Leukemia - news item 1 of 149
|
|
FDA Grants Priority Review For ISTODAX(R) SNDA For Treatment Of Progressive Or Relapsed PTCL
|
|
Celgene Corporation (Nasdaq:CELG) announced that the U.S. Food and Drug Administration (FDA) has granted Priority Review classification to its Supplemental New Drug Application (sNDA) regarding ISTODAX (romidepsin) for injection for the treatment of peripheral T-cell lymphoma (PTCL) in patients who have received at least one prior therapy. The Prescription Drug...
|
|
RSS Source: Med Worm - Leukemia Sat, 5 Mar 2011 8:00:00 am
|
|
|
|
Leukemia - news item 2 of 149
|
|
My Turn: A teen with cancer chooses to grab opportunities
|
|
The high school junior's life was turned upside down. But she was determined to not fall into depression.My life drastically changed two weeks into my junior year of high school, when I was diagnosed with chronic myelogenous leukemia, a rare blood cancer. (Source: L.A. Times - Health)
|
|
RSS Source: Med Worm - Leukemia Sat, 5 Mar 2011 4:46:54 am
|
|
|
|
Leukemia - news item 3 of 149
|
|
Mechanisms and Biology of B-Cell Leukemia/Lymphoma 2/Adenovirus E1B Interacting Protein 3 and Nip-Like Protein X
|
|
Antioxidants & Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)
|
|
RSS Source: Med Worm - Leukemia Sat, 5 Mar 2011 3:00:39 am
|
|
|
|
Leukemia - news item 4 of 149
|
|
Anti-Tumor Necrosis Factor-α Therapy in the Management of Psoriasis and B-Chronic Lymphocytic Leukemia
|
|
Case Rep Dermatol 2011;3:60†63 (DOI:10.1159/000324344) (Source: Karger Publishers)
|
|
RSS Source: Med Worm - Leukemia Fri, 4 Mar 2011 2:17:41 pm
|
|
|
|
Leukemia - news item 5 of 149
|
|
Researchers Discover How Cancer Cheats Immune System: BC Cancer Agency Team Finds Clues In Two Lymphoma Types
|
|
BC Cancer Agency scientists have discovered that a single gene, CIITA, is implicated in almost 40 per cent of primary mediastinal B-cell lymphomas (a type of non-Hodgkin lymphoma) and 15 per cent of all Hodgkin lymphoma cases. The groundbreaking discovery, published in the international science and medical journal Nature, identifies...
|
|
RSS Source: Med Worm - Leukemia Fri, 4 Mar 2011 11:00:00 am
|
|
|
|
Leukemia - news item 6 of 149
|
|
HIV1 Capsid Determinants to Escape TRIM5{alpha} [Microbiology]
|
|
The tropism of retroviruses relies on their ability to exploit cellular factors for their replication as well as to avoid host-encoded inhibitory activities such as TRIM5α. N-tropic murine leukemia virus is sensitive to human TRIM5α (huTRIM5α) restriction, whereas human immunodeficiency virus type 1 (HIV1) escapes this antiviral factor. We previously...
|
|
RSS Source: Med Worm - Leukemia Thu, 3 Mar 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 7 of 149
|
|
Up-regulation of p73 by NO [Cell Biology]
|
|
In conclusion, NO up-regulates several p53 family members displaying pro- and anti-apoptotic effects, suggesting a complex network of interactions and cross-regulations between NO production and p53-related proteins. (Source: Journal of Biological Chemistry)
|
|
RSS Source: Med Worm - Leukemia Thu, 3 Mar 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 8 of 149
|
|
DNA mismatch repair status affects cellular response to Ara-C and other anti-leukemic nucleoside analogs
|
|
Authors: S E Fordham, E C Matheson, K Scott, J A E Irving & J M Allan (Source: Leukemia)
|
|
RSS Source: Med Worm - Leukemia Thu, 3 Mar 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 9 of 149
|
|
Meta-analysis of randomised trials comparing thiopurines in childhood acute lymphoblastic leukaemia
|
|
Authors: G M Escherich, S Richards, L C Stork & A J Vora (Source: Leukemia)
|
|
RSS Source: Med Worm - Leukemia Thu, 3 Mar 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 10 of 149
|
|
IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells
|
|
Authors: M Coscia, F Pantaleoni, C Riganti, C Vitale, M Rigoni, S Peola, B Castella, M Foglietta, V Griggio, D Drandi, M Ladetto, A Bosia, M Boccadoro & M Massaia (Source: Leukemia) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant,...
|
|
RSS Source: Med Worm - Leukemia Thu, 3 Mar 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 11 of 149
|
|
EpiCept Identifies Ceplene(R) Survival Benefit in Key AML Subgroup
|
|
Files New Patent Applications for Ceplene® in AML of Monocyte Origin TARRYTOWN, N.Y.--(Healthcare Sales & Marketing Network)-- EpiCept Corporation (Nasdaq and Nasdaq OMX Stockholm Exchange: EPCT) today announced the Company has identified a statisti... Biopharmaceuticals, OncologyEpiCept, Acute Myeloid Leukemia, Ceplene, histamine dihydrochloride (Source: HSMN NewsFeed) MedWorm Message: Watch the new...
|
|
RSS Source: Med Worm - Leukemia Thu, 3 Mar 2011 11:51:12 am
|
|
|
|
Leukemia - news item 12 of 149
|
|
Researchers Predict Age Of T Cells To Improve Cancer Treatment
|
|
Manipulation of cells by a new microfluidic device may help clinicians improve a promising cancer therapy that harnesses the body's own immune cells to fight such diseases as metastatic melanoma, non-Hodgkin's lymphoma, chronic lymphocytic leukemia and neuroblastoma. The therapy, known as adoptive T cell transfer, has shown encouraging results in...
|
|
RSS Source: Med Worm - Leukemia Thu, 3 Mar 2011 11:00:00 am
|
|
|
|
Leukemia - news item 13 of 149
|
|
Initiation Of Phase I Clinical Trial Of Brentuximab Vedotin In Combination With Chemotherapy For Front-Line Systemic ALCL Announced
|
|
Seattle Genetics, Inc. (Nasdaq: SGEN) and Millennium: The Takeda Oncology Company have announced that they have initiated a phase I clinical trial of brentuximab vedotin (SGN-35) in combination with chemotherapy for the treatment of newly diagnosed systemic anaplastic large cell lymphoma (ALCL) patients. Brentuximab vedotin is an antibody-drug conjugate (ADC)...
|
|
RSS Source: Med Worm - Leukemia Thu, 3 Mar 2011 9:00:00 am
|
|
|
|
Leukemia - news item 14 of 149
|
|
Alveolar Granulocytic Sarcoma of the Mandible in a Patient with HIV.
|
|
Conclusions: Granulocytic sarcoma is extremely rare in patients with HIV. The case is discussed with reference to the literature. PMID: 21346387 [PubMed - in process] (Source: Onkologie)
|
|
RSS Source: Med Worm - Leukemia Thu, 3 Mar 2011 2:45:04 am
|
|
|
|
Leukemia - news item 15 of 149
|
|
Risk factors for invasive aspergillosis in acute myeloid leukemia patients prophylactically treated with posaconazole
|
|
Michallet M, Sobh M, Morisset S, Kraghel S, Nicolini FE, Thomas X, Bienvenu AL, Picot S, Nicolle MC, Vanhems P (Source: The Aspergillus Website - articles)
|
|
RSS Source: Med Worm - Leukemia Wed, 2 Mar 2011 11:25:17 pm
|
|
|
|
Leukemia - news item 16 of 149
|
|
Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice
|
|
The NR4A subfamily of nuclear receptors (NR4A1, NR4A2, and NR4A3) function as transcription factors that transduce diverse extracellular signals into altered gene transcription to coordinate apoptosis, proliferation, cell cycle arrest, and DNA repair. We previously discovered that 2 of these receptors, NR4A1 and NR4A3, are potent tumor suppressors of acute...
|
|
RSS Source: Med Worm - Leukemia Wed, 2 Mar 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 17 of 149
|
|
Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia
|
|
The type I interferons (IFNs) normally suppress tumor growth by phosphorylating and activating the signal transducer and activator of transcription 1 (STAT1), but also briefly activate STAT3, which promotes cell growth. In chronic lymphocytic leukemia (CLL) cells, the duration of IFN-mediated STAT3 phosphorylation was found to exhibit significant interpatient variability...
|
|
RSS Source: Med Worm - Leukemia Wed, 2 Mar 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 18 of 149
|
|
Towards individualized follow-up in adult acute myeloid leukemia in remission
|
|
An increasing body of data has demonstrated that the traditional concept of morphologic complete remission in acute myeloid leukemia, in which less than 5% myeloblasts is regarded as a sufficient response criterion, is not biologically sound. Fortunately, the quantitative reverse-transcribed polymerase chain reaction (RT-PCR) method seems to be a promising...
