Huntington's Disease - news item 1 of 129
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A Huntington's disease phenocopy characterized by pallidoâ€nigroâ€luysian degeneration with brain iron accumulation and p62â€positive glial inclusions
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(Source: Neuropathology and Applied Neurobiology)
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RSS Source: Med Worm - Huntington's Disease Wed, 8 Sep 2010 6:41:50 am
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Huntington's Disease - news item 2 of 129
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Although the symptoms of Huntingtons disease can be treated, the course of the disease cannot currently be altered
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(Source: Drugs)
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RSS Source: Med Worm - Huntington's Disease Wed, 8 Sep 2010 5:46:21 am
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Huntington's Disease - news item 3 of 129
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MR Imaging May Have New Role in Neurological Diagnoses
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Nuclear magnetic resonance (NMR) spectroscopy can distinguish mice with the Huntington's disease (HD) mutation from normal mice, and it holds promise for rapidly and non-invasively diagnosing neurological degenerative diseases, according to a study in the Oct. 15 issue of the Journal of Comparative Neurology. (Source: Modern Medicine)
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RSS Source: Med Worm - Huntington's Disease Tue, 31 Aug 2010 11:00:00 pm
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Huntington's Disease - news item 4 of 129
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Translation of stem cell therapy for neurological diseases.
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Authors: Schwarz SC, Schwarz J "Regenerative medicine" hopefully will provide novel therapies for diseases that remain without effective therapy. This development is also true for most neurodegenerative disorders including Alzheimer's disease, Huntington's disease, or Parkinson's disease. Transplantation of new neurons to the brain has been performed in Parkinson's disease and...
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RSS Source: Med Worm - Huntington's Disease Tue, 31 Aug 2010 10:09:22 pm
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Huntington's Disease - news item 5 of 129
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Derivation of Huntington's Disease-Affected Human Embryonic Stem Cell Lines
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Stem Cells and Development , Vol. 0, No. 0. (Source: Stem Cells and Development)
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RSS Source: Med Worm - Huntington's Disease Tue, 31 Aug 2010 2:11:51 pm
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Huntington's Disease - news item 6 of 129
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Nicotinamide improves motor deficits and upregulates PGC-1alpha and BDNF gene expression in a mouse model of Huntington's disease.
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In this study, both mini-osmotic pumps and drinking water deliveries were tested at 250mg NAM/kg/day, using the B6.HDR6/1 transgenic mouse model. Results were similar for both modes of delivery, and there was no evidence of toxicity. We found that NAM treatment increased mRNA levels of brain-derived neurotrophic factor (BDNF), and...
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RSS Source: Med Worm - Huntington's Disease Fri, 20 Aug 2010 11:00:00 pm
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Huntington's Disease - news item 7 of 129
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Composite Primary Neuronal High-Content Screening Assay for Huntington's Disease Incorporating Non-Cell-Autonomous Interactions
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Huntington’s disease (HD) is a fatal neurodegenerative disease characterized by progressive cognitive, behavioral, and motor deficits and caused by expansion of a polyglutamine repeat in the Huntingtin protein (Htt). Despite its monogenic nature, HD pathogenesis includes obligatory non-cell-autonomous pathways involving both the cortex and the striatum, and therefore effective recapitulation...
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RSS Source: Med Worm - Huntington's Disease Fri, 20 Aug 2010 3:58:35 pm
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Huntington's Disease - news item 8 of 129
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Impaired ATF6alpha processing, decreased Rheb and neuronal cell cycle re-entry in Huntington's disease.
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Authors: Fernandez-Fernandez MR, Ferrer I, Lucas JJ The endoplasmic reticulum-stress response is induced in several neurodegenerative diseases and in cellular models of Huntington s disease. However, here we report that the processing of ATF6alpha to its active nuclear form, one of the three branches of endoplasmic reticulum-stress activation, is impaired...
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RSS Source: Med Worm - Huntington's Disease Thu, 19 Aug 2010 11:00:00 pm
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Huntington's Disease - news item 9 of 129
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Human Cytomegalovirus UL97 Kinase Prevents the Deposition of Mutant Protein Aggregates in Cellular Models of Huntington's Disease and Ataxia.
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We report that UL97 prevents the deposition of aggregates of two non-polyQ proteins: a protein chimera (GFP170*) composed of the green fluorescent protein and a fragment of the Golgi Complex protein (GCP-170); and a chimera composed of the red fluorescent protein (RFP) fused to the Werner Syndrome protein (WRN), a...
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RSS Source: Med Worm - Huntington's Disease Thu, 19 Aug 2010 11:00:00 pm
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Huntington's Disease - news item 10 of 129
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Déjàvu with a twist: transglutaminases in bioenergetics and transcriptional dysfunction in Huntington's disease.
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Authors: Kazemi-Esfarjani P, La Spada AR The article by McConoughey et al in the current issue of EMBO Molecular Medicine examines the contribution of transglutaminase 2 (TG2) to Huntington's disease (HD) pathogenesis. The authors find that TG2 inhibition can ameliorate HD neurodegeneration, and thereby elevate the status of transglutaminases (TGs)...
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RSS Source: Med Worm - Huntington's Disease Thu, 19 Aug 2010 11:00:00 pm
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Huntington's Disease - news item 11 of 129
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Déjà vu with a twist: transglutaminases in bioenergetics and transcriptional dysfunction in Huntington's disease
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(Source: EMBO Molecular Medicine)
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RSS Source: Med Worm - Huntington's Disease Thu, 19 Aug 2010 11:00:00 pm
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Huntington's Disease - news item 12 of 129
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Altered Manganese Homeostasis and Manganese Toxicity in a Huntington's Disease Striatal Cell Model Are Not Explained by Defects in the Iron Transport System
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Expansion of a polyglutamine tract in Huntingtin (Htt) leads to the degeneration of medium spiny neurons in Huntington's disease (HD). Furthermore, the HTT gene has been functionally linked to iron (Fe) metabolism, and HD patients show alterations in brain and peripheral Fe homeostasis. Recently, we discovered that expression of mutant...
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RSS Source: Med Worm - Huntington's Disease Wed, 18 Aug 2010 1:24:45 am
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Huntington's Disease - news item 13 of 129
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Reduced gluconeogenesis and lactate clearance in Huntington's disease.
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Authors: Josefsen K, Nielsen SM, Campos A, Seifert T, Hasholt L, Nielsen JE, Nørremølle A, Skotte NH, Secher NH, Quistorff B We studied systemic and brain glucose and lactate metabolism in Huntington's disease (HD) patients in response to ergometer cycling. Following termination of exercise, blood glucose increased abruptly in control...
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RSS Source: Med Worm - Huntington's Disease Tue, 17 Aug 2010 11:00:00 pm
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Huntington's Disease - news item 14 of 129
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Ageing: Proteins clump with age
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Nature 466, 904 (2010). doi:10.1038/466904b PLoS Biol.8, e1000450 (2010) 10.1371/journal.pbio.1000450Ageing worms accumulate protein clumps similar to those observed in humans with Alzheimer's and Huntington's disease.Cynthia Kenyon and her colleagues at the University of California, San Francisco, searched for proteins made by the nematode (Source: Nature)
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RSS Source: Med Worm - Huntington's Disease Tue, 17 Aug 2010 11:00:00 pm
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Huntington's Disease - news item 15 of 129
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Does Huntingtin play a role in selective macroautophagy?
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Authors: Steffan JS The accumulation of protein aggregates in neurons appears to be a basic feature of neurodegenerative disease. In Huntington's disease (HD), a progressive and ultimately fatal neurodegenerative disorder caused by an expansion of the polyglutamine repeat within the protein Huntingtin (Htt), the immediate proximal cause of disease is...
