Cystic Fibrosis - news item 1 of 137
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Challenges and advances in the development of inhalable drug formulations for cystic fibrosis lung disease
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Expert Opinion on Drug Delivery, Volume 0, Issue 0, Page 1-16, Early Online. (Source: Expert Opinion: Expert Opinion on Drug Delivery: Table of Contents)
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RSS Source: Med Worm - Cystic Fibrosis Sun, 6 Mar 2011 3:03:16 am
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Cystic Fibrosis - news item 2 of 137
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Low abundance of sweat duct Cl- channel CFTR in both healthy and cystic fibrosis athletes with exceptionally salty sweat during exercise
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To understand potential mechanisms explaining interindividual variability observed in human sweat sodium concentration ([Na+]), we investigated the relationship among [Na+] of thermoregulatory sweat, plasma membrane expression of Na+ and Cl– transport proteins in biopsied human eccrine sweat ducts, and basal levels of vasopressin (AVP) and aldosterone. Lower ductal luminal membrane...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 3 Mar 2011 11:00:00 pm
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Cystic Fibrosis - news item 3 of 137
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Mutations of the cystic fibrosis gene in patients with bronchiectasis associated with rheumatoid arthritis
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Conclusions RA-DB should be added to the list of phenotypes in which CFTR mutations are pathogenic. CFTR mutation is the first genetic defect linked to an extra-articular feature of RA to be described. CFTR mutations in patients with RA appear to be an important marker of the risk of associated...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 2 Mar 2011 11:00:00 pm
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Cystic Fibrosis - news item 4 of 137
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Resveratrol rescues cAMPâ€dependent anionic transport in the cystic fibrosis pancreatic cell line CFPAC1
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Conclusion and implications: These results show that resveratrol modulated CFTR expression and localisation and could rescue cAMPâ€dependent chloride transport in delF508CFTR cells. (Source: British Journal of Pharmacology)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 2 Mar 2011 11:00:00 pm
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Cystic Fibrosis - news item 5 of 137
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First drug to tackle cause of cystic fibrosis ¿on sale as soon as next year¿
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If trials on children are as successful, manufacturers Vertex Pharmaceuticals could apply later this year for permission to market the drug in Europe. Clearance is likely in 2012. (Source: the Mail online | Health)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 2 Mar 2011 7:10:44 pm
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Cystic Fibrosis - news item 6 of 137
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Practice Parameters for the Respiratory Indications for Polysomnography in Children
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Conclusions:Current evidence in the field of pediatric sleep medicine indicates that PSG has clinical utility in the diagnosis and management of sleep related breathing disorders. The accurate diagnosis of SRBD in the pediatric population is best accomplished by integration of polysomnographic findings with clinical evaluation.Citation: Aurora RN; Zak RS; Karippot...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 2 Mar 2011 12:45:49 pm
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Cystic Fibrosis - news item 7 of 137
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5th European CF Young Investigator Meeting - Lille (France) 23/26 August 2011
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(Source: Cystic Fibrosis Worldwide)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 2 Mar 2011 10:23:17 am
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Cystic Fibrosis - news item 8 of 137
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Aztreonam Lysine for Inhalation Solution in Cystic Fibrosis: Profile Report
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(Source: Pediatric Drugs)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 2 Mar 2011 1:30:48 am
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Cystic Fibrosis - news item 9 of 137
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Trimethylangelicin reduces IL-8 transcription and potentiates CFTR function
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In conclusion, TMA is a dual-acting compound reducing excessive IL-8 expression and potentiating CFTR function. (Source: AJP: Lung Cellular and Molecular Physiology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Cystic Fibrosis Tue, 1 Mar 2011 11:00:00 pm
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Cystic Fibrosis - news item 10 of 137
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Properties of substance P-stimulated mucus secretion from porcine tracheal submucosal glands
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Human and pig airway submucosal glands secrete mucus in response to substance P (SubP), but in pig tracheal glands the response to SubP is >10-fold greater than in humans and shares features with cholinergically produced secretion. CFTR-deficient pigs provide a model for human cystic fibrosis (CF), and in newborn CF...
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RSS Source: Med Worm - Cystic Fibrosis Tue, 1 Mar 2011 11:00:00 pm
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Cystic Fibrosis - news item 11 of 137
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Nasal potential difference to detect Na+ channel dysfunction in acute lung injury
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Pulmonary fluid clearance is regulated by the active transport of Na+ and Cl– through respiratory epithelial ion channels. Ion channel dysfunction contributes to the pathogenesis of various pulmonary fluid disorders including high-altitude pulmonary edema (HAPE) and neonatal respiratory distress syndrome (RDS). Nasal potential difference (NPD) measurement allows an in vivo...
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RSS Source: Med Worm - Cystic Fibrosis Tue, 1 Mar 2011 11:00:00 pm
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Cystic Fibrosis - news item 12 of 137
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CF Europe Annual meeting Hamburg
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(Source: Cystic Fibrosis Worldwide)
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RSS Source: Med Worm - Cystic Fibrosis Tue, 1 Mar 2011 6:58:38 pm
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Cystic Fibrosis - news item 13 of 137
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Inhaled hypertonic saline in infants and toddlers with cystic fibrosis: shortâ€term tolerability, adherence, and safety
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Conclusions7% HS appears well tolerated for up to 14 days in infants and toddlers with CF, with high adherence. These results provide encouraging shortâ€term tolerability and adherence data for future trials assessing the safety and efficacy of 7% HS in young children with CF. Pediatr. Pulmonol. © 2011 Wileyâ€Liss, Inc. (...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 28 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 14 of 137
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Elevated vascular endothelial growth factor is correlated with elevated erythropoietin in stable, young cystic fibrosis patients
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AbstractAngiogenesis is an important mechanism of airway remodeling in lung disease. We previously demonstrated that serum vascular endothelial growth factor (VEGF) is elevated in cystic fibrosis (CF) patients and declines with therapy for pulmonary exacerbation. We hypothesized that VEGF is elevated early in the course of CF and is associated...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 28 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 15 of 137
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Bronchoscopy in Cystic Fibrosis Infants Diagnosed by Newborn Screening
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ConclusionsThe high yield of microbiology, cytology, and pH probe investigations in NBS infants justifies invasive surveillance. Longitudinal studies to determine if early aggressive treatment results in improved outcome are awaited. Pediatr. Pulmonol. © 2011 Wileyâ€Liss, Inc. (Source: Pediatric Pulmonology)
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RSS Source: Med Worm - Cystic Fibrosis Mon, 28 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 16 of 137
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Cohort study finds improved survival in patients with cystic fibrosis and low lung function
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Source: BMJ Area: News According to the findings of a cohort study conducted by a cystic fibrosis (CF) unit in London, there has been a marked improvement in the survival of patients with CF who have a low lung function, some of which may be due to the use of...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 28 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 17 of 137
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The cystic fibrosis sufferer who defied doctors and took off around the world... with a backpack full of life-saving drugs
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Doctors said Cavan Arrowsmith should be dead by now, but he stuffed a backpack with lifesaving drugs and set out on a global tour. (Source: the Mail online | Health)
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RSS Source: Med Worm - Cystic Fibrosis Mon, 28 Feb 2011 9:45:06 pm
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Cystic Fibrosis - news item 18 of 137
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Improved survival at low lung function in cystic fibrosis: cohort study from 1990 to 2007
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Objectives To evaluate the survival of patients with cystic fibrosis whose lung function has deteriorated to a forced expiratory volume in one second (FEV1) below 30% predicted in the recent... (Source: BMJ Online First)
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RSS Source: Med Worm - Cystic Fibrosis Sun, 27 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 19 of 137
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Personalized Medicine: A Discussion
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I was absolutely thrilled by the conversation generated by my post on the implications of Vertex Pharmaceuticals' success with a new drug to treat cystic fibrosis. The medicine basically undid five years of lung deterioration for patients who took it, but will only work for those whose CF is caused...
