Multiple Sclerosis - news item 1 of 143
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Glatiramer Acetate Not More Effective at Higher Dose in Multiple Sclerosis
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(Source: AccessMedicine Updates)
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RSS Source: Med Worm - Multiple Sclerosis Sat, 5 Mar 2011 2:30:01 am
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Multiple Sclerosis - news item 2 of 143
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Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)
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AbstractExperimental autoimmune encephalomyelitis (EAE) is the most commonly used experimental model for the human inflammatory demyelinating disease, multiple sclerosis (MS). EAE is a complex condition in which the interaction between a variety of immunopathological and neuropathological mechanisms leads to an approximation of the key pathological features of MS: inflammation, demyelination,...
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RSS Source: Med Worm - Multiple Sclerosis Fri, 4 Mar 2011 3:46:16 pm
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Multiple Sclerosis - news item 3 of 143
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Biogen to build blood disorder drug franchise
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BOSTON (Reuters) - Biogen Idec Inc, which makes the multiple sclerosis drugs Tysabri and Avonex, plans to build a portfolio of products to treat noncancerous blood disorders, according to its chief executive. (Source: Reuters: Health)
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RSS Source: Med Worm - Multiple Sclerosis Fri, 4 Mar 2011 3:42:26 pm
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Multiple Sclerosis - news item 4 of 143
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Psychosocial adjustment in children and adolescents with a parent with multiple sclerosis
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Objective: This systematic review explored the potential impact of parental multiple sclerosis on their offspring. It considered adjustment to parental multiple sclerosis at different developmental stages and the factors associated with good versus poor adjustment. (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - Multiple Sclerosis Fri, 4 Mar 2011 11:03:03 am
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Multiple Sclerosis - news item 5 of 143
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The impact of increasing neurological disability of multiple sclerosis on health utilities - a systematic review of the literature
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Objectives: To provide a systematic review of the literature on utilities of relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS) patients and to review changes in utilities associated with the increasing neurological disability of different stages of MS, as measured by the Expanded Disability Status Scale (EDSS). (Source: Neurological Conditions...
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RSS Source: Med Worm - Multiple Sclerosis Fri, 4 Mar 2011 11:02:25 am
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Multiple Sclerosis - news item 6 of 143
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Economic burden of multiple sclerosis - A systematic review of the literature
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This systematic literature review was conducted to document the economic burden of MS. (Source: Neurological Conditions Specialist Library) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Multiple Sclerosis Fri, 4 Mar 2011 11:01:51 am
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Multiple Sclerosis - news item 7 of 143
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Association between allergies and multiple sclerosis - a systematic review and meta-analysis
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The aim of this systematic review and meta-analysis was to determine if there is an association between allergic diseases and MS. (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - Multiple Sclerosis Fri, 4 Mar 2011 11:01:22 am
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Multiple Sclerosis - news item 8 of 143
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Psoriasis and multiple sclerosis - is there a link
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Objectives: To investigate the potential relationship between psoriasis and MS based on a systematic review of the literature. (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - Multiple Sclerosis Fri, 4 Mar 2011 11:00:38 am
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Multiple Sclerosis - news item 9 of 143
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How Sunlight May Reduce The Severity Of Multiple Sclerosis
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New research into the neurodegenerative disease, Multiple Sclerosis (MS) offers new insight into the link between sunlight, vitamin D3, and MS risk and severity. The research, published in the European Journal of Immunology, studies the relationship between the sunlight-dependent vitamin D3 hormone, immune cells, and the risk and severity of...
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RSS Source: Med Worm - Multiple Sclerosis Fri, 4 Mar 2011 10:00:00 am
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Multiple Sclerosis - news item 10 of 143
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Late-breaking news: FDA issues CRL to EMD Serono's MS drug
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FDA issued a complete response letter to EMD Serono, an affiliate of Merck KGaA, requesting additional information on cladribine (Movectro), a drug intended for the treatment of relapsing-remitting multiple sclerosis. (Source: Modern Medicine)
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RSS Source: Med Worm - Multiple Sclerosis Thu, 3 Mar 2011 11:00:00 pm
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Multiple Sclerosis - news item 11 of 143
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Phosphorylated Neurofilament Heavy Chain Correlations to Visual Function, Optical Coherence Tomography, and Treatment
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Conclusions/Relevance. Acute optic neuritis patients who have more severe visual loss during initial presentation have a higher incidence of axonal loss that was slightly suppressed with IVMP treatment. (Source: Clinical and Developmental Immunology)
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RSS Source: Med Worm - Multiple Sclerosis Thu, 3 Mar 2011 1:56:13 pm
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Multiple Sclerosis - news item 12 of 143
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FDA Rejects Oral Cladribine for Multiple Sclerosis
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Drug maker Merck Serono announced today it received a complete response letter from US regulators. Medscape Medical News (Source: Medscape Today Headlines)
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RSS Source: Med Worm - Multiple Sclerosis Wed, 2 Mar 2011 6:06:35 pm
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Multiple Sclerosis - news item 13 of 143
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FDA Wants More Answers About MS Drug From Merck
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The Food and Drug Administration has really been buckling down this year, and rightfully so, demanding more evidence of success and deeper understanding of potential safety risks of new manufactured medications. Merck KGaA in Germany is no different, and today the giant announced today that their new drug application (NDA)...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 2 Mar 2011 3:00:00 pm
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Multiple Sclerosis - news item 14 of 143
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Patterns of Th1/Th2 Cytokines Predict Clinical Response in Multiple Sclerosis Patients Treated with Glatiramer Acetate
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Eur Neurol 2011;65:164†169 (DOI:10.1159/000324035) (Source: Karger Publishers)
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RSS Source: Med Worm - Multiple Sclerosis Wed, 2 Mar 2011 2:54:15 pm
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Multiple Sclerosis - news item 15 of 143
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May Diet and Dietary Supplements Improve the Wellness of Multiple Sclerosis Patients? A Molecular Approach
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Multiple sclerosis is a complex and multifactorial neurological disease, and nutrition is one of the environmental factors possibly involved in its pathogenesis. At present, the role of nutrition is unclear, and MS therapy is not associated to a particular diet. MS clinical trials based on specific diets or dietary supplements...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 2 Mar 2011 2:47:49 pm
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Multiple Sclerosis - news item 16 of 143
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Scientists say higher vitamin D intake will slash cancer, MS, and diabetes risk by half
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(NaturalNews) In findings just published in the journal Anticancer Research, scientists at the University of California (UC) San Diego School of Medicine and Creighton University School of Medicine in Omaha have reported that most people need a much higher intake of vitamin D. And that simple step added to your...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 2 Mar 2011 6:00:00 am
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Multiple Sclerosis - news item 17 of 143
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Sativex® Can Improve The Debilitating Symptoms Of Spasticity Associated With MS, Study
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Results from a phase III clinical study published online yesterday in the European Journal of Neurology Early View showed that about half of all people with moderate to severe spasticity due to multiple sclerosis (MS) who have not responded adequately to standard anti-spasticity therapy, find that adding Sativex® Oromucosal Spray (...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 2 Mar 2011 6:00:00 am
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Multiple Sclerosis - news item 18 of 143
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More than allergies: Histamine may be a possible drug target for multiple sclerosis
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If you think histamines are your nemesis during allergy season, here's something that might change your perspective. New research shows that histamine could be an important molecule to developing new treatments for multiple sclerosis. In the study, the scientists analyzed the role of histamine in an animal model of multiple...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 2 Mar 2011 3:00:00 am
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Multiple Sclerosis - news item 19 of 143
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The work capability assessment is a genuine source of anguish
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Disabled people would love to be healthy and working, yet the government's new medical test is sapping our energy, writes Lucy Glennon (Source: Multiple Sclerosis Trust) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 11:00:00 pm
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Multiple Sclerosis - news item 20 of 143