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RSS Source: Med Worm - Huntington's Disease Tue, 17 Aug 2010 5:33:12 pm
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Huntington's Disease - news item 16 of 129
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A complementary diffusion tensor imaging (DTI)-histological study in a model of Huntington's disease.
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Authors: Van Camp N, Blockx I, Camón L, de Vera N, Verhoye M, Veraart J, Van Hecke W, MartÃÂnez E, Guadalupe S, Sijbers J, Planas AM, Van der Linden A In vivo diffusion tensor imaging (DTI) was performed on the quinolinic acid (QUIN) rat model of Huntington's disease, together with...
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RSS Source: Med Worm - Huntington's Disease Mon, 16 Aug 2010 11:00:00 pm
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Huntington's Disease - news item 17 of 129
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Orienting Cell-Fate Decisions: Huntingtin Joins the Ranks.
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Authors: Feng Y How mitotic cell fate is regulated in the developing mammalian CNS is an important but largely unanswered question. Recently reporting in Neuron, Godin et al. showed that Huntingtin, the protein mutated in Huntington's disease, is required for both cerebral cortical neurogenesis and mitotic spindle function in neural...
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RSS Source: Med Worm - Huntington's Disease Mon, 16 Aug 2010 11:00:00 pm
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Huntington's Disease - news item 18 of 129
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A working life: The pathologist
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Forget Silent Witness and CSI; Stephen Abbs works with 90,000 DNA samples, and no bodies. The results create key advances in medicineUnlike television pathologists in CSI or Silent Witness, Stephen Abbs goes nowhere near cadavers or organs. As head of the Molecular Genetics laboratory at GSTS Pathology at Guy's hospital...
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RSS Source: Med Worm - Huntington's Disease Fri, 13 Aug 2010 11:01:34 pm
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Huntington's Disease - news item 19 of 129
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Huntingtin Linked To Neurogenesis
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New research finds that a protein that is often mutated in Huntington's disease (HD) plays an unexpected role in the process of neurogenesis. The research, published by Cell Press in the August 12 issue of the journal Neuron, provides new insight into HD pathology and has even broader implications for...
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RSS Source: Med Worm - Huntington's Disease Fri, 13 Aug 2010 7:00:00 am
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Huntington's Disease - news item 20 of 129
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Hypothalamic-pituitary-adrenal axis functioning in Huntington's disease mutation carriers compared with mutation-negative first-degree controls.
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Authors: van Duijn E, Selis MA, Giltay EJ, Zitman FG, Roos RA, van Pelt H, van der Mast RC Neurodegeneration in Huntington's disease (HD) occurs in various brain regions including the hypothalamus. In this cross-sectional study, hypothalamic-pituitary-adrenal (HPA) axis functioning was studied in 26 presymptomatic and 58 symptomatic HD mutation...
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RSS Source: Med Worm - Huntington's Disease Thu, 12 Aug 2010 11:00:00 pm
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Huntington's Disease - news item 21 of 129
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Research links huntingtin to neurogenesis
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New research finds that a protein that is often mutated in Huntington's disease (HD) plays an unexpected role in the process of neurogenesis. The research provides new insight into HD pathology and has even broader implications for human health and disease. (Source: ScienceDaily Headlines) MedWorm Message: Register for MedMatcha, MedWorm's...
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RSS Source: Med Worm - Huntington's Disease Thu, 12 Aug 2010 3:00:00 am
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Huntington's Disease - news item 22 of 129
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How huntingtin kills neurons?
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Researchers have revealed new clues to how a defective form of the huntingtin protein may cause the deadly changes that lead to Huntington's disease (Source: The Scientist)
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RSS Source: Med Worm - Huntington's Disease Wed, 11 Aug 2010 11:00:00 pm
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Huntington's Disease - news item 23 of 129
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Genetic connections between neurological disorders and cholesterol metabolism [Thematic Reviews]
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Cholesterol is an essential component of both the peripheral and central nervous systems of mammals. Over the last decade, evidence has accumulated that disturbances in cholesterol metabolism are associated with the development of various neurological conditions. In addition to genetically defined defects in cholesterol synthesis, which will be covered in...
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RSS Source: Med Worm - Huntington's Disease Wed, 11 Aug 2010 8:53:37 pm
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Huntington's Disease - news item 24 of 129
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Mild cognitive impairment in prediagnosed Huntington disease
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Conclusions: Consistent with the Alzheimer disease literature, MCI as a prodromal period is a valid concept in pre-HD, with nearly 40% of individuals showing this level of impairment before diagnosis. Future studies should examine the utility of MCI as a marker of cognitive decline in pre-HD. (Source: Neurology) MedWorm Message:...
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RSS Source: Med Worm - Huntington's Disease Mon, 9 Aug 2010 8:01:05 pm
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Huntington's Disease - news item 25 of 129
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Before chorea: Pre-Huntington mild cognitive impairment
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(Source: Neurology)
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RSS Source: Med Worm - Huntington's Disease Mon, 9 Aug 2010 8:01:05 pm
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Huntington's Disease - news item 26 of 129
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Automated quantitative gait analysis in animal models of movement disorders
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Conclusion: The automated quantitative gait analysis test may be a useful tool to study both motor impairment and recovery associated with various neurological motor disorders. (Source: BioMed Central)
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RSS Source: Med Worm - Huntington's Disease Sun, 8 Aug 2010 11:00:00 pm
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Huntington's Disease - news item 27 of 129
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Strategies or Cognitive Translation from Mouse to Human: Some Examples from Alzheimer's Disease, Huntington's Disease, and Schizophrenia
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NIH Neuroscience Seminar SeriesAir date: 9/20/2010 12:00:00 PM (Source: Videocast - All Events)
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RSS Source: Med Worm - Huntington's Disease Fri, 6 Aug 2010 3:17:00 pm
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Huntington's Disease - news item 28 of 129
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Clinical Research Associate/Senior Clinical Research Associate: Neuroendocrine Study of Huntington's Disease - University College London
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Added via www.jobs.ac.uk Huntington's disease is associated with a variety of endocrine and metabolic changes and this study aims to clearly define these, assess whether they represent biomarkers for disease progression and how they contribute to disease pathogenesis, and identify potential therapeutic targets. Applications are welcome for a GMC-registered clinician...
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RSS Source: Med Worm - Huntington's Disease Fri, 6 Aug 2010 12:00:00 pm
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Huntington's Disease - news item 29 of 129
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Aripiprazole in the Treatment of Olanzapine-Resistant Psychotic and Motor Symptoms of Huntington's Disease [LETTERS TO THE EDITOR]
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(Source: J Neuropsychiatry Clin Neurosci) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Huntington's Disease Wed, 4 Aug 2010 8:07:37 pm
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Huntington's Disease - news item 30 of 129
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Correlates of Apathy in Huntington's Disease [REGULAR ARTICLES]
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The authors aim to study prevalence and clinical correlates of apathy in Huntington’s disease. Apathy was defined as an Apathy Scale score ≥14 points in 152 Huntington’s disease mutation carriers and 56 noncarriers. Correlates of apathy were analyzed cross-sectionally in mutation carriers using multivariable logistic regression analysis. Forty-nine (32%) Huntington’s...
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RSS Source: Med Worm - Huntington's Disease Wed, 4 Aug 2010 8:07:37 pm
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Huntington's Disease - news item 31 of 129
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Clampdown on companies offering genetic disease testing
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Government advisers step into unregulated industry amid fears customers can be misinformedCompanies which sell genetic tests for conditions such as breast cancer and Huntington's disease are facing a clampdown in a bid to stop customers being given wrong information about their health.New rules are planned to improve standards in the...
