Leukemia - news item 1 of 143
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Diet-Induced Obesity Accelerates Leukemia
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The first study to demonstrate that obesity can directly accelerate the progression of acute lymphoblastic leukemia (ALL) has been conducted at The Saban Research Institute of Childrens Hospital Los Angeles and will be published in Cancer Prevention Research, on October 5, 2010. Obesity has been associated with an increased incidence...
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RSS Source: Med Worm - Leukemia Thu, 9 Sep 2010 7:00:00 am
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Leukemia - news item 2 of 143
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Promising New Lymphoma Treatment Effective In Dogs
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Researchers have identified a new target for the treatment of lymphoma and are testing a potential new drug in pet dogs afflicted with the disease. At low doses, the compound, called S-PAC-1, arrested the growth of tumors in three of six dogs tested and induced partial remission in a fourth....
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RSS Source: Med Worm - Leukemia Wed, 8 Sep 2010 12:00:00 pm
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Leukemia - news item 3 of 143
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TenX Biopharma Reinitiates Enrollment In Pivotal Phase III, CTCL Trial
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TenX Biopharma, Inc. announced that it has re-initiated enrollment in the pivotal Phase III clinical trial assessing zanolimumab treatment for cutaneous T-cell lymphoma (CTCL) patients. The trial enrollment was suspended in October 2008 while Genmab (CO:GEN) was seeking a out-license agreement to further develop the compound. TenX Biopharma acquired global...
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RSS Source: Med Worm - Leukemia Wed, 8 Sep 2010 10:00:00 am
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Leukemia - news item 4 of 143
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Biomedical and pharmacological potential of tetrodotoxin-producing bacteria isolated from marine pufferfish Arothron hispidus (Muller, 1841)
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Specimens of the pufferfish Arothron hispidus collected at Parangipettai, on the southeast coast of India, were subjected to bacterial isolation and identification. Three species were identified, namely Bacillus sp., Kytococcus sedentarius and Cellulomonas fimi. Partially-purified microbial filtrates exhibited hemolytic activity on chicken and human erythrocytes of O, B and AB...
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RSS Source: Med Worm - Leukemia Wed, 8 Sep 2010 9:40:58 am
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Leukemia - news item 5 of 143
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St. Jude Researcher Receives Grant To Focus On Cancer Pharmacogenomics In Children
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With its new expansion of the Pharmacogenomics Research Network (PGRN), the National Institutes of Health (NIH) awarded St. Jude Children's Research Hospital a prestigious grant to focus on anticancer agent research in children. The five-year, $8.6 million grant is titled "PAAR4Kids Pharmacogenomics of Anticancer Agents Research in Children." "We've been...
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RSS Source: Med Worm - Leukemia Wed, 8 Sep 2010 8:00:00 am
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Leukemia - news item 6 of 143
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A cancer fate in the hands of a samurai
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Nature Medicine 16, 963 (2010). doi:10.1038/nm0910-963 Author: Malcolm A S Moore Recent studies show that Musashi-2 (MSI2), a molecule that binds RNA, increases proliferation of normal and malignant blood stem cells. In humans, increased amounts of MSI2 correlate with poor prognosis of leukemia—indicating that MSI2 may be a target to...
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RSS Source: Med Worm - Leukemia Wed, 8 Sep 2010 6:37:42 am
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Leukemia - news item 7 of 143
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Bride Fakes Having Cancer to Get a Free Wedding
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I hear more and more stories about people faking that they have cancer in order to gain sympathy, money, and free merchandise. This story from New York takes the cake -- or wedding cake in this case. A 20 -something woman is being accused of claiming to have terminal leukemia...
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RSS Source: Med Worm - Leukemia Wed, 8 Sep 2010 4:44:43 am
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Leukemia - news item 8 of 143
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Kersting heads Leukemia & Lymphoma chapter
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Deborah Kersting was named executive director of the Leukemia & Lymphoma Society’s Gateway Chapter. (Source: bizjournals.com Health Care:Physician Practices headlines)
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RSS Source: Med Worm - Leukemia Wed, 8 Sep 2010 3:08:06 am
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Leukemia - news item 9 of 143
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Researchers at Children's Hospital Los Angeles find diet-induced obesity accelerates leukemia
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(Children's Hospital Los Angeles) The first study to demonstrate that obesity can directly accelerate the progression of acute lymphoblastic leukemia has been conducted at The Saban Research Institute of Childrens Hospital Los Angeles and will be published in Cancer Prevention Research, on Oct. 5, 2010. (Source: EurekAlert! - Medicine and...
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RSS Source: Med Worm - Leukemia Tue, 7 Sep 2010 4:00:00 am
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Leukemia - news item 10 of 143
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Congenital dyserythropoietic anemia.
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Authors: Kamiya T, Manabe A Congenital dyserythropoietic anemias (CDAs) are a heterogeneous group of rare hereditary disorders of erythropoiesis characterized by morphologic abnormal erythroblasts in the bone marrow. Three types of the disease are known as type I, II and III, and the variant type of CDA and several minor...
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RSS Source: Med Worm - Leukemia Mon, 6 Sep 2010 11:00:00 pm
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Leukemia - news item 11 of 143
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Trial Effect in Newly Diagnosed Pediatric Acute Lymphoblastic Leukemia--Reply [The Pediatric Forum]
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(Source: Archives of Pediatrics)
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RSS Source: Med Worm - Leukemia Mon, 6 Sep 2010 7:50:34 pm
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Leukemia - news item 12 of 143
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Trial Effect in Newly Diagnosed Pediatric Acute Lymphoblastic Leukemia [The Pediatric Forum]
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(Source: Archives of Pediatrics)
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RSS Source: Med Worm - Leukemia Mon, 6 Sep 2010 7:50:34 pm
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Leukemia - news item 13 of 143
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Celgene Officially Notified Of ANDA Filing For REVLIMID(R)
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Celgene Corporation (NASDAQ:Â�CELG) announced it has received a Paragraph IV Certification Letter advising that Natco Pharma Limited of Hyderabad, India, submitted an Abbreviated New Drug Application (ANDA) to the U.S. Food and Drug Administration (FDA). The application requests authorization to manufacture and market generic versions of REVLIMID® (lenalidomide) 5, 10,...
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RSS Source: Med Worm - Leukemia Mon, 6 Sep 2010 11:00:00 am
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Leukemia - news item 14 of 143
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When it IsnÂ't Back to School Time
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Although it is back to school time for most kids, children with a new diagnosis of leukemia or lymphoma may not be able to go back right away. Cast your mind back to what school meant to you at their age. Sure, there was the reading and writing, the "learning...
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RSS Source: Med Worm - Leukemia Sun, 5 Sep 2010 11:00:00 pm
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Leukemia - news item 15 of 143
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Role of autotransplantation in the treatment of acute promyelocytic leukemia patients in remission: Fukuoka BMT Group observations and a literature review
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Authors: T Kamimura, T Miyamoto, K Nagafuji, A Numata, H Henzan, K Takase, Y Ito, Y Ohno, T Fujisaki, T Eto, Y Takamatsu, T Teshima, H Gondo, K Akashi, S Taniguchi & M Harada (Source: Bone Marrow Transplantation)
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RSS Source: Med Worm - Leukemia Sun, 5 Sep 2010 11:00:00 pm
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Leukemia - news item 16 of 143
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Blood Publication Shows MLN4924 Preclinical Activity In Lymphoma
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Millennium: The Takeda Oncology Company announced the publication of an article in the journal Blood describing the novel mechanism of action of MLN4924 through targeted pathway modulation in diffuse large B-cell lymphoma (DLBCL). MLN4924 is a small molecule inhibitor of the NEDD8-Activating Enzyme (NAE), a key component of the protein...
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RSS Source: Med Worm - Leukemia Sun, 5 Sep 2010 7:00:00 am
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Leukemia - news item 17 of 143
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3β-acetyl tormentic acid induces apoptosis of resistant leukemia cells independently of P-gp/ABCB1 activity or expression
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Summary Chronic Myeloid Leukemia (CML) is a potentially fatal stem-cell cancer. P-glycoprotein (P-gp/ABCB1) activity has been described as a relevant factor in the chemotherapeutic failure and correlated to a poor prognosis in these malignancies. In the present study, we investigated the mechanism of the antineoplastic activity of 3β-acetyl tormentic acid (...