|
|
RSS Source: Med Worm - Leukemia Wed, 2 Mar 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 19 of 149
|
|
Arkansas Supreme Court Affirms Evidence Rulings, Defense Arsenic Injury Verdict
|
|
LITTLE ROCK, Ark. - In an opinion entered Feb. 17, the Arkansas Supreme Court affirmed a verdict against the parents of a child diagnosed with chronic myelogenous leukemia who allege that exposure to organic arsenic from chicken litter spread on farm fields caused the cancer (Mary E. Green, et al....
|
|
RSS Source: Med Worm - Leukemia Wed, 2 Mar 2011 7:08:32 pm
|
|
|
|
Leukemia - news item 20 of 149
|
|
First Genetic Analysis of Metastatic Melanoma: Prognostic Significance of the BRAF Mutation
|
|
For the first time, a series of metastatic melanoma (MM) patients have been genetically tested for the constitutively activating BRAF mutation and assessed for its prognostic significance as is routinely done for breast cancer (HER2) and chronic myeloid leukemia (ABL). (Source: Cancer Network)
|
|
RSS Source: Med Worm - Leukemia Wed, 2 Mar 2011 3:00:02 pm
|
|
|
|
Leukemia - news item 21 of 149
|
|
Cytotoxicity of Algae Extracts on Normal and Malignant Cells
|
|
We examined the effects of algae extracts on normal hematopoietic cells and leukemia cells. Ethanol extracts were prepared of Dunaliella salina (Dun), Astaxanthin (Ast), Spirulina platensis (Spir), and Aphanizomenon flos-aquae (AFA). Cell viability effects were completed by Annexin staining. Ast and AFA inhibited HL-60 and MV-4-11 whereas Dun and Spir...
|
|
RSS Source: Med Worm - Leukemia Wed, 2 Mar 2011 2:47:49 pm
|
|
|
|
Leukemia - news item 22 of 149
|
|
New Target For Possible Prevention Of A Rare Malignant Leukemia
|
|
New research has identified a small subset of normal white blood cells in the body that gives rise to a rare incurable form of leukemia. The study, led by investigators at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (...
|
|
RSS Source: Med Worm - Leukemia Wed, 2 Mar 2011 11:00:00 am
|
|
|
|
Leukemia - news item 23 of 149
|
|
NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human
|
|
IL-15 may have a role in the development of T cell large granular lymphocyte (T-LGL) or NKT leukemias. However, the mechanisms of action and the identity of the cell subset that undergoes leukemic transformation remain elusive. Here we show that in both mice and humans, NKp46 expression marks a minute...
|
|
RSS Source: Med Worm - Leukemia Wed, 2 Mar 2011 10:10:55 am
|
|
|
|
Leukemia - news item 24 of 149
|
|
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice
|
|
Acute promyelocytic leukemia (APL) is characterized by the t(15;17) translocation that generates the fusion protein promyelocytic leukemia–retinoic acid receptor α (PML-RARA) in nearly all cases. Multiple prior mouse models of APL constitutively express PML-RARA from a variety of non-Pml loci. Typically, all animals develop a myeloproliferative disease, followed by leukemia...
|
|
RSS Source: Med Worm - Leukemia Wed, 2 Mar 2011 10:10:55 am
|
|
|
|
Leukemia - news item 25 of 149
|
|
How Long Do Stem Cells Live?
|
|
When patients receive a bone marrow transplant, they are getting a new population of hematopoietic stem cells. Fresh stem cells are needed when a patient is low on red blood cells, as in anemia, or white blood cells, which can be caused by cancer or even cancer treatments such as...
|
|
RSS Source: Med Worm - Leukemia Wed, 2 Mar 2011 9:00:00 am
|
|
|
|
Leukemia - news item 26 of 149
|
|
Minimal residual disease detected prior to hematopoeitic cell transplantation
|
|
AbstractPrevious studies to evaluate minimal disease in acute lymphoblastic leukemia (ALL) after treatment have relied on the diagnostic specimen to develop patientâ€specific analytical probes. The diagnostic specimen is often not available in a tertiary setting; therefore, we evaluated the use of flow cytometry (FCM) using a “difference from normal†approach...
|
|
RSS Source: Med Worm - Leukemia Tue, 1 Mar 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 27 of 149
|
|
Epstein†Barr virusâ€associated primary central nervous system lymphoma in a patient with adult Tâ€cell leukemia / lymphoma
|
|
We present a case of Epstein†Barr virus (EBV)â€associated primary central nervous system lymphoma (PCNSL) arising from a patient with cutaneousâ€type adult Tâ€cell leukemia/lymphoma (ATLL). Extranodal sites affected by ATLL include the skin, lung, liver, gastrointestinal tract and central nervous system (CNS). CNS involvement usually occurs as an acute and...
|
|
RSS Source: Med Worm - Leukemia Tue, 1 Mar 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 28 of 149
|
|
Targeted therapies: Human CML stem cells insensitive to imatinib even when BCR†ABL is inhibited
|
|
Targeted therapies: Human CML stem cells insensitive to imatinib even when BCR–ABL is inhibited Nature Reviews Clinical Oncology 8, 126 (2011). doi:10.1038/nrclinonc.2011.9 Author: Lisa Hutchinson Treatment with the ABL kinase inhibitor imatinib is extremely effective and has induced complete responses in more than 80% of patients with chronic myeloid leukemia (...
|
|
RSS Source: Med Worm - Leukemia Tue, 1 Mar 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 29 of 149
|
|
Hematology: CLL pathogenesis: novel microRNA/TP53 feedback circuitry
|
|
Nature Reviews Clinical Oncology 8, 125 (2011). doi:10.1038/nrclinonc.2011.7 Author: Lisa Hutchinson Current staging systems for patients with chronic lymphocytic leukemia (CLL)—the most common leukemia in the Western world—fail to precisely differentiate between indolent and aggressive forms. Molecular abnormalities such as 13q, 17p and 11q deletions are associated with CLL but...
|
|
RSS Source: Med Worm - Leukemia Tue, 1 Mar 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 30 of 149
|
|
Hematology: Mitoxantrone improves the survival of children with first relapse of ALL
|
|
Nature Reviews Clinical Oncology 8, 123 (2011). doi:10.1038/nrclinonc.2011.12 Author: Lisa Richards Children with relapsed acute lymphoblastic leukemia (ALL) have substantially better progression-free survival and overall survival when treated with induction therapy containing mitoxantrone compared with that containing idarubicin, data from the ALL R3 trial shows. In fact, because the interim...
|
|
RSS Source: Med Worm - Leukemia Tue, 1 Mar 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 31 of 149
|
|
NICE Requests More Data To Help Appraise Maintenance Treatment For Follicular Non-Hodgkin's Lymphoma
|
|
The National Institute for Health and Clinical Excellence (NICE) is currently appraising the use of rituximab (MabThera, Roche Products) as a first-line maintenance treatment[1] for patients with advanced follicular non-Hodgkin's lymphoma. In draft guidance issued today (1 March), NICE is calling for the manufacturer to provide more analyses to address...
|
|
RSS Source: Med Worm - Leukemia Tue, 1 Mar 2011 11:00:00 am
|
|
|
|
Leukemia - news item 32 of 149
|
|
Rituximab and fludarabine produce long-term remissions in some chronic lymphocytic leukemia patients, study suggests
|
|
New research shows that a combination of the targeted agent rituximab and the chemotherapeutic drug fludarabine can produce long-term remissions in some chronic lymphocytic leukemia patients without increasing the risk of later therapy-related myelodysplastic syndrome. After nearly 10 years of follow-up, 13 percent of patients had remissions lasting more than...
|
|
RSS Source: Med Worm - Leukemia Tue, 1 Mar 2011 8:26:07 am
|
|
|
|
Leukemia - news item 33 of 149
|
|
Understanding cancer through proteomics
|
|
Hypothesis: it is possible to develop better ways of dealing with cancer by better understanding the body's proteins and how they interact (proteomics)Danny Hillis makes a case for the next frontier of cancer research: proteomics, the study of proteins in the body. As Hillis explains it, genomics shows us a...
|
|
RSS Source: Med Worm - Leukemia Tue, 1 Mar 2011 5:33:51 am
|
|
|
|
Leukemia - news item 34 of 149
|
|
A small subset of normal white blood cells gives rise to a rare leukemia, study shows
|
|
(Ohio State University Medical Center) New research has identified a small subset of normal white blood cells in the body that can give rise to large granular lymphocyte leukemia, a rare incurable form of leukemia. The disease occurs in white blood cells called NKT cells, immune cells that share features...