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RSS Source: Med Worm - Huntington's Disease Tue, 3 Aug 2010 11:01:13 pm
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Huntington's Disease - news item 32 of 129
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New Pathway To Parkinson's And Alzheimer's Diseases
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Although their genetic underpinnings differ, Alzheimer's disease, Parkinson's disease and Huntington's disease are all characterized by the untimely death of brain cells. What triggers cell death in the brain? According to a new study published by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) in the July 30 issue of Molecular...
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RSS Source: Med Worm - Huntington's Disease Fri, 30 Jul 2010 8:00:00 am
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Huntington's Disease - news item 33 of 129
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Protease Associated With Damage After Stroke Implicated In Huntington's Toxicity
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A new study reveals that an enzyme linked with multiple disorders is also involved in the generation of toxic, neuron-killing protein fragments in Huntington's disease (HD). The research, published by Cell Press in the July 29 issue of Neuron, provides insight into Huntington's pathology and proposes new therapeutic strategies for...
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RSS Source: Med Worm - Huntington's Disease Fri, 30 Jul 2010 7:00:00 am
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Huntington's Disease - news item 34 of 129
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Major Development In Treatment Of Huntington's Disease
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(Ivanhoe Newswire) -- Huntington's disease is incurable, but scientists believe they have a major development in the treatment of the disease. (Source: Medical Headlines From Ivanhoe.com)
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RSS Source: Med Worm - Huntington's Disease Fri, 30 Jul 2010 5:00:00 am
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Huntington's Disease - news item 35 of 129
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Discovery Provides New Hope For Huntington Disease Treatment
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Australian scientists have identified the behaviour of the mutant protein 'huntingtin' which leads to the fatal Huntington's disease providing potential targets to treat the disease, a University of Melbourne study reveals. Huntington's disease is a genetic disease with no cure, characterized by a steady decline in motor control and the...
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RSS Source: Med Worm - Huntington's Disease Thu, 29 Jul 2010 12:00:00 pm
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Huntington's Disease - news item 36 of 129
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Leap Forward In Efforts To Develop Treatments For Huntington's Disease
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Scientists at the Buck Institute for Age Research have discovered that a particular family of enzymes are involved in the breakdown of proteins that modify the production of toxic fragments that lead to the pathology of Huntington's disease. These enzymes, matrix metalloproteinases (MMPs), provide new targets for drug therapies for...
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RSS Source: Med Worm - Huntington's Disease Thu, 29 Jul 2010 8:00:00 am
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Huntington's Disease - news item 37 of 129
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New Drugs Eyed for Huntington's Disease
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Title: New Drugs Eyed for Huntington's DiseaseCategory: Health NewsCreated: 7/28/2010 12:10:00 PMLast Editorial Review: 7/29/2010 (Source: MedicineNet Cancer General)
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RSS Source: Med Worm - Huntington's Disease Thu, 29 Jul 2010 7:00:00 am
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Huntington's Disease - news item 38 of 129
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Huntington's disease discovery provides new hope for treatment
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Australian scientists have identified the behavior of the mutant protein "huntingtin" which leads to the fatal Huntington's disease providing potential targets to treat the disease, a new study reveals. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Huntington's Disease Thu, 29 Jul 2010 12:00:00 am
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Huntington's Disease - news item 39 of 129
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Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
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Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the gene encoding for huntingtin protein. A lot has been learned about this disease since its first description in 1872 and the identification of its causative gene and mutation in 1993. We now know that the...
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RSS Source: Med Worm - Huntington's Disease Tue, 27 Jul 2010 11:35:54 pm
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Huntington's Disease - news item 40 of 129
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Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects
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Coenzyme Q10 (CoQ10), a potential neuroprotective compound, was previously investigated at a dosage of 600 mg/day in Huntington's disease (HD) patients and demonstrated a trend toward slowing disease progression. Higher CoQ10 dosages may prove beneficial. We investigated the tolerability and blood levels associated with 1,200, 2,400, and 3,600 mg/day of...
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RSS Source: Med Worm - Huntington's Disease Tue, 27 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 41 of 129
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Neuroleptic malignant syndrome with aripiprazole in Huntington's disease
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No abstract. (Source: Movement Disorders)
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RSS Source: Med Worm - Huntington's Disease Tue, 27 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 42 of 129
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Sirtuins and Alzheimer's Disease
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Just when I thought I at least knew the major theories about what causes Alzheimer's and what are the most promising avenues for treatments, the New York Times succeeds in humbling me and my ignorance. In an article published Saturday July 24th, it was reported that researchers from MIT found...
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RSS Source: Med Worm - Huntington's Disease Mon, 26 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 43 of 129
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UB Researchers Propose A Novel Therapeutic Target For The Treatment Of Huntington's Disease
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An article published in The Journal of Biological Chemistry presents a novel pharmacological target that, in combination with a neurotrophic factor, could be used to improve the survival of striatal neurons, the principal nerve cells affected by the neurodegeneration observed in Huntington's disease. The study was conducted by the researchers...
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RSS Source: Med Worm - Huntington's Disease Sun, 25 Jul 2010 8:00:00 am
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Huntington's Disease - news item 44 of 129
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Huntington's Disease Greatly Underestimated In The UK
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The prevalence of Huntington's disease (HD) is substantially underestimated in the UK, with significant implications for those affected, the healthcare system, and research. New estimates of prevalence, and their implications, are discussed in a comment published in an upcoming Lancet, written by Professor Sir Michael Rawlins, who is the Chairman...
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RSS Source: Med Worm - Huntington's Disease Sun, 25 Jul 2010 8:00:00 am
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Huntington's Disease - news item 45 of 129
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[Huntington's disease. Keys and answers to an outstanding challenge.]
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Authors: Solsona F PMID: 20645271 [PubMed - in process] (Source: Revista de Neurologia)
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RSS Source: Med Worm - Huntington's Disease Fri, 23 Jul 2010 11:09:43 pm
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Huntington's Disease - news item 46 of 129
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[Hydrogen magnetic resonance quantitative spectroscopy at 3 T in symptomatic and asymptomatic Huntington's disease patients.]
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CONCLUSIONS. Results may reflect neuronal dysfunction and suggest that creatine and choline may serve as markers for Huntington's disease progression. PMID: 20648464 [PubMed - in process] (Source: Revista de Neurologia)
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RSS Source: Med Worm - Huntington's Disease Fri, 23 Jul 2010 11:09:30 pm
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Huntington's Disease - news item 47 of 129
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Prevalence of Huntington's Disease Underestimated
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In the United Kingdom, the actual number of people with Huntington's does not support previous population estimates; more research is needed. Medscape Medical News (Source: Medscape Today Headlines) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Huntington's Disease Fri, 23 Jul 2010 2:46:25 pm
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Huntington's Disease - news item 48 of 129
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Neuroprotective mechanisms of brain-derived neurotrophic factor against 3-nitropropionic acid toxicity: therapeutic implications for Huntington's disease
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3-Nitropropionic acid (3-NP) is an irreversible inhibitor of mitochondrial succinate dehydrogenase that has been used to explore the molecular mechanisms of cell death associated with mitochondrial dysfunction and neurodegeneration for Huntington's disease (HD). Brain-derived neurotrophic factor (BDNF) is a neurotrophin that may regulate neuronal survival and differentiation. Experimental evidence derived...