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RSS Source: Med Worm - Leukemia Fri, 3 Sep 2010 5:17:48 pm
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Leukemia - news item 18 of 143
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In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors
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Abstract B7-H1 (PD-L1) is a B7-related protein that inhibits T-cell responses. B7-H1 participates in the immunoescape of cancer cells and is also involved in the long-term persistence of leukemic cells in a mouse model of leukemia. B7-H1 can be constitutively expressed by cancer cells, but is also induced by various...
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RSS Source: Med Worm - Leukemia Fri, 3 Sep 2010 3:10:02 pm
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Leukemia - news item 19 of 143
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Specificity of FLVCR Export and Its Dependence on Hemopexin [Cell Biology]
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The feline leukemia virus subgroup C receptor (FLVCR) is a heme export protein that is required for proerythroblast survival and facilitates macrophage heme iron recycling. However, its mechanism of heme export and substrate specificity are uncharacterized. Using [55Fe]heme and the fluorescent heme analog zinc mesoporphyrin, we investigated whether export by...
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RSS Source: Med Worm - Leukemia Fri, 3 Sep 2010 1:38:15 pm
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Leukemia - news item 20 of 143
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Rowe JM, Goldstone AH. How I treat acute lymphocytic leukemia in adults. Blood. 2007;110(7):2268-2275.
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(Source: Blood) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 4:02:22 pm
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Leukemia - news item 21 of 143
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Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation
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Stat5 transcription factors are essential gene regulators promoting proliferation, survival, and differentiation of all hematopoietic cell types. Mutations or fusions of oncogenic tyrosine kinases often result in constitutive Stat5 activation. We have modeled persistent Stat5 activity by using an oncogenic Stat5a variant (cS5). To analyze the hitherto unrecognized role of...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 4:02:21 pm
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Leukemia - news item 22 of 143
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Leukemia regression by vascular disruption and antiangiogenic therapy
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Acute myelogenous leukemias (AMLs) and endothelial cells depend on each other for survival and proliferation. Monotherapy antivascular strategies such as targeting vascular endothelial growth factor (VEGF) has limited efficacy in treating AML. Thus, in search of a multitarget antivascular treatment strategy for AML, we tested a novel vascular disrupting agent,...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 4:02:21 pm
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Leukemia - news item 23 of 143
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The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity
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We report a role for the Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) as an indispensable regulator of self-renewal in human stem cells and show that a functional dependence on Mcl-1 defines the human stem cell hierarchy. In vivo pharmacologic targeting of the Bcl-2 family members in human hematopoietic stem...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 4:02:21 pm
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Leukemia - news item 24 of 143
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P-glycoprotein inhibition using valspodar (PSC-833) does not improve outcomes for patients younger than age 60 years with newly diagnosed acute myeloid leukemia: Cancer and Leukemia Group B study 19808
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Cancer and Leukemia Group B 19808 (CALGB 19808) is the only randomized trial of a second-generation P-glycoprotein (Pgp) modulator in untreated patients with acute myeloid leukemia (AML) younger than age 60 years. We randomly assigned 302 patients to receive induction chemotherapy regimens consisting of cytosine arabinoside (Ara-C; A), daunorubicin (D),...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 4:02:20 pm
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Leukemia - news item 25 of 143
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Activation of Notch signal pathway is associated with a poorer prognosis in acute myeloid leukemia
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Conclusion Taken together, our data suggest for the first time that the activation of Notch pathway may indicate a poor prognosis in AML. Especially, Notch1, Jagged1 and Delta1 expression may be relevant prognostic markers in intermediate risk AML. Content Type Journal ArticleDOI 10.1007/s12032-010-9667-0Authors Xin Xu, The Affiliated Jiangyin Hospital of...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 3:14:13 pm
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Leukemia - news item 26 of 143
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Agent Orange Cases Expanded; Added Costs Raise Fiscal Concerns
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The Associated Press/Washington Post: Hundreds of thousands of Vietnam War veterans are receiving disability compensation for diseases normally associated with aging - not combat - because of the possibility of a link Agent Orange exposure. The diseases in question range from diabetes, for which 270,000 veterans receive Agent Orange-related checks,...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 11:00:00 am
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Leukemia - news item 27 of 143
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Sublobar Resection for Early-Stage Lung Cancer
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The use of sublobar resection techniques (anatomic segmentectomy; extended wedge) in the treatment of early-stage non-small cell lung cancer has been associated with increased local recurrence rates compared with lobectomy. Recent data, however, have suggested that sublobar resection of smaller tumors (especially those ≤2 cm) can be performed with no...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 9:36:47 am
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Leukemia - news item 28 of 143
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Array comparative genomic hybridization in the detection of chromosomal abnormalities in T-cell prolymphocytic leukemia
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T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive disease derived from mature T cells . In T-PLL, the karyotype is usually complex and characterized by the presence of multiple chromosomal changes. Chromosome aberrations involving the T-cell receptor α and δ locus genes (TRA@ and TRD@; hereafter referred to as TCRα/δ)...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 8:28:02 am
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Leukemia - news item 29 of 143
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Acute myeloid leukemia associated with t(10;17)(p13-15;q12-21) and phagocytic activity by leukemic blasts: a clinical study and review of the literature
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Abstract: Translocation (10;17)(p13-15;q12-21) in acute leukemia is rarely reported in the literature. Here, we present both a novel t(10;17) case study and a review of relevant literature on t(10;17) in acute leukemia (10 cases). In summary, we came to the following preliminary conclusions: t(10;17) is associated with poorly differentiated acute...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 8:28:02 am
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Leukemia - news item 30 of 143
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A case of angioimmunoblastic T-cell non-Hodgkin lymphoma with a neocentric inv dup(1)
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Abstract: Neocentromeres are rare epigenetic phenomena in which functional centromeres are formed onto novel chromosomal locations without any α-satellite DNA. To date, constitutional human neocentromeres have been reported in at least 90 cases. In cancer, however, the knowledge is much more limited. Acquired neocentromeres have been described in a particular...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 8:28:02 am
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Leukemia - news item 31 of 143
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Amplification of the RARA gene in acute myeloid leukemia: significant finding or coincidental observation?
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We present a unique case of a 59-year-old female with a history of breast cancer, now presenting with pancytopenia and bilateral infiltration with effusion in nodules of the right upper lobe of the lung. She was diagnosed with AML-M5. Chromosome analysis demonstrated a hypodiploid clone with complex numerical/structural abnormalities including...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 8:28:01 am
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Leukemia - news item 32 of 143
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ETV6†ARNT fusion in a patient with childhood T lymphoblastic leukemia
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Abstract: The ETS variant gene 6 (ETV6) gene is located at 12p13, and is frequently involved in translocations in various human neoplasms, resulting in the expression of fusion proteins consisting of the amino-terminal part of ETV6 and unrelated transcription factors or protein tyrosine kinases. Leukemia with t(1;12)(q21;p13) was previously described...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 8:28:01 am
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Leukemia - news item 33 of 143
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Targeted Signal Transduction Therapies in Myeloid Malignancies
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Abstract The myeloid malignancies include the myeloproliferative neoplasms (MPN) including chronic myeloid leukemia (CML), and acute myeloid leukemia (AML). A growing body of evidence documents that these diseases are caused by genetic mutations that constitutively activate tyrosine kinases. They include the BCR/ABL in CML, the V617F JAK2 in Philadelphia chromosomeâ€...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 8:25:30 am
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Leukemia - news item 34 of 143
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The Addition of Rituximab to Fludarabine and Cyclophosphamide Improves Progression-free Survival in Patients with Previously Treated Chronic Lymphocytic Leukemia
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Content Type Journal ArticleDOI 10.1007/s11912-010-0122-3Authors Amit Mahipal, Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, 834 Chestnut Street, Suite #320, Philadelphia, PA 19107, USAMark Weiss, Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Department of Medical Oncology, Kimmel...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 8:25:28 am
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Leukemia - news item 35 of 143
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Potential role of serum level of soluble CD44 and IFN-γ in B-cell chronic lymphocytic leukemia
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Abstract Evidence indicates that the slowly expanding population of B cells that characterizes chronic lymphocytic leukemia (CLL) results primarily from defects in responses to cytokines. We evaluated the prognostic value of soluble CD44 and IFN-γ in B-cell chronic lymphocytic leukemia (B-CLL) and analyzed their source and regulation secretion in B-CLL...
