Huntington's Disease - news item 1 of 44
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Mechanism uncovered of action of antibiotic able to reduce neuronal cell death in brain
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Research Highlights: Mechanism of action of compound found to induce neurotransmitter activity in brain cells The findings may lead researchers to develop potential novel therapies to treat Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, (Source: Alzheimer's / Dementia News From Medical News Today)
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RSS Source: Med Worm - Huntington's Disease Mon, 12 May 2008 10:00:00 am
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Huntington's Disease - news item 2 of 44
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Mechanism of action of antibiotic able to reduce neuronal cell death in brain uncovered
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Researchers have discovered how an antibiotic works to modulate the activity of a neurotransmitter that regulates brain functions, which eventually could lead to therapies to treat Alzheimer's disease, Huntington's disease, epilepsy, stroke, dementia and malignant gliomas. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Huntington's Disease Mon, 12 May 2008 9:00:00 am
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Huntington's Disease - news item 3 of 44
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Discovery of mechanism of action of antibiotic able to reduce neuronal cell death in brain
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Virginia Commonwealth University researchers have discovered how an antibiotic works to modulate the activity of a neurotransmitter that regulates brain functions, which eventually could lead to therapies to treat Alzheimer's disease, Huntington's disease, epilepsy, stroke, dementia and malignant gliomas. (Source: News-Medical News Feed)
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RSS Source: Med Worm - Huntington's Disease Sun, 11 May 2008 10:45:55 pm
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Huntington's Disease - news item 4 of 44
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Researchers uncover mechanism of action of antibiotic able to reduce neuronal cell death in brain
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(Virginia Commonwealth University) Virginia Commonwealth University researchers have discovered how an antibiotic works to modulate the activity of a neurotransmitter that regulates brain functions, which eventually could lead to therapies to treat Alzheimer's disease, Huntington's disease, epilepsy, stroke, dementia and malignant gliomas. (Source: EurekAlert! - Biology)
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RSS Source: Med Worm - Huntington's Disease Fri, 9 May 2008 4:00:00 am
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Huntington's Disease - news item 5 of 44
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Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts
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Background: The polyglutamine expansion in huntingtin (Htt) protein is a cause of Huntington's disease (HD). Htt is an essential gene as deletion of the mouse Htt gene homolog (Hdh) is embryonic lethal in mice. Therefore, in addition to elucidating the mechanisms responsible for polyQ-mediated pathology, it is also important to...
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RSS Source: Med Worm - Huntington's Disease Tue, 15 Apr 2008 4:00:00 am
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Huntington's Disease - news item 6 of 44
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Spectrum of gait impairments in presymptomatic and symptomatic huntington's disease
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The purpose of this study was to quantify gait impairments in presymptomatic and symptomatic Huntington's disease (HD) subjects, and examine sensitivity of gait measures. Our sample (n = 65) included presymptomatic mutation carriers (PMC) (n = 15), symptomatic HD subjects (SHD) (n = 30) and healthy controls (n = 20). Participants were requested to...
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RSS Source: Med Worm - Huntington's Disease Tue, 15 Apr 2008 4:00:00 am
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Huntington's Disease - news item 7 of 44
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[medical_sciences] artificial mirnas mitigate shrna-mediated toxicity in the brain: implications for the therapeutic development of rnai
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Huntington's disease (HD) is a fatal, dominant neurodegenerative disease caused by a polyglutamine repeat expansion in exon 1 of the... (Source: Proceedings of the National Academy of Sciences)
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RSS Source: Med Worm - Huntington's Disease Tue, 15 Apr 2008 4:00:00 am
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Huntington's Disease - news item 8 of 44
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Impaired ubiquitin-proteasome system activity in the synapses of huntington's disease mice
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(Source: The Journal of Experimental Medicine)
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RSS Source: Med Worm - Huntington's Disease Mon, 14 Apr 2008 4:00:00 am
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Huntington's Disease - news item 9 of 44
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Increased thirst and drinking in huntington's disease and the r6/2 mouse.
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Related Articles Increased thirst and drinking in Huntington's disease and the R6/2 mouse. Brain Res Bull. 2008 May 15;76(1-2):70-9 Authors: Wood NI, Goodman AO, van der Burg JM, Gazeau V, Brundin P, Björkqvist M, Petersén A, Tabrizi SJ, Barker RA, Jennifer Morton A While Huntington's disease (HD) is a condition...