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FDA wants more answers about MS drug cladribine
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Merck KGaA announced today that their new drug application for Cladribine Tablets is denied approval in the United States. (Source: Multiple Sclerosis Trust)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 11:00:00 pm
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Multiple Sclerosis - news item 21 of 143
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MSPs vote to axe NHS prescription charges in Scotland
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MSPs have voted to scrap NHS prescription charges in Scotland, a key SNP pledge in the 2007 elections. (Source: Multiple Sclerosis Trust)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 11:00:00 pm
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Multiple Sclerosis - news item 22 of 143
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FDA request for more MS pill data
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German group Merck KGaA has been told by US drug regulators that more costly studies may be needed to assess the risks of its experimental multiple sclerosis pill cladribine. (Source: Multiple Sclerosis Trust)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 11:00:00 pm
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Multiple Sclerosis - news item 23 of 143
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Scientists probe strategies to repair neuron damage in multiple sclerosis
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Scientists working collaboratively around the world say they are coming closer to developing therapies that may help restore neurologic function in patients with multiple sclerosis (MS). (Source: Multiple Sclerosis Trust)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 11:00:00 pm
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Multiple Sclerosis - news item 24 of 143
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Sativex for spasticity in MS - positive trial results
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Results published today in the European Journal of Neurology found that almost half of a study sample of 572 people with MS whose spasticity was not controlled with current anti-spasticity therapy responded to treatment with the cannabis oromucosal spray Sativex. (Source: Multiple Sclerosis Trust) MedWorm Message: Watch the new MedWorm...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 11:00:00 pm
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Multiple Sclerosis - news item 25 of 143
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FDA request further studies on Cladribine
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The US Food and Drug Administration, in what is known as a "complete response letter" has asked Merck to either provide further analysis of the study results it has already submitted, or to carry out new trials. (Source: Multiple Sclerosis Trust)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 11:00:00 pm
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Multiple Sclerosis - news item 26 of 143
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A film of patients with movement disorders made in Queen Square, London in the Midâ€1920s by Samuel Alexander Kinnier Wilson
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Discussion:SAKW may have been stimulated and facilitated to make this film through his personal contact with Charlie Chaplin with whom he stayed at his Californian estate, probably in the summer of 1924. The first films of neurological patients were made in Europe and USA at the beginning of the 20th...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 11:00:00 pm
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Multiple Sclerosis - news item 27 of 143
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The Mesenchymal Stem Cells in Multiple Sclerosis (MSCIMS) Trial protocol and baseline cohort characteristics: an open-label pre-test : post-test study with blinded outcome assessments
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Conclusions: In addition to determining the safety and feasibility of the intervention and informing design of future studies to address efficacy, MSCIMS adopts a novel strategy for testing neuroprotective agents in MS - the sentinel lesion approach - serving as proof of principle for its future wider applicability.Trial registration: ClinicalTrials.gov (...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 11:00:00 pm
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Multiple Sclerosis - news item 28 of 143
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US FDA rejects cladribine for multiple sclerosis
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Source: PharmaTimes Area: News According to a report by PharmaTimes, the US Food and Drug Administration (FDA) has rejected cladribine for multiple sclerosis. The report states that the manufacturer (Merck) has received a complete response letter from the US Food and Drug Administration which states that "an improved understanding of...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 11:00:00 pm
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Multiple Sclerosis - news item 29 of 143
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Ont. looks at after-care for MS patients who get Liberation therapy
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An expert panel will advise the Ontario government on how doctors can provide followup care for people with multiple sclerosis who undergo so-called liberation therapy in another country. (Source: CTV Health)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 10:23:36 pm
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Multiple Sclerosis - news item 30 of 143
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The majority of infiltrating CD8 T lymphocytes in multiple sclerosis lesions is insensitive to enhanced PDâ€L1 levels on CNS cells
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AbstractCentral nervous system (CNS) cells locally modulate immune responses using numerous molecules that are not fully elucidated. Engagement of programmed deathâ€1 (PDâ€1), expressed on activated T cells, by its ligands (PDâ€L1 or PDâ€L2) suppresses Tâ€cell responses. Enhanced CNS PDâ€1 and PDâ€L1 expression has been documented in inflammatory murine models; however,...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 10:08:48 pm
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Multiple Sclerosis - news item 31 of 143
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Commissioning Guide: Biologic drugs for the treatment of inflammatory disease in rheumatology, dermatology and gastroenterology
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Aims: This commissioning guide provides support for the local implementation of NICE guidance through commissioning, and is a resource for people involved in commissioning health and social care services and public health programmes within the NHS and partner organisations in England. Although this guide focuses on commissioning biologic drugs for...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 6:51:13 pm
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Multiple Sclerosis - news item 32 of 143
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Nocebo effects in multiple sclerosis trials - a meta-analysis
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Objective: To estimate the incidence and severity of nocebo responses in trials of symptomatic treatments (STs) and disease-modifying treatments (DMTs) for multiple sclerosis (MS). (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 1:18:54 pm
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Multiple Sclerosis - news item 33 of 143
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Multiple sclerosis and risk of cancer - a meta-analysis
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There is no formal abstract for this paper as it is a meta-analysis within a letter. Link to the ful (Source: Neurological Conditions Specialist Library) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 1:18:21 pm
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Multiple Sclerosis - news item 34 of 143
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Relation between Epstein-Barr virus and multiple sclerosis - analytic study of scientific production
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This work is a meta-analysis of case-control observational studies published before January 2009 aimed at assessing the degree of association between Epstein-Barr virus (EBV) and multiple sclerosis (MS) infections. (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 1:17:43 pm
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Multiple Sclerosis - news item 35 of 143
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An updated meta-analysis of risk of multiple sclerosis following infectious mononucleosis
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Background: Multiple sclerosis (MS) appears to develop in genetically susceptible individuals as a result of environmental exposures. Epstein-Barr virus (EBV) infection is an almost universal finding among individuals with MS. Symptomatic EBV infection as manifested by infectious mononucleosis (IM) has been shown in a previous meta-analysis to be associated with...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 1:16:49 pm
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Multiple Sclerosis - news item 36 of 143
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Human herpesvirus 6 infection as a trigger of multiple sclerosis
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We systematically reviewed the existing evidence to determine whether a relationship exists between infection with human herpesvirus 6 (HHV-6) and multiple sclerosis (MS) and, if so, to define the strength of that relationship. (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 1:15:22 pm
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Multiple Sclerosis - news item 37 of 143
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Epidemiology of multiple sclerosis in Europe - a review
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The aim of the current study was to review the existing epidemiological data of MS in Europe published during the last decade (2000-2009), using PubMed. (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 1:10:45 pm
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Multiple Sclerosis - news item 38 of 143
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The changing demographic pattern of multiple sclerosis epidemiology
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The uneven distribution of multiple sclerosis (MS) across populations can be attributed to differences in genes and the environment and their interaction. (Source: Neurological Conditions Specialist Library) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 1:09:33 pm
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Multiple Sclerosis - news item 39 of 143
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Assessing changes in relapse rates in multiple sclerosis
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This review examines if there is a trend in the annualized relapse rates (ARRs) for relapsing†remitting Multiple Sclerosis (MS) patients (RRMS) over time and if so, why. (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 1 Mar 2011 1:08:32 pm
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Multiple Sclerosis - news item 40 of 143
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[Review of the novelties presented at the 26th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II).]