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RSS Source: Med Worm - Cystic Fibrosis Fri, 25 Feb 2011 6:16:19 pm
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Cystic Fibrosis - news item 20 of 137
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Health Tip: If Your Child Has Cystic Fibrosis
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Make sure nutritional needs are met (Source: The Doctors Lounge - Health News) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Cystic Fibrosis Fri, 25 Feb 2011 12:00:00 pm
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Cystic Fibrosis - news item 21 of 137
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Heme Induces IL-8 in CF Epithelium via Meprin/EGFR/TLR [Signal Transduction]
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This study illustrates the proinflammatory effects of micro-bleeds in the CF lung, the process by which this occurs, and a potential therapeutic intervention. (Source: Journal of Biological Chemistry)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 24 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 22 of 137
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Cystic Fibrosis: CFTR Correctors to the Rescue.
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Authors: Sheppard DN Cystic fibrosis transmembrane conductance regulator (CFTR) correctors are small molecules that target the most common cause of cystic fibrosis: misfolded F508del-CFTR. Using differential scanning fluorimetry, Sampson et al. (2010) identify a CFTR corrector that interacts directly with the CFTR domain affected by the F508del mutation. PMID: 21338913 [PubMed...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 24 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 23 of 137
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Identification of a NBD1-Binding Pharmacological Chaperone that Corrects the Trafficking Defect of F508del-CFTR.
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Authors: Sampson HM, Robert R, Liao J, Matthes E, Carlile GW, Hanrahan JW, Thomas DY Most cases of cystic fibrosis (CF) are attributable to the F508del allele of CFTR, which causes the protein to be retained in the endoplasmic reticulum (ER) and subsequently degraded. One strategy for CF therapy is...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 24 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 24 of 137
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Cystic Fibrosis Drug Succeeds in Phase III Trial
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An experimental drug developed by Vertex Pharmaceuticals Inc significantly improved lung function in a late-stage trial of patients with cystic fibrosis. Reuters Health Information (Source: Medscape Medical News Headlines)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 24 Feb 2011 9:31:37 pm
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Cystic Fibrosis - news item 25 of 137
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New drug is 'champagne moment' for cystic fibrosis
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The drug has proved a success in clinical trials for improving lung function (Source: New Scientist - Health)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 24 Feb 2011 5:02:19 pm
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Cystic Fibrosis - news item 26 of 137
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A Big And Dangerous Day For Personalized Medicine
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Source: Matthew Herper, Forbes Content: “Twenty-two years ago Francis Collins, who would go on to head the Human Genome Project and run the National Institutes of Health, was part of a team that found the gene that, when mutated, caused cystic fibrosis, a deadly childhood disease in which the lungs...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 24 Feb 2011 1:55:08 pm
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Cystic Fibrosis - news item 27 of 137
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Novel Cystic Fibrosis Agent Passes Another Test
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(MedPage Today) -- In a phase III trial, an investigational drug -- VX-770 -- improved respiratory function in patients with one of the less common mutations causing cystic fibrosis, the company developing the drug announced. (Source: MedPage Today Pulmonary)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 24 Feb 2011 12:00:00 pm
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Cystic Fibrosis - news item 28 of 137
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Phase 3 Study Of VX-770 Shows Marked Improvement In Lung Function Among People With Cystic Fibrosis With G551D Mutation
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The Cystic Fibrosis Foundation and Vertex Pharmaceuticals announced that VX-770, an oral medicine in development that targets the defective protein that causes cystic fibrosis, showed promising results in a Phase 3 clinical trial. The trial was designed to evaluate patients age 12 and up who carry at least one copy...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 24 Feb 2011 11:00:00 am
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Cystic Fibrosis - news item 29 of 137
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Superlawyer Stanley Chesley Faces Disbarment Over Fen-Phen Case% Vertex May Make History With Cystic Fibrosis Drug% Is Randal J. Kirk Biotech's Best Investor?
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2% 0% 0 (Source: Forbes.com Healthcare News)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 23 Feb 2011 11:00:04 pm
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Cystic Fibrosis - news item 30 of 137
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Cystic Fibrosis and The Innate Immune System: Therapeutic Implications.
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Authors: Conese M Cystic Fibrosis (CF), the most common autosomal lethal disorder in Caucasians, is caused by mutation in the CF transmembrane conductance regulator (CFTR) gene. Although CF is multi-organ disease, the lung pathology is the chief cause of morbidity and mortality of CF patients. The hallmarks of CF lung...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 23 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 31 of 137
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Horizon scanning: Promising phase III data for new cystic fibrosis drug VX-770
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Source: BioSpace, Reuters Health News Area: News The Cystic Fibrosis Foundation and Vertex Pharmaceuticals have announced promising results from a phase III clinical trial of VX-770, an investigational oral therapy that targets a defective protein that causes cystic fibrosis (CF). The placebo controlled trial involved 161 patients aged 12 years...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 23 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 32 of 137
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Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients
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Lee B, Schjerling CK, Kirkby N, Hoffmann N, Borup R, Molin S, Høiby N, Ciofu O. Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients. APMIS 2011.Phenotypic and genotypic diversifications of Pseudomonas aeruginosa in the airways of...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 23 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 33 of 137
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Cystic fibrosis transmembrane conductance regulator is helpful in the distinction of extraâ€mammary Paget's disease from squamous cell carcinoma in situ (Bowen's disease)
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Cystic fibrosis transmembrane conductance regulator (CFTR) represents a cAMPâ€dependent channel found in normal apocrine glands. The classification and histogenesis of extraâ€mammary Paget's disease (EMPD) remains controversial, but it is generally accepted that primary EMPD exhibits apocrine differentiation. Therefore, we examined the utility of CFTR in the differential diagnosis of EMPD...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 23 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 34 of 137
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Cystic fibrosis-related diabetes guidelines published
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(Source: PharmacoEconomics and Outcomes News)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 23 Feb 2011 10:05:03 pm
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Cystic Fibrosis - news item 35 of 137
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Vertex shares soar on cystic fibrosis drug data
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NEW YORK (Reuters) - Vertex Pharmaceuticals Inc said its experimental cystic fibrosis drug had met the main goal of a late-stage study, sending shares of the U.S. biotechnology company up 19 percent. (Source: Reuters: Health) MedWorm Message: Watch the new MedWorm demo and find out how to get all the...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 23 Feb 2011 12:07:59 pm
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Cystic Fibrosis - news item 36 of 137
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Prescriptions: Cystic Fibrosis Drug Clears Hurdle
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Vertex said that the drug, VX-770, which is designed to counter one specific genetic mutation, improved lung function in people with cystic fibrosis in a late-stage clinical trial. (Source: NYT Health)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 23 Feb 2011 11:50:29 am
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Cystic Fibrosis - news item 37 of 137
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Vertex May Make History With Cystic Fibrosis Drug
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In a potentially historic victory, a drug targeted to a specific genetic defect has improved the ability of cystic fibrosis patients to exhale. (Source: Forbes.com Healthcare News)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 23 Feb 2011 11:30:09 am
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Cystic Fibrosis - news item 38 of 137
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A 2-year post-authorization safety study of high-strength pancreatic enzyme replacement therapy (pancreatin 40,000) in cystic fibrosis
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Expert Opinion on Drug Safety, Volume 10, Issue 2, Page 197-203, March 2011. (Source: Expert Opinion: Expert Opinion on Drug Safety: Table of Contents)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 23 Feb 2011 11:28:51 am
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Cystic Fibrosis - news item 39 of 137
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DNA Of Cystic Fibrosis Superbug To Be Sequenced
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The bacterium, called Pseudomonas aeruginosa, is the most common cause of persistent and fatal lung infections in cystic fibrosis patients. Scientists at Liverpool identified a particularly virulent strain of the bacteria that is transmissible between patients. The Liverpool Epidemic Strain (LES), referred to as a cystic fibrosis 'superbug', can cause...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 23 Feb 2011 8:00:00 am
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Cystic Fibrosis - news item 40 of 137
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Noninvasive assessment of cystic fibrosis associated liver disease with the acoustic radiation force impulse imaging
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(Source: Hepatology)
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RSS Source: Med Worm - Cystic Fibrosis Tue, 22 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 41 of 137
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In vitro activity of fusidic acid (CEM-102, sodium fusidate) against Staphylococcus aureus isolated from cystic fibrosis patients and its effect on the activities of tobramycin and amikacin against Pseudomonas aeruginosa and Burkholderia cepacia.
