Myasthenia Gravis - news item 1 of 139
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Bayhill Therapeutics Announces The Successful Clearance Of An IND For BHT-3034 For The Treatment Of Myasthenia Gravis
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Bayhill Therapeutics Inc, a clinical-stage biopharmaceutical company utilizing its proprietary BHT-DNAâ„¢ platform to develop novel and targeted autoimmune and immune-mediated disease treatments, has announced the successful clearance of an IND with the US FDA for BHT-3034, a disease-modifying DNA plasmid vaccine immunotherapy for patients with the autoimmune neuromuscular junction disease...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 3 Mar 2011 8:00:00 am
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Myasthenia Gravis - news item 2 of 139
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Video-assisted thoracoscopic surgery versus sternotomy in treating myasthenia gravis: Comparison by a case-matched study
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Conclusion Both RtVATET and TET are effective for treating MG, although this study does indicate an advantage for TET. We suggest that a thymectomy should therefore be performed earlier, or that the procedures should be extensive enough to remove all of the tissue that contains thymic tissue. Content Type Journal...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 2 Mar 2011 8:11:22 am
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Myasthenia Gravis - news item 3 of 139
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Acetylcholinesterase inhibitor treatment for myasthenia gravis
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Objectives: To evaluate the efficacy of acetylcholinesterase inhibitors in all forms of myasthenia gravis. (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - Myasthenia Gravis Mon, 28 Feb 2011 10:15:06 am
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Myasthenia Gravis - news item 4 of 139
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Safety of influenza and H1N1 vaccinations in patients with myasthenia gravis, and patient compliance
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We examined vaccination practices in 74 MG patients. Only 38 patients (51.4%) received the seasonal influenza vaccine, and 24 (32.4%) received the H1N1 vaccine. No exacerbation of MG was found, and therefore seasonal influenza and H1N1 vaccines seem to be safe in MG. (Source: Muscle and Nerve)
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RSS Source: Med Worm - Myasthenia Gravis Fri, 25 Feb 2011 9:54:15 pm
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Myasthenia Gravis - news item 5 of 139
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Surgical treatment of stage III thymic tumors: a multi-institutional review from four Italian centers [Original articles]
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Conclusions: Multimodality treatment of stage III thymic tumors achieved good survival. Radical surgery, even at recurrence, seems to be the most important prognostic factor. (Source: European Journal of Cardio-Thoracic Surgery)
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RSS Source: Med Worm - Myasthenia Gravis Thu, 24 Feb 2011 11:00:00 pm
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Myasthenia Gravis - news item 6 of 139
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Rituximab is successful in an HIV-positive patient with MuSK myasthenia gravis
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(Source: Neurology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Myasthenia Gravis Sun, 20 Feb 2011 11:00:00 pm
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Myasthenia Gravis - news item 7 of 139
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Tetanic failure due to decreased endogenous adenosine A2A tonus operating neuronal Cav1 (Lâ€type) influx in Myasthenia gravis
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This study aimed at investigating whether A2A receptorsâ€operated Ca2+ influx via CaV1 (L)â€type channels contribute to sustain acetylcholine release evoked by 50 Hzâ€bursts in toxinâ€induced Myasthenia gravis (TIMG) rats. In contrast to control animals, inhibition of [3H]ACh release by the CaV2.1 (P/Q) channel blocker, ωâ€Agatoxin IVA (100 nM), in TIMG...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 17 Feb 2011 5:40:39 pm
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Myasthenia Gravis - news item 8 of 139
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Increased serum ILâ€17 levels in patients with myasthenia gravis
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AbstractIt has been suggested that ILâ€17 plays a crucial role in the development of several autoimmune diseases. However, there is no data about the relationship between myasthenia gravis and ILâ€17. The aim of this study was to measure the concentration of ILâ€17 and check whether levels depend on the severity...
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RSS Source: Med Worm - Myasthenia Gravis Tue, 15 Feb 2011 11:00:00 pm
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Myasthenia Gravis - news item 9 of 139
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01 What is seronegative MG? analysis of the Northern Irish MG population
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Conclusion Compared with the distribution of other recognised MG subpopulations, SNMG is indistinct and broadly distributed. There are no recognisable subsets within the NI seronegative cohort. This epidemiological data is consistent with SNMG being either a heterogeneous population or an epiphenomenon resulting from false-negative antibody assays or false-positive diagnoses. (Source:...
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RSS Source: Med Worm - Myasthenia Gravis Mon, 14 Feb 2011 11:00:00 pm
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Myasthenia Gravis - news item 10 of 139
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The oculobulbar facial respiratory score is a tool to assess bulbar function in myasthenia gravis patients
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Conclusions:This study confirmed construct validity of the OBFR and “modified†OBFR scores. Muscle Nerve, 2011 (Source: Muscle and Nerve)
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RSS Source: Med Worm - Myasthenia Gravis Mon, 7 Feb 2011 11:00:00 pm
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Myasthenia Gravis - news item 11 of 139
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Investigation for RAPSN and DOKâ€7 mutations in a cohort of seronegative myasthenia gravis patients
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Conclusions: This study confirms that rapsn CMS can be mistaken for SNMG. In addition, the frequency of rapsn CMS in our nationwide SNMG cohort was found to be low. SNMG patients with an atypical clinical presentation and pediatric cases should be tested for the N88K mutation before initiation of immunosuppressive...
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RSS Source: Med Worm - Myasthenia Gravis Mon, 7 Feb 2011 11:00:00 pm
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Myasthenia Gravis - news item 12 of 139
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Psychosocial aspects in myasthenic patients treated by plasmapheresis
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In this study, the effects of improvement in muscle strength with plasmapheresis treatment on both quality of life (QoL) and psychological status of MG patients were studied. Between January 2008 and December 2009, 29 MG patients were enrolled to receive one course of plasmapheresis treatment. Differences in baseline and posttherapy...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 3 Feb 2011 6:14:50 am
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Myasthenia Gravis - news item 13 of 139
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Refractory bulbar and respiratory dysfunction in a young Chinese woman with seronegative, muscle-specific tyrosine kinase antibody-positive myasthenia gravis: response to cyclophosphamide and rituximab treatment.
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We report on a 31-year-old Chinese woman with acetylcholine receptor antibody-negative and muscle-specific tyrosine kinase antibody-positive generalised myasthenia gravis who had refractory bulbar dysfunction and respiratory failure despite immunosuppressive therapy and thymectomy, and partial and sustained responses to cyclophosphamide and rituximab treatment, respectively. Myasthenia crisis was diagnosed when she presented...