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Authors: Fernandez-Fernandez O, Alvarez-Cermeno JC, Arbizu-Urdiain T, Arroyo-Gonzalez R, Arnal-Garcia C, Casanova-Estruch B, Calles-Hernandez MC, Coret-Ferrer F, Comabella M, Garcia-Merino JA, de Las Heras V, Izquierdo G, Meca-Lallana JE, Munoz-Garcia D, Olascoaga J, Oreja-Guevara C, Prieto JM, Rodriguez-Antiguedad A, Tintore M, Montalban X, Grupo Post-Ectrims GP The new insights presented...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 41 of 143
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Impact of 7â€ketocholesterol and very long chain fatty acids on oligodendrocyte lipid membrane organization: Evaluation via LAURDAN and FAMIS spectral image analysis
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AbstractIn the context of multiple sclerosis and Xâ€linked adrenoleukodystrophy, 7â€ketocholesterol (7KC) and very long chain fatty acids (C24:0, C26:0) are supposed to induce side effects respectively on oligodendrocytes which are myelin (which is a lipoproteic complex) synthesizing cells. The effects of 7KC (25, 50 μM), C24:0 and C26:0 (10, 20...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 42 of 143
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Sativex can improve the debilitating symptoms of spasticity associated with MS, study
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Results from a phase III clinical study published online yesterday in the European Journal of Neurology Early View showed that about half of all people with moderate to severe spasticity due to multiple sclerosis (MS) who have not responded adequately to standard anti-spasticity therapy, find that adding Sativex Oromucosal Spray (...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 43 of 143
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Latest MS Trust Annual Review now available
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We wanted to give the people who matter most a voice in this year's annual review, and so we have included stories from MS nurses, people with MS and people who fundraise for the MS Trust. (Source: Multiple Sclerosis Trust) MedWorm Message: Watch the new MedWorm demo and find out...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 44 of 143
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Autophagy in immunity and cellâ€autonomous defense against intracellular microbes
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Summary:  Autophagy was viewed until very recently primarily as a metabolic and intracellular biomass and organelle quality and quantity control pathway. It has now been recognized that autophagy represents a bona fide immunologic process with a wide array of roles in immunity. The immunologic functions of autophagy, as we understand...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 45 of 143
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Recurrent orbital inflammation in a patient with multiple sclerosis treated with interferonâ€beta
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(Source: Clinical and Experimental Ophthalmology)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 46 of 143
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MS Trust Annual Review 2010 now available
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We wanted to give the people who matter most a voice in this year's annual review, and so we have included stories from MS nurses, people with MS and people who fundraise for the MS Trust. (Source: Multiple Sclerosis Trust)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 47 of 143
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Observations during an elective interruption of natalizumab treatment: a post-marketing study
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In this prospective post-marketing study, 21 patients with multiple sclerosis treated with natalizumab for 24 consecutive months elected a trial of treatment interruption (90–180 days). During a mean duration of treatment interruption of 111.5 days 4 patients (19.0%) experienced a relapse and 9 out of 19 (47.4%) had MRI activity....
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 48 of 143
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Kinetics and incidence of anti-natalizumab antibodies in multiple sclerosis patients on treatment for 18 months
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Natalizumab is a monoclonal antibody shown to be highly effective in the treatment of relapsing–remitting multiple sclerosis (RRMS). Patients treated with natalizumab can develop antibodies directed against this agent that may affect the efficacy and safety of the drug. In this observational study, the kinetics of the appearance and the...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 49 of 143
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High-dose frequency beta-interferons increase the risk of liver test abnormalities in multiple sclerosis: a longitudinal study
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Conclusion: A dose frequency response effect was observed, with high-frequency IFNβs having the greatest risk. The first 15 months of treatment, men, and younger patients were also associated with elevated risk. Regular ALT monitoring in MS patients appears prudent; long-term consequences of ALT elevations should be further investigated. (Source: Multiple...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 50 of 143
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Gender effects on intramuscular interferon beta-1a in relapsing-remitting multiple sclerosis: analysis of 1406 patients
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Conclusions: We conclude that no significant gender-related differences were found in the efficacy and safety of IM IFNβ-1a in patients with RRMS or CIS. (Source: Multiple Sclerosis)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 51 of 143
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Heterogeneity at the HLA-DRB1 allelic variation locus does not influence multiple sclerosis disease severity, brain atrophy or cognition
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Conclusions: This study confirms that heterogeneity of HLA-DRB1 does not influence disease outcome in relapsing MS patients, with the exception of a younger age of onset in HLA-DR15 carriers. (Source: Multiple Sclerosis)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 52 of 143
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Cerebrospinal fluid CXCL13 in multiple sclerosis: a suggestive prognostic marker for the disease course
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Conclusion: CXCL13 was associated with disease exacerbations and unfavourable prognosis in RRMS. Increased CXCL13 was not specific for MS since subjects with viral/bacterial infections exhibited even higher levels. High levels predicted CIS conversion to MS. We suggest that measurement of CSF CXCL13 can be part of the armamentarium in the...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 53 of 143
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Intrathecal IgM synthesis in pediatric MS is not a negative prognostic marker of disease progression: quantitative versus qualitative IgM analysis
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Conclusion: Intrathecal IgM synthesis is not associated with a more rapid progression of disability in pediatric MS. Reevaluation of data from previous reports about the negative predictive value of intrathecal IgM synthesis in adult MS with a CSF statistics tool show that the apparent contradiction is due to a methodological...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 54 of 143
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Relationship between brain MRI lesion load and short-term disease evolution in non-disabling MS: a large-scale, multicentre study
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Conclusions: An overall low rate of brain LV increase during a long-lasting disease course might be a feature of BMS. In BMS patients, a high brain LV might be associated with worsening of locomotor disability at short-term follow up. (Source: Multiple Sclerosis)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 55 of 143
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Predictive factors for multiple sclerosis in patients with clinically isolated spinal cord syndrome
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Conclusion: Two out of three baseline factors (age, periventricular lesions and inflammatory CSF) predicted conversion to MS with better accuracy than the revised McDonald criteria for dissemination in space. (Source: Multiple Sclerosis)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 56 of 143
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Primary progressive versus relapsing-onset multiple sclerosis: presence and prognostic value of cerebrospinal fluid oligoclonal IgM
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Conclusion: This study confirms that, in relapsing-onset MS patients, the presence of CSF OCIgM at onset predicts a worse disease course. In the cohort of PPMS patients, however, CSF OCIgM were rare, suggesting that heterogeneous pathogenetic mechanisms may be involved in the different MS forms. (Source: Multiple Sclerosis)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 57 of 143