|
|
RSS Source: Med Worm - Leukemia Tue, 1 Mar 2011 4:00:00 am
|
|
|
|
Leukemia - news item 35 of 149
|
|
Ulcerating Molluscum Contagiosum in a Boy With Relapsed Acute Lymphoblastic Leukemia.
|
|
In conclusion, molluscum contagiosum may present as an ulcerating lesion during childhood leukemia treatment. A skin biopsy should be performed for the accurate diagnosis of atypical cutaneous lesions in immunocompromised patients. PMID: 21368674 [PubMed - as supplied by publisher] (Source: Herpes) MedWorm Message: Watch the new MedWorm demo and find...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 36 of 149
|
|
Fabrication of nanoparticles using partially purified pomegranate ellagitannins and gelatin and their apoptotic effects
|
|
Conclusion: Pomegranate ellagitannins bind with gelatin to form selfâ€assembled nanoparticles. Ellagitannins encapsulated in nanoparticles had decreased apoptotic effects on leukemia cells HLâ€60. (Source: Nahrung / Food)
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 37 of 149
|
|
The Blood Xenotropic Murine Leukemia Virus-Related Virus Scientific Research Working Group: mission, progress, and plans.
|
|
Authors: Simmons G, Glynn SA, Holmberg JA, Coffin JM, Hewlett IK, Lo SC, Mikovits JA, Switzer WM, Linnen JM, Busch MP, PMID: 21366602 [PubMed - as supplied by publisher] (Source: Transfusion)
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 38 of 149
|
|
Pleural and pericardial effusions in chronic myeloid leukemia patients receiving low-dose dasatinib therapy.
|
|
Authors: Eskazan AE, Soysal T, Ongoren S, Gulturk E, Ferhanoglu B, Aydin Y PMID: 21357709 [PubMed - in process] (Source: Haematologica)
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 39 of 149
|
|
Mutant BCR-ABL clones in chronic myeloid leukemia.
|
|
Authors: Mathisen MS, Kantarjian HM, Cortes J, Jabbour E PMID: 21357713 [PubMed - in process] (Source: Haematologica)
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 40 of 149
|
|
Inflammation, the microenvironment and chronic lymphocytic leukemia.
|
|
Authors: Caligaris-Cappio F PMID: 21357715 [PubMed - in process] (Source: Haematologica) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 41 of 149
|
|
Hammersmith score application is able to identify chronic myeloid leukemia patients with poor prognosis before treatment with secondâ€generation TKIs
|
|
In conclusion, some prognostic factors before starting second generation TKIs might predict cytogenetic response and outcome. The soâ€called Hammersmith score was not yet validated in large series of patients: we demonstrated that this score is able to discriminate patients at high risk of failure and consequent progression before treatment with...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 42 of 149
|
|
A case of mast cell leukemia with exon 9 KIT mutation and good response to imatinib.
|
|
Conclusions:  In the absence of the KITâ€D816V in systemic forms of mast cell proliferation, a search for other mutations is indicated, preferably by sequencing the entire KIT gene, as this can influence the choice of treatment. The finding of the p.A502_Y503dup in exon 9, a mutation which has been observed...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 43 of 149
|
|
H1N1 infection in children with hematological and oncological diseases in Norway
|
|
Conclusion:  In all patients with hematological disease and most cases of oncological diseases, the infections ran a mild course. However, life threatening complications occurred in severely immunosuppressed and neutropenic patients. Delay of antiâ€cancer treatment is a concern even in mild cases. (Source: Acta Paediatrica)
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 44 of 149
|
|
Aggressive cutaneous vasculitis in a patient with chronic lymphatic leukemia following granulocyte colony stimulating factor injection: a case report
|
|
Conclusion: The aim of this case report is to highlight the importance of monitoring patients on granulocytic colony-stimulating factor therapy, especially in the context of other conditions such as a hematological malignancy) that may lead to an adverse outcome. (Source: BioMed Central)
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 45 of 149
|
|
Prevalence and clinical implications of NRAS mutations in childhood AML: a report from the Children's Oncology Group
|
|
Authors: J N Berman, R B Gerbing, T A Alonzo, P A Ho, K Miller, C Hurwitz, N A Heerema, B Hirsch, S C Raimondi, B Lange, J L Franklin, A Gamis & S Meshinchi (Source: Leukemia) MedWorm Message: Watch the new MedWorm demo and find out how to get...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 46 of 149
|
|
The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia
|
|
Authors: J Dürig, U Dührsen, L Klein-Hitpass, J Worm, J B Rode Hansen, H Ørum & M Wissenbach (Source: Leukemia)
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 47 of 149
|
|
Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells
|
|
Cancer-related inflammation recently has been proposed as a major physiological hallmark of malignancy. Some genetic alterations known to promote cellular proliferation and induce malignant transformation also may participate in an intrinsic inflammatory pathway that produces a cancer-promoting inflammatory microenvironment. Little is known about this intrinsic inflammatory pathway in Barrett's esophagus....
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 48 of 149
|
|
High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors
|
|
Proteasome inhibitors such as bortezomib exhibit clinical efficacy in multiple myeloma, but studies in acute myeloid leukemia (AML) have been disappointing to date. The apparent failure in AML likely reflects a lack of biological understanding that might clarify applications of proteosome inhibitors in this disease. Here we show that AML...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 49 of 149
|
|
6-Thioguanine Reactivates Epigenetically Silenced Genes in Acute Lymphoblastic Leukemia Cells by Facilitating Proteasome-mediated Degradation of DNMT1
|
|
Thiopurines including 6-thioguanine (SG), 6-mercaptopurine, and azathioprine are effective anticancer agents with remarkable success in clinical practice, especially in effective treatment of acute lymphoblastic leukemia (ALL). SG is understood to act as a DNA hypomethylating agent in ALL cells, however, the underlying mechanism leading to global cytosine demethylation remains unclear....
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 50 of 149
|
|
Deoxycytidine Kinase Modulates the Impact of the ABC Transporter ABCG2 on Clofarabine Cytotoxicity
|
|
Purine nucleoside antimetabolites, such as clofarabine, are effective antileukemic agents. However, their effectiveness depends on an initial activation step in which they are monophosphorylated by deoxycytidine kinase (dCK). Some purine nucleoside antimetabolites and their monophosphate derivatives are exported by the ABC transporter ABCG2. Because clofarabine is a dCK substrate, and...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 51 of 149
|
|
Prognostic significance of immunophenotypic and karyotypic features of philadelphia positive Bâ€lymphoblastic leukemia in the era of tyrosine kinase inhibitors
|
|
CONCLUSIONS:In the context of intensive, TKIâ€based chemotherapy, the immunophenotypic, karyotypic, and molecular heterogeneity of Phâ€positive ALL no longer influences outcome. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 52 of 149
|
|
Acute myeloid leukemia with complex hypodiploidy and loss of heterozygosity of 17p in a boy with fanconi anemia.
|
|
We report the first in-depth description of a boy with FA who developed acute myeloid leukemia with complex hypodiploidy karyotype after successful stem cell transplantation. Of note, the leukemic cells consistently showed loss of heterozygosity (LOH) of the short arm of chromosome 17 (17p), which harbors the TP53 tumor suppressor...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 10:45:06 pm
|
|
|
|
Leukemia - news item 53 of 149
|
|
A Novel Three-Way Ph Variant t(8;9;22) in Adult Acute Lymphoblastic Leukemia.
|
|
Authors: Cho SY, Kim SY, La Jeon Y, Oh SH, Cho EH, Lee WI, Cho KS, Park TS Although three-way Philadelphia (Ph) variant translocation has been uncommonly (3~8%) reported in chronic myeloid leukemia (CML), it has been even more rarely described in acute leukemias (ALs). When we reviewed the Mitelman...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 10:45:06 pm
|
|
|
|
Leukemia - news item 54 of 149
|
|
Therapy-Related Myelodysplastic Syndrome/Acute Myeloid Leukemia with del(7)(q22) in a Patient with De Novo AML.
