Eplipepsy - news item 1 of 45
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FDA Accepts Lundbeck's Submission Of The New Drug Application For Clobazam
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H. Lundbeck A/S (Lundbeck) announced that the U.S. Food and Drug Administration (FDA) has accepted for review a New Drug Application (NDA) for the investigational compound clobazam as adjunctive therapy in treating seizures associated with Lennox-Gastaut syndrome (LGS) in patients two years and older. The filing was assigned a standard...
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RSS Source: Med Worm - Epilepsy Sat, 5 Mar 2011 9:00:00 am
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Eplipepsy - news item 2 of 45
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Epilepsy Drug Topiramate Linked To Cleft Lip And Palate Birth Defects
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Topamax and its generic versions - topiramate - taken during pregnancy, increase the likelihood of babies being born with cleft lip and cleft palate, new data suggests, the Food and Drug Administration (FDA), USA wrote in a communiqué today. The FDA says that doctors should warn their female patients of...
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RSS Source: Med Worm - Epilepsy Sat, 5 Mar 2011 8:00:00 am
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Eplipepsy - news item 3 of 45
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Epilepsy Durg Topiramate Linked To Cleft Lip And Palate Birth Defects
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Topamax and its generic versions - topiramate - taken during pregnancy increase the likelihood of babies being born with cleft lip and cleft palate, new data suggest, the Food and Drug Administration (FDA), USA wrote in a communiqué today. The FDA says that doctors should warn their female patients of...
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RSS Source: Med Worm - Epilepsy Sat, 5 Mar 2011 8:00:00 am
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Eplipepsy - news item 4 of 45
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U.S. FDA Approves Anti-Epileptic Agent Banzel® (Rufinamide) Oral Suspension, 40mg/Ml
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Eisai Co., Ltd. (Headquarters: Tokyo, President & CEO: Haruo Naito, "Eisai") and its U.S. subsidiary Eisai Inc. announced that the United States Food and Drug Administration (FDA) approved the company's anti-epileptic agent BANZEL® (rufinamide) Oral Suspension, 40 mg/ml on March 3 (U.S. local time) for the adjunctive treatment of seizures...
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RSS Source: Med Worm - Epilepsy Sat, 5 Mar 2011 8:00:00 am
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Eplipepsy - news item 5 of 45
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FDA: migraine drug ups risk for oral birth defects
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WASHINGTON (Reuters) - An epilepsy drug also used to help prevent migraines can increase the risk for oral birth defects in babies born to women taking the medication, U.S. health officials said on Friday. (Source: Reuters: Health)
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RSS Source: Med Worm - Epilepsy Fri, 4 Mar 2011 10:15:22 pm
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Eplipepsy - news item 6 of 45
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New NeuroPI Now Available to Help Members Meet MOC Requirements
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The first available module in the series focuses on Epilepsy. (Source: American Academy of Neurology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Epilepsy Fri, 4 Mar 2011 8:17:00 pm
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Eplipepsy - news item 7 of 45
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Migraine, Epilepsy Drug Topamax May Cause Newborn Cleft Palate
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The FDA has warned that the drug prescribed for epilepsy named Topamax (topiramate) should not be used by women who are pregnant or plan on childbearing, due to a very high risk of offspring bearing cleft lip and palate defects occuring during the first trimester. Topiramate treats epilepsy in children...