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RSS Source: Med Worm - Huntington's Disease Tue, 20 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 49 of 129
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Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease
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Caused by a polyglutamine expansion in the huntingtin protein, Huntington's disease leads to striatal degeneration via the transcriptional dysregulation of a number of genes, including those involved in mitochondrial biogenesis. Here we show that transglutaminase 2, which is upregulated in HD, exacerbates transcriptional dysregulation by acting as a selective corepressor...
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RSS Source: Med Worm - Huntington's Disease Tue, 20 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 50 of 129
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Fine mapping of QTL for prepulse inhibition in LG/J and SM/J mice using F2 and advanced intercross lines
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Prepulse inhibition (PPI) of the startle response is a measure of sensorimotor gating, a process that filters out extraneous sensory, motor and cognitive information. Humans with neurological and psychiatric disorders, including schizophrenia, obsessive-compulsive disorder and Huntington's disease, exhibit a reduction in PPI. Habituation of the startle response is also disrupted...
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RSS Source: Med Worm - Huntington's Disease Tue, 20 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 51 of 129
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Prana's Research Was Presented At International Conference On Alzheimer's Disease On July 14
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Prana Biotechnology Limited (NASDAQ: PRAN) (ASX: PBT), Head of Research, Assoc. Prof. Robert Cherny, presented new data on PBT2, the Company's lead compound in development for Alzheimer's Disease on July 14th at the prestigious International Conference of Alzheimer's Disease (ICAD) in Honolulu. The presentation was entitled "Novel molecular mechanisms for...
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RSS Source: Med Worm - Huntington's Disease Tue, 20 Jul 2010 7:00:00 am
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Huntington's Disease - news item 52 of 129
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Effects of Mutant Huntingtin on mGluR5-Mediated Dual Signaling Pathways: Implications for Therapeutic Interventions.
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Authors: Huang SS, He J, Zhao DM, Xu XY, Tan HP, Li H Glutamate excitotoxicity is thought to play an important role in Huntington's disease (HD), which is caused by a polyglutamine expansion in the HD protein huntingtin (htt). Overactivation of group I metabotropic glutamate receptors (mGluRs), which include mGluR1...
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RSS Source: Med Worm - Huntington's Disease Mon, 19 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 53 of 129
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Huntington's Disease
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Title: Huntington's DiseaseCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 7/19/2010 (Source: MedicineNet Depression General)
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RSS Source: Med Worm - Huntington's Disease Mon, 19 Jul 2010 7:00:00 am
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Huntington's Disease - news item 54 of 129
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[In Context] Uncovering the true prevalence of Huntington's disease
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Legislation exists to ensure that research into drug development for rare diseases is encouraged. But how sure can we be that a rare disease is, in fact, rare, and what happens when the real prevalence is found to be higher, or lower, than official estimates suggest? Laura Spinney reports. (Source:...
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RSS Source: Med Worm - Huntington's Disease Sun, 18 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 55 of 129
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[Leading Edge] Dispelling the stigma of Huntington's disease
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Huntington's disease has historically been one of the most stigmatised disorders, and the profound discrimination against individuals with a family history of Huntington's disease provides a strong incentive for families to conceal the disease. Against this background, and as reported in a feature in this issue of The Lancet Neurology,...
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RSS Source: Med Worm - Huntington's Disease Sun, 18 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 56 of 129
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Tongue force analysis assesses motor phenotype in premanifest and symptomatic Huntington's disease
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Motor symptoms in Huntington's Disease (HD) are commonly assessed by the Unified Huntington's Disease Rating Scale-Total Motor Score (UHDRS-TMS). However, the UHDRS-TMS is limited by interrater variability, its categorical nature, and insensitivity in premanifest subjects. More objective and quantitative measures of motor phenotype may complement the use of the UHDRS-TMS...
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RSS Source: Med Worm - Huntington's Disease Sun, 18 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 57 of 129
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Group I Metabotropic Glutamate Receptor Signalling and Its Implication in Neurological Disease.
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Authors: Ribeiro FM, Paquet M, Cregan SP, Ferguson SS Stimulation of Group I metabotropic glutamate receptors (mGluR1 and mGluR5) leads to activation of a wide variety of signalling pathways. mGluRs couple to Galpha(q/11) proteins, activating phospholipase Cbeta1 resulting in both diacylglycerol and inositol-1,4,5-triphosphate formation followed by the activation of protein...
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RSS Source: Med Worm - Huntington's Disease Thu, 15 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 58 of 129
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Targeting Histone Deacetylases for the Treatment of Huntington's Disease.
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Authors: Gray SG SUMMARY Huntington's disease is a debilitating neurodegenerative condition with significant burdens on both patient and healthcare costs. Despite the identification of the causative element, an expanded toxic polyglutamine tract in the mutant Huntingtin protein, treatment options for patients with this disease remain limited. In the following review...
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RSS Source: Med Worm - Huntington's Disease Tue, 13 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 59 of 129
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Behind the headlines - Huntington's cases underestimated
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“There are far more people with Huntington's disease in the UK than has been assumed,†The Guardian has reported. However, stigma and fear of insurance companies leads many to keep their condition a secret, it added. (Source: Neurological Conditions Specialist Library) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network ,...
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RSS Source: Med Worm - Huntington's Disease Mon, 12 Jul 2010 11:47:43 am
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Huntington's Disease - news item 60 of 129
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Control of RNA silencing and localization by endolysosomes.
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Authors: Gibbings D, Voinnet O Recent advances in the cell biology of RNA silencing have unraveled an intriguing association of post-transcriptionally regulated RNA with endolysosomal membranes in several circumstances of mRNA localization, microRNA activity and viral RNA transport and packaging. Endolysosomal membranes are a nexus of communication and transport between...
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RSS Source: Med Worm - Huntington's Disease Sun, 11 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 61 of 129
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Antipsychotic drug binding in the substantia nigra: An examination of high metoclopramide binding in the brains of normal, Alzheimer's disease, Huntington's disease, and Multiple Sclerosis patients, and its relation to tardive dyskinesia
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This project was done in order to determine why the annual incidence of metoclopramide-associated tardive dyskinesia is much higher than that for the commonly used antipsychotics. To test the hypothesis that metoclopramide tardive dyskinesia may be associated with high concentrations of metoclopramide in the substantia nigra under clinical conditions, the...
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RSS Source: Med Worm - Huntington's Disease Fri, 9 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 62 of 129
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Proteasomal and autophagic degradative activities in spinal and bulbar muscular atrophy.
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Authors: Rusmini P, Bolzoni E, Crippa V, Onesto E, Sau D, Galbiati M, Piccolella M, Poletti A Spinal and bulbar muscular atrophy (SBMA or Kennedy's disease) is a fatal neurodegenerative disease characterized by the selective loss of motorneurons in the bulbar region of the brain and in the anterior horns...
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RSS Source: Med Worm - Huntington's Disease Wed, 7 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 63 of 129
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High insulinlike growth factor I is associated with cognitive decline in Huntington disease
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Conclusions: Our findings in patients with HD suggest that a high IGFI level at baseline may be associated with greater subsequent declines in executive function and attention. (Source: Neurology) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Huntington's Disease Mon, 5 Jul 2010 7:52:54 pm
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Huntington's Disease - news item 64 of 129
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Self-paced timing detects and tracks change in prodromal Huntington disease.