|
|
Authors: Kim YG, Cho SY, Park TS, Oh SH, Yoon HJ A 55-year-old Korean woman was initially diagnosed with acute myelomonocytic leukemia (AML). After induction chemotherapy was performed using cytarabine, idarubicin, and G-CSF, complete remission (CR) was subsequently achieved following reinduction chemotherapy using the same chemotherapeutic agents. Thirty-six months after...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 10:45:06 pm
|
|
|
|
Leukemia - news item 55 of 149
|
|
Chronic Myelogenous Leukemia: Monitoring Response to Therapy
|
|
Abstract Molecular monitoring is a key component of the management of patients with chronic myeloid leukemia. The current recommendation is that molecular monitoring be performed in place of cytogenetic assessment when a major molecular response (MMR) is achieved. With the more potent kinase inhibitors nilotinib and dasatinib now approved as...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 3:48:14 pm
|
|
|
|
Leukemia - news item 56 of 149
|
|
New Insights into the Control of HIV-1 Transcription: When Tat Meets the 7SK snRNP and Super Elongation Complex (SEC)
|
|
Abstract Recent studies aimed at elucidating the mechanism controlling HIV-1 transcription have led to the identification and characterization of two multi-subunit complexes that both contain P-TEFb, a human transcription elongation factor and co-factor for activation of HIV-1 gene expression by the viral Tat protein. The first complex, termed the 7SK...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 3:47:27 pm
|
|
|
|
Leukemia - news item 57 of 149
|
|
PTEN’s regulation of VEGF and VEGFR1 expression and its clinical significance in myeloid leukemia
|
|
In conclusion, PTEN could modulate the function of VEGF/VEGFR signaling pathway down-regulation of Akt phosphorylation and that PTEN would be a candidate target to be addressed for inhibiting angiogenesis along with the treatment of myeloid leukemia. Content Type Journal ArticlePages 1-9DOI 10.1007/s12032-011-9867-2Authors Cheng Zhiyong, Department of Hematology, The First Hospital...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 3:46:10 pm
|
|
|
|
Leukemia - news item 58 of 149
|
|
Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model
|
|
Summary LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. In biochemical and cellular assays, LY2457546 demonstrates potent activity against targets that include VEGFR2 (KDR), PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. With activities against both...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 3:44:41 pm
|
|
|
|
Leukemia - news item 59 of 149
|
|
Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells
|
|
In this study, we explored the effects of THL on acute promyelocytic leukemia (APL) NB4 cells, which could be effectively treated by some traditional Chinese remedies containing arsenic trioxide. The results showed THL could induce G2/M arrest and apoptosis in NB4 cells. Accordingly, the decrease of cyclin A and B1...
|
|
RSS Source: Med Worm - Leukemia Mon, 28 Feb 2011 10:50:44 am
|
|
|
|
Leukemia - news item 60 of 149
|
|
Outcome of patients with chronic myeloid leukemia with multiple ABL1 kinase domain mutations receiving tyrosine kinase inhibitor therapy.
|
|
In conclusion, patients with >1 BCR-ABL1 mutation fare worse than those with no or 1 mutation. PMID: 21357704 [PubMed - as supplied by publisher] (Source: Haematologica)
|
|
RSS Source: Med Worm - Leukemia Sun, 27 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 61 of 149
|
|
Upregulation of homeodomain genes, DLX1/2, by FLT3 signaling.
|
|
Conclusions. These findings suggest that alterations in DLX1/2 contribute to the biologic consequences of FLT3 activation. PMID: 21357706 [PubMed - as supplied by publisher] (Source: Haematologica)
|
|
RSS Source: Med Worm - Leukemia Sun, 27 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 62 of 149
|
|
Leukemia inhibitory factor regulates trafficking of T-type Ca2+ channels
|
|
In this study we investigated the role of LIF in promoting the trafficking of T-type Ca2+ channels in a heterologous expression system. Our results demonstrate that transfection of HEK-293 cells with the rat green fluorescent protein (GFP)-tagged T-type Ca2+ channel α1H-subunit resulted in the generation of transient Ca2+ currents. Overnight...
|
|
RSS Source: Med Worm - Leukemia Sun, 27 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 63 of 149
|
|
Molecular Characterization of Circulating Tumor Cells in Breast Cancer by a Liquid Bead Array Hybridization Assay [Cancer Diagnostics]
|
|
CONCLUSIONS: The expression of 6 genes in CTCs can be measured simultaneously and reliably, thereby saving precious sample and reducing the costs and time of analysis. (Source: Clinical Chemistry) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!...
|
|
RSS Source: Med Worm - Leukemia Sun, 27 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 64 of 149
|
|
Hematopoietic SCT for adult T-cell leukemia/lymphoma: a review
|
|
Hematopoietic SCT for adult T-cell leukemia/lymphoma: a review Bone Marrow Transplantation advance online publication, February 28, 2011. doi:10.1038/bmt.2011.27 Authors: M Jabbour, H Tuncer, J Castillo, J Butera, T Roy, J Pojani, M Al-Malki & A S Al-Homsi (Source: Bone Marrow Transplantation)
|
|
RSS Source: Med Worm - Leukemia Sun, 27 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 65 of 149
|
|
Gene Analysis Illuminates MS Therapy Side Effect (CME/CE)
|
|
(MedPage Today) -- Leukemia that was observed in a small number of mitoxantrone treated multiple sclerosis patients may be the result of patients' genetic makeup, Italian researchers said. (Source: MedPage Today Neurology)
|
|
RSS Source: Med Worm - Leukemia Sun, 27 Feb 2011 9:21:23 pm
|
|
|
|
Leukemia - news item 66 of 149
|
|
Anti-Human FLT3 Monoclonal Antibody That Inhibits Proliferation of Monocytic Leukemia Cell Line SHI-1
|
|
Hybridoma Feb 2011, Vol. 30, No. 1: 61-67. (Source: Hybridoma) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
|
|
RSS Source: Med Worm - Leukemia Sun, 27 Feb 2011 1:49:31 am
|
|
|
|
Leukemia - news item 67 of 149
|
|
Gene analysis illuminates MS therapy side effect
|
|
Leukemia that was observed in a small number of mitoxantrone treated multiple sclerosis patients may be the result of patients' genetic makeup, Italian researchers said. (Source: Multiple Sclerosis Trust)
|
|
RSS Source: Med Worm - Leukemia Sat, 26 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 68 of 149
|
|
A case report of a 33-year chronic phase survivor of chronic myeloid leukemia
|
|
Abstract Here, we report a Philadelphia chromosome-positive chronic myeloid leukemia case with the longest chronic phase and overall survival to our knowledge ever reported in the medical literature. During the 33-year chronic phase, he was asymptomatic without any treatment and had normal blood cell values. BCR†ABL silencing might be...
|
|
RSS Source: Med Worm - Leukemia Sat, 26 Feb 2011 8:43:07 pm
|
|
|
|
Leukemia - news item 69 of 149
|
|
Current status of agents active against the T315I chronic myeloid leukemia phenotype
|
|
Expert Opinion on Emerging Drugs, Volume 16, Issue 1, Page 85-103, March 2011. (Source: Expert Opinion: Expert Opinion on Emerging Drugs: Table of Contents)
|
|
RSS Source: Med Worm - Leukemia Sat, 26 Feb 2011 4:38:21 am
|
|
|
|
Leukemia - news item 70 of 149
|
|
The thrombopoietin/MPL pathway in hematopoeisis and leukemogenesis
|
|
AbstractHematopoietic stem cells (HSC) comprise a small percentage of total hematopoietic cells. Their ability to selfâ€renewal is key to the continuous replenishment of the hematopoietic system with newly formed functional blood cell types while maintaining their multipotential capacity. Understanding the extrinsic signals that are essential to HSC maintenance will provide...
|
|
RSS Source: Med Worm - Leukemia Fri, 25 Feb 2011 11:01:35 pm
|
|
|
|
Leukemia - news item 71 of 149
|
|
Association of a functional polymorphism in the 3′â€untranslated region of SPI1 with systemic lupus erythematosus
|
|
ConclusionOur findings indicate that a SNP in the 3′â€UTR of SPI1 is associated with elevated SPI1 mRNA level and with susceptibility to SLE. (Source: Arthritis and Rheumatism) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
|
|
RSS Source: Med Worm - Leukemia Fri, 25 Feb 2011 8:23:53 pm
|
|
|
|
Leukemia - news item 72 of 149
|
|
Advancing maternal age is associated with lower bone mineral density in young adult male offspring
|
|
Conclusions In conclusion, our results suggest that advancing maternal age could negatively affect bone mass in young adult men. Content Type Journal ArticlePages 1-8DOI 10.1007/s00198-011-1558-5Authors R. Rudäng, Center for Bone and Arthritis Research at the Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, SwedenD. Mellström, Center for...
|
|
RSS Source: Med Worm - Leukemia Fri, 25 Feb 2011 6:20:42 am
|
|
|
|
Leukemia - news item 73 of 149
|
|
Juvenile myelomonocytic leukemia characterized by cutaneous lesion containing Langerhans cell histiocytosis-like cells.