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RSS Source: Med Worm - Myasthenia Gravis Mon, 31 Jan 2011 11:00:00 pm
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Myasthenia Gravis - news item 14 of 139
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Paediatric electromyography in the modern world: a personal view
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Paediatric electromyography (EMG) is an invaluable diagnostic test for the investigation of neuromuscular disease, but its use is inconsistent between and within different countries. One perception is that the procedure is painful; however, in comparison with common investigations performed routinely in children, EMG is better tolerated. While some developments, such...
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RSS Source: Med Worm - Myasthenia Gravis Fri, 28 Jan 2011 3:45:14 am
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Myasthenia Gravis - news item 15 of 139
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Dexamethasone 4.0mg/ml injection
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Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes The revised SPC states that treatment of Acute Respiratory Distress Syndrome (ARDS) with corticosteroids should be initiated within the first two weeks of onset. This has emerged after a randomised, placebo-controlled study suggested an increase in mortality if treatment...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 26 Jan 2011 11:00:00 pm
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Myasthenia Gravis - news item 16 of 139
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Immunomodulatory drugs and their application to the management of canine immuneâ€mediated disease
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This review summarises the current understanding of immune response and T cell subsets in the context of development of autoimmunity in the dog. Mode of action and rational usage in immuneâ€mediated disease in the dog are discussed for the following drugs: glucocorticoids, azathioprine, cyclophosphamide, ciclosporin, tacrolimus, human intravenous immunoglobulin, vincristine,...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 26 Jan 2011 4:08:16 pm
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Myasthenia Gravis - news item 17 of 139
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Successful Low-Dose Azathioprine for Myasthenia Gravis Despite Hepatopathy From Primary Sclerosing Cholangitis: A Case Report
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Immunosuppressive therapy was required to treat this patient's myasthenia gravis, but would it be safe, given her concomitant sclerosing cholangitis? Journal of Medical Case Reports (Source: Medscape Today Headlines)
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RSS Source: Med Worm - Myasthenia Gravis Tue, 25 Jan 2011 3:00:00 am
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Myasthenia Gravis - news item 18 of 139
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MuSK levels differ between adult skeletal muscles and influence postsynaptic plasticity
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AbstractMuscleâ€specific tyrosine kinase (MuSK) is involved in the formation and maintenance of the neuromuscular junction (NMJ), and is necessary for NMJ integrity. As muscle involvement is strikingly selective in pathological conditions in which MuSK is targeted, including congenital myasthenic syndrome with MuSK mutation and MuSK antibodyâ€seropositive myasthenia gravis, we hypothesized...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 23 Jan 2011 11:00:00 pm
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Myasthenia Gravis - news item 19 of 139
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Myasthenic syndrome caused by plectinopathy
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Conclusions: The MyS in plectinopathy is attributed to destruction of the junctional folds and the myopathy to defective anchoring of muscle fiber organelles and defects in sarcolemmal integrity. (Source: Neurology)
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RSS Source: Med Worm - Myasthenia Gravis Sun, 23 Jan 2011 11:00:00 pm
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Myasthenia Gravis - news item 20 of 139
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Does a relationship exist between the number of thoracoscopic thymectomies performed and the learning curve for thoracoscopic resection of thymoma in patients with myasthenia gravis? [Institutional report - Thoracic oncologic]
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This study aimed to analyze surgeons’ learning curve for thymoma resection with video-assisted thoracoscopic surgery (VATS). Two hundred and eleven myasthenia gravis patients had VATS thymic resections, including 25 patients with a thymoma. Three groups of surgeries, according to the order of operations, were analyzed: Group A comprised the first...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 20 Jan 2011 11:00:00 pm
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Myasthenia Gravis - news item 21 of 139
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Simultaneous Operation for Multiple Valvular Disease and Myasthenia in a Woman
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We report a female patient with rheumatic valvular disease and myasthenia gravis who received triple heart valve surgery and thymectomy simultaneously. In her early recovery, two episodes of myasthenic crisis occurred which were treated promptly with a successful surgical outcome. (Source: Heart, Lung and Circulation)
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RSS Source: Med Worm - Myasthenia Gravis Thu, 20 Jan 2011 1:43:15 pm
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Myasthenia Gravis - news item 22 of 139
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Antiâ€ryanodine receptor†positive acetylcholine receptor†negative myasthenia gravis: Evidence of impaired excitation†contraction coupling
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(Source: Muscle and Nerve)
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RSS Source: Med Worm - Myasthenia Gravis Wed, 19 Jan 2011 8:28:46 pm
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Myasthenia Gravis - news item 23 of 139
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Diagnostic utility of stimulated singleâ€fiber electromyography of the orbicularis oculi muscle in patients with suspected ocular myasthenia
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This study confirms a high specificity and sensitivity of SSFEMG when it is performed on patients suspected to have ocular MG. In such patients, a normal SSFEMG of the OO predicts a benign clinical course. Muscle Nerve 43: 168†170, 2011 (Source: Muscle and Nerve)
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RSS Source: Med Worm - Myasthenia Gravis Wed, 19 Jan 2011 8:28:34 pm
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Myasthenia Gravis - news item 24 of 139
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The Etiology of Paraneoplastic Autoimmunity
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Abstract Although they may sometimes appear similar, paraneoplastic autoimmunity has a unique pathogenesis, different from the classical autoimmune diseases not associated with cancer. When distinguished clinically, paraneoplastic autoimmunity is more severe and often presents with a broader range of clinical signs and symptoms. Management of these patients is difficult and...
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RSS Source: Med Worm - Myasthenia Gravis Tue, 18 Jan 2011 6:38:22 pm
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Myasthenia Gravis - news item 25 of 139
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Thymectomy for inducing remission in juvenile myasthenia gravis
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Conclusions Spontaneous remission rates for myasthenia gravis are quoted to be between 20 and 29% while remission rates following thymectomy are 29†68% at 3 years. Although not all of our patients have had 3 years of follow up†the remission rate of 62% demonstrated by this study is encouraging....