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RSS Source: Med Worm - Huntington's Disease Wed, 9 Apr 2008 8:39:25 pm
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Huntington's Disease - news item 10 of 44
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Targeted genetics: targeted genetics announces publication of preclinical data supporting the use of aav vectors to deliver sirna
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SEATTLE, WA (MARKET WIRE) Targeted Genetics Corporation (NASDAQ: TGEN) today announced the publication of preclinical data characterizing the novel use of Adeno-Associated Viral (AAV) vectors to deliver small interfering RNA (siRNA) for the treatment of Huntington's disease. The goal of this research is to assess the use of interfering RNA...
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RSS Source: Med Worm - Huntington's Disease Wed, 9 Apr 2008 11:30:00 am
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Huntington's Disease - news item 11 of 44
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Targeted genetics: targeted genetics acquires rights to sirna development program in huntington's disease from sirna therapeutics
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SEATTLE, WA (MARKET WIRE) Targeted Genetics Corporation (NASDAQ: TGEN) today announced that it has acquired full exclusive rights to its preclinical Huntington's disease (HD) program from Sirna Therapeutics, a wholly owned subsidiary of Merck & Co., Inc. (Source: Market Wire - Pharmaceuticals and Biotech)
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RSS Source: Med Worm - Huntington's Disease Mon, 7 Apr 2008 11:30:00 am
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Huntington's Disease - news item 12 of 44
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Physical activity delays onset of huntington's in mouse model
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The simple act of running in an exercise wheel delays the onset of some symptoms of Huntington's disease in a mouse model of the fatal human disorder according to new research. These findings add insights into the pathogenesis of the disease and suggest possible preventive therapeutic targets. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Huntington's Disease Wed, 2 Apr 2008 8:28:24 am
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Huntington's Disease - news item 13 of 44
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Onset of huntington's delayed by physical activity in mouse model
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The simple act of running in an exercise wheel delays the onset of some symptoms of Huntington's disease in a mouse model of the fatal human disorder according to research published in the open-access journal BMC Neuroscience. These findings add insights into the pathogenesis of the disease and suggest possible...
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RSS Source: Med Worm - Huntington's Disease Tue, 1 Apr 2008 11:00:00 am
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Huntington's Disease - news item 14 of 44
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Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of huntington's disease
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Background: Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat encoding an expanded polyglutamine tract in the N-terminus of the huntingtin protein, closely model HD. We have previously shown that environmental enrichment of these HD mice delays...
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RSS Source: Med Worm - Huntington's Disease Tue, 1 Apr 2008 4:00:00 am
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Huntington's Disease - news item 15 of 44
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Sirtris pharmaceuticals scientific advisor shows sirt1 activation improves huntington's disease in preclinical model
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Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT), a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging, announced that Sirtris Scientific Advisory Board Co-Chair Leonard P. (Source: Health News from Medical News Today)
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RSS Source: Med Worm - Huntington's Disease Mon, 31 Mar 2008 11:00:00 am
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Huntington's Disease - news item 16 of 44
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Falls and gait disturbances in huntington's disease
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Falls are common in patients with Huntington's disease, but the incidence, falling circumstances and contributing factors have never been examined. We recorded falls in 45 early to midstage Huntington's disease patients, both retrospectively (12 months) and prospectively (3 months). Fall rates were related to relevant baseline measures, including the Unified...
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RSS Source: Med Worm - Huntington's Disease Mon, 31 Mar 2008 4:00:00 am
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Huntington's Disease - news item 17 of 44
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Sar and qsar study on 2-aminothiazole derivatives, modulators of transcriptional repression in huntington's disease.
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Related Articles SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease. Bioorg Med Chem. 2008 Mar 30; Authors: Leone S, Mutti C, Kazantsev A, Sturlese M, Moro S, Cattaneo E, Rigamonti D, Contini A REST/NRSF is a multifunctional transcription factor that represses or silences many...
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RSS Source: Med Worm - Huntington's Disease Sun, 30 Mar 2008 4:00:00 am
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Huntington's Disease - news item 18 of 44
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Cerebral cortex and the clinical expression of huntington's disease: complexity and heterogeneity
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The clinical phenotype of Huntington's disease (HD) is far more complex and variable than depictions of it as a progressive movement disorder dominated by neostriatal pathology represent. The availability of novel neuro-imaging methods has enabled us to evaluate cerebral cortical changes in HD, which we have found to occur early...