|
|
We present a 1-year-old boy who developed a cutaneous lesion on the trunk and hepatosplenomegaly. Laboratory examination showed leukocytosis with peripheral blasts, atypical monocytosis, anemia, hyper IgG, and a mild elevation of C-reactive protein. Clinical features and skin biopsy findings matched the diagnostic criteria of both juvenile myelomonocytic leukemia (JMML)...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 74 of 149
|
|
Specific Palatal Infiltration in B-Cell Chronic Lymphocytic Leukemia.
|
|
Authors: Cervigón I, Palomo A, Torres-Iglesias LM, Solano F, Zapata AM PMID: 21354544 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 75 of 149
|
|
Augmented therapy improves outcome for pediatric high risk acute lymphocytic leukemia: Results of Children's Oncology Group trial P9906
|
|
ConclusionsAugmented BFM therapy improved outcome for children with higher risk ALL. Day 8 blood and day 29 marrow MRD were strong prognostic factors in these patients. Pediatr Blood Cancer © 2011 Wileyâ€Liss, Inc. (Source: Pediatric Blood and Cancer) MedWorm Message: Watch the new MedWorm demo and find out how to...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 76 of 149
|
|
Outcome of childhood acute lymphoblastic leukemia in Jordan
|
|
ConclusionTreatment protocols developed by major cooperative groups and institutions to treat childhood ALL was successfully adapted and suggest that such an approach may be useful in other low†and middleâ€income countries. Pediatr Blood Cancer © 2011 Wileyâ€Liss, Inc. (Source: Pediatric Blood and Cancer)
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 77 of 149
|
|
Clinical impact of the baseline echocardiogram in children with highâ€risk acute lymphoblastic leukemia
|
|
ConclusionsIn our experience, findings on echocardiograms in childhood HRâ€ALL did not impact anthracycline administration. This study suggests that induction chemotherapy should not be delayed for an echocardiogram. However, whenever possible, a preâ€therapy echocardiogram is still recommended for determining baseline function and to identify associated problems like pericardial effusions which were...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 78 of 149
|
|
Pediatric Phase I Trial and Pharmacokinetic Study of Dasatinib: A Report From the Children's Oncology Group Phase I Consortium [Pediatric Oncology]
|
|
Conclusion Overall, drug disposition and tolerability of dasatinib were similar to those observed in adult patients. (Source: Journal of Clinical Oncology)
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 79 of 149
|
|
Risk Factors for the Development of Secondary Malignancy After High-Dose Chemotherapy and Autograft, With or Without Rituximab: A 20-Year Retrospective Follow-Up Study in Patients With Lymphoma [Hematologic Malignancies]
|
|
Conclusion This analysis has relevant implications for the design and use of intensive chemoimmunotherapy with autograft. In addition, it offers useful insights toward the understanding and prevention of tumor development. (Source: Journal of Clinical Oncology)
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 80 of 149
|
|
Reducing the Risk for Transplantation-Related Mortality After Allogeneic Hematopoietic Cell Transplantation: How Much Progress Has Been Made? [Hematologic Malignancies]
|
|
Conclusion Our results suggest that innovations in transplantation care since the 1980s and 1990s have reduced the risk of TRM in patients undergoing allogeneic HCT for AML and that this reduction has been accompanied by improvements in overall survival. (Source: Journal of Clinical Oncology) MedWorm Message: Watch the new MedWorm...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 81 of 149
|
|
Targeting PKC mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid Leukemiaâ€Derived cell lines and blast cells
|
|
AbstractRecent studies in acute myeloid leukemia (AML) suggest activation of proâ€proliferative signaling cascades including those mediated by Protein Kinase C (PKC) represent a poor prognostic factor for patients. The classical PKC isoforms α and β generally support survival signaling and have emerged as important targets for antiâ€cancer therapy. Enzastaurin is...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 82 of 149
|
|
HTLV-1 p30, REG{gamma}, ATM, and Cell Survival [Molecular Bases of Disease]
|
|
Human T-lymphotropic virus type 1 (HTLV-1) is a causative agent of adult T cell leukemia/lymphoma and a variety of inflammatory disorders. HTLV-1 encodes a nuclear localizing protein, p30, that selectively alters viral and cellular gene expression, activates G2-M cell cycle checkpoints, and is essential for viral spread. Here, we used...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 83 of 149
|
|
cAMP Extrusion by MRP4 in Leukemia Cells [Signal Transduction]
|
|
Increased intracellular cAMP concentration plays a well established role in leukemic cell maturation. We previously reported that U937 cells stimulated by H2 receptor agonists, despite a robust increase in cAMP, fail to mature because of rapid H2 receptor desensitization and phosphodiesterase (PDE) activation. Here we show that intracellular cAMP levels...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 84 of 149
|
|
p53 stabilization induces apoptosis in chronic myeloid leukemia blast crisis cells
|
|
Authors: L F Peterson, E Mitrikeska, D Giannola, Y Lui, H Sun, D Bixby, S N Malek, N J Donato, S Wang & M Talpaz (Source: Leukemia)
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 85 of 149
|
|
HLA homozygosity and haplotype bias among patients with chronic lymphocytic leukemia: implications for disease control by physiological immune surveillance
|
|
Authors: N Shah, W K Decker, R Lapushin, D Xing, S N Robinson, H Yang, S Parmar, S S Tung, S O'Brien, M Fernandez-Viña, E J Shpall & W G Wierda (Source: Leukemia) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest,...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 86 of 149
|
|
Incidence of extramedullary disease in patients with multiple myeloma in the era of novel therapy, and the activity of pomalidomide on extramedullary myeloma
|
|
Authors: K Detweiler Short, S V Rajkumar, D Larson, F Buadi, S Hayman, A Dispenzieri, M Gertz, S Kumar, J Mikhael, V Roy, R A Kyle & M Q Lacy (Source: Leukemia)
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 87 of 149
|
|
Features of Epstein-Barr Virus (EBV) reactivation after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation
|
|
Authors: Z Peric, X Cahu, P Chevallier, E Brissot, F Malard, T Guillaume, J Delaunay, S Ayari, V Dubruille, S Le Gouill, B Mahe, T Gastinne, N Blin, B Saulquin, J-L Harousseau, P Moreau, N Milpied, M Coste-Burel, B-M Imbert-Marcille & M Mohty (Source: Leukemia)
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 88 of 149
|
|
Immunomodulatory effects of anti-angiogenic drugs
|
|
Authors: A Heine, S A E Held, A Bringmann, T A W Holderried & P Brossart (Source: Leukemia)
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 89 of 149
|
|
Annual Clinical Updates in Hematological Malignancies: A Continuing Medical Education Series: Polycythemia vera and essential thrombocythemia: 2011 update on diagnosis, riskâ€stratification, and management
|
|
AbstractDisease overview:Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms primarily characterized by erythrocytosis and thrombocytosis, respectively. Other disease features include leukocytosis, splenomegaly, thrombohemorrhagic complications, vasomotor disturbances, pruritus, and a small risk of disease progression into acute leukemia or myelofibrosis.Diagnosis:Diagnosis is based on JAK2 mutation status (PV and ET),...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 4:38:16 pm
|
|
|
|
Leukemia - news item 90 of 149
|
|
Flow cytometric detection of leukemic stem cells (LSCs) in Egyptian pediatric B-acute lymphoblastic leukemia
|
|
Abstract Identifying leukemia stem cells (LSCs) is a challenge and a critical step in understanding their respective biology and may provide insights into a more efficient treatment of acute lymphoblastic leukemia (ALL). This cohort study aimed at detecting LSCs expressing CD19, CD34, and CD38Low in the bone marrow of 20...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 4:26:54 pm
|
|
|
|
Leukemia - news item 91 of 149
|
|
Molecular diagnosis and risk-adjusted therapy in pediatric hematologic malignancies: a primer for pediatricians
|
|
Conclusion Pediatricians need to be familiar with the changes in diagnostic and therapeutic approaches, because these changes have impact on: the laboratory tests that should be ordered at the time of specialist referral; counseling of patients and their families; and with the advent of “shared care models†pediatricians will need...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 4:23:34 pm
|
|
|
|
Leukemia - news item 92 of 149
|
|
Successful alemtuzumab retreatment in progressive B-cell chronic lymphocytic leukemia: a multicenter survey in 30 patients
|
|
Abstract Although retreatment with alemtuzumab in relapsing B-cell chronic lymphocytic leukemia (CLL) may be beneficial, there has thus far been no thorough analysis available on this topic. Data were collected from 30 chemotherapy-pretreated patients with progressive CLL who had received alemtuzumab twice in consecutive, distinct therapy lines. The median dose...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 4:19:54 pm
|
|
|
|
Leukemia - news item 93 of 149
|
|
Therapy-related myeloproliferative neoplasm with ETV6-PDGFRB rearrangement following treatment of acute promyelocytic leukemia
|
|
Content Type Journal ArticlePages 1-3DOI 10.1007/s00277-011-1188-1Authors Jean-Valère Malfuson, Hematology Department, HIA Percy, 92141 Clamart, FranceJohanna Konopacki, Hematology Department, HIA Percy, 92141 Clamart, FranceThierry Fagot, Hematology Department, HIA Percy, 92141 Clamart, FranceFrançois Desangles, Hematology Department, HIA Percy, 92141 Clamart, FranceDominique Bories, Biology Department, CHU Henri Mondor, 94010 Creteil, FranceBertrand Souleau, Hematology...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 4:19:53 pm
|
|
|
|
Leukemia - news item 94 of 149
|
|
Key Cell- Survival Proteins Exploited By Cancer-Causing Virus
|
|
A cancer-causing retrovirus exploits key proteins in its host cells to extend the life of those cells, thereby prolonging its own survival and ability to spread, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J....