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RSS Source: Med Worm - Myasthenia Gravis Mon, 17 Jan 2011 7:24:25 pm
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Myasthenia Gravis - news item 26 of 139
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Evidence-based guideline update: Plasmapheresis in neurologic disorders: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
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Objective: To reassess the role of plasmapheresis in the treatment of neurologic disorders. Methods: We evaluated the available evidence based on a structured literature review for relevant articles from 1995 through September 2009. In addition, due to revision of the definitions of classification of evidence since the publication of the...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 16 Jan 2011 11:00:00 pm
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Myasthenia Gravis - news item 27 of 139
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Neuromuscular junction toxicity with tandutinib induces a myasthenic-like syndrome
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Conclusion: These observations suggest that tandutinib is toxic to the neuromuscular junction, possibly by reversibly binding to a molecule on the postsynaptic acetylcholine receptor complex. Classification of evidence: This study provides Class III evidence that tandutinib 500 mg twice daily induces reversible muscle weakness and electrophysiologic changes consistent with neuromuscular...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 16 Jan 2011 11:00:00 pm
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Myasthenia Gravis - news item 28 of 139
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Thymoma-associated myasthenia gravis without acetylcholine receptor antibodies
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We describe a case of seronegative thymoma-associated myasthenia gravis as a further evidence of the variability of myasthenia gravis in terms of antibody profile and thymic pathological findings. (Source: Journal of the Neurological Sciences)
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RSS Source: Med Worm - Myasthenia Gravis Thu, 13 Jan 2011 11:00:00 pm
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Myasthenia Gravis - news item 29 of 139
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Proton magnetic resonance spectroscopy of the intrinsic tongue muscles in patients with myasthenia gravis with different autoantibodies
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This study included 15 MG patients with antibodies against muscle-specific kinase (MuSK), 15 matched MG patients with antibodies against acetylcholine receptor (AChR) and 15 matched healthy subjects. Middle posterior region of the tongue was analyzed by single voxel point-resolved proton magnetic resonance spectroscopy (MRS) using 1.5T MRI scanner.Results: MRS obtained...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 13 Jan 2011 11:00:00 pm
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Myasthenia Gravis - news item 30 of 139
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Erratum to: Comparison of muscle ultrastructure in myasthenia gravis with anti-MuSK and anti-AChR antibodies
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Content Type Journal ArticlePages 1-1DOI 10.1007/s00415-010-5881-0Authors Giovanna Cenacchi, Clinical Department of Radiological and Histopathological Sciences, “Alma Mater Studiorum†University of Bologna, Via Massarenti, 9, 40137 Bologna, ItalyValentina Papa, Clinical Department of Radiological and Histopathological Sciences, “Alma Mater Studiorum†University of Bologna, Via Massarenti, 9, 40137 Bologna, ItalyMarina Fanin, Department of...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 13 Jan 2011 8:31:21 pm
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Myasthenia Gravis - news item 31 of 139
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Peripheral nerve hyperexcitability: A clinical and immunologic study of 38 patients
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Conclusions: PNH is a heterogeneous disorder involving the peripheral nerves in patients with a high propensity for developing autoimmunity. Associated muscle diseases are frequent in the form of myositis, myasthenia gravis, or nonspecific myopathic pathologic findings. VGKC-Abs were uncommon in this series. (Source: Neurology) MedWorm Message: Watch the new MedWorm...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 9 Jan 2011 11:00:00 pm
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Myasthenia Gravis - news item 32 of 139
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Risk of venous thromboembolism in people admitted to hospital with selected immune-mediated diseases: record-linkage study
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Conclusions: People admitted to hospital with immune-mediated diseases may be at an increased risk of subsequent VTE. Our findings need independent confirmation or refutation; but, if confirmed, there may be a role for thromboprophylaxis in some patients with these diseases. (Source: BMC Medicine)
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RSS Source: Med Worm - Myasthenia Gravis Sun, 9 Jan 2011 11:00:00 pm
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Myasthenia Gravis - news item 33 of 139
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Recent cases of Non-toxigenic Corynebacterium diptheriae in Scotland: justification for continued surveillance.
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We describe three cases of non-toxigenic Corynebacterium diptheriae infection in immunocompetent adults. The strains were isolated and identified as C. diptheriae, their toxin minus status and biotype (gravis) was confirmed by the reference laboratory. Our report confirms the increasing importance of non-toxigenic C. diptheriae strains as causes of disease in...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 5 Jan 2011 11:00:00 pm
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Myasthenia Gravis - news item 34 of 139
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Matrix Metalloproteinases in Myasthenia Gravis
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Eur Neurol 2011;65:53†58 (DOI:10.1159/000322737) (Source: Karger Publishers)
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RSS Source: Med Worm - Myasthenia Gravis Wed, 5 Jan 2011 3:01:26 pm
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Myasthenia Gravis - news item 35 of 139
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Rituximab in the treatment of three coexistent neurological autoimmune diseases: chronic inflammatory demyelinating polyradiculoneuropathy, Morvan syndrome and myasthenia gravis
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A 76-year-old man with a pre-existing diagnosis of myasthenia gravis was admitted to an intensive care unit with pneumonia and type II respiratory failure. In addition, muscle weakness, widespread myokymia, neuropsychiatric disturbance and autonomic disturbance were present. Antivoltage gated potassium channel antibodies, antistriated muscle antibodies and antiacetylcholine receptor antibodies were...
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RSS Source: Med Worm - Myasthenia Gravis Tue, 4 Jan 2011 11:00:00 pm
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Myasthenia Gravis - news item 36 of 139
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Clinical features, complications and mortality in critically ill patients with 2009 influenza A(H1N1) in Sfax,Tunisia
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Conclusion  Critical illness from the 2009 influenza A(H1N1) in Sfax occurred in young individuals and was associated with severe acute respiratory and additional organ system failure. SAPS II and SOFA scores at ICU admission, and also during evolution, constitute a good predictor of death. (Source: Influenza and Other Respiratory Viruses)
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RSS Source: Med Worm - Myasthenia Gravis Fri, 31 Dec 2010 11:00:00 pm
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Myasthenia Gravis - news item 37 of 139
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Association of oral lichen planus with thyroid disease in a Finnish population: A retrospective case-control study: “A different finding from a Mediterranean areaâ€
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Siponen et al. report an association of oral lichen planus/oral lichenoid lesions (OLP/OLL) with thyroid disease in the Finnish population. As they point out, OLP has been associated with a number of systemic disorders, generally of autoimmune origin (myasthenia gravis, Sjögren's syndrome, ulcerative colitis, psoriasis, celiac disease, some liver diseases,...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 29 Dec 2010 11:33:25 pm
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Myasthenia Gravis - news item 38 of 139
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Clinical efficacy and immunological impact of tacrolimus in Chinese patients with generalized myasthenia gravis.