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Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children
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Conclusions: This study independently corroborates recently published results of seroprevalence and specificity of the assay. Due to their low sensitivity anti-MOG antibodies will not serve as disease-specific biomarkers, but could help to support the diagnosis of ADEM in difficult cases. (Source: Multiple Sclerosis)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 58 of 143
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Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T
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Conclusion: The lower GSH levels in these patients indicate the presence of oxidative stress in SPMS. This process could be at least partially responsible for ongoing functional decline in SPMS. (Source: Multiple Sclerosis) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest,...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 59 of 143
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The (AAT)n repeat of the cannabinoid CB1 receptor gene influences disease progression in relapsing multiple sclerosis
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Conclusions: The results of the present investigation point to CB1R as an important modulator of disease severity in relapsing MS subjects. (Source: Multiple Sclerosis)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 60 of 143
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Increasing frequency of multiple sclerosis in Catania, Sicily: a 30-year survey
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Conclusions: Incidence rates have further increased in this population, suggesting that the risk of MS is still increasing. (Source: Multiple Sclerosis)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 61 of 143
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Towards molecular imaging of multiple sclerosis
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Magnetic resonance imaging (MRI) has had a profound impact on both research and clinical management of multiple sclerosis (MS), but signal changes reflect underlying neuropathology only indirectly and often non-specifically. Positron emission tomography (PET) offers the potential to complement MRI with quantitative measures of molecularly specific markers of cellular and...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 62 of 143
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Cannabinoids and B cells: emerging targets for treating progressive multiple sclerosis
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(Source: Multiple Sclerosis)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 63 of 143
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A randomized, doubleâ€blind, placeboâ€controlled, parallelâ€group, enrichedâ€design study of nabiximols* (Sativex®), as addâ€on therapy, in subjects with refractory spasticity caused by multiple sclerosis
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Conclusions:  The enriched study design provides a method of determining the efficacy and safety of nabiximols in a way that more closely reflects proposed clinical practice, by limiting exposure to those patients who are likely to benefit from it. Hence, the difference between active and placebo should be a reflection...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 64 of 143
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Predictive value of motor evoked potentials in clinically isolated syndrome
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Conclusions †  Contralateral silent period (SP) seems to be a valuable parameter to early distinguish patients who will develop MS or not. This result about SP during CIS has never been described until now. An increased contralateral silent period would predict a conversion to MS with a positive predictive value...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 65 of 143
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Bilateral Subdural Hematoma Following Implantation of Intrathecal Drug Delivery Device
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Conclusions:  Medical and nursing staff dealing with intrathecal therapy should be aware of this potentially severe complication. (Source: Neuromodulation)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 66 of 143
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Scientists Probe Strategies to Repair Neuron Damage in Multiple Sclerosis [Medical News & Perspectives]
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(Source: JAMA)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 67 of 143
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Pharmacologic treatment of depression in multiple sclerosis
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Objectives: To investigate the efficacy and tolerability of pharmacologic treatments for depression in patients with MS. (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 10:16:35 am
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Multiple Sclerosis - news item 68 of 143
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Neuroprotection by Spice-Derived Nutraceuticals: You Are What You Eat!
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Abstract Numerous lines of evidence indicate that chronic inflammation plays a major role in the development of various neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, brain tumor, and meningitis. Why these diseases are more common among people from some countries than others is not fully understood, but lifestyle...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 5:39:54 am
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Multiple Sclerosis - news item 69 of 143
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Falls requiring medical attention among veterans with multiple sclerosis: A cohort study. - Cameron MH, Poel AJ, Haselkorn JK, Linke A, Bourdette D.
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The purpose of this study was to estimate the relative risk of an injurious fall requiring medical attention in veterans with multiple sclerosis (MS) compared with veterans without MS after controlling for sex, age, and healthcare use. The sample included ... (Source: SafetyLit: All (Unduplicated))
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RSS Source: Med Worm - Multiple Sclerosis Mon, 28 Feb 2011 1:56:23 am
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Multiple Sclerosis - news item 70 of 143
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Intellectual enrichment lessens the effect of brain atrophy on learning and memory in multiple sclerosis
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(Source: Neurology)
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RSS Source: Med Worm - Multiple Sclerosis Sun, 27 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 71 of 143
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HLA-DRB1 confers increased risk of pediatric-onset MS in children with acquired demyelination
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Conclusion: DRB1*15 alleles confer increased susceptibility to pediatric-onset MS, supporting a fundamental similarity in genetic contribution to MS risk in both pediatric- and adult-onset disease. The specificity of the DRB1*15 risk allele for children with subsequent MS diagnosis, but not for all children with ADS, indicates that the risk conveyed...
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RSS Source: Med Worm - Multiple Sclerosis Sun, 27 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 72 of 143
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Mitochondrial DNA haplogroups and mutations in children with acquired central demyelination
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Conclusion: These data suggest an association between mtDNA variants and the risk of PD-ADS and of a subsequent MS diagnosis. Replication of these findings in an independent population of subjects with PD-ADS is required. (Source: Neurology)
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RSS Source: Med Worm - Multiple Sclerosis Sun, 27 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 73 of 143
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Do old HLA and mitochondrial DNA variants associate with demyelination types in young patients?
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(Source: Neurology)
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RSS Source: Med Worm - Multiple Sclerosis Sun, 27 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 74 of 143
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Maternal and perinatal factors associated with hospitalised infectious mononucleosis in children, adolescents and young adults: record linkage study
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Background: There is current interest in the role of perinatal factors in the aetiology of diseases that occur later in life. Infectious mononucleosis (IM) can follow late primary infection with Epstein-Barr virus (EBV), and has been shown to increase the risk of multiple sclerosis and Hodgkin's disease. Little is known...