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 8:24:57 am
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Leukemia - news item 36 of 143
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Membranoproliferative glomerulonephritis following allogeneic hematopoietic stem cell transplantation
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Abstract Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation has been increasingly described as a manifestation of chronic graft-versus-host disease (GVHD); however, GVHD-associated membranoproliferative glomerulonephritis is extremely rare. A 44-year-old man developed nephrotic syndrome 24 months after HSCT for acute lymphoblastic leukemia. The renal biopsy showed type I membranoproliferative glomerulonephritis....
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RSS Source: Med Worm - Leukemia Thu, 2 Sep 2010 6:36:33 am
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Leukemia - news item 37 of 143
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Comment on ‘Integrative genomic profiling of human prostate cancer’
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Comment on ‘Integrative genomic profiling of human prostate cancer’ Leukemia advance online publication, September 2, 2010. doi:10.1038/leu.2010.194 Authors: L Bullinger, J Krönke, V Gaidzik, H Döhner & K Döhner (Source: Leukemia) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Leukemia Wed, 1 Sep 2010 11:00:00 pm
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Leukemia - news item 38 of 143
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Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138+ cells
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Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138+ cells Leukemia advance online publication, September 2, 2010. doi:10.1038/leu.2010.193 Authors: S Colla, P Storti, G Donofrio, K Todoerti, M Bolzoni, M Lazzaretti, M Abeltino, L Ippolito, A...
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RSS Source: Med Worm - Leukemia Wed, 1 Sep 2010 11:00:00 pm
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Leukemia - news item 39 of 143
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Acute myeloid leukemia cells fail to activate native human dendritic cells: a potential mechanism of immune evasion
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Authors: R Wehner, P Schumacher, M Bornhäuser, G Ehninger, K Schäkel, M Bachmann & M Schmitz (Source: Leukemia)
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RSS Source: Med Worm - Leukemia Wed, 1 Sep 2010 11:00:00 pm
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Leukemia - news item 40 of 143
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OCT-1 activity measurement provides a superior imatinib response predictor than screening for single-nucleotide polymorphisms of OCT-1
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Authors: D L White, V A Saunders, P Dang, J Engler & T P Hughes (Source: Leukemia)
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RSS Source: Med Worm - Leukemia Wed, 1 Sep 2010 11:00:00 pm
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Leukemia - news item 41 of 143
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Patients with chronic myeloid leukemia who maintain a complete molecular response after stopping imatinib treatment have evidence of persistent leukemia by DNA PCR
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Authors: D M Ross, S Branford, J F Seymour, A P Schwarer, C Arthur, P A Bartley, C Slader, C Field, P Dang, R J Filshie, A K Mills, A P Grigg, J V Melo & T P Hughes (Source: Leukemia)
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RSS Source: Med Worm - Leukemia Wed, 1 Sep 2010 11:00:00 pm
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Leukemia - news item 42 of 143
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The use of biochemical markers of bone remodeling in multiple myeloma: a report of the International Myeloma Working Group
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Authors: E Terpos, M A Dimopoulos, O Sezer, D Roodman, N Abildgaard, R Vescio, P Tosi, R Garcia-Sanz, F Davies, A Chanan-Khan, A Palumbo, P Sonneveld, M T Drake, J-L Harousseau, K C Anderson & B G M Durie (Source: Leukemia) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network ,...
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RSS Source: Med Worm - Leukemia Wed, 1 Sep 2010 11:00:00 pm
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Leukemia - news item 43 of 143
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JAK2 46/1 haplotype analysis in myeloproliferative neoplasms and acute myeloid leukemia
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JAK2 46/1 haplotype analysis in myeloproliferative neoplasms and acute myeloid leukemia Leukemia advance online publication, September 2, 2010. doi:10.1038/leu.2010.172 Authors: H Andrikovics, S Nahajevszky, M Koszarska, N Meggyesi, A Bors, G Halm, S Lueff, N Lovas, Z Matrai, J Csomor, R Rasonyi, M Egyed, J Varkonyi, G Mikala, A Sipos,...
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RSS Source: Med Worm - Leukemia Wed, 1 Sep 2010 11:00:00 pm
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Leukemia - news item 44 of 143
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Targeting base excision repair suggests a new therapeutic strategy of fludarabine for the treatment of chronic lymphocytic leukemia
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Authors: A D Bulgar, M Snell, J R Donze, E B Kirkland, L Li, S Yang, Y Xu, S L Gerson & L Liu (Source: Leukemia)
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RSS Source: Med Worm - Leukemia Wed, 1 Sep 2010 11:00:00 pm
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Leukemia - news item 45 of 143
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Robust in vivo differentiation of t(8;21)-positive acute myeloid leukemia blasts to neutrophilic granulocytes induced by treatment with dasatinib
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Authors: N Chevalier, M L Solari, H Becker, M Pantic, F Gärtner, A Maul-Pavicic, J Hübner, R Wäsch, A Schmitt-Gräff & M Lübbert (Source: Leukemia)
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RSS Source: Med Worm - Leukemia Wed, 1 Sep 2010 11:00:00 pm
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Leukemia - news item 46 of 143
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Gene amplification as double minutes or homogeneously staining regions in solid tumors: Origin and structure [RESEARCH]
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Double minutes (dmin) and homogeneously staining regions (hsr) are the cytogenetic hallmarks of genomic amplification in cancer. Different mechanisms have been proposed to explain their genesis. Recently, our group showed that the MYC-containing dmin in leukemia cases arise by excision and amplification (episome model). In the present paper we investigated...
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RSS Source: Med Worm - Leukemia Wed, 1 Sep 2010 2:02:24 pm
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Leukemia - news item 47 of 143
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Cytogenetic Instability in Childhood Acute Lymphoblastic Leukemia Survivors
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Contemporary anticancer therapies have largely improved the outcome for children with cancer, especially for Acute Lymphoblastic Leukemia (ALL). Actually, between 78% and 85% of patients achieve complete remission and are alive after 5 years of therapy completion. However, as cure rates increase, new concerns about the late effects of genotoxic...
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RSS Source: Med Worm - Leukemia Wed, 1 Sep 2010 9:11:15 am
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Leukemia - news item 48 of 143
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SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity
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The pyrrolobenzodiazepines (PBD) are naturally occurring antitumor antibiotics, and a PBD dimer (SJG-136, SG2000) is in phase II trials. Many potent PBDs contain a C2-endo-exo unsaturated motif associated with the pyrrolo C-ring. The novel compound SG2202 is a PBD dimer containing this motif. SG2285 is a water-soluble prodrug of SG2202...
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RSS Source: Med Worm - Leukemia Wed, 1 Sep 2010 4:07:46 am
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Leukemia - news item 49 of 143
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Spi-1/PU.1 Oncogene Accelerates DNA Replication Fork Elongation and Promotes Genetic Instability in the Absence of DNA Breakage
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The multistage process of cancer formation is driven by the progressive acquisition of somatic mutations. Replication stress creates genomic instability in mammals. Using a well-defined multistep leukemia model driven by Spi-1/PU.1 overexpression in the mouse and Spi-1/PU.1–overexpressing human leukemic cells, we investigated the relationship between DNA replication and cancer progression....
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RSS Source: Med Worm - Leukemia Wed, 1 Sep 2010 4:07:45 am
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Leukemia - news item 50 of 143
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The Promyelocytic Leukemia Zinc Finger (PLZF ) gene is a novel transcriptional target of the CCAATâ€Displacementâ€Protein (CUX1) repressor
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This article identifies the Promyelocytic Leukemia Zinc Finger (Source: FEBS Journal)
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RSS Source: Med Worm - Leukemia Tue, 31 Aug 2010 11:00:00 pm
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Leukemia - news item 51 of 143
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Dasatinib, even at low doses, is an effective secondâ€line therapy for chronic myeloid leukemia patients resistant or intolerant to imatinib. Results from a real lifeâ€based Italian multicenter retrospective study on 114 patients
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(Source: American Journal of Hematology) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Leukemia Tue, 31 Aug 2010 11:00:00 pm
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Leukemia - news item 52 of 143
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Ring/marker chromosome derived from chromosome 7 in childhood acute megakaryoblastic leukemia with monosomy 7.
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Authors: Fujino H, Fujita N, Hamamoto K, Oobu S, Kita M, Tanaka A, Matsubara H, Watanabe KI, Heike T, Adachi S In some cases of childhood acute megakaryoblastic leukemia (AMKL), G-band analysis reveals supernumerary ring/marker chromosomes along with monosomy 7. However, their origin and relevance are poorly understood. We experienced...
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RSS Source: Med Worm - Leukemia Tue, 31 Aug 2010 11:00:00 pm
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Leukemia - news item 53 of 143
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Acute erythroid leukemia.