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 8:00:00 am
|
|
|
|
Leukemia - news item 95 of 149
|
|
New Treatment To Benefit Certain Patients With Leukaemia Thanks To New NICE Guidance
|
|
The National Institute for Health and Clinical Excellence (NICE) has published final guidance to the NHS recommending the use of a new treatment that can help extend the lives of certain people with the most common form of leukaemia. The guidance recommends bendamustine (Levact, Napp Pharmaceuticals) as a first-line treatment...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 7:00:00 am
|
|
|
|
Leukemia - news item 96 of 149
|
|
Nilotinib: evaluation and analysis of its role in chronic myeloid leukemia
|
|
Future Oncology , February 2011, Vol. 7, No. 2, Pages 201-218. (Source: Future Oncology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 4:22:43 am
|
|
|
|
Leukemia - news item 97 of 149
|
|
Rituximab and fludarabine produce long-term remissions in CLL
|
|
(Ohio State University Medical Center) New research shows that a combination of the targeted agent rituximab and the chemotherapeutic drug fludarabine can produce long-term remissions in some chronic lymphocytic leukemia patients without increasing the risk of later therapy-related myelodysplastic syndrome. After nearly 10 years of follow-up, 13 percent of patients...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 4:00:00 am
|
|
|
|
Leukemia - news item 98 of 149
|
|
Extract of North American Ginseng (Panax Quinquefolius), Administered to Leukemic, Juvenile Mice Extends their Life Span
|
|
In a recent study involving normal, juvenile mice, we showed that CVT-E002, a proprietary extract (Afexa Life Sciences, Inc.) of North American ginseng, Panax quinquefolius, significantly enhanced the absolute levels of cells acting at the first line of defense in tumor combat, i.e., natural killer (NK) cells. The present study...
|
|
RSS Source: Med Worm - Leukemia Thu, 24 Feb 2011 12:10:06 am
|
|
|
|
Leukemia - news item 99 of 149
|
|
Study on synthesis of thalidomide analogues and their bioactivities; inhibition on iNOS pathway and cytotoxic effects
|
|
In conclusion, inhibition of NO synthesis is a new development in cancer therapy for now and in the future. We modified the structures of the thalidomide analogues to have a stronger anticancer effect and a good therapeutic effect. Content Type Journal ArticlePages 1-11DOI 10.1007/s00044-011-9603-7Authors Chao-Bin Yeh, School of Medicine, Chung...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:11:14 pm
|
|
|
|
Leukemia - news item 100 of 149
|
|
Nilotinib-induced hypothyroidism in a patient with chronic myeloid leukemia.
|
|
We report nilotinib-induced hypothyroidism, and suggest that hypothyroidism should be considered as a possible etiology when patients receivingTKIs suffer from edema. PMID: 21347645 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 101 of 149
|
|
Promotion of Apoptosis in Cancer Cells by Selective Purine-Derived Pharmacological CDK Inhibitors: One Outcome, Many Mechanisms.
|
|
This article focuses on the impact of inhibiting individual cellular CDKs on apoptosis. We discuss in detail the molecular mechanisms by which CDK inhibitors are able to bypass chemoresistance in tumor cells and trigger apoptosis. Remarkably, recent findings suggest that the pharmacological utility of CDK inhibitors may not be restricted...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 102 of 149
|
|
Nonâ€adherence to imatinib adversely affects event free survival in chronic phaseâ€chronic myeloid leukemia
|
|
Conclusions:A significant proportion of patients of CPâ€CML have drug interruptions due to nonâ€adherence during therapy and this compromises the EFS. Adherence to therapy must be must be included as an important evaluation parameter in all future studies of CML. Am. J. Hematol., 2011. © 2011 Wileyâ€Liss, Inc. (Source: American Journal...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 103 of 149
|
|
Dysplastic macropolycytes in myelodysplasiaâ€related acute myeloid leukemia
|
|
(Source: American Journal of Hematology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 104 of 149
|
|
Transient bone marrow lymphoproliferation after umbilical cord blood transplantation: inâ€adult exacerbated reconstitution of Bâ€cell ontogeny
|
|
We describe a transient bone marrow heterogeneous Bâ€cell lymphoproliferation with a complex spectrum of cytological, phenotypic, molecular and immune features in the setting of adult patients with acute myeloid leukemia following umbilical cord blood transplantation (UCBT) procedure. In our view the lymphoproliferation described herein could add another element to the...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 105 of 149
|
|
Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity
|
|
We evaluated concurrent gene mutations, clinical outcome, and gene expression signatures of CCAAT/enhancer binding protein alpha (CEBPA) double mutations (CEBPAdm) versus single mutations (CEBPAsm) in 1182 cytogenetically normal acute myeloid leukemia (AML) patients (16-60 years of age). We identified 151 (12.8%) patients with CEBPA mutations (91 CEBPAdm and 60 CEBPAsm)....
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 106 of 149
|
|
Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice
|
|
RARA (retinoic acid receptor alpha) haploinsufficiency is an invariable consequence of t(15;17)(q22;q21) translocations in acute promyelocytic leukemia (APL). Retinoids and RARA activity have been implicated in hematopoietic self-renewal and neutrophil maturation. We and others therefore predicted that RARA haploinsufficiency would contribute to APL pathogenesis. To test this hypothesis, we crossed...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 107 of 149
|
|
c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells
|
|
Chronic lymphocytic leukemia (CLL) is a malignancy characterized by clonal expansion of mature B cells that are resistant to apoptosis. This resistance to apoptosis partly results from Mcl-1 expression because high levels of this protein in CLL cells correlate with poor disease prognosis and resistance to chemotherapy. Thus, understanding the...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 108 of 149
|
|
A randomized comparison of 4 courses of standard-dose multiagent chemotherapy versus 3 courses of high-dose cytarabine alone in postremission therapy for acute myeloid leukemia in adults: the JALSG AML201 Study
|
|
We conducted a prospective randomized study to assess the optimal postremission therapy for adult acute myeloid leukemia in patients younger than 65 years in the first complete remission. A total of 781 patients in complete remission were randomly assigned to receive consolidation chemotherapy of either 3 courses of high-dose cytarabine (...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 109 of 149
|
|
Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: the JALSG AML201 Study
|
|
This study is registered at http://www.umin.ac.jp/ctrj/ as C000000157. (Source: Blood)
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 110 of 149
|
|
RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis
|
|
Analyses of 164 RUNX1 mutations (RUNX1mut) in 147 of 449 patients (32.7%) with normal karyotype or noncomplex chromosomal imbalances were performed. RUNX1mut were most frequent in acute myeloid leukemia French-American-British classification M0 (65.2%) followed by M2 (32.4%) and M1 (30.2%). Considering cytogenetics, RUNX1mut were most frequent in cases with +13 (...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 111 of 149
|
|
Pharmacokinetic, pharmacodynamic, and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia
|
|
Osteonecrosis is a severe glucocorticoid-induced complication of acute lymphoblastic leukemia treatment. We prospectively screened children (n = 364) with magnetic resonance imaging of hips and knees, regardless of symptoms; the cumulative incidence of any (grade 1-4) versus symptomatic (grade 2-4) osteonecrosis was 71.8% versus 17.6%, respectively. We investigated whether age, race,...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 112 of 149
|
|
Allogeneic hematopoietic cell transplantation for adults with acute myeloid leukemia: myths, controversies, and unknowns
|
|
Progress in the last decade has improved the understanding of leukemia biology. Molecular markers in combinations with cytogenetics have improved the risk stratification of acute myeloid leukemia (AML) and informed decision-making. In parallel, several important advances in the transplant field, such as better supportive care, improved transplant technology, increased availability...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 113 of 149
|
|
Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib
|
|
Several cancer treatments are shifting from traditional, time-limited, nonspecific cytotoxic chemotherapy cycles to continuous oral treatment with specific protein-targeted therapies. In this line, imatinib mesylate, a selective tyrosine kinases inhibitor (TKI), has excellent efficacy in the treatment of chronic myeloid leukemia. It has opened the way to the development of...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 114 of 149