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Conclusions: The self-paced timing paradigm has potential for use as a screening tool and outcome measure in pr-HD clinical trials to gauge therapeutically mediated improvement or maintenance of function. (PsycINFO Database Record (c) 2010 APA, all rights reserved) (Source: Neuropsychology)
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RSS Source: Med Worm - Huntington's Disease Sun, 4 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 65 of 129
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Huntington's disease prevalance double previous estimates
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The number of people in England and Wales with the hereditary degenerative condition Huntington’s disease is twice that currently assumed, according to the chair of the NICE. (Source: Nursing Times Breaking News)
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RSS Source: Med Worm - Huntington's Disease Sat, 3 Jul 2010 6:11:21 am
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Huntington's Disease - news item 66 of 129
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New PBT2 Data In 2010 Hot Topics Session At International Conference On Alzheimer's Disease
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Prana Biotechnology Limited (NASDAQ: PRAN) (ASX: PBT) announced that its Head of Research, Assoc. Prof. Robert Cherny, will present new data on PBT2, the Company's lead compound in development for Alzheimer's disease, at the Hot Topics Therapeutics/Intervention session on July 14th at the International Conference of Alzheimer's Disease (ICAD) in...
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RSS Source: Med Worm - Huntington's Disease Fri, 2 Jul 2010 8:00:00 am
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Huntington's Disease - news item 67 of 129
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The potential role of Ask1 in caspase-6-related huntingtin cleavage and striatal vulnerability.
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Authors: Cho KJ, Kim HW, Cheon SY, Kim GW Huntington's Disease (HD) is pathologically characterized by neuronal inclusions and neurotoxic mutant huntingtin (mHtt). The systemic administration of 3-nitropropionic acid (3-NP) facilitates the development of selected striatal lesions mimicking the HD and it remains unclear whether specific neurons are selectively targeted...
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RSS Source: Med Worm - Huntington's Disease Thu, 1 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 68 of 129
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[Perspectives] Stigma, history, and Huntington's disease
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Until my mother was diagnosed with Huntington's disease†a hereditary degenerative neurological and psychiatric disorder characterised by chorea, cognitive impairment, and emotional disturbance†she never mentioned that her father and three brothers had all died with this disease. Perhaps that missing family history was why I became a historian. I...
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RSS Source: Med Worm - Huntington's Disease Thu, 1 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 69 of 129
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Clinical review: Huntington's disease
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Source: British Medical Journal Area: News This Clinical Review article on Huntington's disease looks at its features, recent advances in management, and advances in the practice and ethics of genetic testing that may be relevant to a wide spectrum of health professionals. The authors comment that "the current major push...
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RSS Source: Med Worm - Huntington's Disease Thu, 1 Jul 2010 11:00:00 pm
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Huntington's Disease - news item 70 of 129
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Changes in the store-dependent calcium influx in a cellular model of Huntington's disease.
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Authors: Glushankova LN, Zimina OA, Vigont VA, Mozhaeva GN, Bezprozvanny IB, Kaznacheeva EV PMID: 20711881 [PubMed - in process] (Source: Doklady Biological Sciences)
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RSS Source: Med Worm - Huntington's Disease Wed, 30 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 71 of 129
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Sirtuins: Common Targets in Aging and in Neurodegeneration.
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Authors: de Oliveira RM, Pais TF, Outeiro TF Aging has been a subject of interest since primordial times. More recently, it became clear that aging is the major known risk factor for several neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and Huntington's disease. A major focus in the field...
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RSS Source: Med Worm - Huntington's Disease Wed, 30 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 72 of 129
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The Role of PGC-1alpha in the Pathogenesis of Neurodegenerative Disorders.
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Authors: Róna-Vörös K, Weydt P Mitochondrial dysfunction is a common hallmark of ageing-related diseases involving neurodegeneration. Huntington's disease (HD) is one of the most common monogenetic forms of neurodegenerative disorders and shares many salient features with the major sporadic disease of neurodegeneration, such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (...
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RSS Source: Med Worm - Huntington's Disease Wed, 30 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 73 of 129
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Hypothalamic and Neuroendocrine Changes in Huntington's Disease.
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Authors: Hult S, Schultz K, Soylu R, Petersén A Huntington's disease (HD) is a fatal hereditary neurodegenerative disorder without satisfactory treatments nor a cure. It is caused by a CAG repeat expansion in the huntingtin gene. The clinical symptoms involve motor-, cognitive- and psychiatric disturbances. Recent studies have shown that...
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RSS Source: Med Worm - Huntington's Disease Wed, 30 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 74 of 129
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Mitochondrial-Associated Metabolic Changes and Neurodegeneration in Huntington's Disease - From Clinical Features to the Bench.
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Authors: Rosenstock TR, Duarte AI, Rego AC Huntington's disease (HD) is a genetic neurodegenerative disease selectively leading to striatal neurodegeneration, but also affecting the cortex and the hypothalamus. Although it is hard to predict the sequence of cell-damaging events occurring in HD patients, several pathological mechanisms have been proposed to...
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RSS Source: Med Worm - Huntington's Disease Wed, 30 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 75 of 129
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Articles on Huntington's disease published in Lancet and Lancet Neurology
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Source: Lancet, Lancet Neurology Area: News Early online articles have been published in the The Lancet and Lancet Neurology relating to Huntington's disease to coincide with the launch of an All Party Parliamentary Group to promote greater understanding and awareness of the disease. The first article is a narrative review...
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RSS Source: Med Worm - Huntington's Disease Wed, 30 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 76 of 129
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Huntington's Disease is twice as common as thought as stigma stops sufferers seeking help
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The incurable brain illness Huntington's disease is at least twice as common as previously thought, medical experts said today. (Source: the Mail online | Health) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Huntington's Disease Wed, 30 Jun 2010 8:42:03 pm
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Huntington's Disease - news item 77 of 129
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Prevalence of Huntington's disease is underestimated in UK
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(Source: BMJ Online First)
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RSS Source: Med Worm - Huntington's Disease Wed, 30 Jun 2010 3:04:48 pm
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Huntington's Disease - news item 78 of 129
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Huntington's cases underestimated
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Conclusion Huntington’s disease is a distressing disorder for which at present there is no cure. Therefore any articles that can promote awareness of the disease or shed light on its prevalence and historical attitudes, are to be welcomed. Although both these articles present personal opinions, based on an assessment of...
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RSS Source: Med Worm - Huntington's Disease Wed, 30 Jun 2010 11:18:00 am
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Huntington's Disease - news item 79 of 129
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Huntington's disease figures underestimated
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More people in the UK suffer from Huntington’s disease (HD) than is assumed, according to medical experts. (Source: Nursing Times Breaking News) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Huntington's Disease Wed, 30 Jun 2010 9:52:00 am
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Huntington's Disease - news item 80 of 129
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British doctors say there could be twice as many cases of Huntington's disease as once thought
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LONDON (AP) — British officials say there may be twice as many cases of Huntington's disease in Britain than previously thought. To investigate how often the rare and inherited degenerative disease actually occurs, a government group is starting... (Source: OrlandoSentinel: Medical Research)
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RSS Source: Med Worm - Huntington's Disease Wed, 30 Jun 2010 4:29:00 am
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Huntington's Disease - news item 81 of 129
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Huntington's cases may be twice as high: British MDs
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British officials say there may be twice as many cases of Huntington's disease in Britain than previously thought. (Source: CTV Health)
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RSS Source: Med Worm - Huntington's Disease Wed, 30 Jun 2010 1:36:47 am
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Huntington's Disease - news item 82 of 129
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Huntington's sufferers stay in shadows
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The neurodegenerative disease is said to affect seven people in 100,000, but experts believe the proportion is higherThere are far more people with Huntington's disease in the UK than has been assumed, but stigma and fear of insurance companies has kept them in the shadows, experts say today.Huntington's disease is...