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Conclusions.-The current WHO criteria for establishing the diagnosis of AEL reduce the frequency of this entity, as cases once classified as the erythroleukemia subtype are now reclassified as other types of AML, particularly AML with myelodysplasia-related changes and therapy-related AML. This reclassification also may have prognostic significance for patients with...
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RSS Source: Med Worm - Leukemia Tue, 31 Aug 2010 11:00:00 pm
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Leukemia - news item 54 of 143
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Leukemia: Methods and Protocols Chi Wai Eric So . Leukemia: Methods and Protocols . 428 pp with illus . New York, New York . Humana Press . 2009 .
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Authors: O'Hare JT PMID: 20807049 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
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RSS Source: Med Worm - Leukemia Tue, 31 Aug 2010 11:00:00 pm
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Leukemia - news item 55 of 143
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Enhanced effects of secreted soluble factor preserve better pluripotent state of embryonic stem cell culture in a membrane-based compartmentalized micro-bioreactor.
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Authors: Chowdhury MM, Katsuda T, Montagne K, Kimura H, Kojima N, Akutsu H, Ochiya T, Fujii T, Sakai Y Pluripotent stem cells are under the influence of soluble factors in a diffusion dominant in vivo microenvironment. In order to investigate the effects of secreted soluble factors on embryonic stem cell (...
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RSS Source: Med Worm - Leukemia Tue, 31 Aug 2010 11:00:00 pm
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Leukemia - news item 56 of 143
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Impact of nuclear organization and dynamics on epigenetic regulation in the central nervous system: implications for neurological disease states
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Epigenetic mechanisms that are highly responsive to interoceptive and environmental stimuli mediate the proper execution of complex genomic programs, such as cell type†specific gene transcription and posttranscriptional RNA processing, and are increasingly thought to be important for modulating the development, homeostasis, and plasticity of the central nervous system (CNS)....
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RSS Source: Med Worm - Leukemia Tue, 31 Aug 2010 11:00:00 pm
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Leukemia - news item 57 of 143
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Function of UDP-glucuronosyltransferase 2B17 (UGT2B17) is involved in endometrial cancer
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Endometrial cancer (EC) is a steroid hormone-dependent cancer. Uridine 5'-diphospho-glucuronosyltransferase enzymes conjugate and detoxify endogenous and exogenous steroid hormones and environmental carcinogens. Among these enzymes, the function of UGT2B17 is unknown except for glucuronidation. The messenger RNA expression of UGT2B17 and myeloid cell leukemia-1 (Mcl-1) was significantly increased in EC...
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RSS Source: Med Worm - Leukemia Tue, 31 Aug 2010 3:33:58 pm
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Leukemia - news item 58 of 143
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A dying patient is not a battlefield
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The patient, in his late 70s, had survived prostate cancer and had a new diagnosis of leukemia. A few days before, he'd been healthy and fine, but now his white blood cell count was so high that it was clogging his circulatory system, making it hard for him to breathe. (...
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RSS Source: Med Worm - Leukemia Tue, 31 Aug 2010 2:30:17 pm
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Leukemia - news item 59 of 143
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Taking Aim At Pre-Leukemia Disorders: NewYork-Presbyterian/Columbia Establishes Myelodysplastic Syndromes Center
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NewYork-Presbyterian Hospital/Columbia University Medical Center has established a new center devoted to research and treatment of pre-leukemia blood disorders. Known as the Myelodysplastic Syndromes Center, it is one of the largest programs of its kind in the nation. Myelodysplastic syndromes (MDS) are disorders interfering with blood production in the bone...
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RSS Source: Med Worm - Leukemia Tue, 31 Aug 2010 8:00:00 am
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Leukemia - news item 60 of 143
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Childhood Acute Leukemia, Early Common Infections, and Allergy: The ESCALE Study.
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This study investigated the role of factors considered related to early stimulation of the immune system in the etiology of childhood acute leukemia. The national registry-based case-control study ESCALE was carried out in France in 2003-2004. Population controls were frequency matched to cases on age and gender. Data were obtained...
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RSS Source: Med Worm - Leukemia Mon, 30 Aug 2010 11:00:00 pm
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Leukemia - news item 61 of 143
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Some Eggcellent Advice
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The recent recall of eggs by the FDA has got many leukemia and lymphoma patients wondering about salmonella infection and how to reduce the risk of getting sick. Salmonella food poisoning is caused by a bacteria, and is most often associated with eating raw or undercooked meats, shellfish, and eggs. People...
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RSS Source: Med Worm - Leukemia Mon, 30 Aug 2010 11:00:00 pm
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Leukemia - news item 62 of 143
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Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors
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Conclusions: Our analysis demonstrates that XMRV exhibits a distinct pattern of nucleoside analog susceptibility that correlates with the structure of the pseudosugar moiety and that XMRV is sensitive to a broader range of antiretroviral drugs than has previously been reported. We suggest that the divergent drug sensitivity profiles of XMRV...
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RSS Source: Med Worm - Leukemia Mon, 30 Aug 2010 11:00:00 pm
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Leukemia - news item 63 of 143
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Glucarpidase, Leucovorin, and Thymidine for High-Dose Methotrexate-Induced Renal Dysfunction: Clinical and Pharmacologic Factors Affecting Outcome [Pediatric Oncology]
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Conclusion Early intervention with the combination of leucovorin and glucarpidase is highly effective in patients who develop HDMTX-induced renal dysfunction. Severe toxicity and mortality occurred in patients in whom glucarpidase rescue was delayed and occurred despite thymidine administration. (Source: Journal of Clinical Oncology)
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RSS Source: Med Worm - Leukemia Mon, 30 Aug 2010 10:02:09 pm
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Leukemia - news item 64 of 143
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Vitamin D really does prevent cancer, autoimmune diseases
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(NaturalNews) A new study out of Oxford University pinpoints vitamin D deficiency as a culprit in serious illnesses like cancer and autoimmune disorders. According to the report, which was recently published online in the journal Genome Research, genetic receptors throughout the body need adequate vitamin D levels to prevent these...
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RSS Source: Med Worm - Leukemia Mon, 30 Aug 2010 7:00:00 am
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Leukemia - news item 65 of 143
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Excellence in Radiation Therapy Nursing Award
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Award: Monetary award of $1000 and a plaque. Purpose: To recognize and support excellence in radiation therapy nursing. Nominee's Eligibility Criteria: The candidate must meet the following criteria: Be a registered professional nurse and an active ONS member Have at least two years of oncology nursing experience Be a recognized...
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RSS Source: Med Worm - Leukemia Sun, 29 Aug 2010 11:00:00 pm
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Leukemia - news item 66 of 143
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Oncology Nursing Society Clinical Lectureship
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Award: A $2,000 honorarium, one coach airfare to ONS Annual Congress, two-day per diem for Congress, and a plaque. The paper is published in the September issue of the Oncology Nursing Forum. Purpose: To recognize and support excellence in clinical nursing practice. The lecture is presented at the ONS Annual...
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RSS Source: Med Worm - Leukemia Sun, 29 Aug 2010 11:00:00 pm
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Leukemia - news item 67 of 143
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Oncology Nursing Society Trish Greene Memorial Quality of Life Lectureship
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Award: A $2,000 honorarium, one coach airfare to IOL, two-day per diem for IOL, and a plaque. The paper will be published in the Clinical Journal of Oncology Nursing. Purpose: This award was established to focus attention of the membership on quality-of-life issues in cancer care; describe the contributions of...
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RSS Source: Med Worm - Leukemia Sun, 29 Aug 2010 11:00:00 pm
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Leukemia - news item 68 of 143
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Hedgehog signaling maintains chemoresistance in myeloid leukemic cells
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Authors: K C S Queiroz, R R Ruela-de-Sousa, G M Fuhler, H L Aberson, C V Ferreira, M P Peppelenbosch & C A Spek (Source: Oncogene) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Leukemia Sun, 29 Aug 2010 11:00:00 pm
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Leukemia - news item 69 of 143
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Outcome of therapyâ€related acute promyelocytic leukemia with or without arsenic trioxide as a component of frontline therapy
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Abstract (Source: Cancer)
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RSS Source: Med Worm - Leukemia Sat, 28 Aug 2010 5:12:51 am
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Leukemia - news item 70 of 143
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Hematology: Patients with high-risk APL benefit from risk-adapted consolidation therapy
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Nature Reviews Clinical Oncology 7, 484 (2010). doi:10.1038/nrclinonc.2010.128 Author: Lisa Hutchinson A previous (LPA99) trial had demonstrated a high antileukemic efficacy of a risk-adapted strategy of all-trans retinoic acid (ATRA) and anthracycline chemotherapy as induction and consolidation therapy for patients with acute promyelocytic leukemia (APL). To improve the outcomes of...