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Authors: Zhao CB, Zhang X, Zhang H, Hu XQ, Lu JH, Lu CZ, Xiao BG In this multicenter, open-label pilot study, the efficacy, safety, and immunological impact of tacrolimus in Chinese patients with generalized myasthenia gravis are assessed. Forty-seven generalized myasthenia gravis (MG) patients were enrolled into this study and...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 29 Dec 2010 11:00:00 pm
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Myasthenia Gravis - news item 39 of 139
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Blocking of IL-6 suppresses experimental autoimmune myasthenia gravis.
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Authors: Aricha R, Mizrachi K, Fuchs S, Souroujon MC Suppressive regulatory T cells (Treg) and pathogenic T helper 17 (Th17) cells are two lymphocyte subsets with opposing activities in autoimmune diseases. The proinflammatory cytokine IL-6 is a potent factor in switching immune responses in vivo from the induction of Treg...
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RSS Source: Med Worm - Myasthenia Gravis Mon, 27 Dec 2010 11:00:00 pm
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Myasthenia Gravis - news item 40 of 139
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Comparative Clinical Features and Immune Responses After Extended Thymectomy for Myasthenia Gravis in Patients With Atrophic Versus Hyperplastic Thymus [ORIGINAL ARTICLES: GENERAL THORACIC]
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Conclusions Atrophic thymus may contribute to the progression of MG. Patients with MG who have a atrophic thymus show similar postoperative prognosis as those with hyperplastic thymus, suggesting that surgical therapy should also be considered for the former subset. (Source: The Annals of Thoracic Surgery)
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RSS Source: Med Worm - Myasthenia Gravis Sun, 26 Dec 2010 11:00:00 pm
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Myasthenia Gravis - news item 41 of 139
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Comparative clinical features and immune responses after extended thymectomy for myasthenia gravis in patients with atrophic versus hyperplastic thymus.
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Authors: Chen Z, Luo H, Peng Y, Cai L, Zhang J, Su C, Zou J Although extended thymectomy is believed to be suitable for myasthenia gravis (MG) patients with hyperplastic thymus, it is not clear whether surgical treatment is indicated for MG patients with atrophic thymus. We therefore assessed the...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 23 Dec 2010 11:33:22 pm
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Myasthenia Gravis - news item 42 of 139
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Causes of camptocormia.
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Conclusions. Camptocormia is organic in the vast majority of the cases due to neurological disease, or rarely drugs, trauma, orthopedic abnormalities or idiopathic. PMID: 21182366 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 22 Dec 2010 11:00:00 pm
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Myasthenia Gravis - news item 43 of 139
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Boosting supply of key brain chemical reduces fatigue in mice
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Researchers have "engineered" a mouse that can run on a treadmill twice as long as a normal mouse by increasing its supply of acetylcholine, the neurotransmitter essential for muscle contraction. The finding could lead to new treatments for neuromuscular disorders such as myasthenia gravis, which occurs when cholinergic nerve signals...
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RSS Source: Med Worm - Myasthenia Gravis Tue, 21 Dec 2010 8:39:32 am
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Myasthenia Gravis - news item 44 of 139
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Muscle strength and fatigue in patients with generalized myasthenia gravis
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(Source: Muscle and Nerve)
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RSS Source: Med Worm - Myasthenia Gravis Tue, 21 Dec 2010 7:54:06 am
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Myasthenia Gravis - news item 45 of 139
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Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage - Implications for early Myasthenia gravis treatment.
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Authors: Musilek K, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Nachon F, Dolezal M, Kuca K Inhibitors of acetylcholinesterase are compounds widely used in the treatment of various diseases, such as Alzheimer's disease, glaucoma and Myasthenia gravis (MG). Compounds used in the therapy of MG posses a...
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RSS Source: Med Worm - Myasthenia Gravis Mon, 20 Dec 2010 11:00:00 pm
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Myasthenia Gravis - news item 46 of 139
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Video-assisted thoracoscopic surgery or transsternal thymectomy in the treatment of myasthenia gravis? [Best evidence topic - Thoracic non-oncologic]
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A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was how video-assisted thoracoscopic surgery (VATS) compares to median sternotomy in the surgical management of patients with myasthenia gravis (MG)? Overall 74 papers were found using the reported search, of which 15 represented...
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RSS Source: Med Worm - Myasthenia Gravis Mon, 20 Dec 2010 11:00:00 pm
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Myasthenia Gravis - news item 47 of 139
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Superimposed myasthenia gravis in chronic spinal cord injury: a case report
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Authors: S Kolli, K M Mathew, P Thumbikat, M R McClelland & K P S Nair (Source: Spinal Cord)
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RSS Source: Med Worm - Myasthenia Gravis Mon, 20 Dec 2010 11:00:00 pm
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Myasthenia Gravis - news item 48 of 139
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Thymoma-associated paraneoplastic encephalitis (TAPE): Diagnosis and treatment of a potentially fatal condition
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We report a case of a malignant thymoma presenting as paraneoplastic encephalitis and review the clinical characteristics, treatments used, and outcome of 28 patients with this disorder published according to a PubMed and MEDLINE search (1950†2010). (Source: The Journal of Thoracic and Cardiovascular Surgery) MedWorm Message: Watch the new...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 16 Dec 2010 11:00:00 pm
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Myasthenia Gravis - news item 49 of 139
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Assembly of MHC Class II Molecules [Immunology]
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The MHC is central to the adaptive immune response. The human MHC class II is encoded by three different isotypes, HLA-DR, -DQ, and -DP, each being highly polymorphic. In contrast to HLA-DR, the intracellular assembly and trafficking of HLA-DP molecules have not been studied extensively. However, different HLA-DP variants can...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 16 Dec 2010 11:00:00 pm
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Myasthenia Gravis - news item 50 of 139
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Plasma exchange vs. intravenous immunoglobulin for myasthenia gravis
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Source: Annals of Neurology Area: News A cohort study has examined the clinical and economic outcomes following plasma exchange (PLEX) and intravenous immunoglobulin (IVIG) in U.S. patients with myasthenia gravis (MG). Patients were identified for the study from the Nationwide Inpatient Sample database for 2000-2005. The following findings were reported: ....