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RSS Source: Med Worm - Huntington's Disease Tue, 29 Jun 2010 11:01:31 pm
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Huntington's Disease - news item 83 of 129
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A death sentence has been lifted
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MY HEALTH EXPERIENCE: CATHERINE DEARDENdescribes living in the 'black shadow' of Huntington's disease (Source: The Irish Times - Health) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Huntington's Disease Mon, 28 Jun 2010 11:58:29 pm
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Huntington's Disease - news item 84 of 129
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Lack of neuroprotective effects of simvastatin and minocycline in a model of cervical spinal cord injury.
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In conclusion, both minocycline and simvastatin failed to improve functional and histological recovery in our model of contusive cervical spinal cord injury. PMID: 20599974 [PubMed - as supplied by publisher] (Source: Experimental Neurology)
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RSS Source: Med Worm - Huntington's Disease Sun, 27 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 85 of 129
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The effect of formalin fixation on the levels of brain transition metals in archived samples.
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In this study, we evaluated the effect of formalin fixation of brain on the levels of three important transition metals (iron, copper, and zinc) by atomic absorption spectroscopy. Paired brain specimens were obtained at autopsy for each case; one was conserved by formalin archival (averaging four years), the other was...
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RSS Source: Med Worm - Huntington's Disease Fri, 25 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 86 of 129
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The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study
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Conclusions Degeneration of structural connectivity may play an important role in early HD symptoms. Assessment of WM and GM changes will be important in understanding the complexity of HD and its treatment. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
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RSS Source: Med Worm - Huntington's Disease Fri, 25 Jun 2010 9:19:30 am
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Huntington's Disease - news item 87 of 129
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Mitochondrial dynamics in cell death and neurodegeneration.
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Authors: Cho DH, Nakamura T, Lipton SA Mitochondria are highly dynamic organelles that continuously undergo two opposite processes, fission and fusion. Mitochondrial dynamics influence not only mitochondrial morphology, but also mitochondrial biogenesis, mitochondrial distribution within the cell, cell bioenergetics, and cell injury or death. Drp1 mediates mitochondrial fission, whereas Mfn1/2...
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RSS Source: Med Worm - Huntington's Disease Thu, 24 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 88 of 129
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Differences in activation of ERK1/2 and p38 kinase in Jnk3 null mice following KA treatment
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J. Neurochem. (2010) 10.1111/j.1471-4159.2010.06853.x The MAPK family is formed by extracellular signal-regulated kinases p38 kinase and stress-activated protein kinases (SAPK/JNK). There are three genes that encode for three JNK proteins. JNK3 is mainly expressed in the central nervous system and has been related to various processes in that tissue. Specifically,...
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RSS Source: Med Worm - Huntington's Disease Thu, 24 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 89 of 129
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The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease
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Conclusions: Our data suggests that beneficial behavioral effects of everolimus in R6/2 mice result primarily from effects on muscle. Even though everolimus significantly modulated its target brain S6 kinase, this did not decrease mutant huntingtin levels or provide neuroprotection. (Source: Molecular Neurodegeneration)
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RSS Source: Med Worm - Huntington's Disease Mon, 21 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 90 of 129
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Cystamine metabolism and brain transport properties: clinical implications for neurodegenerative diseases
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J. Neurochem. (2010) 10.1111/j.1471-4159.2010.06874.x Cystamine has shown significant neuroprotective properties in preclinical studies of Parkinson's disease (PD) and Huntington's disease (HD). Cysteamine, its FDA-approved reduced form, is scheduled to be tested for clinical efficacy in HD patients. Here, we studied the key cystamine metabolites, namely cysteamine, hypotaurine and taurine, as...
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RSS Source: Med Worm - Huntington's Disease Sat, 19 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 91 of 129
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Earliest functional declines in Huntington disease
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We examined the gold standard for Huntington disease (HD) functional assessment, the Unified Huntington's Disease Rating Scale (UHDRS), in a group of at-risk participants not yet diagnosed but who later phenoconverted to manifest HD. We also sought to determine which skill domains first weaken and the clinical correlates of declines....
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RSS Source: Med Worm - Huntington's Disease Sat, 19 Jun 2010 7:46:35 am
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Huntington's Disease - news item 92 of 129
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Abnormal Protein Makes Huntington's Disease Patients Sick
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An aggregating protein causes many of the symptoms of Huntington's disease, an incurable and frequently fatal brain disorder. Mosaic winner Ahmad Aziz discovered that the abnormal protein also aggregates in the hypothalamus, the part of the brain that regulates the autonomic nervous system and the endocrine system. Ahmad Aziz investigated...
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RSS Source: Med Worm - Huntington's Disease Wed, 16 Jun 2010 9:00:00 am
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Huntington's Disease - news item 93 of 129
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Program Will Use Stem Cell Modeling And Genome Sequencing To Identify And Screen Potential Therapies For Huntington's Disease
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The Institute for Systems Biology (ISB) of Seattle, WA, is collaborating with the Gladstone Institute of Neurological Disease (GIND) and its Taube-Koret Center for Huntington's Disease Research to use whole-genome sequencing to identify genes and novel drug targets related to the onset and progression of Huntington's disease (HD). The research...
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RSS Source: Med Worm - Huntington's Disease Wed, 16 Jun 2010 8:00:00 am
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Huntington's Disease - news item 94 of 129
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A two-step path to inclusion formation of huntingtin peptides revealed by number and brightness analysis.
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We describe the use of the recently developed number and brightness method (N&B) that uses confocal images to monitor aggregation of Huntingtin exon 1 protein (Httex1p) directly in living cells. N&B measures the molecular brightness of protein aggregates in the entire cell noninvasively based on intensity fluctuations at each pixel...
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RSS Source: Med Worm - Huntington's Disease Tue, 15 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 95 of 129
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Gladstone and Institute for Systems Biology collaborate on Huntington's disease
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(Gladstone Institutes) The Institute for Systems Biology of Seattle, Wash., is collaborating with the Gladstone Institute of Neurological Disease and its Taube-Koret Center for Huntington's Disease Research to use whole-genome sequencing to identify genes and novel drug targets related to the onset and progression of Huntington's disease. (Source: EurekAlert! -...
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RSS Source: Med Worm - Huntington's Disease Tue, 15 Jun 2010 4:00:00 am
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Huntington's Disease - news item 96 of 129
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Altered sensitivity to excitotoxic cell death and glutamate receptor expression between two commonly studied mouse strains
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We report here that primary cerebellar granule cell cultures from C57BL/6J mice are more sensitive to N-methyl-D-aspartate (NMDA)-mediated cell death. Moreover, sensitivity to AMPA-mediated excitotoxicity is more variable and is dependent on the treatment conditions and age of the cultures. Glutamate receptor surface expression levels examined in vitro by in...
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RSS Source: Med Worm - Huntington's Disease Thu, 10 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 97 of 129
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Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease
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Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in...
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RSS Source: Med Worm - Huntington's Disease Thu, 10 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 98 of 129
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Episodic Memory in Dementia: Characteristics of New Learning that Differentiate Alzheimer's, Huntington's, and Parkinson's Diseases.
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Authors: Aretouli E, Brandt J Differences in the memory characteristics of patients with Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD) were investigated with tests that assess learning and retention of words, line-drawn objects, and locations. Large groups of AD, HD, and PD patients were administered the Hopkins...
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RSS Source: Med Worm - Huntington's Disease Mon, 7 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 99 of 129
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Mutant huntingtin-impaired degradation of β-catenin causes neurotoxicity in Huntington's disease
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Mutant huntingtin-impaired degradation of β-catenin causes neurotoxicity in Huntington's disease The EMBO Journal. doi:10.1038/emboj.2010.117 Authors: Juliette D Godin, Ghislaine Poizat, Miriam A Hickey, Florence Maschat & Sandrine Humbert (Source: The EMBO Journal AOP) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Huntington's Disease Mon, 7 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 100 of 129
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Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate
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Conclusions: This is the first study attempting to define neuronal gene expression patterns in response to chronic, endogenous Glu hyperactivity at brain synapses. The patterns observed were characterized by a combination of responses to stress and stimulation of nerve growth, intracellular transport and recovery. (Source: BMC Genomics - Latest articles)
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RSS Source: Med Worm - Huntington's Disease Sun, 6 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 101 of 129
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Drosophila melanogaster in the Study of Human Neurodegeneration.