|
|
Identification of the STAT5Bâ€RARα fusion transcript in an acute promyelocytic leukemia patient without FLT3, NPM1, câ€Kit and C/EBPα mutation
|
|
AbstractT(15;17) is the most common chromosomal aberration in acute promyelocytic leukemia (APL) patients, leading to the formation of PML†RARα fusion gene. In a small subset of APL patients, the RARα gene is fused with different partners. Here we report a rare APL case with STAT5Bâ€RARα fusion transcript. Cytomorphologic and...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 115 of 149
|
|
Antiproliferative Activity of Three Methoxylated Flavonoids Isolated from Zeyheria montana Mart. (Bignoniaceae) Leaves
|
|
In conclusion, three antiproliferative compounds were isolated for the first time from Zeyheria montana and its leaves were characterized as an important source of methoxylated flavones and flavanone as potential antitumor compounds. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Phytotherapy Research)
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 116 of 149
|
|
A twist on admixture mapping
|
|
Nature Genetics 43, 178 (2011). doi:10.1038/ng0311-178 Author: Stephen J Chanock A new study uses genome-wide SNP genotypes to identify a subset of children undergoing therapy for acute lymphoblastic leukemia that are at increased risk for relapse. Borrowing from the classical approach of admixture mapping, the work shows how genome-wide assessment...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 117 of 149
|
|
Acute Budd-Chiari syndrome as an initial presentation of acute promyelocytic leukemia
|
|
We report a case of acute promyelocytic leukemia where the clinical onset of the hematological disease was with acute BCS. (Source: Journal of Cancer Research and Therapeutics)
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 118 of 149
|
|
Apoptosis induced by Magnolia Grandiflora extract in chlorambucil-resistant B-chronic lymphocytic leukemia cells
|
|
Conclusion: This article discusses the apoptosis properties of Magnolia on B-CLL cells. The evidence suggests a potentially effective repertoire for B-CLL treatment. This herb extract might have promising therapy strategies in treating B-CLL or other hematological disease resistant to alkylating agents in clinical practice. (Source: Journal of Cancer Research and...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 119 of 149
|
|
Treatment with lenalidomide modulates Tâ€cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia
|
|
CONCLUSIONS:Treatment with lenalidomide resulted in the normalization of functional Tâ€cell subsets in responders, suggesting that lenalidomide may modulate cellâ€mediated immunity in patients with CLL. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer)
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 120 of 149
|
|
Charcotâ€Leyden crystals and bone marrow necrosis in acute myeloid leukemia
|
|
(Source: European Journal of Haematology)
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 4:22:06 pm
|
|
|
|
Leukemia - news item 121 of 149
|
|
Cutaneous sarcoidosis developing after treatment with pegylated interferon and ribavirin: a new case and review of the literature
|
|
We present a new case of cutaneous sarcoidosis after treatment with pegylated IFN, and a review of the literature. (Source: International Journal of Dermatology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 3:30:20 pm
|
|
|
|
Leukemia - news item 122 of 149
|
|
Sunesis Receives FDA Fast Track Designation for Vosaroxin in AML
|
|
SOUTH SAN FRANCISCO, Calif., Feb. 23, 2011 --(HSMN NewsFeed) -- Sunesis Pharmaceuticals, Inc. (Nasdaq:SNSSD ) today announced that vosaroxin, the Company's lead drug candidate, has been granted Fast Track designation by the U.S. Food and Drug Administratio... Biopharmaceuticals, Oncology, FDASunesis Pharmaceuticals, Vosaroxin, acute myeloid leukemia (Source: HSMN NewsFeed)
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 12:21:16 pm
|
|
|
|
Leukemia - news item 123 of 149
|
|
The Journal Of Clinical Oncology Publishes Phase 3 XGEVAâ„¢ (Denosumab) Results In Advanced Cancer Patients With Solid Tumors Or Multiple Myeloma
|
|
Amgen (Nasdaq: AMGN) announced the publication of results from a pivotal Phase 3 study of 1,776 advanced cancer patients with different types of solid tumors (not including breast and prostate cancer) or multiple myeloma, which compared XGEVA™ (denosumab) to Zometa® (zoledronic acid) in preventing skeletal-related events (SREs). The study, which...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 10:00:00 am
|
|
|
|
Leukemia - news item 124 of 149
|
|
Cardiff Study Suggests Targeted Treatment For Leukaemia Group
|
|
Antibody-directed chemotherapy offers improved survival to particular sub-groups of leukaemia sufferers, a Cardiff University-led study has found. The findings suggest that the treatment may be effective for the majority of younger acute myeloid leukaemia (AML) sufferers, who can be identified by genetic profiling. The research team studied more than a...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 10:00:00 am
|
|
|
|
Leukemia - news item 125 of 149
|
|
Cancer-causing virus exploits key cell-survival proteins
|
|
The human T-lymphotropic virus type 1, a cancer-causing retrovirus, exploits key proteins in host cells to extend the life of those cells, thereby prolonging its own survival and ability to spread, according to a new study. The virus, which causes adult T-cell leukemia and lymphoma, produces a protein called p30...
|
|
RSS Source: Med Worm - Leukemia Wed, 23 Feb 2011 9:00:00 am
|
|
|
|
Leukemia - news item 126 of 149
|
|
Hsp90-mediated inactivation of NF{kappa}B switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells.
|
|
Authors: Jiang Q, Wang Y, Li T, Shi K, Li Z, Ma Y, Li F, Luo H, Yang Y, Xu C Autophagy can protect cells while also contributing to cell damage, but the precise interplay between apoptosis and autophagy and the contribution of autophagy to cell death are still not...
|
|
RSS Source: Med Worm - Leukemia Tue, 22 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 127 of 149
|
|
Further Considerations for the Implausibility of Leukemia Induction by Formaldehyde
|
|
(Source: Toxicological Sciences)
|
|
RSS Source: Med Worm - Leukemia Tue, 22 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 128 of 149
|
|
Considerations for the Implausibility of Leukemia Induction by Formaldehyde
|
|
(Source: Toxicological Sciences)
|
|
RSS Source: Med Worm - Leukemia Tue, 22 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 129 of 149
|
|
Prenatal Exposure to Flavonoids: Implication for Cancer Risk
|
|
Flavonoids are potent antioxidants, freely available as high-dose dietary supplements. However, they can induce DNA double-strand breaks (DSB) and rearrangements in the mixed-lineage leukemia (MLL) gene, which are frequently observed in childhood leukemia. We hypothesize that a deficient DSB repair, as a result of an Atm mutation, may reinforce the...
|
|
RSS Source: Med Worm - Leukemia Tue, 22 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 130 of 149
|
|
Cytotoxic Triterpenoid Saponins from the Rhizomes of Anemone taipaiensis
|
|
Planta MedDOI: 10.1055/s-0030-1270821AbstractTwo new oleanane-type triterpenoid saponins, 1 and 2, and a new natural product, 3, together with five known saponins, 4-8, were isolated from the rhizomes of Anemone taipaiensis. Their structures were elucidated by extensive spectroscopic analysis and chemical evidences. Six saponins, 1, 2, 4-7, which possessed a free...
|
|
RSS Source: Med Worm - Leukemia Tue, 22 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 131 of 149
|
|
Is birth weight associated with childhood lymphoma? A metaâ€analysis
|
|
AbstractSeveral risk factors have been identified for childhood lymphomas. The purpose of this metaâ€analysis was to synthesize current evidence regarding the association between birth weight with primarily the risk for Nonâ€Hodgkin lymphoma (NHL), given its similarity to acute lymphoblastic leukemia, Hodgkin lymphoma (HL) and any category of lymphoma. Two cohort (...
|
|
RSS Source: Med Worm - Leukemia Tue, 22 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 132 of 149
|
|
Antibody-directed chemotherapy offers improved survival for some leukemia patients
|
|
Antibody-directed chemotherapy offers improved survival to particular sub-groups of leukemia sufferers, a new study has found. (Source: ScienceDaily Headlines)
|
|
RSS Source: Med Worm - Leukemia Tue, 22 Feb 2011 9:00:00 pm
|
|
|
|
Leukemia - news item 133 of 149
|
|
Tribbles in disease: signaling pathways important for cellular function and neoplastic transformation
|
|
SummaryThe tribbles family of genes encodes pseudokinase proteins that are highly conserved in evolution. Instead of direct phosphorylation of target proteins, tribbles act as adaptors in signaling pathways for important cellular processes. Those include MAPKKs, C/EBPs, ATF4, and CHOP. Trib1 and Trib2 have been identified as myeloid oncogenes, and both...