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RSS Source: Med Worm - Myasthenia Gravis Thu, 16 Dec 2010 11:00:00 pm
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Myasthenia Gravis - news item 51 of 139
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Non-radioactive serological diagnosis of myasthenia gravis and clinical features of patients from Tianjin, China
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Abstract: Purpose: To establish non-radioactive assays for detection of antibodies (Abs) to the acetylcholine receptor (AChR) and to muscle specific kinase (MuSK). To show that the assays can be used in Tianjin for testing patients with MG.Method: AChR and MuSK Abs in 51 Chinese MG patients' sera were tested in...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 5 Dec 2010 11:00:00 pm
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Myasthenia Gravis - news item 52 of 139
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Myasthenia Gravis and Related Disorders
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series:Current Clinical NeurologyAdvances in the study and understanding of myasthenia gravis have led to the need for the publication of this important new edition. The goal of Myasthenia Gravis and Related Disorders, Second Edition is identical to the first -- to provide the clinician and the scientist with a common...
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RSS Source: Med Worm - Myasthenia Gravis Fri, 3 Dec 2010 11:08:13 pm
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Myasthenia Gravis - news item 53 of 139
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Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia
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This study was registered at http://clinicaltrials.gov as NCT00001355. (Source: Blood)
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RSS Source: Med Worm - Myasthenia Gravis Wed, 1 Dec 2010 11:00:00 pm
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Myasthenia Gravis - news item 54 of 139
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Expanding the evidence base for therapeutics in myasthenia gravis
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(Source: Annals of Neurology)
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RSS Source: Med Worm - Myasthenia Gravis Tue, 30 Nov 2010 11:00:00 pm
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Myasthenia Gravis - news item 55 of 139
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Early Aggressive Treatment Strategy against Myasthenia Gravis
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Eur Neurol 2011;65:16†22 (DOI:10.1159/000322497) (Source: Karger Publishers) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Myasthenia Gravis Mon, 29 Nov 2010 10:00:00 pm
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Myasthenia Gravis - news item 56 of 139
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Maternal myasthenia gravis complicated by fetal arthrogryposis multiplex congenita
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We report the management of a 24-year-old primigravid woman who was diagnosed with myasthenia gravis at 20weeks of gestation. Maternal symptoms improved with therapeutic plasma exchange, steroids, immunoglobulin therapy and pyridostigmine. Despite this, the fetus had arthrogryposis multiplex congenita due to trans-placental transfer of anti-acetylcholine receptor antibodies. The baby was...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 28 Nov 2010 11:00:00 pm
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Myasthenia Gravis - news item 57 of 139
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Shape Variability of Potentials Recorded by a Single-Fiber Electrode and its Effect on Jitter Estimation.
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This study aims (1) to measure the variability observed in RT of a large number of sets of consecutive potentials recorded by a single-fiber (SF) electrode and (2) to evaluate the effect of such variability on the jitter estimation. Using a SF electrode, 140 sets of consecutive potentials were recorded...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 24 Nov 2010 11:00:00 pm
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Myasthenia Gravis - news item 58 of 139
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Association with HLA DQ of early onset myasthenia gravis in Southeast Texas region of the United States
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This report finds common ground with European studies regarding MuSK association; however similarities in association for typical early onset disease resembled HLA risk factors in East Asia and Southern Europe. (Source: International Journal of Immunogenetics)
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RSS Source: Med Worm - Myasthenia Gravis Wed, 24 Nov 2010 11:00:00 pm
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Myasthenia Gravis - news item 59 of 139
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Congenital fibre type disproportion associated with mutations in the tropomyosin 3 (TPM3) gene mimicking congenital myasthenia
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We report the clinico-pathological and electrophysiological features of 2 unrelated cases with heterozygous TPM3 mutation. Case1 is a 19-year-old lady who presented with motor delay in infancy, respiratory failure in early teens requiring non-invasive ventilation despite being ambulant, ptosis, axial more than proximal weakness and scoliosis. Case 2 is a...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 24 Nov 2010 5:52:47 am
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Myasthenia Gravis - news item 60 of 139
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Identification of Corynebacterium diphtheriae gene involved in adherence to epithelial cells.
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In conclusion, the disruption of the C. diphtheriae DIP1621 gene led to decreased adherence to epithelial cells; its exact function remains to be established. PMID: 21111065 [PubMed - as supplied by publisher] (Source: Infection, Genetics and Evolution) MedWorm Message: Watch the new MedWorm demo and find out how to get...
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RSS Source: Med Worm - Myasthenia Gravis Mon, 22 Nov 2010 11:00:00 pm
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Myasthenia Gravis - news item 61 of 139
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Multiple Sclerosis Drug Serves As Model For Potential Drugs To Treat Botulism Poisoning
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Scientists are reporting that variants of a drug already approved for treating multiple sclerosis show promise as a long sought treatment for victims of bioterrorist attack with botulinum neurotoxin - which is 10,000 times deadlier than cyanide and the most poisonous substance known to man. The potential drugs also could...
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RSS Source: Med Worm - Myasthenia Gravis Fri, 19 Nov 2010 9:00:00 am
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Myasthenia Gravis - news item 62 of 139
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Comparison of muscle ultrastructure in myasthenia gravis with anti-MuSK and anti-AChR antibodies
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Abstract Patients with myasthenia gravis (MG) with antibodies to muscle-specific receptor tyrosine kinase (MuSK) differ from acetylcholine receptor (AChR)-positive MG patients, as they frequently present with severe oculobulbar muscle weakness or with neck, shoulder, and respiratory muscle involvement. The neuromuscular junction (NMJ) has been confirmed to be the main target...
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RSS Source: Med Worm - Myasthenia Gravis Fri, 19 Nov 2010 6:27:27 am
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Myasthenia Gravis - news item 63 of 139
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Efficacy of postural techniques assessed by videofluoroscopy for myasthenia gravis with dysphagia as the presenting symptom: a case report
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Conclusion: Videofluoroscopy is a valuable technique for evaluating myasthenia gravis dysphagia because swallowing interventions can be precisely individualized in accordance with the results obtained. (Source: BioMed Central)
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RSS Source: Med Worm - Myasthenia Gravis Thu, 18 Nov 2010 11:00:00 pm
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Myasthenia Gravis - news item 64 of 139
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The MGâ€QOL15 for following the healthâ€related quality of life of patients with myasthenia gravis
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AbstractThe MGâ€QOL15 is helpful in informing the clinician about the patient's perception of the extent of and dissatisfaction with myasthenia gravis (MG)â€related dysfunction. The aims of this study were to determine the usefulness of the MGâ€QOL15 for following individuals with MG and to guide clinical researchers who plan to use...