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RSS Source: Med Worm - Epilepsy Fri, 4 Mar 2011 5:00:00 pm
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Eplipepsy - news item 8 of 45
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US Warns Of Birth Defects With Topamax
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The U.S. Food and Drug Administration is warning women of child-bearing age that the epilepsy drug Topamax can increase the risk of birth defects around the mouth. (Source: WDSU.com - Health)
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RSS Source: Med Worm - Epilepsy Fri, 4 Mar 2011 4:16:23 pm
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Eplipepsy - news item 9 of 45
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FDA warns of birth defects with Topamax
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The U.S. Food and Drug Administration is warning women of child-bearing age that the epilepsy drug Topamax can increase the risk of birth defects ... (Source: USATODAY.com Health) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Epilepsy Fri, 4 Mar 2011 4:03:24 pm
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Eplipepsy - news item 10 of 45
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Health Highlights: March 4, 2011
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Fla. Judge Suspends His Ruling Against Health Reform Law FDA Warns of Birth Defects Tied to Epilepsy Drug High Blood Pressure Affects 1 in 4 U.S. Adults Congresswoman Giffords Continues Recovery Progress (Source: The Doctors Lounge - Health News)
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RSS Source: Med Worm - Epilepsy Fri, 4 Mar 2011 11:43:00 am
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Eplipepsy - news item 11 of 45
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New Birth Defect Warning for Topamax
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Taking the epilepsy drug topiramate (Topamax) during pregnancy raises the risk of oral cleft birth defects such as cleft lip and cleft palate, according to a new warning issued by the FDA. (Source: WebMD Health)
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RSS Source: Med Worm - Epilepsy Fri, 4 Mar 2011 4:00:00 am
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Eplipepsy - news item 12 of 45
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Whole class ban on substances is needed to control designer drugs, says UN agency
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(Source: BMJ Online First)
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RSS Source: Med Worm - Epilepsy Thu, 3 Mar 2011 11:00:00 pm
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Eplipepsy - news item 13 of 45
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Lower Socioeconomic Status Affects Epilepsy Outcomes
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Researchers speculate the disparities may be linked to differences in continuity of care. Medscape Medical News (Source: Medscape Today Headlines) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Epilepsy Thu, 3 Mar 2011 3:46:48 pm
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Eplipepsy - news item 14 of 45
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Mortality, Morbidity Low After Surgery for Intractable Epilepsy
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A new analysis using the Nationwide Inpatient Sample shows the incidence of morbidity is 8% after anterior temporal lobectomy for intractable temporal lobe epilepsy. Medscape Medical News (Source: Medscape Today Headlines)
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RSS Source: Med Worm - Epilepsy Thu, 3 Mar 2011 2:51:53 pm
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Eplipepsy - news item 15 of 45
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Clearing the smoke: the science of cannabis
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This video investigates the scientific basis underlying the medical utility of marijuana (cannabis)This morning, I was surprised to read about Seattle, my original hometown, in the Mail Online. Even more surprising was the reason for the story: a public cannabis farmer's market. A quick look around the internet unearthed a...
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RSS Source: Med Worm - Epilepsy Thu, 3 Mar 2011 8:15:49 am
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Eplipepsy - news item 16 of 45
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Protein kinase inhibitor as a potential candidate for epilepsy treatment
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SummaryPurpose:  Effects of the “VIDâ€82925†kinase inhibitor molecule were investigated both during the developing phase as well as during the stable phase of the focus with spontaneous recurrent seizures using the 4â€APâ€induced in vivo epilepsy model in anesthetized rats.Methods:  In electrophysiologic experiments, VIDâ€82925 (0.85 mg/kg) was injected intravenously either before the...
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RSS Source: Med Worm - Epilepsy Wed, 2 Mar 2011 11:00:00 pm
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Eplipepsy - news item 17 of 45
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The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway
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SummaryThe ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. We investigated the hypothesis that the KD inhibits mammalian target of rapamycin (mTOR) pathway signaling. The expression of pS6 and pAkt, markers of mTOR pathway activation, was reduced in hippocampus and liver...
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RSS Source: Med Worm - Epilepsy Wed, 2 Mar 2011 11:00:00 pm
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Eplipepsy - news item 18 of 45
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Adults with a history of possible Dravet syndrome: An illustration of the importance of analysis of the SCN1A gene
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We report on two unrelated fathers with severe childhood epilepsy compatible with a possible diagnosis of Dravet syndrome, who both have a child with Dravet syndrome. Analysis of the SCN1A gene revealed a pathogenic mutation in both children. One father exhibited somatic mosaicism for the mutation detected in his son....
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RSS Source: Med Worm - Epilepsy Wed, 2 Mar 2011 11:00:00 pm
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Eplipepsy - news item 19 of 45
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Physical conditions and challenging behaviour in people with intellectual disability: a systematic review
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Conclusion  Medical conditions can play a role in challenging behaviour, and this should be evaluated in the clinical setting. So far, the level of evidence is generally low, and longitudinal studies are completely lacking. We recommend a systematic approach to research examining the role of physical conditions in challenging behaviour,...