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Authors: McGhee P, Clark C, Credito K, Beachel L, Pankuch GA, Appelbaum PC, Kosowska-Shick K We tested the MICs of fusidic acid (CEM-102) + other agents against 40 MRSA from cystic fibrosis patients; and fusidic acid activity ± tobramycin or amikacin, against Pseudomonas aeruginosa, MRSA, and Burkholderia cepacia from cystic patients...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 21 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 42 of 137
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In Vitro Activities against Cystic Fibrosis Pathogens of Synthetic Host Defence Propeptides Processed by Neutrophil Elastase.
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Authors: Desgranges S, Le Prieult F, Daly A, Lydon J, Brennan M, Rai DK, Subasinghage AP, Hewage CM, Cryan SA, Greene C, McElvaney NG, Smyth TP, Fitzgerald-Hughes D, Humphreys H, Devocelle M The antimicrobial and haemolytic activities of a host defence peptide can be controlled by modification as a propeptide...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 21 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 43 of 137
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Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease [Biochemistry]
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Cystic fibrosis is caused by impaired ion transport due to mutated cystic fibrosis transmembrane conductance regulator, accompanied by elevated activity of the amiloride-sensitive epithelial Na+ channel (ENaC). Here we show that knockout of the ubiquitin ligase Nedd4L (Nedd4-2) specifically in lung epithelia (surfactant protein C-expressing type II and Clara cells)...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 21 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 44 of 137
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Bacteria's role in colon cancer, cystic fibrosis; burning paper to measure carbon
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Here's a not-so-savory news flash: There are more bacterial cells living in our bodies than human cells. Researchers are learning how the balance of these bugs affects our health, but reaping the benefits of bacteria is not quite as simple as eating probiotic yogurt. That's the gist of "The Good,... (...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 21 Feb 2011 3:57:00 pm
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Cystic Fibrosis - news item 45 of 137
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Scientists to sequence DNA of cystic fibrosis superbug
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(University of Liverpool) Scientists at the University of Liverpool are using the latest DNA sequencing technology to understand the diversity of a bacterium that causes severe lung infection in cystic fibrosis patients. (Source: EurekAlert! - Infectious and Emerging Diseases)
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RSS Source: Med Worm - Cystic Fibrosis Mon, 21 Feb 2011 4:00:00 am
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Cystic Fibrosis - news item 46 of 137
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The effect of early Pseudomonas aeruginosa treatment on lung function in pediatric cystic fibrosis
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ConclusionsLung function was not different between patients with early P. aeruginosa infection and those that never had P. aeruginosa infection. However given the slow rate of FEV1 decline in the study population, a longer observation period and/or more sensitive outcomes measures may be required to exclude longâ€term detrimental effects of...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 17 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 47 of 137
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Complementary and alternative therapies: Use in pediatric pulmonary medicine
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AbstractWith increased awareness of complementary/alternative medicine (CAM) and concern of potential adverse effects or limited effectiveness of conventional medications, patients and parents are looking to CAM approaches as either an alternative or as adjunct therapy, especially for chronic diseases such as asthma or cystic fibrosis. It is important that practitioners...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 17 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 48 of 137
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Plasma TGFâ€Î²1 in pediatric cystic fibrosis: Potential biomarker of lung disease and response to therapy
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ConclusionIn pediatric CF, plasma (but not serum) TGFâ€Î²1 is increased in association with Pseudomonas infection and lung disease, and is reduced in response to therapy. These findings emphasize the importance of optimizing biospecimen selection for future studies investigating the role of TGFâ€Î²1 in CF lung disease. Pediatr. Pulmonol. © 2011...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 17 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 49 of 137
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Influenza A/H1N1 in patients with cystic fibrosis in Italy: a multicentre cohort study
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(Source: Thorax) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Cystic Fibrosis Thu, 17 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 50 of 137
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Immunogenicity and safety profile of the monovalent A/H1N1 MF59-adjuvanted vaccine in patients affected by cystic fibrosis
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(Source: Thorax)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 17 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 51 of 137
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Clinical outcomes of pandemic (H1N1) 2009 influenza (swine flu) in adults with cystic fibrosis
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(Source: Thorax)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 17 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 52 of 137
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Neural respiratory drive, pulmonary mechanics and breathlessness in patients with cystic fibrosis
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Conclusion sEMGpara%max provides a non-invasive marker of neural drive, which reflects disease severity and exercise-induced breathlessness in CF. (Source: Thorax)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 17 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 53 of 137
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Epidemiology of borderline oxacillinâ€resistant Staphylococcus aureus in Pediatric Cystic Fibrosis
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AbstractA singleâ€center retrospective study was undertaken in children with cystic fibrosis (CF) to evaluate (1) risk factors for acquisition; (2) molecular epidemiology; and (3) impact on disease progression of borderline oxacillinâ€resistant Staphylococcus aureus (BORSA) versus mecAâ€positive methicillinâ€resistant Staphylococcus aureus (MRSA). The study comprised of (1) identification of all children with...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 17 Feb 2011 8:49:40 pm
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Cystic Fibrosis - news item 54 of 137
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Homogenisation of cystic fibrosis sputum by sonication - An essential step for Aspergillus PCR
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Baxter CG, Jones AM, Webb K, Denning DW (Source: The Aspergillus Website - articles) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Cystic Fibrosis Thu, 17 Feb 2011 12:52:44 pm
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Cystic Fibrosis - news item 55 of 137
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Marketing Survey for Parents of CF Patients
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(Source: Cystic Fibrosis Worldwide)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 17 Feb 2011 9:37:56 am
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Cystic Fibrosis - news item 56 of 137
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Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions.