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RSS Source: Med Worm - Multiple Sclerosis Sun, 27 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 75 of 143
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Gene Analysis Illuminates MS Therapy Side Effect (CME/CE)
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(MedPage Today) -- Leukemia that was observed in a small number of mitoxantrone treated multiple sclerosis patients may be the result of patients' genetic makeup, Italian researchers said. (Source: MedPage Today Neurology)
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RSS Source: Med Worm - Multiple Sclerosis Sun, 27 Feb 2011 9:21:23 pm
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Multiple Sclerosis - news item 76 of 143
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Gene analysis illuminates MS therapy side effect
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Leukemia that was observed in a small number of mitoxantrone treated multiple sclerosis patients may be the result of patients' genetic makeup, Italian researchers said. (Source: Multiple Sclerosis Trust)
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RSS Source: Med Worm - Multiple Sclerosis Sat, 26 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 77 of 143
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Targeting T cells effectively blocks multiple sclerosis in mice
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In an effort to develop therapeutic remedies for multiple sclerosis, scientists debate two possible interventional approaches -- but they're on opposite sides of the spectrum. Researchers however, think they have now reached a definitive conclusion as to which approach is correct, putting an end to a long-disputed issue. They found...
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RSS Source: Med Worm - Multiple Sclerosis Sat, 26 Feb 2011 12:00:00 am
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Multiple Sclerosis - news item 78 of 143
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Acrolein induces myelin damage in mammalian spinal cord
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AbstractMyelin damage can lead to the loss of axonal conduction and paralysis in multiple sclerosis (MS) and spinal cord injury (SCI). Here, we show that acrolein, a lipid peroxidation product, can cause significant myelin damage in isolated guinea pig spinal cord segments. Acroleinâ€mediated myelin damage is particularly conspicuous in the...
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RSS Source: Med Worm - Multiple Sclerosis Fri, 25 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 79 of 143
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Researchers Publish Results Settling Multiple Sclerosis Debate: Findings Support Therapeutic Approach For Common Form Of MS
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In an effort to develop therapeutic remedies for multiple sclerosis, scientists debate two possible interventional approaches - but they're on opposite sides of the spectrum. Researchers at Wayne State University's School of Medicine, however, have reached a definitive conclusion as to which approach is correct, putting an end to a...
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RSS Source: Med Worm - Multiple Sclerosis Fri, 25 Feb 2011 9:00:00 am
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Multiple Sclerosis - news item 80 of 143
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Management of breakthrough disease in patients with multiple sclerosis: when an increasing of Interferon beta dose should be effective?
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Background: In daily clinical setting, some patients affected by relapsing-remitting Multiple Sclerosis (RRMS) are switched from the low-dose to the high-dose Interferon beta (IFNB) in order to achieve a better control of the disease. In this observational, post-marketing study we reported the 2-year clinical outcomes of patients switched to the...
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RSS Source: Med Worm - Multiple Sclerosis Thu, 24 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 81 of 143
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Sensitivity to heat in MS patients: a factor strongly influencing symptomology - an explorative survey
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Background: Many individuals diagnosed with Multiple Sclerosis (MS) are sensitive to increased body temperature, which has been recognized to correlate with the symptom of fatigue. The need to investigate this association has been highlighted. The aim of the study was to investigate the occurrence of heat sensitivity and its relations...
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RSS Source: Med Worm - Multiple Sclerosis Thu, 24 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 82 of 143
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Using diffusion tensor imaging and immunofluorescent assay to evaluate the pathology of multiple sclerosis
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Conclusion:Aberrant λl, λr, and FA relative to normal values are strong indicators of demyelination. DTI indices are not specific for axon loss. IFA analysis is a reliable method to demonstrate myelin and axon pathology within the ex vivo setting. J. Magn. Reson. Imaging 2011;33:557†564. © 2011 Wileyâ€Liss, Inc. (Source:...
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RSS Source: Med Worm - Multiple Sclerosis Thu, 24 Feb 2011 8:17:55 pm
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Multiple Sclerosis - news item 83 of 143
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Analysis of multiple sclerosis lesions using a fusion of 3.0 T FLAIR and 7.0 T SWI phase: FLAIR SWI
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ConclusionFLAIRâ€SWI provides radiologically known, hyperintense definition of MS lesions overlaid with highâ€resolution visualization of iron deposits and venous blood vessels and offers new insights into MS lesions. J. Magn. Reson. Imaging 2011;33:543†549. © 2011 Wileyâ€Liss, Inc. (Source: Journal of Magnetic Resonance Imaging) MedWorm Message: Watch the new MedWorm demo...
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RSS Source: Med Worm - Multiple Sclerosis Thu, 24 Feb 2011 8:17:54 pm
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Multiple Sclerosis - news item 84 of 143
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Molecular signaling how do axons die?
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Authors: Coleman M Axons depend critically on axonal transport both for supplying materials and for communicating with cell bodies. This chapter looks at each activity, asking what aspects are essential for axon survival. Axonal transport declines in neurodegenerative disorders, such as Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis, and...
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RSS Source: Med Worm - Multiple Sclerosis Thu, 24 Feb 2011 2:36:26 am
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Multiple Sclerosis - news item 85 of 143
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[Plasma exchanges in severe and acute inflammatory demyelinating attacks of the central nervous system.]
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CONCLUSIONS: Early initiation of PE seems to be a predictor of a good response. PMID: 21353760 [PubMed - as supplied by publisher] (Source: Presse Medicale)
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 86 of 143
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One-fifth of children with MS fail to respond to first-line treatment
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Researchers from the National Network of Pediatric MS Centers of Excellence, in the first retrospective study of the response of children with multiple sclerosis to standard, or first-line, therapies, found that one-fifth of patients involved in the review required "second-line" treatments. (Source: Multiple Sclerosis Trust)
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 87 of 143
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Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility
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This study replicated the genetic association of tyrosine kinase 2 with multiple sclerosis in a cohort of 1366 French patients and 1802 controls. Furthermore, we assessed the functional consequences of this polymorphism on human T lymphocytes by comparing the reactivity and cytokine profile of T lymphocytes isolated from individuals expressing...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 88 of 143
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Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
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Inflammation and oxidative stress are thought to promote tissue damage in multiple sclerosis. Thus, novel therapeutics enhancing cellular resistance to free radicals could prove useful for multiple sclerosis treatment. BG00012 is an oral formulation of dimethylfumarate. In a phase II multiple sclerosis trial, BG00012 demonstrated beneficial effects on relapse rate...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 89 of 143
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Locus coeruleus damage and noradrenaline reductions in multiple sclerosis and experimental autoimmune encephalomyelitis
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The endogenous neurotransmitter noradrenaline exerts anti-inflammatory and neuroprotective effects in vitro and in vivo. Several studies report that noradrenaline levels are altered in the central nervous system of patients with multiple sclerosis and rodents with experimental autoimmune encephalomyelitis, which could contribute to pathology. Since the major source of noradrenaline are...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 90 of 143
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Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis
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In this study, we investigated potential interactions between genetic risk factors and smoking in relation to risk of developing multiple sclerosis. A population-based case–control study involving incident cases of multiple sclerosis (843 cases, 1209 controls) was performed in Sweden. Cases and controls were classified according to their smoking status and...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 91 of 143
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The major histocompatibility complex and multiple sclerosis: a smoking gun?