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RSS Source: Med Worm - Epilepsy Wed, 2 Mar 2011 11:00:00 pm
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Eplipepsy - news item 20 of 45
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Poor People with Epilepsy More Prone to Uncontrolled Seizures
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Drug side effects, ER visits also more frequent than in more affluent people with the disorder, study finds Source: HealthDay Related MedlinePlus Pages: Epilepsy, Health Disparities, Seizures (Source: MedlinePlus Health News)
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RSS Source: Med Worm - Epilepsy Wed, 2 Mar 2011 6:00:00 pm
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Eplipepsy - news item 21 of 45
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Potential Therapeutic Intervention For Lafora Disease
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A new study offers critical insight into the biochemistry of a rare and fatal form of epilepsy known as Lafora disease, a genetic condition that typically strikes children in their teens. The disease is characterized by the buildup of a "wrecked" form of glycogen, a stored form of glucose, in...
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RSS Source: Med Worm - Epilepsy Wed, 2 Mar 2011 10:00:00 am
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Eplipepsy - news item 22 of 45
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Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model
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This study provides evidence that sialic acid degradation can reduce the number of interictal spikes. Furthermore, the results suggest that modifying surface charge created by negatively charged sialic acid may provide new opportunities for reducing aberrant epileptiform events in epilepsy. (Source: Epilepsia)
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RSS Source: Med Worm - Epilepsy Tue, 1 Mar 2011 11:00:00 pm
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Eplipepsy - news item 23 of 45
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Refractory absence epilepsy associated with GLUTâ€1 deficiency syndrome
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We report two boys who presented with refractory absence epilepsy associated with hypoglycorrhachia, both of whom have genetically confirmed GLUTâ€1 DS. We propose that these children serve to expand the phenotype of GLUTâ€1 DS and suggest that this condition should be considered as a cause of refractory absence seizures in...
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RSS Source: Med Worm - Epilepsy Tue, 1 Mar 2011 11:00:00 pm
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Eplipepsy - news item 24 of 45
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In vivo diffusion tensor imaging and ex vivo histologic characterization of white matter pathology in a post†status epilepticus model of temporal lobe epilepsy
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SummaryAlthough epilepsy is historically considered a disease of gray matter, recent diffusion tensor imaging (DTI) studies have shown white matter abnormalities in patients with epilepsy. The histopathologic correlate of these findings, and whether they are a cause or consequence of epilepsy, remains unclear. To characterize these changes and their underlying...
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RSS Source: Med Worm - Epilepsy Tue, 1 Mar 2011 11:00:00 pm
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Eplipepsy - news item 25 of 45
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An assessment of MEG coherence imaging in the study of temporal lobe epilepsy
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This study examines whether magnetoencephalographic (MEG) coherence imaging is more sensitive than the standard single equivalent dipole (ECD) model in lateralizing the site of epileptogenicity in patients with drugâ€resistant temporal lobe epilepsy (TLE).Methods:  An archival review of ECD MEG analyses of 30 presurgical patients with TLE was undertaken with data...
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RSS Source: Med Worm - Epilepsy Tue, 1 Mar 2011 11:00:00 pm
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Eplipepsy - news item 26 of 45
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Development of later life spontaneous seizures in a rodent model of hypoxiaâ€induced neonatal seizures
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SummaryPurpose:  To study the development of epilepsy following hypoxiaâ€induced neonatal seizures in Longâ€Evans rats and to establish the presence of spontaneous seizures in this model of early life seizures.Methods:  Longâ€Evans rat pups were subjected to hypoxiaâ€induced neonatal seizures at postnatal day 10 (P10). Epidural cortical electroencephalography (EEG) and hippocampal depth electrodes...
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RSS Source: Med Worm - Epilepsy Tue, 1 Mar 2011 11:00:00 pm
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Eplipepsy - news item 27 of 45
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Copy Number Variants in Schizophrenia: Confirmation of Five Previous Findings and New Evidence for 3q29 Microdeletions and VIPR2 Duplications [Articles]
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Conclusions: The data strongly confirm the association of schizophrenia with 1q21.1, 15q13.3, and 22q11.21 deletions, 16p11.2 duplications, and exonic NRXN1 deletions. These CNVs, as well as 3q29 deletions, are also associated with mental retardation, autism spectrum disorders, and epilepsy. Additional candidate genes and regions, including VIPR2, were identified. Study of...
