to Creutzfeldt-Jakob disease, according to Spanish study
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A new study spearheaded by Spanish scientists demonstrates a causal relationship between the onset of Creutzfeldt-Jakob disease (CJD), caused by a protein called a prion, and general surgery. (Source: ScienceDaily Headlines) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Fri, 9 Jul 2010 2:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 60 of 88
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Cathepsin D (C224T) Polymorphism in Sporadic and Genetic Creutzfeldt-Jakob Disease
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Accumulation of cathepsin D immunoreactive lysosomes correlates with tissue pathology in sporadic Creutzfeldt-Jakob disease (CJD) brains. The C-to-T transition within exon 2 of the cathepsin D (CTSD) gene is associated with altered enzymatic activity. Possession of the TT genotype is a risk factor for variant CJD. To verify the association...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 8 Jul 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 61 of 88
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Proliferative arrest of neural cells induces prion protein synthesis, nanotube formation, and cell-to-cell contacts
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Host prion protein (PrP) is most abundant in neurons where its functions are unclear. PrP mRNA transcripts accumulate at key developmental times linked to cell division arrest and terminal differentiation. We sought to find if proliferative arrest was sufficient to cause an increase in PrP in developing neurons. Rat neuronal...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 5 Jul 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 62 of 88
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Familial Creutzfeldt-Jakob disease with V180I mutation.
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We report a 75-yr-old woman with familial CJD carrying a V180I mutation which features late onset, slow progression, no periodic sharp wave complexes on electroencephalography, and extensive cortical ribboning with spared the cerebellum and the medial occipital lobes posterior to the parieto-occipital sulcus on MRI. To our knowledge, this is...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Wed, 30 Jun 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 63 of 88
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Genetic Creutzfeldt-Jakob disease associated with the E200K mutation: characterization of a complex proteinopathy
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Abstract The E200K mutation is the most frequent prion protein gene (PRNP) mutation detected worldwide that is associated with Creutzfeldt-Jakob disease (CJD) and thought to have overlapping features with sporadic CJD, yet detailed neuropathological studies have not been reported. In addition to the prion protein, deposition of tau, α-synuclein, and...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Wed, 30 Jun 2010 2:20:51 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 64 of 88
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Heidenhain variant of Creutzfeldt†Jakob disease diagnosis: Place of MRI
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We report a new case of Heidenhaim variant and present MRI evolution at different stages of disease. Despite the fact that cerebral MRI is helpful for diagnosis particularly with the sensitivity and specificity of fluid-attenuated inversion recovery (FLAIR), diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping, this imaging must...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sun, 27 Jun 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 65 of 88
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In Prion Disease Transmission Sequence And Structure Is Key
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Prion diseases are lethal neurodegenerative disorders that include Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE; commonly known as mad cow disease) in cows. A team of researchers, led by Adriano Aguzzi and Christina Sigurdson, at UniversitätsSpital Zürich, Switzerland, has generated data in mice that provides greater understanding...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Tue, 15 Jun 2010 8:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 66 of 88
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Sporadic Creutzfeldt†Jakob disease presenting as nonconvulsive status epilepticus case report and review of the literature
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We report a 64-year-old woman with rapid cognitive decline who had electroencephalographic (EEG) changes suggestive of nonconvulsive status epilepticus (NCSE). She was later diagnosed with sporadic CJD (sCJD). We also reviewed the literature for published cases on this topic. MEDLINE was employed to identify all published reports of CJD and...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Fri, 4 Jun 2010 2:15:26 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 67 of 88
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Cortical propagation of Creutzfeldt†Jakob disease with codon 180 mutation
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Abstract: A patient with Creutzfeldt†Jakob disease (CJD) with prion protein (PrP) gene codon 180 mutation (CJD 180) experienced cognitive decline over the 1.5-year period before her death. Serial magnetic resonance imaging (MRI) studies tracked stepwise propagation of cortical abnormal swelling and T2 elongations.On postmortem examination, the cortical areas affected...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Fri, 4 Jun 2010 2:15:25 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 68 of 88
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Detecting CJD Through The Eyes Of Cattle
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The eyes may or may not be windows to the soul, as the old adage goes, but scientists are reporting evidence that a peek into the eyes of cattle may become the basis for a long-sought test to detect infection with the agent that causes Mad Cow Disease. That test...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 3 Jun 2010 12:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 69 of 88
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Dyshoric capillary cerebral amyloid angiopathy mimicking Creutzfeldt†Jakob disease
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Discussion: Patients with a clinical suspicion of CJD, supported by EEG and/or CSF abnormalities can have severe capillary CAA with dyshoric changes in addition to the presence of neurofibrillary tangles. Possibly dyshoric capillary CAA can contribute to rapid clinical progression in dementia. (Source: Journal of the Neurological Sciences)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 31 May 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 70 of 88
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Guidance for Industry: Revised Preventive Measures to Reduce the Possible Risk of Transmission of Creutzfeldt-Jakob Disease (CJD) and Variant Creutzfeldt-Jakob Disease (vCJD) by Blood and Blood Products
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(Source: What's New at CBER)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 27 May 2010 3:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 71 of 88
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Development of an Ultra-Rapid Diagnostic Method Based on Heart-Type Fatty Acid Binding Protein Levels in the CSF of CJD Patients.