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Authors: Lorentzen D, Durairaj L, Pezzulo AA, Nakano Y, Launspach J, Stoltz DA, Zamba G, McCray PB, Zabner J, Welsh MJ, Nauseef WM, Bánfi B A recently discovered enzyme system produces antibacterial hypothiocyanite (OSCN(-)) in the airway lumen by oxidizing the secreted precursor thiocyanate (SCN(-)). Airway epithelial cultures have been...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 16 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 57 of 137
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Accurate assessment of adherence: Self and clinician report versus electronic monitoring of nebulizers.
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CONCLUSIONS: Self and clinician reporting of adherence does not provide accurate measurement of adherence when compared to electronic monitoring. Using inaccurate measures has implications for treatment burden, clinician prescribing practices, cost and accuracy of trial data. PMID: 21330381 [PubMed - as supplied by publisher] (Source: Chest)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 16 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 58 of 137
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Managing Cystic Fibrosis: Strategies that Increase Life Expectancy and Improve Quality of Life.
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Authors: Cohen-Cymberknoh M, Shoseyov D, Kerem E The survival of patients with cystic fibrosis (CF) continues to improve. The discovery and cloning of the CFTR gene over 21 years ago led to the identification of the structure and function of the CFTR chloride channel. New therapies based on the understanding...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 16 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 59 of 137
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Nebulised Hypertonic Saline Decreases Interleukin-8 in Sputum of Patients With Cystic Fibrosis.
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CONCLUSION: Glycosaminoglycans possess the ability to influence the chemokine profile of the CF lung by binding and stabilizing IL-8, which promotes neutrophil chemotaxis and activation. Nebulised hypertonic saline treatment disrupts the interaction between glycosaminoglycans and IL-8, rendering IL-8 susceptible to proteolytic degradation with subsequent decrease in neutrophil chemotaxis, thereby facilitating...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 16 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 60 of 137
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NICE Consults On Improving Donor Identification And Consent Rates For Deceased Organ Donation
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NICE has published draft guidelines on improving donor identification and consent rates for deceased organ donation[1]. Transplanted organs are needed because of organ failure due to diseases such as chronic inflammatory disease of the kidney, or because of secondary effects of a disease such as people needing a lung transplant...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 16 Feb 2011 11:00:00 am
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Cystic Fibrosis - news item 61 of 137
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The skinny on tuna fat: health implications.
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CONCLUSIONS: Light tuna canned in water may be a better choice of providing n-3 PUFA to individuals in a healthy population, whereas oil-packaged products may be preferable for those individuals with a need for increased EFA, such as for patients with cystic fibrosis. Awareness regarding PUFA content may aid in...
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RSS Source: Med Worm - Cystic Fibrosis Tue, 15 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 62 of 137
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(Italian) Belgio ed Emirati Arabi Uniti
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Translated by Elisa Pisani (Source: Cystic Fibrosis Worldwide)
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RSS Source: Med Worm - Cystic Fibrosis Tue, 15 Feb 2011 3:55:32 pm
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Cystic Fibrosis - news item 63 of 137
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Outpatient Treatment of Pseudomonas aeruginosa Bronchial Colonization With Long-term Inhaled Colistin, Tobramycin, or Both in Adults Without Cystic Fibrosis
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Which inhaled antibiotics can decrease duration of hospitalization? Pharmacotherapy (Source: Medscape Today Headlines)
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RSS Source: Med Worm - Cystic Fibrosis Tue, 15 Feb 2011 3:00:00 am
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Cystic Fibrosis - news item 64 of 137
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Eradication of Pseudomonas aeruginosa in an adult patient with cystic fibrosis.
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Conclusion The administration of continuous-infusion cefepime and high-dose, extended-interval tobramycin led to the successful eradication of P. aeruginosa in an adult patient with CF. PMID: 21289326 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
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RSS Source: Med Worm - Cystic Fibrosis Mon, 14 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 65 of 137
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Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR-/- mice [Medical Sciences]
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Gene transfer could provide a novel therapeutic approach for cystic fibrosis (CF), and adeno-associated virus (AAV) is a promising vector. However, the packaging capacity of AAV limits inclusion of the full-length cystic fibrosis transmembrane conductance regulator (CFTR) cDNA together with other regulatory and structural elements. To overcome AAV size constraints,...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 14 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 66 of 137
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Variants in CFTR untranslated regions are associated with congenital bilateral absence of the vas deferens
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Conclusions As the vas deferens seems to be one of the tissues most susceptible to a reduction in the normal CFTR transcripts levels, and as two mild mutations are sufficient to induce CBAVD phenotype, these findings raise the possibility that these uncommon variants may be a novel cause of CBAVD. (...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 14 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 67 of 137
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In Vitro Susceptibility of Burkholderia vietnamiensis to Aminoglycosides.
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Authors: Jassem AN, Zlosnik JE, Henry DA, Hancock RE, Ernst RK, Speert DP Burkholderia cepacia complex (BCC) bacteria are opportunistic pathogens that can cause severe disease in cystic fibrosis (CF) patients and other immunocompromised individuals, and are typically multi-drug resistant. Here we observed that, unlike other BCC species, most environmental...
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RSS Source: Med Worm - Cystic Fibrosis Sun, 13 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 68 of 137
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The Implication of Pseudomonas aeruginosa Biofilms in Infections.
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Authors: Rybtke MT, Jensen PO, Høiby N, Givskov M, Tolker-Nielsen T, Bjarnsholt T Biofilm formation by bacteria is recognized as a major problem in chronic infections due to their recalcitrance against the immune defense and available antibiotic treatment schemes. The opportunistic pathogen Pseudomonas aeruginosa has drawn special attention in this...
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RSS Source: Med Worm - Cystic Fibrosis Sun, 13 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 69 of 137
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Malate synthase expression is deregulated in the Pseudomonas aeruginosa cystic fibrosis isolate FRD1
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Jessica M. Hagins, Jessica Scoffield, Sang-Jin Suh, and Laura Silo-Suh - Pseudomonas aeruginosa causes chronic pulmonary infections, which can persist for decades, in patients with cystic fibrosis (CF). Current evidence suggests that the glyoxylate pathway is... (Source: Canadian Journal of Microbiology) MedWorm Message: Watch the new MedWorm demo and find...
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RSS Source: Med Worm - Cystic Fibrosis Sun, 13 Feb 2011 12:04:20 am
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Cystic Fibrosis - news item 70 of 137
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Pregnancy in Cystic Fibrosis
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This article reviews maternal and fetal outcomes for CF in pregnancy. (Source: Clinics in Chest Medicine)
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RSS Source: Med Worm - Cystic Fibrosis Sat, 12 Feb 2011 8:12:53 pm
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Cystic Fibrosis - news item 71 of 137
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Preface
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It has been close to two decades since Clinics in Chest Medicine has devoted an issue to lung disease in pregnancy. Pregnancy is a unique and special time in a woman’s life and most pregnancies are healthy and uneventful. In the twenty-first century, pregnancies are likely more medically complicated than...