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(Source: Brain)
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 92 of 143
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A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility
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Authors: W S Bush, J L McCauley, P L DeJager, S M Dudek, D A Hafler, R A Gibson, P M Matthews, L Kappos, Y Naegelin, C H Polman, S L Hauser, J Oksenberg, J L Haines & M D Ritchie (Source: Genes and Immunity)
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 93 of 143
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Progressive MS video added to webcast
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A new clip that discusses the issues associated with progressive forms of MS has been added to the MS Trust's webcast on disease modifying drugs. (Source: Multiple Sclerosis Trust) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 94 of 143
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Safer insertion of suprapubic catheters: summary of a safety report from the National Patient Safety Agency
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(Source: BMJ Online First)
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 95 of 143
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Cardiac arrhythmia induced by interferon betaâ€1a
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We report a case of left bundle branch block in a 35â€yearâ€old woman treated with INF betaâ€1a for multiple sclerosis. Five years after INF therapy, she presented loss of consciousness, retrosternal pains, short breath and lowered tolerance of effort. ECG and Holter 24â€h ECG monitoring revealed permanent complete left bundle...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 96 of 143
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TCRâ€like antibodies distinguish conformational and functional differences in two vs. fourâ€domain autoâ€reactive MHC IIâ€peptide complexes
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AbstractAntigen presenting cellâ€associated fourâ€domain MHC classâ€II molecules play a central role in activating autoreactive CD4+Tâ€cells involved in Multiple Sclerosis (MS) and Type 1 Diabetes (T1D). In contrast, twoâ€domain MHCâ€II structures with the same covalentlyâ€attached self peptide (Recombinant Tâ€cell receptor Ligands=RTLs) can regulate pathogenic CD4+Tâ€cells and reverse clinical signs of experimental...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 97 of 143
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Cutaneous sarcoidosis developing after treatment with pegylated interferon and ribavirin: a new case and review of the literature
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We present a new case of cutaneous sarcoidosis after treatment with pegylated IFN, and a review of the literature. (Source: International Journal of Dermatology)
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 3:30:20 pm
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Multiple Sclerosis - news item 98 of 143
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Experimental leprosy: a model of epithelioid cell granuloma
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AbstractAn animal model of granulomatous hypersensitivity has been developed, which reproduces some features of the pathologies of important chronic granulomatous disorders, including tuberculosis, tuberculoid leprosy, sarcoidosis, berylliosis, Crohn’s disease, and sensitivity to zirconium. The lesions consist of focal collections of epithelioid cells surrounded by lymphocytes to form tubercles. The epithelioid...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 3:30:17 pm
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Multiple Sclerosis - news item 99 of 143
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Antiphospholipid antibodies and the brain: A consensus report.
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This report discusses the difference between antiphospholipid antibodies (aPL) as a predictor for first and recurrent ischemic stroke, whether or not concomitant systemic lupus erythematosus (SLE) increases aPL-associated risk, and the association of aPL with other neurological manifestations. The neurological manifestations covered in this report were selected because they are...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 4:00:07 am
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Multiple Sclerosis - news item 100 of 143
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Wayne State University researchers publish results settling multiple sclerosis debate
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(Wayne State University - Office of the Vice President for Research) In an effort to develop therapeutic remedies for multiple sclerosis, scientists debate two possible interventional approaches -- but they're on opposite sides of the spectrum. Researchers at Wayne State University's School of Medicine, however, have reached a definitive conclusion...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 4:00:00 am
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Multiple Sclerosis - news item 101 of 143
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Microglial cystatin F expression is a sensitive indicator for ongoing demyelination with concurrent remyelination
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AbstractDemyelination coincides with numerous changes of gene expression in the central nervous system (CNS). Cystatin F, which is a papainâ€like lysosomal cysteine proteinase inhibitor that is normally expressed by immune cells and not in the brain, is massively induced in the CNS during acute demyelination. We found that microglia, which...
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RSS Source: Med Worm - Multiple Sclerosis Wed, 23 Feb 2011 1:15:29 am
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Multiple Sclerosis - news item 102 of 143
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Spinal Cord Herniation: A Missing Piece in the Pathogenesis of Amyotrophic Lateral Sclerosis and Multiple Sclerosis?
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Conclusions: Persistent central nervous system trauma due to idiopathic SCH might provide an unexpected hint about the pathogenesis of amyotrophic lateral sclerosis and multiple sclerosis. PMID: 21346318 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases) MedWorm Message: Watch the new MedWorm demo and find out how to get all...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 22 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 103 of 143
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Merck Serono pulls European application for oral MS drug Movectro
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Merck Serono Europe informed the European Medicines Agency that it was withdrawing its marketing authorization application for oral cladribine (Movectro), 10-mg tablets, intended for the treatment of relapsing-remitting multiple sclerosis. (Source: Modern Medicine)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 22 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 104 of 143
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Management of optic neuritis
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Vimla Menon, Rohit Saxena, Ruby Misra, Swati PhuljheleIndian Journal of Ophthalmology 2011 59(2):117-122Optic neuritis is an inflammatory condition of the optic nerve characterized by a sudden onset of unilateral visual loss, usually affecting young females. Demyelination associated with multiple sclerosis (MS) is the most common cause in regions where MS...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 22 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 105 of 143
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Visual fields in neuro-ophthalmology
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Sachin Kedar, Deepta Ghate, James J CorbettIndian Journal of Ophthalmology 2011 59(2):103-109Visual field assessment is important in the evaluation of lesions involving the visual pathways and should be performed at baseline and periodically in the follow-up. Standard automated perimetry has been shown to be adequate in neuro-ophthalmic practise and is...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 22 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 106 of 143
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Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila
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AbstractCentral nervous system (CNS) physiology requires special chemical, metabolic, and cellular privileges for normal function, and blood†brain barrier (BBB) structures are the anatomic and physiologic constructs that arbitrate communication between the brain and body. In the vertebrate BBB, two primary cell types create CNS exclusion biology, a polarized vascular...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 22 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 107 of 143
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Late-breaking news: Merck Serono pulls European application for oral MS drug Movectro
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Merck Serono Europe informed the European Medicines Agency that it was withdrawing its marketing authorization application for oral cladribine (Movectro), 10-mg tablets, intended for the treatment of relapsing-remitting multiple sclerosis. (Source: Modern Medicine)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 22 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 108 of 143
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Ophthalmopathology in rats with MBP-induced experimental autoimmune encephalomyelitis
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Conclusions Immunization with MBP not only causes neuron loss in the retinal ganglion cell layer, but also triggers antibody reactivity against ocular tissue. Possibly some of these antibodies are involved in the induction of neuronal apoptosis. This study suggests that, apart from T-cell mediation, alteration of antibody reactivity and activated...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 22 Feb 2011 4:08:34 pm
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Multiple Sclerosis - news item 109 of 143
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In this issue
|
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AbstractCover imageThe cover image of this issue consists of sections from the small intestine (proximal ileum) of Ncr1GFP/+ mice stained with antiâ€GFP (green) and antiâ€RORγt (red) antibodies, and is taken from Satohâ€Takayama et al. (pp 780†786). In this article, the authors use lymphotoxinâ€Î² receptor (LTβR)â€deficient Ncr1GFP/+ mice, which lack...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 22 Feb 2011 1:56:02 pm
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Multiple Sclerosis - news item 110 of 143
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MS spasticity treatment granted national reimbursement in Spain
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A treatment for multiple sclerosis spasticity has been granted national reimbursement in Spain. (Source: Pharmacy Europe) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Multiple Sclerosis Tue, 22 Feb 2011 10:47:00 am
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Multiple Sclerosis - news item 111 of 143
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Neutralizing antibodies in interferon beta treated patients with multiple sclerosis: knowing what to do now
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Content Type Journal ArticlePages 1-4DOI 10.1007/s00415-011-5941-0Authors Til Menge, Department of Neurology, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, GermanyHans-Peter Hartung, Department of Neurology, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, GermanyBernd C. Kieseier, Department of Neurology, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, Germany Journal Journal of NeurologyOnline ISSN 1432-1459Print...