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In conclusion, Rapicheck((R)) H-FABP of CSF specimens enabled quick and frequent diagnosis of CJD. H-FABP represents a new biomarker for CJD distinct from 14-3-3 protein and total tau protein. PMID: 20499272 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Neurobiology)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 24 May 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 72 of 88
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Somatic mosaicism in a case of apparently sporadic Creutzfeldt-Jakob disease carrying a de novo D178N mutation in the PRNP gene
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Transmissible spongiform encephalopathies (TSEs) are a group of rare fatal neurodegenerative disorders. Creutzfeldt-Jakob disease (CJD) represents the most common form of TSE and can be classified into sporadic, genetic, iatrogenic and variant forms. Genetic cases are related to prion protein gene mutations but they only account for 10-20% of cases....
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sun, 23 May 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 73 of 88
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Tau, prions and Aβ: the triad of neurodegeneration
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This article highlights the features that connect prion diseases with other cerebral amyloidoses and how these relate to neurodegeneration, with focus on tau phosphorylation. It also discusses similarities between prion disease and Alzheimer’s disease: mechanisms of amyloid formation, neurotoxicity, pathways involved in triggering tau phosphorylation, links to cell cycle pathways...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Sat, 15 May 2010 7:02:03 am
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Creutzfeldt-Jakob Disease (CJD) - news item 74 of 88
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[Protection from BSE : Efforts, measures, success, and costs.]
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Authors: Deischl K, Habereder P, Hautmann W, Hellwig M, Ludwig M, Mitschek C, Nottenkämper-Gerth D, Schick M, Sing A, Wildner M, Zapf A By the mid 1980s, bovine spongiform encephalopathy (BSE) emerged in the United Kingdom (UK) and reached its peak in the early 1990s with up to 37,000 cases....
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Fri, 7 May 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 75 of 88
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What Are The Treatment Options For Creutzfeldt-Jakob Disease (CJD)? Prevention Of CJD
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As of 2010, no generally accepted treatment for CJD exists; the disease is invariably fatal and research continues. No effective treatment exists for Creutzfeldt-Jakob disease or any of its variants. Clinical studies are being carried out and a number of drugs have been tested including steroids, antibiotics and antiviral agents....
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 19 Apr 2010 6:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 76 of 88
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How Is Creutzfeldt-Jakob Disease (CJD) Diagnosed? Diagnosing Creutzfeldt-Jakob Disease (CJD)
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Only a brain biopsy or an examination of brain tissue after death during autopsy can confirm (diagnose) the presence of Creutzfeldt-Jakob disease (CJD). However, doctors often can make an accurate diagnosis based on the patient's medical and personal history, a neurological exam, and certain diagnostic tests... (Source: CJD / vCJD / Mad...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 19 Apr 2010 6:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 77 of 88
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What Are The Risk Factors Of Creutzfeldt-Jakob Disease (CJD)?
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Most cases of Creutzfeldt-Jakob disease (CJD) occur for unknown reasons. Furthermore, no precise risk factors can be identified. However, a few factors seem to be associated with different kinds of CJD. Age. Sporadic CJD tends to develop later in life, usually around the age of 60. Onset of familial CJD...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 19 Apr 2010 6:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 78 of 88
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How Is Creutzfeldt-Jakob Disease (CJD) Transmitted? Can CJD Be Transmitted From Person To Person?
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Researchers have identified three basic ways that Creutzfeldt-Jakob disease (CJD) may develop: Spontaneously. Most people with classic CJD develop the disease for no apparent reason. CJD cases occurring without explanation are called spontaneous CJD or sporadic CJD. This is the great majority of all cases. Normally, sCJD affects people over...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 19 Apr 2010 6:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 79 of 88
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What Are The Causes Of Creutzfeldt-Jakob Disease (CJD)?