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RSS Source: Med Worm - Myasthenia Gravis Mon, 15 Nov 2010 11:00:00 pm
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Myasthenia Gravis - news item 65 of 139
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Clinical diagnosis and different management of acquired myasthenia gravis in a Pekingese
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This report focuses on the clinical diagnosis and treatment of this disease in a Pekingese using alternative dosages than those published in the literature. A 7-year-old Pekingese-crossbreed bitch was diagnosed with generalized acquired myasthenia gravis without any signs of megaesophagus based on physical examination, clinical signs, and response to IV...
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RSS Source: Med Worm - Myasthenia Gravis Mon, 15 Nov 2010 5:14:44 pm
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Myasthenia Gravis - news item 66 of 139
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Clinical and immunological differences between early and late-onset myasthenia gravis in Japan
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We examined several autoantibodies and HLA-DRB1 genotyping in 260 Japanese MG patients. Sixty-two MG patients had thymoma. The others were divided into early-onset and late-onset groups separated by an age of 50years. The ocular form was more frequent in late-onset compared to early-onset group. Seropositivity of anti-muscle-specific tyrosine kinase antibody...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 14 Nov 2010 11:00:00 pm
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Myasthenia Gravis - news item 67 of 139
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Quality of life and life circumstances in German myasthenia gravis patients
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Conclusion: Results indicate that despite prolonged life expectancy among MG patients, health-related quality of life is low. This outcome resulted mainly from impaired mobility and depression. Physical and mental well-being might be improved by additional therapy options. Additionally, health care resources could be used more efficiently in these patients. (Source:...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 10 Nov 2010 11:00:00 pm
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Myasthenia Gravis - news item 68 of 139
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Management of Myasthenic Patients with Thymoma
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Myasthenia gravis (MG) associated with thymomas differs from nonthymomatous MG, and thymomas associated with MG are also different from non-MG thymomas. According to the World Health Organization classification, the incidence of MG in thymomas was the highest in the subtypes B2, B1, and AB. Transsternal approach is still regarded as...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 10 Nov 2010 5:46:31 pm
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Myasthenia Gravis - news item 69 of 139
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Diagnosis and Management of Autoimmune Myasthenia Gravis
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(Source: Clinical Drug Investigation)
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RSS Source: Med Worm - Myasthenia Gravis Wed, 10 Nov 2010 1:05:56 am
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Myasthenia Gravis - news item 70 of 139
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The CD45 77C/G allele is not associated with myasthenia gravis - a reassessment of the potential role of CD45 in autoimmunity
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Conclusions: The 77C/G mutation does not predispose to MG, and its role in autoimmunity may have to be re-evaluated. (Source: BMC Research Notes)
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RSS Source: Med Worm - Myasthenia Gravis Tue, 9 Nov 2010 11:00:00 pm
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Myasthenia Gravis - news item 71 of 139
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Comparative analysis of therapeutic options used for myasthenia gravis
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AbstractObjectiveTo compare clinical and economic outcomes following plasma exchange (PLEX) and intravenous immunoglobulin (IVIG) in U.S. patients with primary diagnoses of myasthenia gravis (MG).MethodsOur cohort was identified from the Nationwide Inpatient Sample database for years 2000†2005 using codes from the International Classification of Diseases, 9th edition. Multivariate regression analyses...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 7 Nov 2010 11:00:00 pm
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Myasthenia Gravis - news item 72 of 139
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Anti-cytokine vaccination in autoimmune diseases.
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Authors: Delavallée L, Duvallet E, Semerano L, Assier E, Boissier MC The concept of therapeutic vaccination represents a novel strategy of active immunotherapy that can be applied to autoimmune disease. The principle is to design molecules which can trigger an immune response, targeting a cytokine that is pathogenic and over-expressed...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 3 Nov 2010 5:55:12 pm
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Myasthenia Gravis - news item 73 of 139
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Five-year follow-up with low-dose tacrolimus in patients with myasthenia gravis
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Abstract: Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junction, and prednisolone (PSL) and immunosuppressive drugs are available for treatment. Tacrolimus, a macrolide that suppresses the immune system, is used as a second-line treatment for MG. There have been several reports of the effects of tacrolimus over...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 31 Oct 2010 11:00:00 pm
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Myasthenia Gravis - news item 74 of 139
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Erosive Pustular Dermatosis of the Scalp and Leg Associated with Myasthenia Gravis: A Possible Pathogenetic Role for Neutrophil-stimulating Cytokines and Chemokines.
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Authors: Sawada Y, Bito T, Kawakami C, Shimauchi T, Nakamura M, Tokura Y PMID: 21057760 [PubMed - in process] (Source: Acta Dermato-Venereologica)
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RSS Source: Med Worm - Myasthenia Gravis Sun, 31 Oct 2010 11:00:00 pm
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Myasthenia Gravis - news item 75 of 139
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A 75â€yearâ€old caucasian man with unusual presentation of myasthenia gravis
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(Source: Journal of the American Geriatrics Society)
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RSS Source: Med Worm - Myasthenia Gravis Sun, 31 Oct 2010 11:00:00 pm
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Myasthenia Gravis - news item 76 of 139
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Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L [Research Papers]
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Agrin, released by motor neurons, promotes neuromuscular synapse formation by stimulating MuSK, a receptor tyrosine kinase expressed in skeletal muscle. Phosphorylated MuSK recruits docking protein-7 (Dok-7), an adaptor protein that is expressed selectively in muscle. In the absence of Dok-7, neuromuscular synapses fail to form, and mutations that impair Dok-7...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 31 Oct 2010 11:00:00 pm
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Myasthenia Gravis - news item 77 of 139
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The susceptibility of Aire(-/-) mice to experimental myasthenia gravis involves alterations in regulatory T cells.
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Authors: Aricha R, Feferman T, Scott HS, Souroujon MC, Berrih-Aknin S, Fuchs S The autoimmune regulator (Aire) is involved in the prevention of autoimmunity by promoting thymic expression of tissue restricted antigens which leads to elimination of self-reactive T cells. We found that Aire knockout (KO) mice as well as...
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RSS Source: Med Worm - Myasthenia Gravis Tue, 26 Oct 2010 11:00:00 pm
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Myasthenia Gravis - news item 78 of 139
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Extreme gigantomastia in pregnancy: case report†my experience with two cases in last 5 years
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We present an extreme case of gigantomastia in pregnancy during the second gemelar pregnancy of a 30-year-old woman. Her first pregnancy was 8 years ago, was also gemelar and she delivered with caesarean section. From the beginning of her current pregnancy, the patient noted steady growth of both of her...