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RSS Source: Med Worm - Leukemia Sat, 28 Aug 2010 5:12:00 am
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Leukemia - news item 71 of 143
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Synchronous occurrence of acute promyelocytic leukemia and non-Hodgkin lymphoma
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Content Type Journal ArticleDOI 10.1007/s00277-010-1053-7Authors Wen Wang, Department of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan, Shandong 250012, People’s Republic of ChinaYuan Yu, Department of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan, Shandong 250012, People’s Republic of ChinaJun Peng, Department of Hematology, Qilu Hospital,...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 5:12:22 pm
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Leukemia - news item 72 of 143
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NICE Proposes To Restrict Access To Velcade(R) In Newly Diagnosed Multiple Myeloma Patients Janssen-Cilag To Challenge NICE Recommendation
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Janssen-Cilag is disappointed that recommendations from the National Institute for Health and Clinical Excellence (NICE) will limit patient access to Velcade (bortezomib) in newly diagnosed (front-line) multiple myeloma... (Source: Health News from Medical News Today)
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 8:00:00 am
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Leukemia - news item 73 of 143
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LFB's Recombinant Anti-CD20 Monoclonal Antibody Is Granted Orphan Drug Status In The USA For Chronic Lymphocytic Leukemia
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The recombinant anti-CD20 monoclonal antibody produced by LFB Biotechnologies received orphan drug status for the treatment of Chronic Lymphocytic Leukemia (CLL). This approval from the FDA Office of Orphan Products Development was granted on August 6th, 2010. Chronic lymphocytic leukemia is the most common form of leukemia in the United...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 8:00:00 am
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Leukemia - news item 74 of 143
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Overdose with 16,000mg of imatinib mesylate
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We report on a 53 years old woman, who ingested 16,000mg in a suicide attempt. (Source: Leukemia Research) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:33 am
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Leukemia - news item 75 of 143
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B-cell acute lymphoblastic leukemia as evolution of a 8p11 myeloproliferative syndrome with t(8;22)(p11;q11) and BCR-FGFR1 fusion gene
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Rearrangement of fibroblast growth factor receptor 1 (FGFR1) gene, mapped on chromosome band 8p11, is the genetic hallmark of a rare atypical chronic myeloproliferative disorder that is usually characterized by myeloid hyperplasia, eosinophilia and high incidence of T-lymphoblastic lymphoma referred as 8p11 myeloproliferative syndrome (EMS) . (Source: Leukemia Research)
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:33 am
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Leukemia - news item 76 of 143
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ABVD associated with imatinib for coexisting chronic myeloid leukaemia and relapsed Hodgkin lymphoma
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A 30-year-old Caucasian male has been referred to our institution in June 2009 because for 3 months he presented recurrent fever, night sweats and asthenia. Nine years before the patient has been diagnosed with nodular sclerosis classical HL; at that time a computer tomography (CT) scan demonstrated a mediastinal bulky,...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:32 am
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Leukemia - news item 77 of 143
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Is there still a role for G-banding in CLL?
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Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder characterized by progressive monomorphic lymphocytosis caused by clonal accumulation of CD5+ CD19+ B cells in peripheral blood, bone marrow and lymphoid organs . Clinical course is heterogeneous. Molecular and biologic factors have been found to be useful predictors of response to treatment and...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:29 am
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Leukemia - news item 78 of 143
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Intravascular large B-cell lymphoma, an exclusively small vessel disease? A case report and review of literature
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We report a case with recurrent lymphoma exclusively in the SVC. This case highlights that IVLBCL can occur in large blood vessels. Further considerations are required to classify this type of lymphoma. Awareness of this disease will result in appropriate use of diagnostic studies and avoid unnecessary surgical procedures. (Source:...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:29 am
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Leukemia - news item 79 of 143
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Facilitating studies of cell proliferation in chronic lymphocytic leukemia
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We read with interest the report by Hayes et al., “Isolation of malignant B cells from patients with chronic lymphocytic leukemia (CLL) for analysis of cell proliferation: Validation of a simplified method suitable for multi-center clinical studies.†The authors describe helpful developments for analyzing in vivo proliferation rates of leukemic...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:29 am
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Leukemia - news item 80 of 143
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Sorafenib induces sustained molecular remission in FLT3-ITD positive AML with relapse after second allogeneic stem cell transplantation without exacerbation of acute GVHD: A case report
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Relapsed acute leukemia after allogeneic stem cell transplantation (SCT) has a very poor prognosis and treatment still remains a challenge . Infections and/or severe acute GvHD often preclude conventional myeloablative chemotherapy. Cellular therapies with donor lymphocyte infusions (DLI) or a second allogeneic SCT do not induce stable remissions in the majority...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:28 am
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Leukemia - news item 81 of 143
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A case of blast clearance on sorafenib in relapsed FLT3-ITD acute myeloid leukemia: Evidence of efficacy continues to mount
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We present a case of sorafenib use in relapsed FLT3-ITD positive AML which supports both the in vitro finding and the in vivo efficacy demonstrated in the German report. (Source: Leukemia Research)
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:28 am
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Leukemia - news item 82 of 143
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Localized graft-versus-host disease of the skin provoked by radiotherapy
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In multiple myeloma allogeneic stem cell transplantation (allo-SCT) is associated with the highest rate of molecular remissions and a lower risk of recurrence compared with other treatment options including autologous SCT . This is due to the graft-versus-myeloma effect, which was proven by the achievement of sustained complete remissions by donor...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:28 am
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Leukemia - news item 83 of 143
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Central nervous system involvement at second relapse in acute promyelocytic leukemia treated with ATRA and chemotherapy
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Acute promyelocytic leukemia is highly curable with molecularly targeted therapy against its specific genetic abnormality. The combination of all-trans retinoic acid (ATRA) and anthracycline based chemotherapy and maintenance treatment has improved the outcome of acute promyelocytic leukemia (APL), but relapse still occurs in 10†25% of the patients . Extramedullary (EM)...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:28 am
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Leukemia - news item 84 of 143
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Persistent detection of a novel MLL†SACM1L rearrangement in the absence of leukemia
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Abstract: Most chromosomal rearrangements including the mixed lineage leukemia (MLL) gene are manifested as leukemia and predict a poor prognosis. Although more than 50 MLL-rearrangement partners are characterized, MLL-related leukemogenesis remains to be understood. Here we report a case of a 3-year old boy bearing a novel MLL-rearrangement with the...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:28 am
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Leukemia - news item 85 of 143
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Reversibility of renal failure in newly diagnosed patients with multiple myeloma and the role of novel agents
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Abstract: The purpose of this analysis was to assess the effect of novel agent-based regimens on the improvement of renal impairment (RI) in newly diagnosed patients with multiple myeloma. Ninety-six consecutive patients with RI received conventional chemotherapy (CC)-based regimens (n=32), IMiDs-based regimens (n=47) or bortezomib-based regimens (n=17) as frontline therapy....