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RSS Source: Med Worm - Cystic Fibrosis Sat, 12 Feb 2011 8:12:53 pm
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Cystic Fibrosis - news item 72 of 137
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Improving antibiotic treatment outcomes through the implementation of a midline: Piloting a change in practice for cystic fibrosis patients
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Midline catheters have many advantages for chronically ill patients needing up to six weeks intravenous therapy and medications, and when inserted in a sterile environment and correctly monitored and maintained, have a significantly lower association of infection and thrombus than previously suggested. Furthermore, there is a reduction in central collateral...
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RSS Source: Med Worm - Cystic Fibrosis Sat, 12 Feb 2011 6:24:42 pm
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Cystic Fibrosis - news item 73 of 137
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Positive Expiratory Pressure Delivery System for Hypertonic Saline in Patients with Cystic Fibrosis Who Failed Traditional Nebulization Strategies: A Case Series.
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CONCLUSION: This case series demonstrates HS administered via a PEP nebulizer is a novel therapeutic strategy for patients who cannot tolerate this therapy through traditional jet nebulizers, including those patients with severe CF pulmonary disease. PMID: 21333079 [PubMed - as supplied by publisher] (Source: Respiratory Care)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 10 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 74 of 137
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Innate Inflammatory Responses of Pediatric Cystic Fibrosis Airway Epithelial Cells: Effects of Non-Viral and Viral Stimulation.
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CONCLUSIONS: CF and healthy AEC have similar basal and stimulated expression of IL-8 in response to pro-inflammatory stimuli but elevated IL-8 release in response to HRV infection. The elevated IL-8 together with dampened apoptotic responses by CF cells to HRV could contribute to augmented airway inflammation in the setting of...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 10 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 75 of 137
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ER-associated Degradation-modifying Genes [Membrane Biology]
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The hexameric AAA-ATPase, Cdc48p, catalyzes an array of cellular activities, including endoplasmic reticulum (ER)-associated degradation (ERAD), ER/Golgi membrane dynamics, and DNA replication. Accumulating data suggest that unique Cdc48p partners, such as Npl4p-Ufd1p and Ubx1p/Shp1p (p47 in vertebrates), target Cdc48p for these diverse functions. Other Cdc48p-associated proteins have been identified, but...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 10 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 76 of 137
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From children to young adults: Cystic fibrosis and siblingship
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Conclusion:  The selfâ€esteem of women in the sibling pairs (whether with CF or healthy sisters) has improved since their childhood. Overall, the results indicate that young adults with CF today are medically well controlled and psychosocially well adapted, albeit aware of their precarious future. (Source: Acta Paediatrica)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 10 Feb 2011 7:04:30 pm
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Cystic Fibrosis - news item 77 of 137
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The Cystic Fibrosis Neutrophil: A Specialized Yet Potentially Defective Cell
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Abstract Cystic fibrosis (CF) is one of the commonest genetically inherited diseases in the world. It is characterized by recurrent respiratory tract infections eventually leading to respiratory failure. One of the hallmarks of this disease is a persistent and predominantly neutrophil driven inflammation. Neutrophils provide the first line of defence...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 10 Feb 2011 6:58:57 pm
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Cystic Fibrosis - news item 78 of 137
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Vivacta Initiates Development Of Point Of Care Test For Vitamin D
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Vivacta Limited, the medical diagnostics company with a revolutionary system for point-of-care testing, announces it has initiated development of a new rapid diagnostic test for measuring Vitamin D. Diagnosis of Vitamin D deficiencies and regular monitoring of Vitamin D levels and obtaining results rapidly is potentially important in improving management...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 10 Feb 2011 7:00:00 am
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Cystic Fibrosis - news item 79 of 137
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Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease
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Conclusion In patients with COPD, sequential SPECT showed increased lung accumulation of 99mTc-labelled neutrophils, while whole-body counting demonstrated subsequent higher losses of 111In-labelled neutrophils in patients who continued to smoke. Sequential SPECT as a means of quantifying neutrophil migration deserves further evaluation. Content Type Journal ArticlePages 1-9DOI 10.1007/s00259-010-1715-7Authors Prina Ruparelia,...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 10 Feb 2011 5:48:08 am
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Cystic Fibrosis - news item 80 of 137
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Cystic fibrosis transmembrane regulator potentiators as promising cystic fibrosis therapies
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Expert Opinion on Investigational Drugs, Volume 0, Issue 0, Page 1-3, Early Online. (Source: Expert Opinion: Expert Opinion on Investigational Drugs: Table of Contents)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 10 Feb 2011 3:04:44 am
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Cystic Fibrosis - news item 81 of 137
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From children to young adults: cystic fibrosis and siblingship A longitudinal study
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Conclusion:  The selfâ€esteem of women in the sibling pairs (whether with CF or healthy sisters) has improved since their childhood. Overall, the results indicate that young adults with CF today are medically well controlled and psychosocially well adapted, albeit aware of their precarious future. (Source: Acta Paediatrica)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 9 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 82 of 137
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Bronchoalveolar lavage in children with cystic fibrosis: how many lobes should be sampled?
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Conclusion A single-lobe BAL is insufficient in assessing patients with CF for lower airway infection. Even when BAL specimens are taken from two lobes, a number of infections may be missed. (Source: Archives of Disease in Childhood)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 9 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 83 of 137
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Molecular characterization and phylogenetic analysis of quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC and parE gene loci in viridans group streptococci isolated from adult patients with cystic fibrosis
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Conclusions Treatment of P. aeruginosa with oral ciprofloxacin in patients with CF may concurrently reduce antibiotic susceptibility in the commensal VGS flora, where these organisms may potentially act as a reservoir of fluoroquinolone resistance gene determinants for newly acquired and antibiotic-susceptible pathogens, particularly the Streptococcus milleri group. (Source: Journal of...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 9 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 84 of 137
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Use of nebulized amphotericin B in the treatment of allergic bronchopulmonary aspergillosis in cystic fibrosis
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Proesmans M, Vermeulen F, Vreys M, De Boeck K (Source: The Aspergillus Website - articles) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Cystic Fibrosis Tue, 8 Feb 2011 5:34:36 pm
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Cystic Fibrosis - news item 85 of 137
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Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice
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Conclusions Lack of functional CFTR in neutrophils can promote LPS-induced acute lung inflammation and injury. Content Type Journal ArticlePages 1-14DOI 10.1007/s00011-011-0313-xAuthors Xiao Su, Cardiovascular Research Institute, University of California, San Francisco, HSW 825, 505 Parnassus AVE, San Francisco, CA 94143-0130, USAMark R. Looney, Cardiovascular Research Institute, University of California, San...
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RSS Source: Med Worm - Cystic Fibrosis Tue, 8 Feb 2011 12:14:09 pm
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Cystic Fibrosis - news item 86 of 137
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Lung and vascular function during chronic severe pulmonary ischemia
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Bronchial vascular angiogenesis takes place in a variety of lung inflammatory conditions such as asthma, cystic fibrosis, lung cancer, and chronic pulmonary thromboembolic disease. However, it is unclear whether neovascularization is predominantly appropriate and preserves lung tissue or whether it contributes further to lung pathology through edema formation and inflammation....