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RSS Source: Med Worm - Multiple Sclerosis Tue, 22 Feb 2011 5:58:30 am
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Multiple Sclerosis - news item 112 of 143
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Cold Weather Affects Cognitive Behavior in People with MS
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(Ivanhoe Newswire) -- Scientists say that multiple sclerosis (MS) appears to flare up during warmer weather. (Source: Medical Headlines From Ivanhoe.com)
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RSS Source: Med Worm - Multiple Sclerosis Tue, 22 Feb 2011 4:00:00 am
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Multiple Sclerosis - news item 113 of 143
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Neurolaryngology.
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Authors: Núñez-Batalla F, DÃaz-Molina JP, Costales-Marcos M, Moreno Galindo C, Suárez-Nieto C The neuroanatomy of voice and speech is complex. An intricate neural network is responsible for ensuring the main functions of the larynx: airway protection, cough and Valsalva production, and providing voice. Coordination of these roles is very susceptible...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 21 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 114 of 143
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New disability test 'is a complete mess', says the man who designed it
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Welfare reform expert Professor Paul Gregg says a rushed roll out of the work capability assessment will cause more anguish. (Source: Multiple Sclerosis Trust)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 21 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 115 of 143
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Government Bill must change or MS services could suffer
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The MS Society, MND Association and Parkinson's UK have joined forces to ensure the Government?s new plans, as set out in the Health and Social Care Bill, do not overlook neurological conditions. (Source: Multiple Sclerosis Society Press Releases) MedWorm Message: Watch the new MedWorm demo and find out how to...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 21 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 116 of 143
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Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: An application in multiple sclerosis
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AbstractIn recent years adaptive seamless phase II/III designs (ASDs) allowing treatment or dose selection at an interim analysis have gained much attention because of their potential to save development costs and to shorten timeâ€toâ€market of a new compound compared to conventional drug development programmes with separate trials for individual phases....
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RSS Source: Med Worm - Multiple Sclerosis Mon, 21 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 117 of 143
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In brief
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(Source: BMJ Online First)
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RSS Source: Med Worm - Multiple Sclerosis Mon, 21 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 118 of 143
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Falls requiring medical attention among veterans with multiple sclerosis: A cohort study.
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Authors: Cameron MH, Poel AJ, Haselkorn JK, Linke A, Bourdette D The purpose of this study was to estimate the relative risk of an injurious fall requiring medical attention in veterans with multiple sclerosis (MS) compared with veterans without MS after controlling for sex, age, and healthcare use. The sample...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 21 Feb 2011 8:00:04 pm
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Multiple Sclerosis - news item 119 of 143
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Measurement of lower-limb muscle spasticity: Intrarater reliability of Modified Modified Ashworth Scale.
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Authors: Ghotbi N, Nakhostin Ansari N, Naghdi S, Hasson S The Modified Modified Ashworth Scale (MMAS) is a clinical instrument for measuring spasticity. Few studies have been performed on the reliability of the MMAS. The aim of the present study was to investigate the intrarater reliability of the MMAS for...
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RSS Source: Med Worm - Multiple Sclerosis Mon, 21 Feb 2011 8:00:04 pm
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Multiple Sclerosis - news item 120 of 143
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Future clinical challenges in multiple sclerosis: Relevance to sphingosine 1-phosphate receptor modulator therapy
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The limitations of established therapies for multiple sclerosis (MS) are well-known and include the need for injections, treatment adherence and convenience issues, partial efficacy, and, in some cases, a risk of potentially life-threatening adverse events, such as progressive multifocal leukoencephalopathy. Recently, attention has focused on developing more effective therapies that...
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RSS Source: Med Worm - Multiple Sclerosis Sun, 20 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 121 of 143
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Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis
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The oral sphingosine 1-phosphate (S1P) receptor (S1PR) modulator fingolimod has been shown to be effective in the treatment of patients with relapsing multiple sclerosis (MS). The drug binds with high affinity to 4 of the 5 G-protein–coupled S1P receptors (S1P1–5). After binding, the receptors are internalized, degraded, and thus functionally...
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RSS Source: Med Worm - Multiple Sclerosis Sun, 20 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 122 of 143
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Impact of sphingosine 1-phosphate modulation on immune outcomes
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Viral infections may have an important role in the precipitation or relapse of multiple sclerosis (MS) and its treatment. This review describes the normal immune response to viral infection, the possible associations between viral infections and MS therapy, and the impact of sphingosine 1-phosphate (S1P) receptor (S1PR) modulation with fingolimod (...
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RSS Source: Med Worm - Multiple Sclerosis Sun, 20 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 123 of 143
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The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators
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Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a prototypical S1PR modulator. It has recently been approved as the...
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RSS Source: Med Worm - Multiple Sclerosis Sun, 20 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 124 of 143
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Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation
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Sphingosine 1-phosphate (S1P) and 5 specific high-affinity S1P receptor (S1PR) subtypes, S1P1–5, have important regulatory functions in normal physiology and disease processes, particularly involving the immune, central nervous, and cardiovascular systems. Within the immune system, downmodulation of S1P1 prevents the egress of B and T cells from lymph nodes (LN)...
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RSS Source: Med Worm - Multiple Sclerosis Sun, 20 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 125 of 143
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Welfare Reform Bill published
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On 16 February, the government began the process of reforming the benefit system by introducing the Welfare Reform Bill to Parliament. (Source: Multiple Sclerosis Trust) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Multiple Sclerosis Sun, 20 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 126 of 143
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Temperature affects thinking in MS
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New research has demonstrated the effects of changes in temperature on thinking skills in people with MS. (Source: Multiple Sclerosis Trust)
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RSS Source: Med Worm - Multiple Sclerosis Sun, 20 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 127 of 143
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Neutralizing antibodies against interferon-{beta} do not predispose antibodies against natalizumab
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(Source: Neurology)
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RSS Source: Med Worm - Multiple Sclerosis Sun, 20 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 128 of 143
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Asymptomatic spinal cord lesions predict disease progression in radiologically isolated syndrome
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Conclusion: These findings suggest that the presence of asymptomatic spinal cord lesions place subjects with RIS at substantial risk for clinical conversion to either an acute or progressive event, a risk that is independent of brain lesions on MRI. (Source: Neurology)
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RSS Source: Med Worm - Multiple Sclerosis Sun, 20 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 129 of 143
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The radiologically isolated syndrome revisited: When is it presymptomatic multiple sclerosis?