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Authors: Hirth F Human neurodegenerative diseases are devastating illnesses that predominantly affect elderly people. The majority of the diseases are associated with pathogenic oligomers from misfolded proteins, eventually causing the formation of aggregates and the progressive loss of neurons in the brain and nervous system. Several of these proteinopathies are...
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RSS Source: Med Worm - Huntington's Disease Thu, 3 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 102 of 129
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Transgenic Mouse Models of Parkinson's Disease and Huntington's Disease.
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This article will provide an overview of the genetics underlying PD and HD, the animal models developed, and their potential utility to the study of disease pathophysiology. PMID: 20522011 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
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RSS Source: Med Worm - Huntington's Disease Thu, 3 Jun 2010 11:00:00 pm
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Huntington's Disease - news item 103 of 129
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Raptor Pharmaceutical Licenses Intellectual Property Related to Huntington's Disease From the Weizmann Institute of Science and Niigata University
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NOVATO, Calif., June 2, 2010 (GLOBE NEWSWIRE) -- Raptor Pharmaceutical Corp. ("Raptor" or the "Company") (Nasdaq:RPTP), announced that the Company has acquired an exclusive worldwide license to intellectual property related to the potential treatment of Huntington's Disease from the Weizmann Institute of Science in Israel and Niigata University in Japan....
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RSS Source: Med Worm - Huntington's Disease Wed, 2 Jun 2010 10:30:00 am
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Huntington's Disease - news item 104 of 129
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pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking
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Conclusion: We report the validation of a synthetic gene encoding full-length htt protein that will facilitate analyses of its structure/function. This may help provide relevant information about the cellular dysfunctions operating during the disease. As proof of principle, we show that either polyQ expansion or deletion of key interacting domains...
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RSS Source: Med Worm - Huntington's Disease Mon, 31 May 2010 11:00:00 pm
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Huntington's Disease - news item 105 of 129
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Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: A multimodal imaging study
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This study, using a multimodal imaging approach, aims to assess in vivo the functional and structural integrity of regions and regional networks linked with motor, cognitive and psychiatric function. Predicting disease onset in at risk individuals is problematic and thus we sought to investigate this by computing the 5-year probability...
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RSS Source: Med Worm - Huntington's Disease Thu, 27 May 2010 11:00:00 pm
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Huntington's Disease - news item 106 of 129
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Synthesis of pathological and nonpathological human exon 1 huntingtin
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Huntington's disease (HD) is a neurodegenerative disorder that affects approximately 1 in 10 000 individuals. The underlying gene mutation was identified as a CAG-triplet repeat expansion in the gene huntingtin. The CAG sequence codes for glutamine, and in HD, an expansion of the polyglutamine (poly-Q) stretch above 35 glutamine residues...
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RSS Source: Med Worm - Huntington's Disease Wed, 26 May 2010 11:00:00 pm
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Huntington's Disease - news item 107 of 129
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Localization of BDNF mRNA with the Huntington's disease protein in rat brain
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Conclusions: In cultured neurons and sections of the rat cortex, we found BDNF mRNA associated with Htt and components of neuronal RNA granules, which are centers for regulating RNA transport and local translation. Htt may play a role in post-transcriptional transport/targeting of mRNA for BDNF, thus contributing to neurotrophic support...
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RSS Source: Med Worm - Huntington's Disease Wed, 26 May 2010 11:00:00 pm
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Huntington's Disease - news item 108 of 129
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Dietary anaplerotic therapy improves peripheral tissue energy metabolism in patients with Huntington's disease
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Authors: Fanny Mochel, Sandrine Duteil, Cécilia Marelli, Céline Jauffret, Agnès Barles, Janette Holm, Lawrence Sweetman, Jean-François Benoist, Daniel Rabier, Pierre G Carlier & Alexandra Durr (Source: European Journal of Human Genetics) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Huntington's Disease Tue, 25 May 2010 11:00:00 pm
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Huntington's Disease - news item 109 of 129
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Hypokinesia in Huntington's disease co-occurs with cognitive and global dysfunctioning
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In conclusion, the presence of moderate to severe hypokinesia in HD patients co-occurs with executive cognitive dysfunction and adversely affects global functioning. © 2010 Movement Disorder Society (Source: Movement Disorders)
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RSS Source: Med Worm - Huntington's Disease Mon, 24 May 2010 11:00:00 pm
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Huntington's Disease - news item 110 of 129
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Scientists make important step toward stopping plaque-like formations in Huntington's disease
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Researchers describe a laboratory test that allows scientists to evaluate large numbers of fruit fly genes for a possible role in the formation of plaque-like protein aggregates within cells. Those genes often have counterparts in humans, which might then be manipulated to stop or slow the formation of plaque-like protein...
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RSS Source: Med Worm - Huntington's Disease Mon, 24 May 2010 12:00:00 pm
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Huntington's Disease - news item 111 of 129
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Huntington's Disease: The Value of Transcranial Meganetic Stimulation.
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This study focuses on the effect of TMS on oxidative stress and neurogenesis in studies and its possible usefulness in HD. PMID: 20491647 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Huntington's Disease Sun, 23 May 2010 11:00:00 pm
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Huntington's Disease - news item 112 of 129
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Gardening with Huntington's disease clients - creating a programme of winter activities.
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Conclusions. The inexpensive programme of activities enabled creativity and self-expression, stimulated social contact and helped with therapeutic goals of the clients. In addition, it engaged the multi-disciplinary team and the unit staff, was practical and enhanced the environment. PMID: 20491614 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)...
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RSS Source: Med Worm - Huntington's Disease Sun, 23 May 2010 11:00:00 pm
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Huntington's Disease - news item 113 of 129
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BimEL as a possible molecular link between proteasome dysfunction and cell death induced by mutant huntingtin
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Huntington's disease (HD) is a devastating neurodegenerative disorder caused by an expanded polyglutamine repeat within the N-terminus of the huntingtin protein. It is characterized by a selective loss of medium spiny neurons in the striatum. It has been suggested that impaired proteasome function and endoplasmic reticulum (ER) stress play important...
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RSS Source: Med Worm - Huntington's Disease Sun, 23 May 2010 11:00:00 pm
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Huntington's Disease - news item 114 of 129
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Sleep and circadian rhythm alterations correlate with depression and cognitive impairment in Huntington's disease
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Conclusions: HD is primarily accompanied by night-time sleep disturbances and a delayed sleep phase, which are associated with depression and lower cognitive as well as functional performance. (Source: Parkinsonism and Related Disorders)
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RSS Source: Med Worm - Huntington's Disease Fri, 21 May 2010 1:37:21 pm
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Huntington's Disease - news item 115 of 129
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Genetically-Engineered Mesenchymal Stem Cells Reduce Behavioral Deficits in the YAC 128 Mouse Model of Huntington's Disease.
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Authors: Dey ND, Bombard MC, Roland BP, Davidson S, Lu M, Rossignol J, Sandstrom MI, Skeel RL, Lescaudron L, Dunbar GL The purpose of this study was to evaluate the therapeutic effects of the transplantation of bone-marrow mesenchymal stem cells (MSCs), genetically-engineered to over-express brain-derived neurotrophic factor (BDNF) or nerve...