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RSS Source: Med Worm - Huntington's Disease Sat, 29 Mar 2008 4:00:00 am
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Huntington's Disease - news item 19 of 44
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Language processing within the striatum: evidence from a pet correlation study in huntington's disease
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The role of sub-cortical structures in language processing, and more specifically of the striatum, remains controversial. In line with psycholinguistic models stating that language processing implies both the recovery of lexical information and the application of combinatorial rules, the striatum has been claimed to be involved either in the former...
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RSS Source: Med Worm - Huntington's Disease Sat, 29 Mar 2008 4:00:00 am
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Huntington's Disease - news item 20 of 44
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Sirtris pharmaceuticals scientific advisor shows sirt1 activation improves huntington's disease in preclinical model
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CAMBRIDGE, Mass.--(BUSINESS WIRE)--Mar 28, 2008 - Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT), a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging, announced that Sirtris Scientific... (Source: Drugs.com - Clinical Trials)
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RSS Source: Med Worm - Huntington's Disease Fri, 28 Mar 2008 1:00:04 pm
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Huntington's Disease - news item 21 of 44
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Promising new drug targets identified for huntington's disease
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Research funded by the Wellcome Trust has provided a number of promising new drug targets for Huntington's disease, a neurodegenerative disease. Scientists at the University of Cambridge have identified a number of candidate drugs to investigate further which encourage cells to "eat" the malformed proteins that lead to the disease. (...
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RSS Source: Med Worm - Huntington's Disease Mon, 24 Mar 2008 10:00:00 am
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Huntington's Disease - news item 22 of 44
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Novel targets for huntington's disease in an mtor-independent autophagy pathway
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Novel targets for Huntington's disease in an mTOR-independent autophagy pathway Nature Chemical Biology 4, 295 (2008). doi:10.1038/nchembio.79 Authors: Andrea Williams, Sovan Sarkar, Paul Cuddon, Evangelia K Ttofi, Shinji Saiki, Farah H Siddiqi, Luca Jahreiss, Angeleen Fleming, Dean Pask, Paul Goldsmith, Cahir J O'Kane, Rodrigo Andres Floto & David C Rubinsztein (...
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RSS Source: Med Worm - Huntington's Disease Sun, 23 Mar 2008 4:00:00 am
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Huntington's Disease - news item 23 of 44
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Restorative neuroscience: concepts and perspectives.
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Related Articles Restorative neuroscience: concepts and perspectives. Swiss Med Wkly. 2008 Mar 22;138(11-12):155-72 Authors: Andres R, Meyer M, Ducray A, Widmer H There is increasing interest in the search for therapeutic options for diseases and injuries of the central nervous system (CNS), for which currently no effective treatment strategies are...
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RSS Source: Med Worm - Huntington's Disease Sat, 22 Mar 2008 3:00:00 am
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Huntington's Disease - news item 24 of 44
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Avicena's hd-02 to proceed to nih sponsored phase iii huntington's disease trial
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Avicena Group, Inc. (OTC Bulletin Board: AVGO), a late stage biotechnology company that develops central nervous system therapeutics for neurodegenerative diseases, announced that it met with the Food and Drug Administration (FDA) and will proceed with a Phase III trial of its lead drug candidate, HD-02, for the treatment of...
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RSS Source: Med Worm - Huntington's Disease Thu, 13 Mar 2008 6:00:00 am
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Huntington's Disease - news item 25 of 44
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Stimulus-response compatibility in huntington's disease: a cognitive-neurophysiological analysis
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The basal ganglia are assumed to be of importance in action/response selection, but results regarding the importance are contradictive. We investigate these processes in relation to attentional processing using event-related potentials (ERPs) in Huntington's disease (HD), an autosomal genetic disorder expressed by degeneration of the basal ganglia, using a flanker...
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RSS Source: Med Worm - Huntington's Disease Wed, 12 Mar 2008 3:00:00 am
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Huntington's Disease - news item 26 of 44
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Genetic alteration improved by new stem cell technique
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UC Irvine researchers have discovered a dramatically improved method for genetically manipulating human embryonic stem cells, making it easier for scientists to study and potentially treat thousands of disorders ranging from Huntington's disease to muscular dystrophy and diabetes.The technique for the first time blends two existing cell-handling methods to improve...