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:27 am
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Leukemia - news item 86 of 143
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Differential NOD/SCID mouse engraftment of peripheral blood CD34+ cells and JAK2V617F clones from patients with myeloproliferative neoplasms
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Abstract: We evaluated the NOD/SCID engraftment of CD34+ cells from polycythemia vera (PV) and secondary polycythemia patients (SP) and the JAK2V617F clone before and after transplantation. Peripheral blood CD34+ cells were transplanted intra-femorally. In the injected BM, successful engraftment (>0.1%) occurred in 8/26 mice transplanted with CD34+ cells from 5/13...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:27 am
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Leukemia - news item 87 of 143
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A fluorescent biomarker of the polyamine transport system to select patients with AML for F14512 treatment
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In conclusion, the identification of PTS-positive AML with F98982 probe offers new perspectives to select patients prone to respond to F14512. (Source: Leukemia Research)
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:27 am
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Leukemia - news item 88 of 143
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Engineered regulatory T cells prevent graft-versus-host disease while sparing the graft-versus-leukemia effect after bone marrow transplantation
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Abstract: Regulatory T cells (Tregs) can prevent graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT). Here we developed a lentivirus-based strategy to ectopically express Foxp3 in mouse CD4+CD25âˆ' T cells. These cells shared similar immunophenotypes and biological features of natural Tregs. Co-injection of engineered Tregs with donor bone marrow...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:27 am
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Leukemia - news item 89 of 143
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NFκB modulators in a model of glucocorticoid resistant, childhood acute lymphoblastic leukemia
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Abstract: Glucocorticoids (GCs) are pivotal agents in the treatment of childhood acute lymphoblastic leukaemia (ALL) but the molecular basis of GC-resistance remains unclear. Expression-array studies have shown that commonly upregulated genes associated with GC-sensitivity include GR, glucocorticoid-induced leucine zipper (GILZ) and IκBα, which all negatively interact with components of the...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:27 am
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Leukemia - news item 90 of 143
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Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors
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Abstract: Acute myeloid leukemia (AML) is maintained by rare leukemia-initiating cells (L-ICs). FLT3 and/or PI3K pathways are often dysregulated in AML and may be important for L-IC survival. The presence of PI3K pathway intermediate integrin linked kinase (ILK), and FLT3 was confirmed in five L-IC-enriched AML patient samples. Treatment of...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:27 am
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Leukemia - news item 91 of 143
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Comparative analysis of MVA-CD40L and MVA-TRICOM vectors for enhancing the immunogenicity of chronic lymphocytic leukemia (CLL) cells
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This study compares the same vector (modified vaccinia virus strain Ankara (MVA)) encoding CD40L or TRICOM for its ability to enhance the immunogenicity of CLL cells. CLL cells from some patients showed differential responses to each vector in terms of induction of autologous T-cell responses. This study supports the rationale...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:27 am
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Leukemia - news item 92 of 143
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Hypoplastic myelodysplastic syndrome (h-MDS) is a distinctive clinical entity with poorer prognosis and frequent karyotypic and FISH abnormalities compared to aplastic anemia (AA)
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Abstract: The aims of the present study are two-fold: (1) to define the clinical features of hypoplastic myelodysplastic syndrome (h-MDS) in comparison with aplastic anemia (AA) and (2) to evaluate the prognostic roles of karyotyping and fluorescent in situ hybridization (FISH) in these hypoplastic marrow syndromes.Based on a medical record...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:26 am
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Leukemia - news item 93 of 143
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Validation of the International Prognostic Scoring System (IPSS) for Waldenstrom's macroglobulinemia (WM) and the importance of serum lactate dehydrogenase (LDH)
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Abstract: The recently proposed, ISSWM staging system for symptomatic patients with WM was based on patients treated with alkylating agents and nucleoside analogs and has not been externally validated nor has been validated for cause-specific survival (CSS). We independently validated ISSWM both for overall survival (OS) and for CSS and...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:26 am
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Leukemia - news item 94 of 143
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Abnormal phenotype of bone marrow plasma cells in patients with chronic myeloid leukemia undergoing therapy with Imatinib
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Abstract: Imatinib induces several effects on the immune system, including hypogammaglobulinemia and has been associated with multiple myeloma in some patients. We studied the phenotype of plasma cells from patients with chronic myeloid leukemia (CML) undergoing therapy with Imatinib mesylate (Glivec). Bone marrow samples from 30 CML patients were evaluated...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:26 am
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Leukemia - news item 95 of 143
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The efficacy and safety of the low-thalidomide dose CTD (cyclophosphamide, thalidomide, dexamethasone) regimen in patients with multiple myeloma†A report by the Polish Myeloma Study Group
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This study included 132 untreated and relapsing/resistant patients treated with the low-thalidomide dose CTD regimen. The patients received CY 500mg/m2 i.v. or 625mg/m2 orally at day 1, THAL 100mg/day á la longue and DEX 20mg/day at days 1†4 and 8†11, every 28 days. Patients received 6†9 cycles;...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:26 am
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Leukemia - news item 96 of 143
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Survivin is upregulated in myeloma cell lines cocultured with mesenchymal stem cells
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In this study we investigated the influence of the mesenchymal stem cells on the survival of U266 and H929 myeloma cell lines. We found that both soluble factors and direct cell contact inhibited daunorubicin-induced apoptosis of U266 and H929 cells. The mRNA and protein levels of survivin were upregulated in...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:26 am
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Leukemia - news item 97 of 143
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Circulating Ki-67 index in plasma as a biomarker and prognostic indicator in chronic lymphocytic leukemia
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Abstract: Ki-67 is a nuclear antigen that is expressed in all stages of the cell cycle, except G0, and is widely used as a marker of cellular proliferation in human tumors. We recently showed that elevated levels of Ki-67 circulating in plasma (cKi-67) are associated with shorter survival in patients...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:25 am
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Leukemia - news item 98 of 143
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Combined analysis of minimal residual disease at two time points and its value for risk stratification in childhood B-lineage acute lymphoblastic leukemia
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This study stratified 105 patients into three MRD risk groups: standard-risk, MRD (Source: Leukemia Research) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:25 am
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Leukemia - news item 99 of 143
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Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients
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Abstract: The role of the Smac/DIABLO protein, a novel apoptosis agonist, in acute myeloid leukemia (AML) is not clearly determined. The expression of Smac/DIABLO protein in AML leukemic cells and its relationship with clinical outcome was evaluated in this study.The intracellular expression of Smac/DIABLO protein was assessed using multi-color flow...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:25 am
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Leukemia - news item 100 of 143
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FLT3 and KIT mutated pediatric acute myeloid leukemia (AML) samples are sensitive in vitro to the tyrosine kinase inhibitor SU11657
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In this study we investigated whether pediatric AML samples (N=61) were sensitive to the tyrosine kinase inhibitor SU11657 (similar to the clinically available drug sunitinib) in vitro, and whether sensitivity was related to expression of, and mutations in, FLT3 and KIT. Overall, SU11657 showed only moderate cytotoxicity. A FLT3 mutation...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:25 am
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Leukemia - news item 101 of 143
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FISH analysis of circulating CD34+ cells as a new tool for genetic monitoring in MDS: Verification of the method and application to 27 MDS patients
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We present a novel method using peripheral blood (pb) for frequent cytogenetic monitoring: after immunomagnetic cell separation circulating CD34+ cells were analysed by fluorescence in situ hybridization (FISH). We compared FISH analyses of enriched and non-enriched pb and bm cells with conventional chromosome banding analyses of bm metaphases: analysing circulating...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:25 am
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Leukemia - news item 102 of 143
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Differential cytogenomics and miRNA signature of the Acute Myeloid Leukaemia Kasumi-1 cell line CD34+38âˆ' compartment
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Abstract: The t(8;21) Acute Myeloid Leukaemia (AML) Kasumi-1 cell line with N822K KIT mutation, is a model system for leukemogenesis. As AML initiating cells reside in the CD34+CD38âˆ' fraction, we addressed the refined cytogenomic characterization and miRNA expression of Kasumi-1 cell line and its FACS-sorted subpopulations focussing on this compartment....
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:24 am
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Leukemia - news item 103 of 143
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The MIF âˆ'173G/C polymorphism and risk of childhood acute lymphoblastic leukemia in a Chinese population
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Abstract: Migration inhibitory factor (MIF) has recently been defined as a novel pro-tumorigenic factor that promotes cell proliferation, migration, and invasion. The MIF âˆ'173C allele results in increased MIF promoter activity and is associated with a higher serum MIF level. We hypothesized that this polymorphism may contribute to childhood acute...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:24 am
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Leukemia - news item 104 of 143
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DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia
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In this study, we investigated the possible association of X-ray repair cross-complimenting group 1 (XRCC1) Arg399Gln and Arg194Trp variants with the risk of incidence of childhood acute lymphoblastic leukemia (ALL) in Turkish population comprised of 190 healthy controls and 167 ALL patients. For Arg399Gln polymorphism, the heterozygous (Arg/Gln) and homozygous...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:24 am
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Leukemia - news item 105 of 143
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Genome-wide association study of childhood acute lymphoblastic leukemia in Korea
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Abstract: We conducted a genome-wide association study of childhood acute lymphoblastic leukemia (ALL) in a case†control study conducted in Korea. Incident childhood ALL cases (n=50) and non-cancer controls (n=50) frequency-matched to cases by age and sex, recruited from three teaching hospitals in Seoul between 2003 and 2008, were genotyped...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:23 am
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Leukemia - news item 106 of 143
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Genetic variation and the risk of acute lymphoblastic leukemia
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Acute lymphoblastic leukemia (ALL) is the commonest childhood malignancy, and has long been one of the best characterized tumors at the genetic level . ALL may be of B or T lymphoid lineage, and comprises a group of disorders characterized by recurring chromosomal alterations including aneuploidy (hyper- and hypodiploidy) and chromosomal...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:23 am
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Leukemia - news item 107 of 143
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BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: A review
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Abstract: Chronic Myeloid Leukemia (CML) is a clonal disease characterized by the presence of the Philadelphia (Ph+) chromosome and its oncogenic product, BCR-ABL, a constitutively active tyrosine kinase, that is present in >90% of the patients. Epidemiologic data indicates that almost 5000 new cases are reported every year and 10%...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:23 am
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Leukemia - news item 108 of 143
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Editorial Board
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(Source: Leukemia Research) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 6:28:23 am
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Leukemia - news item 109 of 143
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Current and Future Clinical Strategies in the Management of Chronic Myeloid Leukemia
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Pharmacotherapy 30(9, part 2): 77S-101S Abstract Rational design of tyrosine kinase inhibitors, such as imatinib, against leukemogenic Bcr-Abl kinase has resulted in unprecedented responses and survival rates in patients with chronic myeloid leukemia (CML). Although these responses are sustained for years in the majority of patients, a fraction of the...