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RSS Source: Med Worm - Huntington's Disease Tue, 18 May 2010 11:00:00 pm
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Huntington's Disease - news item 116 of 129
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Cognitive and functional decline in Huntington's disease: Dementia criteria revisited
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The importance of designating criteria for diagnosing dementia lies in its implications for clinical treatment, research, caregiving, and decision-making. Dementia diagnosis in Huntington's disease (HD) is often based on criteria developed for Alzheimer's disease requiring memory loss. However, it is likely that other cognitive deficits contribute to functional impairment in...
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RSS Source: Med Worm - Huntington's Disease Thu, 13 May 2010 11:00:00 pm
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Huntington's Disease - news item 117 of 129
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Chaperone networks: Tipping the balance in protein folding diseases.
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Authors: Voisine C, Pedersen JS, Morimoto RI Adult-onset neurodegeneration and other protein conformational diseases are associated with the appearance, persistence, and accumulation of misfolded and aggregation prone proteins. To protect the proteome from long-term damage, the cell expresses a highly integrated protein homeostasis (proteostasis) machinery to ensure that proteins are...
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RSS Source: Med Worm - Huntington's Disease Wed, 12 May 2010 11:00:00 pm
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Huntington's Disease - news item 118 of 129
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BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease
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Authors: A Giralt, H C Friedman, B Caneda-Ferrón, N Urbán, E Moreno, N Rubio, J Blanco, A Peterson, J M Canals & J Alberch (Source: Gene Therapy)
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RSS Source: Med Worm - Huntington's Disease Wed, 12 May 2010 11:00:00 pm
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Huntington's Disease - news item 119 of 129
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Non-Pharmacological Treatments in a Patient with Dementia Due to Huntington's Disease [LETTERS TO THE EDITOR]
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(Source: J Neuropsychiatry Clin Neurosci)
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RSS Source: Med Worm - Huntington's Disease Wed, 12 May 2010 3:26:42 pm
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Huntington's Disease - news item 120 of 129
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"Frontal" Behaviors Before the Diagnosis of Huntington's Disease and Their Relationship to Markers of Disease Progression: Evidence of Early Lack of Awareness [REGULAR ARTICLES]
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Huntington’s disease has been linked with fronto-subcortical neuropathology and behaviors consistent with this dysfunction. Little is known about these "frontal" behaviors in the earliest phase of the illness. Comparisons between participants in the Predict-HD study (745 "expansion-positive" and 163 "expansion-negative" control subjects) on the Frontal System Behavior Scale looked for...
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RSS Source: Med Worm - Huntington's Disease Wed, 12 May 2010 3:26:42 pm
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Huntington's Disease - news item 121 of 129
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A Genomewide RNA Interference Screen for Modifiers of Aggregates Formation by Mutant Huntingtin in Drosophila [Genome and systems biology]
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Protein aggregates are a common pathological feature of most neurodegenerative diseases (NDs). Understanding their formation and regulation will help clarify their controversial roles in disease pathogenesis. To date, there have been few systematic studies of aggregates formation in Drosophila, a model organism that has been applied extensively in modeling NDs...
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RSS Source: Med Worm - Huntington's Disease Mon, 10 May 2010 9:29:38 pm
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Huntington's Disease - news item 122 of 129
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Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL/6J) Huntington's disease transgenic mice.
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Authors: Brooks S, Higgs G, Janghra N, Jones L, Dunnett S To determine the suitability of mouse models of disease for therapeutic trials, the models must be characterised to determine their similarity to the human condition, and utility for specific therapeutic approaches. The YAC128 mouse model of HD has been...
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RSS Source: Med Worm - Huntington's Disease Fri, 7 May 2010 11:00:00 pm
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Huntington's Disease - news item 123 of 129
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Longitudinal analysis of the behavioural phenotype in Hdh(Q92) Huntington's disease knock-in mice.
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Authors: Brooks S, Higgs G, Jones L, Dunnett SB Huntington's disease is caused by a single mutation resulting in an expanded polyglutamine sequence which causes the production of a mutant variant of the protein huntingtin, which is ultimately responsible for the motor, cognitive and emotional symptoms and early death of...
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RSS Source: Med Worm - Huntington's Disease Thu, 6 May 2010 11:00:00 pm
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Huntington's Disease - news item 124 of 129
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Longitudinal analysis of the behavioural phenotype in Hdh((CAG)150) Huntington's disease knock-in mice.
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Authors: Brooks S, Higgs G, Jones L, Dunnett S In people with Huntington's disease, an expanded CAG repeat sequence on the HTT gene confers a toxic gain function resulting in a progressive and fatal neurodegeneration. The Hdh((CAG)Q150) Huntington's disease mouse line is a knock-in model of the disease that carries...
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RSS Source: Med Worm - Huntington's Disease Thu, 6 May 2010 11:00:00 pm
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Huntington's Disease - news item 125 of 129
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Copy number variation, eicosapentaenoic acid and neurological disorders. with particular reference to Huntington's disease and associated CAG repeats, and to myalgic encephalomyelitis and viral infection.
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Authors: Puri BK, Manku MS PMID: 20436249 [PubMed - in process] (Source: World Review of Nutrition and Dietetics)
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RSS Source: Med Worm - Huntington's Disease Thu, 6 May 2010 6:52:03 am
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Huntington's Disease - news item 126 of 129
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Eventual Huntington's Drug May Have Clear Path To Affected Brain Region, Solomon Snyder Tells Pharmacy Students
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If a drug was developed to block a key protein linked to the onset of Huntington's Disease, it could have a clear path to the part of the brain most affected by the disease, while not bothering other parts of the brain and body, said distinguished neuroscientist Solomon H. Snyder,...
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RSS Source: Med Worm - Huntington's Disease Wed, 5 May 2010 11:00:00 am
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Huntington's Disease - news item 127 of 129
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Altered micro RNAs in STHdh(Q111)/Hdh(Q111) cells: miR-146a targets TBP.
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Authors: Sinha M, Ghose J, Das E, Bhattarcharyya NP We studied expression of 90 miRNAs in STHdh(Q111)/Hdh(Q111) cells, a model for Huntington's disease and compared with that obtained in STHdh(Q7)/Hdh(Q7) cells. Fifteen miRNA were down regulated and 12 miRNA were up regulated more than 2 fold. Such changes were statistically...
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RSS Source: Med Worm - Huntington's Disease Tue, 4 May 2010 11:00:00 pm
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Huntington's Disease - news item 128 of 129
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Termination of pregnancy following prenatal diagnosis in France: how severe are the foetal anomalies?
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To determine how severe were the conditions leading to termination of pregnancy for foetal anomaly (TOPFA) in France.Detailed indications for TOPFA were extracted from medical charts.Of 2465 completed records, indications were: chromosomal anomalies n = 963 (39.1%), malformations of a single organ without chromosomal or genetic aetiologies n = 898 (36.4%), multiple...
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RSS Source: Med Worm - Huntington's Disease Tue, 4 May 2010 11:00:00 pm
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Huntington's Disease - news item 129 of 129
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Human accelerated region 1 noncoding RNA is repressed by REST in Huntington's disease
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In the neurons of Huntington's disease (HD) patients, gene regulatory networks are disrupted by aberrant nuclear localization of the master transcriptional repressor REST. Emerging evidence suggests that, in addition to protein-coding genes, noncoding RNAs (ncRNAs) may also contribute to neurodegenerative processes. To discover ncRNAs that are involved in HD, we...
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RSS Source: Med Worm - Huntington's Disease Tue, 4 May 2010 8:56:48 pm
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