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RSS Source: Med Worm - Myasthenia Gravis Tue, 26 Oct 2010 3:45:59 pm
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Myasthenia Gravis - news item 79 of 139
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Invasive Spindle Cell Thymomas (WHO Type A): A Clinicopathologic Correlation of 41 Cases.
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This study stresses the fact that histologic features do not correlate with invasion or encapsulation because all thymomas, regardless of their histologic type, are capable of invasion. PMID: 20959663 [PubMed - in process] (Source: American Journal of Clinical Pathology)
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RSS Source: Med Worm - Myasthenia Gravis Mon, 25 Oct 2010 9:20:52 pm
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Myasthenia Gravis - news item 80 of 139
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Muscle Specific Kinase: organiser of synaptic membrane domains.
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Authors: Ghazanfari N, Fernandez KJ, Murata Y, Morsch M, Ngo ST, Reddel SW, Noakes PG, Phillips WD Muscle Specific Kinase (MuSK) is a transmembrane tyrosine kinase vital for forming and maintaining the mammalian neuromuscular junction (NMJ: the synapse between motor nerve and skeletal muscle). MuSK expression switches on during skeletal...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 21 Oct 2010 10:00:00 pm
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Myasthenia Gravis - news item 81 of 139
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PONM23 The falling incidence of ITU admission in myasthenia gravis: does the early introduction of immunosuppression save lives?
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The Greater Manchester Neuroscience Centre serves a population of 3.5 million. Between 1998 and 2009, 25 patients were admitted to the ITU with exacerbations of myasthenia gravis (MG), excluding those relating to thymectomy. We reviewed these patients to identify changes in MG treatment prior to admission that might explain these...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 21 Oct 2010 10:00:00 pm
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Myasthenia Gravis - news item 82 of 139
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PONM20 Should acetylcholine receptor antibody requesting be restricted to hospital clinicians? No difference demonstrated in the proportion of positive assay results between primary and secondary care
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Conclusion Perhaps surprisingly, we found no difference between positive acetylcholine receptor antibody assay results requested by different specialities. On the basis of this study we cannot recommend that Ach assay requests are restricted to secondary care services. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
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RSS Source: Med Worm - Myasthenia Gravis Thu, 21 Oct 2010 10:00:00 pm
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Myasthenia Gravis - news item 83 of 139
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PONM11 "The eyes have it": initial genetic screening in suspected congenital myasthenia
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The congenital myasthenic syndromes (CMS) are a heterogenous group of inheritable disorders of neuromuscular transmission. Screening each of the eight genes thus far identified as commonly causing CMS in every suspected patient would be inefficient. We propose a strategy for targeted initial screening, based on the ophthalmoplegia present. The four...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 21 Oct 2010 10:00:00 pm
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Myasthenia Gravis - news item 84 of 139
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PONM09 Thymectomy: its role in the management of myasthenia gravis
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Conclusion Thymectomy is commonly performed for MG and is associated with a sustained improvement in the majority of our patients. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
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RSS Source: Med Worm - Myasthenia Gravis Thu, 21 Oct 2010 10:00:00 pm
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Myasthenia Gravis - news item 85 of 139
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PATU3 Autoantibodies in "seronegative" myasthenia gravis
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This study highlights the potential importance of cell based assays for diagnosis and management of MG. The detection of antibodies in early stages of disease suggests the initial autoimmune response may be dominated by low affinity antibodies. AV and her department receive royalties and payments for antibody assays. (Source: Journal...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 21 Oct 2010 10:00:00 pm
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Myasthenia Gravis - news item 86 of 139
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PATH49 Use of intravenous immunoglobulin by neurologists in the UK: reporting from year 1 of the DoH IVIG database
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Following a critical shortage of IVIG in the UK in 2006, the DoH commissioned a review of use. There was a perception that unlicensed indications for IVIG were proliferating without supportive clinical evidence, and that usage was increasing. The Demand Management Plan, Clinical Guidelines for IVIG use and the IVIG...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 21 Oct 2010 10:00:00 pm
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Myasthenia Gravis - news item 87 of 139
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Should asymptomatic enlarged thymus glands be resected?
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Objective: Patients frequently have an “enlarged thymus†incidentally identified on imaging. We sought to determine whether thymectomy is appropriate in patients with diffusely enlarged thymus glands.Methods: A retrospective review was conducted of patients undergoing thymectomy without myasthenia gravis at 1 institution over 15 years.Results: Of 117 patients undergoing thymectomy, 109...
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RSS Source: Med Worm - Myasthenia Gravis Mon, 18 Oct 2010 3:32:40 pm
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Myasthenia Gravis - news item 88 of 139
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Subclinical Myasthenia Gravis causing increased sensitivity to botulinum toxin therapy
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Abstract In rare patients receiving botulinum toxin (BT) therapy the potency of the BT drug may be increased by pre-existent impairment of neuromuscular transmission (INT). Appropriate dose adjustment may correct for this. Subclinical INT has previously been described by us for the first time in a patient with Lambert†Eaton...
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RSS Source: Med Worm - Myasthenia Gravis Sat, 16 Oct 2010 7:37:08 am
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Myasthenia Gravis - news item 89 of 139
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Lack of association of the CIITA -168A/G promoter SNP with Myasthenia gravis and its role in autoimmunity
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Conclusions: We thus conclude that previous findings with regard to the role of the CIITA -168A/G SNP in autoimmunity may have to be reconsidered. (Source: BMC Medical Genetics - Latest articles)
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RSS Source: Med Worm - Myasthenia Gravis Tue, 12 Oct 2010 10:00:00 pm
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Myasthenia Gravis - news item 90 of 139
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Using mouse cranial muscles to investigate neuromuscular pathology in vivo
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Abstract: Neuromuscular pathology is a classic hallmark of many diseases such as muscular dystrophy, myasthenia gravis, amyotrophic lateral sclerosis and spinal muscular atrophy. It is also a feature of many congenital and acquired myopathies and neuropathies such as diabetic neuropathy and toxin-exposure. The availability of experimentally accessible nerve†muscle preparations...
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RSS Source: Med Worm - Myasthenia Gravis Tue, 12 Oct 2010 6:32:01 pm
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Myasthenia Gravis - news item 91 of 139
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Medicinal leech therapy (hirudotherapy): a brief overview.
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Authors: Singh AP Hirudotherapy is a treatment using medicinal leeches. Hirudo medicinali, have been used to treat patients for centuries. In the past, leeches have proved to be an effective treatment for a number of conditions including battle wound treatment. Currently leeches may be used to assist in the treatment...