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RSS Source: Med Worm - Epilepsy Tue, 1 Mar 2011 11:00:00 pm
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Eplipepsy - news item 28 of 45
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Intellectual disability without epilepsy associated with STXBP1 disruption
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Authors: Fadi F Hamdan, Julie Gauthier, Sylvia Dobrzeniecka, Anne Lortie, Laurent Mottron, Michel Vanasse, Guy D'Anjou, Jean Claude Lacaille, Guy A Rouleau & Jacques L Michaud (Source: European Journal of Human Genetics)
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RSS Source: Med Worm - Epilepsy Tue, 1 Mar 2011 11:00:00 pm
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Eplipepsy - news item 29 of 45
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In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury
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Authors: Tobias Engel, Nikolaus Plesnila, Jochen H M Prehn & David C Henshall (Source: Journal of Cerebral Blood Flow)
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RSS Source: Med Worm - Epilepsy Tue, 1 Mar 2011 11:00:00 pm
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Eplipepsy - news item 30 of 45
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Elan Drug Firm to Pay $203 Million in Penalties
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From UPI Business News (March 1, 2011) A U.S. subsidiary of Irish drug maker Elan Corp. will pay $203 million in criminal and civil penalties for the way it promoted its epilepsy medication Zonegran. Elan Pharmaceuticals Inc. pleaded guilty... (Source: Drugs.com - Pharma News)
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RSS Source: Med Worm - Epilepsy Tue, 1 Mar 2011 11:12:59 am
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Eplipepsy - news item 31 of 45
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[Development of Lennox-Gastaut syndrome in adulthood.]
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CONCLUSIONS. Despite the fact that the diagnosis of LGS is serious, we observed a decrease in the number of seizures after several years of development, although the antiepileptic combination therapy remains constant. The mental retardation and behavioural disorders lead to a poor functional prognosis. PMID: 21341220 [PubMed - as supplied...
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RSS Source: Med Worm - Epilepsy Mon, 28 Feb 2011 11:00:00 pm
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Eplipepsy - news item 32 of 45
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Dural sinus thrombosis: a not so unusual clinical presentation
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(Source: Emergency Medicine Journal)
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RSS Source: Med Worm - Epilepsy Mon, 28 Feb 2011 11:00:00 pm
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Eplipepsy - news item 33 of 45
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Mortality in Childhood Epilepsy
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(Source: AAP Grand Rounds)
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RSS Source: Med Worm - Epilepsy Mon, 28 Feb 2011 11:00:00 pm
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Eplipepsy - news item 34 of 45
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How a good tune could cure our ills
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Scientists believe music can soothe pain, make you fitter, benefit epilepsy sufferers and speed recovery after a stroke. KATE HILPERN explains how. (Source: Daily Express - Health)
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RSS Source: Med Worm - Epilepsy Mon, 28 Feb 2011 11:00:00 pm
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Eplipepsy - news item 35 of 45
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Pre†and postâ€synaptic functions of kainate receptors at glutamate and GABA synapses in the rat entorhinal cortex
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AbstractOscillatory network activity in cortical areas is seen as vital to physiological processes of cognition, learning, and memory, and fundamental to disorders such as epilepsy. Increasing attention is being paid to the role of kainate receptors (KAr) in the generation of network oscillations and synchrony. The entorhinal cortex (EC) plays...
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RSS Source: Med Worm - Epilepsy Mon, 28 Feb 2011 11:00:00 pm
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Eplipepsy - news item 36 of 45
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The prevalence and demographic distribution of treated epilepsy: a communityâ€based study in Tasmania, Australia
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Conclusions†  Although our estimates are likely to be affected by access to health services, overall treated epilepsy prevalence of 4.4 per 1000 is similar to previous studies. Our finding of high elderly prevalence has been reported in a few recent studies in developed countries and has important clinical and...