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RSS Source: Med Worm - Cystic Fibrosis Mon, 7 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 87 of 137
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Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis [Medical Sciences]
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Renal cyst development and expansion in autosomal dominant polycystic kidney disease (ADPKD) involves both fluid secretion and abnormal proliferation of cyst-lining epithelial cells. The chloride channel of the cystic fibrosis transmembrane conductance regulator (CFTR) participates in secretion of cyst fluid, and the mammalian target of rapamycin (mTOR) pathway may drive...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 7 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 88 of 137
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IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway
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Fluid and HCO3– secretion are fundamental functions of epithelia and determine bodily fluid volume and ionic composition, among other things. Secretion of ductal fluid and HCO3– in secretory glands is fueled by Na+/HCO3– cotransport mediated by basolateral solute carrier family 4 member 4 (NBCe1-B) and by Cl–/HCO3– exchange mediated by...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 7 Feb 2011 10:32:41 pm
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Cystic Fibrosis - news item 89 of 137
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Pseudomonas aeruginosa Biofilms in Cystic Fibrosis
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Pseudomonas aeruginosa lung infections in cystic fibrosis patients can be deadly, and difficult to eradicate, due to the organism's propensity to form biofilms. How can it be attacked? Future Microbiology (Source: Medscape Today Headlines) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 7 Feb 2011 10:07:18 am
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Cystic Fibrosis - news item 90 of 137
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Cystic Fibrosis Research At Queen's Boosted By $2.8 Million Grant
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Scientists at Queen's University Belfast have begun work into improving the lives of thousands of Cystic Fibrosis sufferers thanks to the award of a 1.74 million pound US-Ireland Research and Development Partnership grant. The grant has been approved by the National Institutes of Health (NIH) in the USA with funding...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 7 Feb 2011 10:00:00 am
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Cystic Fibrosis - news item 91 of 137
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Combating Cystic Fibrosis: In Search for CF Transmembrane Conductance Regulator (CFTR) Modulators.
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Authors: Noy E, Senderowitz H PMID: 21275046 [PubMed - in process] (Source: ChemMedChem)
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RSS Source: Med Worm - Cystic Fibrosis Sun, 6 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 92 of 137
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Burkholderia cepacia complex: Beyond pseudomonas and acinetobacter
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V Gautam, L Singhal, P RayIndian Journal of Medical Microbiology 2011 29(1):4-12Burkholderia cepacia complex (BCC) is an important nosocomial pathogen in hospitalised patients, particularly those with prior broad-spectrum antibacterial therapy. BCC causes infections that include bacteraemia, urinary tract infection, septic arthritis, peritonitis and respiratory tract infection. Due to high intrinsic...
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RSS Source: Med Worm - Cystic Fibrosis Sun, 6 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 93 of 137
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Pregnancy outcomes in the current era of cystic fibrosis care: A 15â€year experience
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Conclusion:  Most women tolerated pregnancy well without major complications despite many having at least moderate lung function impairment. Preâ€pregnancy FEV1 and BMI were important predictors of outcomes. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)
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RSS Source: Med Worm - Cystic Fibrosis Sun, 6 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 94 of 137
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(Portuguese) Um Estudo sobre o Processo de Transição
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Translated by Katia Perry (Source: Cystic Fibrosis Worldwide) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Cystic Fibrosis Fri, 4 Feb 2011 9:27:23 am
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Cystic Fibrosis - news item 95 of 137
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$2.8 million grant boosts cystic fibrosis research at Queen's
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(Queen's University Belfast) Scientists at Queen's University Belfast have begun work into improving the lives of thousands of cystic fibrosis sufferers thanks to the award of a £1.74 ($2.8) million US-Ireland Research and Development Partnership grant. (Source: EurekAlert! - Medicine and Health)
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RSS Source: Med Worm - Cystic Fibrosis Fri, 4 Feb 2011 4:00:00 am
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Cystic Fibrosis - news item 96 of 137
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Pseudomonas Aeruginosa Population Diversity and Turnover in Cystic Fibrosis Chronic Infections.
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CONCLUSIONS: These results significantly advance our understanding of the within-host population biology of P. aeruginosa during infection of cystic fibrosis patients, and provide in vivo evidence for a link between pyocyanin production and patient morbidity. PMID: 21297072 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 3 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 97 of 137
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Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis: A review and meta-analysis
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Mannose-binding lectin (MBL) is an innate immune protein produced by the liver. MBL binds to glycoconjugates containing mannose, fucose or N-acetylglucosamine that are present in a wide variety of bacteria, viruses and fungi. Upon binding, MBL may active the lectin pathway of complement or directly opsonize organisms to enhance phagocytosis....
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RSS Source: Med Worm - Cystic Fibrosis Thu, 3 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 98 of 137
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Cystic fibrosis: an-ion transport issue?
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Nature Medicine 17, 166 (2011). doi:10.1038/nm0211-166 (Source: Nature Medicine)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 3 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 99 of 137
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Forum: CF clearance techniqes/devices research Survey
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(Source: Cystic Fibrosis Worldwide) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Cystic Fibrosis Thu, 3 Feb 2011 5:56:14 am
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Cystic Fibrosis - news item 100 of 137
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Parallel evolution and local differentiation in quinoloneresistance in Pseudomonas aeruginosa.
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Authors: Wong A, Kassen R The emergence and spread of antibiotic resistance in pathogens is a major impediment to the control of microbial disease. Here, we review mechanisms of quinolone resistance in Pseudomonas aeruginosa, an important nosocomial pathogen and a major cause of morbidity in cystic fibrosis patients. In a...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 2 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 101 of 137
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"Bone health, daily physical activity and exercise tolerance in cystic fibrosis patients"
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CONCLUSIONS: The most active patients with better exercise capacity had higher BMD. Those with more affected pulmonary function had greater prevalence of vertebral fractures and dorsal kyphosis. PMID: 21292759 [PubMed - as supplied by publisher] (Source: Chest)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 2 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 102 of 137
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Cystic Fibrosis Gene Mutation Tied to Pancreatitis Risk
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Patients with pancreatic-sufficient cystic fibrosis carrying genotypes associated with mild phenotypes appear to be at an increased risk of developing pancreatitis as compared to patients with the disease carrying genotypes associated with moderate-severe phenotypes, according to a study published in the January issue of Gastroenterology. (Source: Modern Medicine)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 2 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 103 of 137
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Duration of intravenous antibiotic therapy in people with cystic fibrosis.
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Authors: Plummer A, Wildman M Respiratory disease is the major cause of mortality and morbidity in cystic fibrosis (CF). Life expectancy of people with CF has increased dramatically in the last 40 years. One of the major reasons for this increase is the mounting use of antibiotics to treat chest...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 2 Feb 2011 3:15:07 pm
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Cystic Fibrosis - news item 104 of 137
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Vitamin K supplementation for cystic fibrosis.
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Authors: Jagannath VA, Fedorowicz Z, Thaker V, Chang AB Cystic fibrosis is a genetic disorder which can lead to multiorgan dysfunction. Malabsorption of fat and fat-soluble vitamins (A, D, E, K) may occur and can cause subclinical deficiencies of some of these vitamins. Vitamin K is known to play an...