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(Source: Neurology)
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RSS Source: Med Worm - Multiple Sclerosis Sun, 20 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 130 of 143
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Th17 cell, the New Player of Neuroinflammatory Process in Multiple Sclerosis
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AbstractMultiple sclerosis (MS) is an autoimmune disease characterized by recurrent episodes of demyelination and axonal lesion mediated by CD4+ T cells with a proinflammatory Th1 and Th17 phenotype, macrophages, and soluble inflammatory mediators. Identification of Th17 cells led to breaking the dichotomy of Th1/Th2 axis in immunopathogenesis of autoimmune diseases...
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RSS Source: Med Worm - Multiple Sclerosis Sun, 20 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 131 of 143
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Meaningful change in cognition in multiple sclerosis: method matters.
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Conclusions: Methodology has a significant impact on interpretation of longitudinal data. In the same group of subjects, traditional group analyses documented no change in individual test scores or change on a single composite score. Analyses of individual results documented change from 16 to 58% of the sample. Advantages and disadvantages...
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RSS Source: Med Worm - Multiple Sclerosis Sat, 19 Feb 2011 12:46:27 pm
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Multiple Sclerosis - news item 132 of 143
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Relapse risk in patients with multiple sclerosis after H1N1 vaccination, with or without seasonal influenza vaccination
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Content Type Journal ArticlePages 1-3DOI 10.1007/s00415-011-5944-xAuthors Nuala McNicholas, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG UKJeremy Chataway, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG UK Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)
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RSS Source: Med Worm - Multiple Sclerosis Sat, 19 Feb 2011 6:18:17 am
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Multiple Sclerosis - news item 133 of 143
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Cladribine tablets: in relapsing-remitting multiple sclerosis.
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Authors: Muir VJ, Plosker GL Cladribine, an immunosuppressant that selectively reduces peripheral lymphocyte levels, has potential as an oral therapy for relapsing-remitting multiple sclerosis. An oral (tablet) formulation is being investigated in clinical trials. In the large, well designed, phase III CLARITY trial, short-course treatment with oral cladribine (cumulative dose...
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RSS Source: Med Worm - Multiple Sclerosis Fri, 18 Feb 2011 9:02:26 pm
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Multiple Sclerosis - news item 134 of 143
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Herpes labialis in multiple sclerosis with a trigeminal lesion.
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Authors: Suzuki N, Mizuno H, Nakashima I, Itoyama Y PMID: 21297331 [PubMed - in process] (Source: Herpes) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Multiple Sclerosis Fri, 18 Feb 2011 9:00:04 pm
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Multiple Sclerosis - news item 135 of 143
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Warm Weather May Hurt Thinking Skills In People With MS
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People with multiple sclerosis (MS) may find it harder to learn, remember or process information on warmer days of the year, according to new research released today that will be presented at the American Academy of Neurology's 63rd Annual Meeting in Honolulu April 9 to April 16, 2011... (Source: Health...
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RSS Source: Med Worm - Multiple Sclerosis Fri, 18 Feb 2011 10:00:00 am
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Multiple Sclerosis - news item 136 of 143
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Warm weather may hurt thinking skills in people with multiple sclerosis
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People with multiple sclerosis may find it harder to learn, remember or process information on warmer days of the year, according to new research. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Multiple Sclerosis Fri, 18 Feb 2011 9:00:00 am
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Multiple Sclerosis - news item 137 of 143
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Merck Serono Europe Limited Withdraws Its Marketing Authorisation Application For Movectro (Cladribine)
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The European Medicines Agency has been formally notified by Merck Serono Europe Limited of its decision to withdraw its application for a centralised marketing authorisation for the medicine Movectro (cladribine), 10 mg tablets. Movectro was intended to be used for the treatment of relapsing-remitting multiple sclerosis. The application for the...
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RSS Source: Med Worm - Multiple Sclerosis Fri, 18 Feb 2011 8:00:00 am
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Multiple Sclerosis - news item 138 of 143
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Retinal nerve fiber layer thickness changes following optic neuritis caused by multiple sclerosis
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Conclusions ON caused morphological changes in the peripapillary RNFL, and recurrent ON aggravated the deterioration and caused diffuse rather than regional damage to the peripapillary RNFL. Content Type Journal ArticlePages 45-48DOI 10.1007/s10384-010-0902-1Authors Toru Urano, Department of Ophthalmology, Kurume University School of Medicine, Kurume, JapanToyoaki Matsuura, Department of Ophthalmology, Nara Medical...
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RSS Source: Med Worm - Multiple Sclerosis Fri, 18 Feb 2011 5:55:06 am
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Multiple Sclerosis - news item 139 of 143
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Painful and involuntary multiple sclerosis
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Expert Opinion on Pharmacotherapy, Volume 0, Issue 0, Page 1-15, Early Online. (Source: Expert Opinion: Expert Opinion on Pharmacotherapy: Table of Contents) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Multiple Sclerosis Fri, 18 Feb 2011 3:04:57 am
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Multiple Sclerosis - news item 140 of 143
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AAN: Warm Weather Tied to Worse Cognition in MS
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Warmer weather is associated with worse cognitive functioning among individuals with multiple sclerosis, according to research released Feb. 17 to be presented at the annual meeting of the American Academy of Neurology, which will be held from April 9 to 16 in Honolulu. (Source: Modern Medicine)
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RSS Source: Med Worm - Multiple Sclerosis Thu, 17 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 141 of 143
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Survey of MS services across England and Wales
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We are sorry that some people may have had problems accessing the survey, particularly over the last two weekends. The Royal College of Physicians assures us that the problems with their website have now been rectified. Your input is really important to us and we would be really grateful if...
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RSS Source: Med Worm - Multiple Sclerosis Thu, 17 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 142 of 143
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Cladribine licence application withdrawn
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The manufacturer of cladribine (Movectro) has announced that it has withdrawn its application for a licence for the drug in Europe. (Source: Multiple Sclerosis Trust)
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RSS Source: Med Worm - Multiple Sclerosis Thu, 17 Feb 2011 11:00:00 pm
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Multiple Sclerosis - news item 143 of 143
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Benefits shakeup: what it means for people with MS and what we're doing about it
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Yesterday the government published radical plans to change the benefits system in its Welfare Reform Bill. Today, the MS Society explains what these mean to people with MS, what we?re saying and doing about it and how you can get involved. (Source: Multiple Sclerosis Society Press Releases)
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RSS Source: Med Worm - Multiple Sclerosis Thu, 17 Feb 2011 11:00:00 pm
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