|
|
RSS Source: Med Worm - Leukemia Tue, 22 Feb 2011 2:14:12 pm
|
|
|
|
Leukemia - news item 134 of 149
|
|
International Study Shows That Reprogramming Cells Leads To Genomic Aberrations
|
|
An international study shows that reprogramming cells leads to genomic aberrations It's a discordant note in the symphony of good news that usually accompanies stem cell research announcements. Stem cells hold enormous promise in regenerative medicine, thanks to their ability to regenerate diseased or damaged tissues. They have made it...
|
|
RSS Source: Med Worm - Leukemia Tue, 22 Feb 2011 10:00:00 am
|
|
|
|
Leukemia - news item 135 of 149
|
|
Children's Medical Center Initiates Study To Diagnose And Treat Pediatric Strokes
|
|
Children's Medical Center Dallas (Children's) is launching a critical stroke initiative to diagnose and treat strokes in children. Pediatric strokes is a little-known condition that occurs as often as leukemia and brain tumors but often is not recognized by parents or physicians, despite the serious short- and long-term health consequences....
|
|
RSS Source: Med Worm - Leukemia Tue, 22 Feb 2011 8:00:00 am
|
|
|
|
Leukemia - news item 136 of 149
|
|
Advancell Announces Positive Phase I/IIa Results With Acadra (Acadesine) In Chronic Lymphocytic Leukemia - CLL
|
|
ADVANCELL , an emerging biopharmaceutical company, announced positive results from a clinical study conducted with Acadra (Acadesine) in Chronic Lymphocytic Leukemia (CLL) patients resistant to current therapies. The company also announced promising non-clinical results in Multiple Myeloma (MM), Mantle Cell Lymphoma (MCL) and other lymphoproliferative disorders. Synergism of Acadra in combination...
|
|
RSS Source: Med Worm - Leukemia Tue, 22 Feb 2011 8:00:00 am
|
|
|
|
Leukemia - news item 137 of 149
|
|
Scientists Bioengineer A Protein To Fight Leukemia
|
|
Scientists at the Children's Center for Cancer and Blood Diseases and The Saban Research Institute of Children's Hospital Los Angeles announced a breakthrough discovery in understanding how the body fights leukemia. They have identified a protein called CD19-ligand (CD19-L) located on the surface of certain white blood cells that facilitates...
|
|
RSS Source: Med Worm - Leukemia Tue, 22 Feb 2011 8:00:00 am
|
|
|
|
Leukemia - news item 138 of 149
|
|
Multivariate analysis of the relation between immune dysfunction and treatment intensity in children with acute lymphoblastic leukemia
|
|
ConclusionsOur findings demonstrate the utility of PCA and PLS in detecting hidden structures in complex data and suggest that, even 6 months after therapy, patients treated with intermediate and high intensity have attenuated responses to de novo antigens whereas those with high intensity also respond poorly to recall antigens. Pediatr...
|
|
RSS Source: Med Worm - Leukemia Mon, 21 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 139 of 149
|
|
Sensitive measurement of quantity dynamics of FLT3 internal tandem duplication at early time points provides prognostic information
|
|
Conclusions: Though the mutation may disappear at relapse in a few patients, FLT3-ITD levels at early TPs after chemotherapy provide prognostic information. FLT3-ITD is significantly more stable in those with mutant NPM1. (Source: Annals of Oncology)
|
|
RSS Source: Med Worm - Leukemia Mon, 21 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 140 of 149
|
|
Impact of first- and second-line treatment for Hodgkin's lymphoma on the incidence of AML/MDS and NHL--experience of the German Hodgkin's Lymphoma Study Group analyzed by a parametric model of carcinogenesis
|
|
Conclusions: BEACOPP escalated moderately increases the risk of secondary AML/MDS but not NHL. No differences were found between other chemotherapies of advanced stages and intermediate stages. Secondary AML/MDS occurs faster after relapse treatment than after primary treatment. (Source: Annals of Oncology)
|
|
RSS Source: Med Worm - Leukemia Mon, 21 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 141 of 149
|
|
Fused FDG-PET/contrast-enhanced CT detects occult subdiaphragmatic involvement of Hodgkin's lymphoma thereby identifying patients requiring six cycles of anthracycline-containing chemotherapy and consolidation radiation of spleen
|
|
Conclusion: FDG–PET/contrast-enhanced CT is an accurate frontline single imaging diagnostic tool enabling effective tailored treatment in HL patients. (Source: Annals of Oncology)
|
|
RSS Source: Med Worm - Leukemia Mon, 21 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 142 of 149
|
|
Collagen I regulates the selfâ€renewal of mouse embryonic stem cells through α2β1 integrin†and DDR1â€dependent Bmiâ€1
|
|
AbstractAdhesion of cells to extracellular matrix (ECM) influences vital aspects of anchorageâ€dependent cell behavior including survival, proliferation, and differentiation. However, the role of collagen I in mouse embryonic stem cells (mESCs) is not wellâ€known. Therefore, in the present study we examined the effect of collagen I on mESC selfâ€renewal and...
|
|
RSS Source: Med Worm - Leukemia Mon, 21 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 143 of 149
|
|
Serologic and PCR testing of persons with chronic fatigue syndrome in the United States shows no association with xenotropic or polytropic murine leukemia virus-related viruses
|
|
In 2009, a newly discovered human retrovirus, xenotropic murine leukemia virus (MuLV)-related virus (XMRV), was reported by Lombardi et al. in 67% of persons from the US with chronic fatigue syndrome (CFS) by PCR detection of gag sequences. Although six subsequent studies have been negative for XMRV, CFS was defined...
|
|
RSS Source: Med Worm - Leukemia Mon, 21 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 144 of 149
|
|
Regression analysis of longitudinal data with informative observation times and application to medical cost data
|
|
AbstractLongitudinal data analysis is one of the most discussed and applied areas in statistics and a great deal of literature has been developed for it. However, most of the existing literature focus on the situation where observation times are fixed or can be treated as fixed constants. This paper considers...
|
|
RSS Source: Med Worm - Leukemia Mon, 21 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 145 of 149
|
|
Estimating and testing for center effects in competing risks
|
|
AbstractThe problems of fitting Gaussian frailties proportional hazards models for the subdistribution of a competing risk and of testing for center effects are considered. In the analysis of competing risks data, Fine and Gray proposed a proportional hazards model for the subdistribution to directly assess the effects of covariates on...
|
|
RSS Source: Med Worm - Leukemia Mon, 21 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 146 of 149
|
|
Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing
|
|
Authors: P A Greif, S H Eck, N P Konstandin, A Benet-Pagès, B Ksienzyk, A Dufour, A T Vetter, H D Popp, B Lorenz-Depiereux, T Meitinger, S K Bohlander & T M Strom (Source: Leukemia)
|
|
RSS Source: Med Worm - Leukemia Mon, 21 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 147 of 149
|
|
Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulation
|
|
Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulation Leukemia advance online publication, February 22, 2011. doi:10.1038/leu.2011.17 Authors: A Gandillet, S Park, F Lassailly, E Griessinger, J Vargaftig, A Filby, T A Lister & D Bonnet (Source: Leukemia) MedWorm Message: Watch the new MedWorm demo and find out how...
|
|
RSS Source: Med Worm - Leukemia Mon, 21 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 148 of 149
|
|
Factors predicting outcome after unrelated donor stem cell transplantation in primary refractory acute myeloid leukaemia
|
|
Authors: C Craddock, M Labopin, S Pillai, J Finke, D Bunjes, H Greinix, G Ehninger, N-K Steckel, A R Zander, R Schwerdtfeger, S Buchholz, H-J Kolb, L Volin, A Fauser, E Polge, C Schmid, M Mohty & V Rocha (Source: Leukemia)
|
|
RSS Source: Med Worm - Leukemia Mon, 21 Feb 2011 11:00:00 pm
|
|
|
|
Leukemia - news item 149 of 149
|
|
Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance
|
|
Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance Leukemia advance online publication, February 22, 2011. doi:10.1038/leu.2011.10 Authors: V Grossmann, A Kohlmann, C Eder, C Haferlach, W Kern, N C P Cross, T Haferlach & S Schnittger (...
|
|
RSS Source: Med Worm - Leukemia Mon, 21 Feb 2011 11:00:00 pm
|
|
|