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RSS Source: Med Worm - Leukemia Fri, 27 Aug 2010 5:52:55 am
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Leukemia - news item 110 of 143
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Tanji H, Ishikawa C, Sawada S, Nakachi S, Takamatsu R, Matsuda T, Okudaira T, Uchihara J-N, Ohshiro K, Tanaka Y, Senba M, Uezato H, Ohshima K, Duc Dodon M, Wu K-J, Mori N. Aberrant expression of the transcription factor Twist in adult T-cell leukemia [published online ahead of print January 13, 2010]. Blood. doi:10.1182/blood-2009-07-232231.
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(Source: Blood)
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 4:02:33 pm
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Leukemia - news item 111 of 143
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Sawada S, Ishikawa C, Tanji H, Nakachi S, Senba M, Okudaira T, Uchihara J-N, Taira N, Ohshiro K, Yamada Y, Tanaka Y, Uezato H, Ohshima K, Sasai K, Burgering BMT, Duc Dodon M, Fujii M, Sunakawa H, Mori N. Overexpression of caveolin-1 in adult T-cell leukemia. Blood. 2010; 115(11):2220-2230.
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(Source: Blood) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 4:02:33 pm
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Leukemia - news item 112 of 143
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Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study
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In conclusion, allogeneic HSCT using currently available graft source is an effective treatment in selected patients with ATL, although greater effort is warranted to reduce treatment-related mortality. (Source: Blood)
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 4:02:33 pm
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Leukemia - news item 113 of 143
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In search of the original leukemic clone in chronic myeloid leukemia patients in complete molecular remission after stem cell transplantation or imatinib
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In conclusion, in IM-treated patients, absence of transcripts should not be interpreted as absence of the leukemic clone, although continuing IM after achievement of CMR may lead to further reduction of residual disease. Post-SCT, we found little evidence that the transcripts occasionally detected originate from the leukemic clone. (Source: Blood)
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 4:02:33 pm
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Leukemia - news item 114 of 143
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Differential ability of Tribbles family members to promote degradation of C/EBP{alpha} and induce acute myelogenous leukemia
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Trib1, Trib2, and Trib3 are mammalian homologs of Tribbles, an evolutionarily conserved Drosophila protein family that mediates protein degradation. Tribbles proteins function as adapters to recruit E3 ubiquitin ligases and enhance ubiquitylation of the target protein to promote its degradation. Increased Trib1 and Trib2 mRNA expression occurs in human myeloid...
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 4:02:33 pm
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Leukemia - news item 115 of 143
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Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies
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Sequence variants at the TERT-CLPTM1L locus in chromosome 5p have been recently associated with disposition for various cancers. Here we show that this locus including the gene encoding the telomerase reverse-transcriptase TERT at 5p13.33 is rarely but recurrently targeted by somatic chromosomal translocations to IGH and non-IG loci in B-cell...
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 4:02:33 pm
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Leukemia - news item 116 of 143
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c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development
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We report herein mechanistic details concerning the role of these transcription factors in human peripheral blood Th2 cell development. Silencing c-Myb in normal human naive CD4+ cells under Th2 cell-promoting conditions blocked up-regulation of GATA-3 and interleukin-4, and in effector/memory CD4+ T cells, decreased expression of GATA-3 and Th2 cytokines....
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 4:02:33 pm
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Leukemia - news item 117 of 143
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Are antibody deficiency disorders associated with a narrower range of cancers than other forms of immunodeficiency?
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Analysis of cancer risk in primary immune deficiency (PID) offers insight into the relationship between immune function and cancer. Data on Australian patients (n = 1132) notified voluntarily to the Australasian Society of Clinical Immunology and Allergy PID Registry (1990-2008) were linked with national death and cancer registries. Person-years of follow-up...
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 4:02:32 pm
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Leukemia - news item 118 of 143
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Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan
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Definitive risk factors for the development of adult T-cell leukemia (ATL) among asymptomatic human T-cell leukemia virus type I (HTLV-1) carriers remain unclear. Recently, HTLV-1 proviral loads have been evaluated as important predictors of ATL, but a few small prospective studies have been conducted. We prospectively evaluated 1218 asymptomatic HTLV-1...
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 4:02:32 pm
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Leukemia - news item 119 of 143
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NICE Draft Guidance Recommends Bortezomib And Thalidomide For Multiple Myeloma
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In draft guidance published today (26 August 2010) NICE has recommended two treatments for multiple myeloma. Thalidomide (Thalidomide, Celgene) in combination with an alkylating agent and a corticosteroid is recommended for the first-line treatment of multiple myeloma in people for whom high-dose chemotherapy with stem cell transplantation is considered inappropriate....
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 1:00:00 pm
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Leukemia - news item 120 of 143
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Anti-human very late antigen-alpha4 (CD49d) monoclonal antibody (BU49) cross-reacts with the canine B-cell leukemia cell line GL-1, resulting in the induction of homotypic cell aggregation.
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Authors: Ikewaki N, Nakaichi M, Mizuno T, Takamura N, Tokunaga J, Ogata K, Inoko H, Otsu R We have found that the anti-human very late antigen-alpha4 (VLA-alpha4) (CD49d) monoclonal antibody (mAb) BU49 cross-reacts with the canine B-cell leukemia cell line GL-1. Interestingly, the BU49 mAb specifically induced the homotypic cell...
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 11:12:04 am
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Leukemia - news item 121 of 143
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The Role of Mechanistic Factors in Promoting Chromosomal Translocations Found in Lymphoid and Other Cancers.
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Authors: Zhang Y, Gostissa M, Hildebrand DG, Becker MS, Boboila C, Chiarle R, Lewis S, Alt FW Recurrent chromosomal abnormalities, especially chromosomal translocations, are strongly associated with certain subtypes of leukemia, lymphoma and solid tumors. The appearance of particular translocations or associated genomic alterations can be important indicators of disease...
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 10:57:04 am
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Leukemia - news item 122 of 143
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Acute Lymphoblastic Leukemia: An Unusual Cause of Nephromegaly in Infancy
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Content Type Journal ArticleDOI 10.1007/s12098-010-0165-3Authors Mukta Mantan, Department of Pediatrics, Maulana Azad Medical College and associated Hospitals, University of Delhi, Delhi, 110002 IndiaGulshan Raj Sethi, Department of Pediatrics, Maulana Azad Medical College and associated Hospitals, University of Delhi, Delhi, 110002 India Journal Indian Journal of PediatricsOnline ISSN 0973-7693Print ISSN 0019-5456 (...
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 7:46:55 am
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Leukemia - news item 123 of 143
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CAS Chemistry Research Report: A Decade Later Human Genome Discoveries...
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Today, leukemia patients who have struggled with cancer therapy resistance and intolerance will now have more options thanks to targeted drug therapy. Such new treatment options are due, in part, to a...(PRWeb August 24, 2010)Read the full story at http://www.prweb.com/releases/08-2010/CAS-Report-Gleevec/prweb4417494.htm (Source: PRWeb: Medical Pharmaceuticals)
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RSS Source: Med Worm - Leukemia Thu, 26 Aug 2010 7:32:40 am
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Leukemia - news item 124 of 143
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The impact of CD4(+)Foxp3(+) Treg on immunity to murine cytomegalovirus after bone marrow transplantation depends on the peripheral or thymic source of T cell regeneration.