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Creutzfeldt-Jakob disease (CJD) and its variants belong to a broad group of human and animal diseases known as transmissible spongiform encephalopathies (TSEs). The name "spongiform" comes from the spongy holes that develop in affected brain tissue and are visible under a microscope... (Source: CJD / vCJD / Mad Cow Disease News From...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 19 Apr 2010 6:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 80 of 88
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What Are The Signs And Symptoms Of Creutzfeldt-Jakob Disease (CJD)? What Are The Complications Of CJD?
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Creutzfeldt-Jakob disease or CJD is characterized by rapid mental deterioration. The disease typically starts by causing mental and emotional problems, then progresses to affect motor skills, such as walking and talking. Sometimes, however, motor problems are experienced from the start... (Source: CJD / vCJD / Mad Cow Disease News From Medical News...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 19 Apr 2010 6:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 81 of 88
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What Is Creutzfeldt-Jakob Disease (CJD)? What Is Mad Cow Disease?
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Creutzfeldt-Jakob disease, also known as CJD, or mad cow disease, is a rare and fatal brain disorder. It is a neurological illness that causes damage to the brain. The early symptoms resemble those of Alzheimer's and other types of dementia. However, Creutzfeldt-Jakob disease progresses much more rapidly... (Source: CJD / vCJD /...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 19 Apr 2010 6:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 82 of 88
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Chronix Biomedical Partners With University Of Calgary To Commercialize Serum DNA-Based Blood Test For Mad Cow Disease
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Chronix Biomedical today announced that it is partnering with the University of Calgary to develop a commercial version of its serum DNA-based blood test for the early detection of bovine spongiform encephalopathy (BSE), also known as mad cow disease. Chronix researchers have published data demonstrating that the company's proprietary techniques...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Thu, 15 Apr 2010 7:00:00 am
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Creutzfeldt-Jakob Disease (CJD) - news item 83 of 88
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The first Chinese case of Creutzfeldt-Jakob disease with mutation of E200K in PRNP.
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CONCLUSION: The CJD patient who was first reported in China has a missense mutation in codon 200 (E200K) of the PRNP, and the codon 129 is a methionine homozygous genotype. PMID: 20514992 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Wed, 31 Mar 2010 10:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 84 of 88
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Video - Creutzfeldt-Jakob disease real stories
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Francesca has a genetic form of Creutzfeldt-Jakob disease (CJD) and Colin's wife was diagnosed with sporadic CJD in 2006. In this video they explain how it affects their lives. (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Tue, 30 Mar 2010 4:34:17 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 85 of 88
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Video - Creutzfeldt-Jakob disease
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In this video Professor John Collinge of the National Prion Clinic explains different variants of CJD, a rare neurological illness that causes damage to the brain and for which there is no cure. (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Tue, 30 Mar 2010 4:33:20 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 86 of 88
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[Creutzfeldt-Jakob disease - Possible to treat in the future?]
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Authors: Stølsmark T, Tysnes OB Background. Creutzfeldt-Jakob disease (CJD) is a rare neurological disease which is always terminal, often within months. The disease attracted attention in the 1990s, when reports appeared about people acquiring the disease by eating meat from cattle infected with BSE (bovin spongiform encephalopathy). Recent progress within...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Wed, 24 Mar 2010 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 87 of 88
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Quantification of Thymosin beta 4 in Human Cerebrospinal Fluid using MALDI TOF Mass Spectrometry.
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Authors: Urso E, Pera ML, Bossio S, Sprovieri T, Qualtieri A Matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry (TOF MS) has been applied to the analysis of a wide range of biomolecules. To date there are two specific areas of application where MALDI-TOF-MS has been viewed as impractical: i.e., the...
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Tue, 23 Mar 2010 11:00:00 pm
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Creutzfeldt-Jakob Disease (CJD) - news item 88 of 88
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High-b-Value Diffusion MR Imaging and Basal Nuclei Apparent Diffusion Coefficient Measurements in Variant and Sporadic Creutzfeldt-Jakob Disease [BRAIN]
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CONCLUSIONS: Our results demonstrate that b = 3000 DWI, being more sensitive to slowly diffusing tissue water, is more sensitive to pathology in sCJD than is conventional DWI. High-b-value DWI increases confidence in the radiologic diagnosis of human prion disease. (Source: American Journal of Neuroradiology)
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RSS Source: Med Worm - CJD (Creutzfeldt-Kakob Disease) Mon, 15 Mar 2010 2:24:07 pm
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