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RSS Source: Med Worm - Cystic Fibrosis Wed, 2 Feb 2011 3:15:07 pm
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Cystic Fibrosis - news item 105 of 137
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History of cryptorchidism and ejaculate volume as simple predictors for the presence of testicular sperm.
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In this study, the possible predictive value of very simple parameters such as systematic history, clinical examination, and determination of ejaculate volume have been evaluated. Two-hundred and sixty-two consecutive non-vasectomized men with azoospermia/aspermia were evaluated by systematic history, clinical examination, ultrasonography of the scrotal content, and hormonal and genetic analyses....
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RSS Source: Med Worm - Cystic Fibrosis Tue, 1 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 106 of 137
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An asthmatic child with a troublesome cough
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(Source: BMJ Online First)
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RSS Source: Med Worm - Cystic Fibrosis Tue, 1 Feb 2011 11:00:00 pm
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Cystic Fibrosis - news item 107 of 137
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Biotech Busts And Breakthroughs In January
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The year got off to an interesting start for biotechnology stocks, with new drug approvals leading to big gains for Clinical Data and DepoMed. (I've noted my skepticism on the label, but not so much the buyout prospects, of Clinical Data's Viibryd here.) The biggest losers were MannKind, which saw...
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RSS Source: Med Worm - Cystic Fibrosis Tue, 1 Feb 2011 10:43:03 pm
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Cystic Fibrosis - news item 108 of 137
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CF Canada announces the appointment of Maureen Adamson as Chief Executive Officer
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(Source: Cystic Fibrosis Worldwide)
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RSS Source: Med Worm - Cystic Fibrosis Tue, 1 Feb 2011 7:02:00 pm
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Cystic Fibrosis - news item 109 of 137
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Hope is in the air
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(Source: Cystic Fibrosis Worldwide) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Cystic Fibrosis Tue, 1 Feb 2011 7:01:00 pm
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Cystic Fibrosis - news item 110 of 137
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The Canadian Cystic Fibrosis Foundation is changing its name and logo
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(Source: Cystic Fibrosis Worldwide)
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RSS Source: Med Worm - Cystic Fibrosis Tue, 1 Feb 2011 7:00:00 pm
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Cystic Fibrosis - news item 111 of 137
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Yearâ€inâ€review 2010: asthma, copd, cystic fibrosis and airway biology
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(Source: Respirology)
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RSS Source: Med Worm - Cystic Fibrosis Mon, 31 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 112 of 137
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Effects of Ginseng on Pseudomonas aeruginosa motility and biofilm formation
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AbstractBiofilm associated chronic Pseudomonas aeruginosa lung infections in patients with Cystic Fibrosis (CF) are virtually impossible to eradicate with antibiotics because biofilm growing bacteria are highly tolerant to antibiotics and host defence mechanisms. Previously we found that Ginseng treatments protected animal models from development of chronic lung infection by P....
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RSS Source: Med Worm - Cystic Fibrosis Mon, 31 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 113 of 137
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Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells
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Airway neutrophil infiltration is a pathological hallmark observed in multiple lung diseases including pneumonia and cystic fibrosis. Bacterial pathogens such as Pseudomonas aeruginosa instigate neutrophil recruitment to the air space. Excessive accumulation of neutrophils in the lung often contributes to tissue destruction. Previous studies have unveiled hepoxilin A3 as the...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 31 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 114 of 137
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Parental Understanding of Newborn Screening for Cystic Fibrosis After a Negative Sweat-Test
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CONCLUSIONS: Parental knowledge about CF is high, but confusion about the child's carrier status and the concept of residual risk persist despite genetic counseling. Relatives express low interest in carrier testing. (Source: PEDIATRICS)
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RSS Source: Med Worm - Cystic Fibrosis Mon, 31 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 115 of 137
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Cystic fibrosis †cirrhosis, portal hypertension and liver biopsy: Reply
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(Source: Hepatology)
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RSS Source: Med Worm - Cystic Fibrosis Sun, 30 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 116 of 137
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Achromobacter xylosoxidans respiratory tract infection in cystic fibrosis patients
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Abstract The aims of this study were to evaluate the frequency of Achromobacter xylosoxidans infection in a cohort of cystic fibrosis patients, to investigate antimicrobial sensitivity, to establish possible clonal likeness among strains, and to address the clinical impact of this infection or colonization on the general outcome of these...
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RSS Source: Med Worm - Cystic Fibrosis Sun, 30 Jan 2011 7:01:38 am
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Cystic Fibrosis - news item 117 of 137
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Chemoenzymatic routes to enantiomerically pure 2-azatyrosine and 2-, 3- and 4-pyridylalanine derivatives.
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Authors: Moussa A, Meffre P, Martinez J, Rolland V Enantiomerically pure 2-, 3- or 4-pyridylalanine (pya) and 2-azatyrosine (azatyr) are known to present various biological activities. After incorporation into appropriate peptide sequences, these heterocyclic non natural α-amino acids could behave as new substrates or inhibitors of elastase from Pseudomonas aeruginosa....
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RSS Source: Med Worm - Cystic Fibrosis Fri, 28 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 118 of 137
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Sinonasal inhalation of dornase alfa in CF: A double-blind placebo-controlled cross-over pilot trial
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Conclusion: This first clinical study with the novel device gives promising results for the new therapeutic concept of sinonasal inhalation with vibrating aerosols in regard to further analysis involving larger collectives. (Source: Auris, Nasus, Larynx)
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RSS Source: Med Worm - Cystic Fibrosis Fri, 28 Jan 2011 3:03:34 pm
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Cystic Fibrosis - news item 119 of 137
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Asymmetric Dimethylarginine Contributes to Airway Nitric Oxide Deficiency in Patients with Cystic Fibrosis.