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RSS Source: Med Worm - Epilepsy Mon, 28 Feb 2011 11:00:00 pm
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Eplipepsy - news item 37 of 45
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Vigabatrin for Infantile Spasms
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Pharmacotherapy 31(3): 298-311 Abstract Infantile spasms describe a pediatric epilepsy syndrome characterized by frequent clusters of brief symmetric muscle contractions; the condition is often associated with developmental delay. When infantile spasms are accompanied by hypsarrhythmia on electroencephalogram, the condition is labeled West syndrome. The mainstay of treatment for infantile spasms...
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RSS Source: Med Worm - Epilepsy Mon, 28 Feb 2011 11:00:00 pm
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Eplipepsy - news item 38 of 45
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Migralepsy, hemicrania epileptica, post-ictal headache and “ictal epileptic headacheâ€: a proposal for terminology and classification revision
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Abstract Despite the fact that migraine and epilepsy are among the commoner brain diseases and that comorbidity of these conditions is well known, only few reports of migralepsy and hemicrania epileptica (HE) have been published according to the current ICHD-II criteria. Particularly, ICHD-II describes “migraine-triggered seizure†(i.e., migralepsy) among complications...
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RSS Source: Med Worm - Epilepsy Mon, 28 Feb 2011 4:12:52 pm
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Eplipepsy - news item 39 of 45
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Nuclear Factor-Kappa B Activity Regulates Brain Expression of P-Glycoprotein in the Kainic Acid-Induced Seizure Rats
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This study was aimed to investigate the effect of NF-κB activity on the seizure susceptibility, brain damage, and P-gp expression in kainic acid- (KA-) induced seizure rats. Male SD rats were divided into saline control group (NS group), KA induced epilepsy group (EP group), and epilepsy group intervened with NF-κB...
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RSS Source: Med Worm - Epilepsy Mon, 28 Feb 2011 10:50:44 am
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Eplipepsy - news item 40 of 45
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Repeat Surgery for Hypothalamic Hamartoma in Refractory Epilepsy
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If the first surgery for hypothalamic hamartoma fails, can a second surgery succeed? Neurosurgical Focus (Source: Medscape Today Headlines)
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RSS Source: Med Worm - Epilepsy Mon, 28 Feb 2011 3:00:00 am
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Eplipepsy - news item 41 of 45
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Induction of epileptic negative myoclonus by addition of lacosamide to carbamazepine.
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Authors: Belcastro V, Arnaboldi M, Taborelli A, Prontera P PMID: 21367668 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
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RSS Source: Med Worm - Epilepsy Sun, 27 Feb 2011 11:00:00 pm
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Eplipepsy - news item 42 of 45
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POLG1 manifestations in childhood
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Conclusions: POLG1 analysis should belong to the first-line DNA diagnostic tests for children with an encephalitis-like presentation evolving into epileptic encephalopathy with liver involvement (Alpers syndrome), even if brain MRI and morphology, respiratory chain activities, and the amount of mitochondrial DNA in the skeletal muscle are normal. POLG1 analysis should...
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RSS Source: Med Worm - Epilepsy Sun, 27 Feb 2011 11:00:00 pm
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Eplipepsy - news item 43 of 45
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Motor vehicle accidents, suicides, and assaults in epilepsy: A population-based study
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Conclusion: In this cohort-controlled population-based study, once important medical and psychiatric comorbidities were adjusted for, people with epilepsy were not more likely to attempt suicide or experience MVAs, but were still more likely to be assaulted compared to those without epilepsy. (Source: Neurology)
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RSS Source: Med Worm - Epilepsy Sun, 27 Feb 2011 11:00:00 pm
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Eplipepsy - news item 44 of 45
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GABAB receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders
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Conclusions: GABABR-ab are the most common antibodies found in LE associated with SCLC previously considered "seronegative." In patients with GAD-ab, the frequency of GABABR-ab is low and only observed in the context of cancer. (Source: Neurology) MedWorm Message: Watch the new MedWorm demo and find out how to get all...
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RSS Source: Med Worm - Epilepsy Sun, 27 Feb 2011 11:00:00 pm
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Eplipepsy - news item 45 of 45
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Motor vehicle crashes, suicides, and assaults: The dangers of epilepsy?
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(Source: Neurology)
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RSS Source: Med Worm - Epilepsy Sun, 27 Feb 2011 11:00:00 pm
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