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RSS Source: Med Worm - Huntington's Disease Mon, 10 Mar 2008 8:00:00 am
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Huntington's Disease - news item 27 of 44
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New stem cell technique improves genetic alteration
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Researchers have discovered a dramatically improved method for genetically manipulating human embryonic stem cells, making it easier for scientists to study and potentially treat thousands of disorders ranging from Huntington's disease to muscular dystrophy and diabetes. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Huntington's Disease Sun, 9 Mar 2008 5:00:02 am
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Huntington's Disease - news item 28 of 44
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Large isoform of mrj (dnajb6) reduces malignant activity of breast cancer
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Background: MRJ, (DNAJB6), a novel member of the human DnaJ family, encodes two isoforms. The smaller isoform, MRJ(S), is studied mainly for a possible role in Huntington's disease. There are no reports about any biological activity of the longer isoform, MRJ(L). We investigated a possible role of this molecule in...
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RSS Source: Med Worm - Huntington's Disease Fri, 7 Mar 2008 4:00:00 am
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Huntington's Disease - news item 29 of 44
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Huntington's disease association
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Research Project Grants Amount: £10K - £50K Closing Date : 14 April 2008 Studentship Amount: £50K - £100K Closing Date : 14 April 2008 (Source: RDFunding RSS feed)
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RSS Source: Med Worm - Huntington's Disease Thu, 6 Mar 2008 8:31:24 pm
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Huntington's Disease - news item 30 of 44
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[genetics] dna instability in postmitotic neurons
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Huntington's disease (HD) is caused by a CAG repeat expansion that is unstable upon germ-line transmission and exhibits mosaicism in... (Source: Proceedings of the National Academy of Sciences)
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RSS Source: Med Worm - Huntington's Disease Tue, 4 Mar 2008 4:00:00 am
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Huntington's Disease - news item 31 of 44
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Ideomotor limb apraxia in huntington's disease
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Abstract Introduction Ideomotor limb apraxia is the disturbance of planning and of execution of motor activity,which is not caused by a dysfunction of the motor or sensory nervous system. Apraxia is a diagnostic criterion in dementialike Alzheimer's disease. However, this symptom may also occur in dementia with subcortical lesions like...
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RSS Source: Med Worm - Huntington's Disease Thu, 28 Feb 2008 2:53:24 pm
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Huntington's Disease - news item 32 of 44
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Huntington's disease as caused by 34 cag repeats
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Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by an abnormal expansion of a polymorphic stretch of CAG repeats in the coding 5[prime] part of the HD gene on chromosome 4p. Expansions of CAG blocks beyond 35 repeats are associated with the clinical presentation of HD. There...
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RSS Source: Med Worm - Huntington's Disease Thu, 28 Feb 2008 4:00:00 am
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Huntington's Disease - news item 33 of 44
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Behavioural problems in huntington's disease using the problem behaviours assessment.
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Related Articles Behavioural problems in Huntington's disease using the Problem Behaviours Assessment. Gen Hosp Psychiatry. 2008 Mar-Apr;30(2):155-61 Authors: Kingma EM, van Duijn E, Timman R, van der Mast RC, Roos RA OBJECTIVE: To investigate behavioural problems in Huntington's disease (HD). METHOD: In 152 HD mutation carriers and a control group...
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RSS Source: Med Worm - Huntington's Disease Sat, 23 Feb 2008 8:05:35 pm
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Huntington's Disease - news item 34 of 44
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Sustained striatal ciliary neurotrophic factor expression negatively affects behavior and gene expression in normal and r6/1 mice
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Huntington's disease (HD) is a neurodegenerative disorder caused by an elongation of CAG repeats in the HD gene, which encodes a mutant copy of huntingtin with an expanded polyglutatmine repeat. Individuals who are affected by the disease suffer from motor, cognitive, and emotional impairments. Levels of certain striatal-enriched mRNAs decrease...
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RSS Source: Med Worm - Huntington's Disease Thu, 21 Feb 2008 4:00:00 am
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Huntington's Disease - news item 35 of 44
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[developmental and behavioral genetics] the glucose transporter (glut4) enhancer factor is required for normal wing positioning in drosophila
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Many of the transcription factors and target genes that pattern the developing adult remain unknown. In the present study, we find that an ortholog of the poorly understood transcription factor, glucose transporter (GLUT4) enhancer factor (Glut4EF, GEF) [also known as the Huntington's disease gene regulatory region-binding protein (HDBP) 1], plays...
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RSS Source: Med Worm - Huntington's Disease Wed, 20 Feb 2008 4:00:00 am
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Huntington's Disease - news item 36 of 44
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Excitotoxic neuronal death and the pathogenesis of huntington's disease.