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CONCLUSIONS: Asymmetric dimethylarginine is increased in cystic fibrosis airways and may contribute airways obstruction in cystic fibrosis patients by reducing nitric oxide formation. PMID: 21278301 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 27 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 120 of 137
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Effects of carbon monoxide on ion transport across rat distal colon
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The aim of the present study was to investigate whether carbon monoxide (CO) induces changes in ion transport across the distal colon of rats and to study the mechanisms involved. In Ussing chamber experiments, tricarbonyldichlororuthenium(II) dimer (CORM-2), a CO donor, evoked a concentration-dependent increase in short-circuit current (Isc). A maximal...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 27 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 121 of 137
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Decreased virulence of cystic fibrosis Pseudomonas aeruginosa in Dictyostelium discoideum
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ABSTRACTThe characteristics of Pseudomonas aeruginosa clinical and environmental isolates from both hospital and community settings were analysed in a eukaryotic virulence model employing the AX2 and X22 mutants of Dictyostelium discoideum. Thirtyâ€one strains of P. aeruginosa were analysed, five from environmental sources, six from clinical sources other than cystic fibrosis (...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 27 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 122 of 137
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Outcomes of patients with cystic fibrosis undergoing lung transplantation with and without cystic fibrosisâ€associated liver cirrhosis*
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This study provides evidence that CF patients with liver cirrhosis caused by CFLD can safely be considered for sole lung transplantation provided there is no evidence of significant hepatocellular dysfunction with decompensated cirrhosis or hepatic synthetic failure. (Source: Clinical Transplantation)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 27 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 123 of 137
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Breakthrough On Cystic Fibrosis One Step Closer As New Research Alliance Formed
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McGill University and GlaxoSmithKline plc (GSK) have signed a collaboration agreement to develop a potential breakthrough approach to treat cystic fibrosis, a fatal genetic disease. The trans-Atlantic effort between researchers from McGill's Faculty of Medicine and their GSK collaborators in the UK, will focus on developing molecules that could treat...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 27 Jan 2011 10:00:00 am
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Cystic Fibrosis - news item 124 of 137
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New Method Attacks Bacterial Infections On Contact Lenses
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Researchers at National Jewish Health and the University of Texas Southwestern Medical Center have discovered a new method to fight bacterial infections associated with contact lenses. The method may also have applications for bacterial infections associated with severe burns and cystic fibrosis. The results were published online in the journal...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 27 Jan 2011 7:00:00 am
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Cystic Fibrosis - news item 125 of 137
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Breakthrough on cystic fibrosis 1 step closer as new research alliance formed
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(McGill University) McGill University and GlaxoSmithKline PLC have signed a collaboration agreement to develop a potential breakthrough approach to treat cystic fibrosis, a fatal genetic disease. The trans-Atlantic effort between researchers from McGill's Faculty of Medicine and their GSK collaborators in the UK, will focus on developing molecules that could...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 27 Jan 2011 4:00:00 am
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Cystic Fibrosis - news item 126 of 137
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Cystic fibrosis modifier genes related to Pseudomonas aeruginosa infection
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Authors: J E Park, R Yung, D Stefanowicz, K Shumansky, L Akhabir, P R Durie, M Corey, J Zielenski, R Dorfman, D Daley & A J Sandford (Source: Genes and Immunity)
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RSS Source: Med Worm - Cystic Fibrosis Wed, 26 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 127 of 137
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Newborns to be routinely screened for cystic fibrosis
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The screening, which was first mooted 11 years ago, will be carried out as part of the heel prick test, and is due to begin in June, writes RONAN McGREEVY (Source: The Irish Times - Health)
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RSS Source: Med Worm - Cystic Fibrosis Tue, 25 Jan 2011 1:44:50 pm
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Cystic Fibrosis - news item 128 of 137
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A multitask biosensor for micro-volumetric detection of N-3-oxo-dodecanoyl-homoserine lactone quorum sensing signal.
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Authors: Massai F, Imperi F, Quattrucci S, Zennaro E, Visca P, Leoni L N-3-oxo-dodecanoyl-homoserine lactone (3OC(12)-HSL) is the main quorum sensing (QS) signal produced by the human pathogen Pseudomonas aeruginosa, a major cause of hard-to-treat nosocomial infections and years-lasting chronic biofilm infections in the lungs of cystic fibrosis (CF) patients....
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RSS Source: Med Worm - Cystic Fibrosis Mon, 24 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 129 of 137
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Listeria monocytogenes exploits cystic fibrosis transmembrane conductance regulator (CFTR) to escape the phagosome [Microbiology]
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Virulence of the intracellular pathogen Listeria monocytogenes (Listeria) requires escape from the phagosome into the host cytosol, where the bacteria replicate. Phagosomal escape is a multistep process characterized by perforation, which is dependent on the pore-forming toxin listeriolysin O (LLO), followed by rupture. The contribution of host factors to Listeria...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 24 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 130 of 137
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Clinical evaluation of the infertile male with respect to genetic etiologies.
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Authors: Oates RD Severe male factor infertility may have a presently identifiable genetic basis. Y chromosomal microdeletions (e.g., an AZFc microdeletion), karyotypic anomalies (e.g., Klinefelter Syndrome), and mutations in both alleles of the cystic fibrosis transmembrane conductance regulator (CFTR) gene may be found, depending upon the etiology of the reproductive...
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RSS Source: Med Worm - Cystic Fibrosis Mon, 24 Jan 2011 6:46:10 am
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Cystic Fibrosis - news item 131 of 137
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Neonatal functional intestinal obstruction and the presence of severely immature ganglion cells on rectal biopsy: 6 year experience
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Conclusion Immature ganglion cells on rectal biopsy may be an indicator of transient functional immaturity of the intestine. Content Type Journal ArticlePages 1-4DOI 10.1007/s00383-010-2850-8Authors Tariq Burki, Department of Paediatric Surgery, Royal London Hospital, London, UKLiina Kiho, Department of Cellular Pathology, Royal London Hospital, London, UKIrene Scheimberg, Department of Cellular Pathology,...
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RSS Source: Med Worm - Cystic Fibrosis Sat, 22 Jan 2011 7:11:58 pm
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Cystic Fibrosis - news item 132 of 137
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(Italian) FC Gaza: Programma per la Fibrosi Cistica nella striscia di Gaza
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Translated by Elisa Pisani (Source: Cystic Fibrosis Worldwide)
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RSS Source: Med Worm - Cystic Fibrosis Sat, 22 Jan 2011 9:52:27 am
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Cystic Fibrosis - news item 133 of 137
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High concentrations of pepsin in bronchoalveolar lavage fluid from children with cystic fibrosis are associated with high interleukin-8 concentrations
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Conclusions Many children with CF have increased levels of pepsin in the BAL fluid compared with normal controls. Increased pepsin levels were associated with higher IL-8 concentrations in BAL fluid. These data suggest that aspiration of gastric contents occurs in a subset of patients with CF and is associated with...
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RSS Source: Med Worm - Cystic Fibrosis Fri, 21 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 134 of 137
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Cystic Fibrosis Europe (CFE) has a vacancy for an Operations Manager (F/M)
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(Source: Cystic Fibrosis Worldwide)
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RSS Source: Med Worm - Cystic Fibrosis Fri, 21 Jan 2011 11:25:38 am
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Cystic Fibrosis - news item 135 of 137
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Glucose Intolerance in Patients With Cystic Fibrosis: Gender-Based Differences in Clinical Score, Pulmonary Function, Radiograph Score and Six Minute Walk Test.
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Conclusion The degree of impairment of glucose tolerance was associated with poor clinical score, lower SpOâ‚‚ at rest and greater desaturation after a 6MWT, poor lung function and lower radiograph score in patients with CF. Overall, a multivariate analysis indicated poorer performance for female patients with glucose intolerance for these...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 20 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 136 of 137
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Classification and identification of the Burkholderia cepacia complex: Past, present and future.
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Authors: Vandamme P, Dawyndt P The Burkholderia cepacia complex is a group of closely related species with conflicting biological properties. Triggered by the devastating effect of pulmonary infections in cystic fibrosis patients, the scientific community generated an unusually large amount of taxonomic data for these bacteria during the past 15...
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RSS Source: Med Worm - Cystic Fibrosis Thu, 20 Jan 2011 11:00:00 pm
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Cystic Fibrosis - news item 137 of 137
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A polymorphism in the 5’ UTR of the DEFB1 gene is associated with the lung phenotype in F508del homozygous Italian cystic fibrosis patients
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Conclusions: Our results, although necessary to be confirmed in larger and multiethnic populations, reinforce DEFB1 as a candidate modifier gene of the CF pulmonary phenotype. (Source: Clinical Chemistry and Laboratory Medicine)
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RSS Source: Med Worm - Cystic Fibrosis Thu, 20 Jan 2011 12:06:47 am
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