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CONCLUSION: The effect of Treg on T cell-mediated immunocompetence against mCMV early after BMT depends on the relative contribution of peripheral expansion and thymopoiesis to T cell regenration. PMID: 20801217 [PubMed - as supplied by publisher] (Source: Transplant Immunology)
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 11:00:00 pm
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Leukemia - news item 125 of 143
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Production of monoclonal antibodies to P-glycoprotein: its application in detection of soluble and surface P-glycoprotein of leukemia patients.
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In this study, two monoclonal antibodies (mAbs) specific for the extracellular domain of P-gp were generated. By employing the generated mAbs, a two-color lysed whole blood flow cytometric method for surface P-gp and an efficient sandwich ELISA for soluble P-gp determinations were established. By using the established methods, surface and...
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 11:00:00 pm
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Leukemia - news item 126 of 143
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Tosedostat Appears to Be Effective Leukemia Treatment
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Tosedostat, a novel metalloenzyme inhibitor, appears to be well tolerated at 130 mg daily and to have a favorable risk-benefit profile for patients with acute myeloid leukemia or myelodysplastic syndrome, according to research published online Aug. 23 in the Journal of Clinical Oncology. (Source: Modern Medicine)
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 11:00:00 pm
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Leukemia - news item 127 of 143
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Basic Mechanisms of Arsenic Trioxide (ATO)-Induced Apoptosis in Human Leukemia (HL-60) Cells
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Background: Acute promyelocytic leukemia (APL) is a blood cancer that affects people of all ages and strikes about 1,500 patients in the United States each year. The standard treatment of APL has been based on the combined administration of all-trans retinoic acid and chemotherapy including anthracyclins and cytarabine. However, 10-20%...
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 11:00:00 pm
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Leukemia - news item 128 of 143
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High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias
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Authors: S Morisot, A S Wayne, O Bohana-Kashtan, I M Kaplan, C D Gocke, R Hildreth, M Stetler-Stevenson, R L Walker, S Davis, P S Meltzer, S J Wheelan, P Brown, R J Jones, L D Shultz & C I Civin (Source: Leukemia)
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 11:00:00 pm
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Leukemia - news item 129 of 143
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Identification of disease- and therapy-associated proteome changes in the sera of patients with myelodysplastic syndromes and del(5q)
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Authors: C Chen, D T Bowen, A A N Giagounidis, B Schlegelberger, S Haase & E G Wright (Source: Leukemia)
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 11:00:00 pm
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Leukemia - news item 130 of 143
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Analysis of BCR†ABL1 tyrosine kinase domain mutational spectra in primitive chronic myeloid leukemia cells suggests a unique mutator phenotype
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Analysis of BCR–ABL1 tyrosine kinase domain mutational spectra in primitive chronic myeloid leukemia cells suggests a unique mutator phenotype Leukemia advance online publication, August 26, 2010. doi:10.1038/leu.2010.179 Authors: H Grant, X Jiang, J Stebbing, L Foroni, C Craddock, M Griffiths, R E Clark, S O'Brien, J S Khorashad, G Gerrard,...
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 11:00:00 pm
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Leukemia - news item 131 of 143
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Genomic profiling of high-risk acute lymphoblastic leukemia
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Authors: J R Collins-Underwood & C G Mullighan (Source: Leukemia)
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 11:00:00 pm
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Leukemia - news item 132 of 143
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Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies
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Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies Leukemia advance online publication, August 26, 2010. doi:10.1038/leu.2010.175 Authors: M A Dimopoulos, E Kastritis, D Christoulas, M Migkou, M Gavriatopoulou, M Gkotzamanidou, M...
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 11:00:00 pm
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Leukemia - news item 133 of 143
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Meis1 disrupts the genomic imprint of Dlk1 in a NUP98-HOXD13 leukemia model
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Authors: B Argiropoulos, L Palmqvist, S Imren, M Miller, A Rouhi, D L Mager & R K Humphries (Source: Leukemia)
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 11:00:00 pm
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Leukemia - news item 134 of 143
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2-Methoxyestradiol blocks cell-cycle progression at the G2/M phase and induces apoptosis in human acute T lymphoblastic leukemia CEM cells.
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Authors: Zhang X, Huang H, Xu Z, Zhan R 2-Methoxyestradiol (2-ME2) is an endogenous metabolite of 17beta-estradiol (E2) with estrogen receptor-independent anti-cancer activity. The current study sought to determine the mechanism of anti-cancer activity of 2-ME2 in human acute T lymphoblastic leukemia CEM cells. Results showed that 2-ME2 markedly suppressed...
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 2:54:14 pm
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Leukemia - news item 135 of 143
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Murine leukemia virus-related gene sequences observed in patients with chronic fatigue syndrome
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Lo S. Proc Natl Acad Sci. 2010;doi:10.1073/pnas.1006901107. (Source: HemOncToday.com)
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 10:00:00 am
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Leukemia - news item 136 of 143
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CAS Chemistry Research Report, A Decade Later Human Genome Discoveries Spur Growth Of Cancer Treatments
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Today, leukemia patients who have struggled with cancer therapy resistance and intolerance will now have more options thanks to targeted drug therapy. Such new treatment options are due, in part, to a rapid increase in journal and patent publications following the discovery of Gleevec, as reported by Chemical Abstracts Service (...
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 9:00:00 am
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Leukemia - news item 137 of 143
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Brain Perfusion in Adult Patients with Acute Myeloblastic Leukemia before and after Cytosine Arabinoside
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Conclusions HMPAO SPECT demonstrated a decrease in thalamus, cerebellar, and parieto-occipital perfusion after conventional doses of ara-C in AML patients, although the neurological examinations were normal and the patients had no neurological adverse effects. Content Type Journal ArticleDOI 10.1007/s11307-010-0409-7Authors Romain Modzelewski, Department of Nuclear Medicine, Henri Becquerel Centre and Rouen...
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RSS Source: Med Worm - Leukemia Wed, 25 Aug 2010 6:13:36 am
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Leukemia - news item 138 of 143
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Stem Cell Ruling Stops Federal Disease Studies
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Researchers Experimenting with Treatments for Down Syndrome, Childhood Leukemia Examine Judge's Ruling (Source: Health News: CBSNews.com) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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RSS Source: Med Worm - Leukemia Tue, 24 Aug 2010 11:19:08 pm
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Leukemia - news item 139 of 143
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Monocytes/macrophages express CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation
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Conclusions: CCR9 expression by monocytes is increased in RA. CCL25 may be involved in the differentiation of monocytes to macrophages particularly in RA. (Source: Arthritis Research and Therapy)
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RSS Source: Med Worm - Leukemia Tue, 24 Aug 2010 11:00:00 pm
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Leukemia - news item 140 of 143
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Elizabeth Munsterberg Koppitz Child Psychology Graduate Student Fellowship
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This fellowship promotes the advancement of knowledge and learning in the field of child psychology. Deadline: November 15, 2010 Sponsor: American Psychological Foundation Dr. Werner Koppitz made a bequest of more than $4 million to APF to honor his late wife, Elizabeth Munsterberg Koppitz, Ph.D., a school and educational psychologist,...
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RSS Source: Med Worm - Leukemia Tue, 24 Aug 2010 11:00:00 pm
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Leukemia - news item 141 of 143
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Presence of Murine Leukemia Virus Related Gene Sequences Found in CFS Patients
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Source: Food and Drug Administration Related MedlinePlus Page: Chronic Fatigue Syndrome (Source: MedlinePlus Health News)
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RSS Source: Med Worm - Leukemia Tue, 24 Aug 2010 10:47:23 pm
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Leukemia - news item 142 of 143
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More Evidence Links Murine Virus to Chronic Fatigue Syndrome
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Scientists find murine leukemia virus in blood of patients diagnosed as having chronic fatigue syndrome and also in some healthy blood donors. Medscape Medical News (Source: Medscape Today Headlines)
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RSS Source: Med Worm - Leukemia Tue, 24 Aug 2010 4:02:01 pm
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Leukemia - news item 143 of 143
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Is b3a2 a better prognostic variant in childhood chronic myeloid leukemia?
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KP Malhotra, CB Sharma, J Jain, RK GroverJournal of Postgraduate Medicine 2010 56(3):221-222 (Source: Journal of Postgraduate Medicine)
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RSS Source: Med Worm - Leukemia Tue, 24 Aug 2010 8:25:15 am
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