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Related Articles Excitotoxic Neuronal Death and the Pathogenesis of Huntington's Disease. Arch Med Res. 2008 Apr;39(3):265-276 Authors: Estrada Sánchez AM, Mejía-Toiber J, Massieu L Huntington's disease (HD) is a neurodegenerative hereditary illness originated by the mutation of the gene encoding the huntingtin-protein (htt). Mutated htt (mhtt) is characterized by an...
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RSS Source: Med Worm - Huntington's Disease Tue, 19 Feb 2008 7:54:29 pm
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Huntington's Disease - news item 37 of 44
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Breaking down huntington's disease one protein at a time
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Hoping to piece together the intricate series of interactions that lead to Huntington's disease, scientists have determined the shape and structure of a binding site that may prove useful in combating the neurodegenerative disease. Huntington's disease is a hereditary disorder that causes large numbers of nerve cells to die. About...
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RSS Source: Med Worm - Huntington's Disease Fri, 8 Feb 2008 6:00:00 am
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Huntington's Disease - news item 38 of 44
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Huntington's disease broken down one protein at a time
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Hoping to piece together the intricate series of interactions that lead to Huntington's disease, Indiana University Bloomington scientists have determined the shape and structure of a binding site that may prove useful in combating the neurodegenerative disease.In the Feb. (Source: Huntingtons Disease News From Medical News Today)
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RSS Source: Med Worm - Huntington's Disease Tue, 5 Feb 2008 12:00:00 pm
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Huntington's Disease - news item 39 of 44
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Continuous infusions of apomorphine show promise in the treatment of some patients with huntington's disease,.
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Page: 13 (Source: Inpharma Weekly)
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RSS Source: Med Worm - Huntington's Disease Tue, 5 Feb 2008 7:41:45 am
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Huntington's Disease - news item 40 of 44
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Phylogenetic comparison of huntingtin homologues reveals the appearance of a primitive polyq in sea urchin
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Huntingtin is a completely soluble 3,144 amino acid (aa) protein characterized by the presence of an amino-terminal polymorphic polyglutamine (polyQ) tract, whose aberrant expansion causes the progressively neurodegenerative Huntington's disease (HD). Biological evidence indicates that huntingtin (htt) is beneficial to cells (particularly to brain neurons) and that loss of its...
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RSS Source: Med Worm - Huntington's Disease Mon, 4 Feb 2008 4:00:00 am
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Huntington's Disease - news item 41 of 44
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[structural plasticity in the adult central nervous system]
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Related Articles [Structural plasticity in the adult central nervous system] Tidsskr Nor Laegeforen. 2008 Jan 31;128(3):298-302 Authors: Elvsåshagen T, Malt UF BACKGROUND: Neurobiological research indicates that the adult central nervous system is more plastic than previously believed. This article reviews structural plasticity in the adult central nervous system. MATERIAL AND...
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RSS Source: Med Worm - Huntington's Disease Thu, 31 Jan 2008 5:00:00 am
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Huntington's Disease - news item 42 of 44
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Mental and physical exercise delays dementia in fatal genetic disease
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Scientists have discovered that mental and physical stimulation delays the onset of dementia in the fatal genetic disease, Huntington's disease. This research opens up new therapeutic possibilities for other devastating and difficult to treat brain diseases, including Alzheimer's disease where dementia is a key component. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Huntington's Disease Wed, 30 Jan 2008 3:00:00 am
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Huntington's Disease - news item 43 of 44
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Chromosomal profiles of gene expression in huntington's disease
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Recent studies suggested that Huntington's disease is due to aberrant interactions between mutant huntingtin protein, transcription factors and transcriptional co-activators resulting in widespread transcriptional dysregulation. Mutant huntingtin also interacts with histone acetyltransferases, consequently interfering with the acetylation and deacetylation states of histones. Because histone modifications and chromatin structure coordinate the...
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RSS Source: Med Worm - Huntington's Disease Fri, 25 Jan 2008 4:00:00 am
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Huntington's Disease - news item 44 of 44
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Mental, physical activity delays dementia
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Australian researchers say they discovered that mental and physical stimulation delays the onset of dementia in Huntington's disease. (Source: United Press International - Health Business)
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RSS Source: Med Worm - Huntington's Disease Fri, 25 Jan 2008 2:22:16 am
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