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RSS Source: Med Worm - Myasthenia Gravis Sat, 9 Oct 2010 6:00:31 pm
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Myasthenia Gravis - news item 92 of 139
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Benefits from sustained-release pyridostigmine bromide in myasthenia gravis: Results of a prospective multicenter open-label trial
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Abstract: Introduction: For more than 50years the acetylcholinesterase inhibitor pyridostigmine bromide has been the drug of choice in the symptomatic therapy for myasthenia gravis. The sustained-release dosage form of pyridostigmine (SR-Pyr) is only available in a limited number of countries (e.g. in the United States and Germany). Astonishingly, the therapeutic...
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RSS Source: Med Worm - Myasthenia Gravis Fri, 8 Oct 2010 11:02:49 pm
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Myasthenia Gravis - news item 93 of 139
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Treatment of Myasthenia Gravis
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Abstract Myasthenia gravis (MG) is an antibody-mediated, neuromuscular transmission disorder, which ranges in clinical manifestations of ocular myasthenia that may be visually disabling to myasthenic crisis with patients suffering life-threatening respiratory insufficiency. MG also has pathophysiologic subgroups based on presence or absence of acetylcholine receptor or muscle-specific kinase antibodies and...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 6 Oct 2010 3:46:38 pm
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Myasthenia Gravis - news item 94 of 139
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[A renal tumour with eosinophilic cells.]
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Authors: Torrents J, Marcy M, Souraud JB, Lafage-Pochitaloff M, Laibe S, Simonin O, Gravis G, Bladou F, Xerri L PMID: 21055532 [PubMed - as supplied by publisher] (Source: Annales de Pathologie)
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RSS Source: Med Worm - Myasthenia Gravis Thu, 30 Sep 2010 11:00:00 pm
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Myasthenia Gravis - news item 95 of 139
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[Articles] Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial
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Prostate cancer is the second most common cause of cancer death in men in the USA and the third most common cause of death in developed countries. For patients with metastatic prostate cancer, androgen deprivation therapy improves symptoms, but patients invariably develop progressive disease. On the basis of an improvement...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 30 Sep 2010 10:00:00 pm
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Myasthenia Gravis - news item 96 of 139
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A Non-invasive Thymoma that Occurred 29 Years After Complete Resection of a Non-invasive Thymoma Accompanied by a Microthymoma
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A 55-year-old woman with a 7 cm non-invasive thymoma and myasthenia gravis had been treated by extended thymectomy via median sternotomy 29 years ago. A microscopic 0.15 cm thymoma (microthymoma) was incidentally found in the thymus during surgery. Twenty-nine years later, a 5 cm thymoma developed in the anterior mediastinum...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 30 Sep 2010 12:07:37 pm
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Myasthenia Gravis - news item 97 of 139
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Extra thoracic Castleman’s disease associated with myasthenia gravis
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We report a patient with Castleman’s disease with myasthenia gravis who successfully underwent thymectomy for control of his symptoms. Content Type Journal ArticleDOI 10.1007/s12055-010-0056-2Authors Sumit Yadav, Department of Cardio Thoracic Surgery, The Townsville Hospital, 100 Angus Smith Drive, Douglas, Townsville, QLD Australia 4814Carl Lesic, Department of Cardio Thoracic Surgery, The...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 30 Sep 2010 7:00:20 am
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Myasthenia Gravis - news item 98 of 139
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Neurological manifestations of chronic graft-versus-host disease after allogeneic haematopoietic stem cell transplantation: report from the Consensus Conference on Clinical Practice in chronic graft-versus-host disease
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A major obstacle of allogeneic haematopoietic stem cell transplantation is graft-versus-host disease, an immune-mediated disorder that affects multiple tissues and organs with varying severity. Neurological complications of acute and chronic graft-versus-host disease are rare but can produce severe clinical problems with significant morbidity and mortality. In this article, we review...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 29 Sep 2010 3:34:19 pm
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Myasthenia Gravis - news item 99 of 139
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Naturally Occurring CD4+CD25+ Regulatory T Cells Prevent but Do Not Improve Experimental Myasthenia Gravis.
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Authors: Nessi V, Nava S, Ruocco C, Toscani C, Mantegazza R, Antozzi C, Baggi F In the current study, we investigated whether naturally occurring CD4(+)CD25(+) T cells, separated by immunomagnetic anti-CD4 and anti-CD25 Abs from naive animals, are able to protect from experimental autoimmune myasthenia gravis (EAMG) and modify the...
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RSS Source: Med Worm - Myasthenia Gravis Tue, 28 Sep 2010 10:00:00 pm
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Myasthenia Gravis - news item 100 of 139
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025 Guest Lecture
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Abstract: It is well recognised that diseases of the peripheral nervous system can be caused by autoantibodies and respond well to immunotherapies associated with a fall in antibody levels. The best examples are, of course, myasthenia gravis and the Lambert Eaton myasthenic syndrome with antibodies to the acetylcholine receptor and...
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RSS Source: Med Worm - Myasthenia Gravis Fri, 24 Sep 2010 2:41:34 pm
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Myasthenia Gravis - news item 101 of 139
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Undiminished regulatory t cells in the thymus of patients with myasthenia gravis
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(No abstract is available for this citation) (Source: Neurology)
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RSS Source: Med Worm - Myasthenia Gravis Mon, 20 Sep 2010 7:01:29 pm
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Myasthenia Gravis - news item 102 of 139
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Current approach to seronegative myasthenia
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Abstract The group of patients with weakness or fatigue who have electrophysiological evidence of neuromuscular transmission defects, but no antibodies against either acetyl choline receptor or muscle specific kinase, need special evaluation and therapeutic consideration. Such seronegative patients may have low affinity antibodies but may also be late onset of...
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RSS Source: Med Worm - Myasthenia Gravis Sat, 18 Sep 2010 4:49:21 am
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Myasthenia Gravis - news item 103 of 139
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Causes and Outcomes of Acute Neuromuscular Respiratory Failure [Original Contribution]
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Conclusions Among patients with neuromuscular respiratory failure, those without known diagnosis before admission have poorer outcomes. Patients whose diagnoses remain unclear at discharge have the highest rates of disability. (Source: Archives of Neurology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest,...
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RSS Source: Med Worm - Myasthenia Gravis Mon, 13 Sep 2010 6:50:49 pm
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Myasthenia Gravis - news item 104 of 139
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[Intravenous immune globulin (IVIG) for treatment of neurological diseases.]
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Authors: Vedeler CA, Mellgren SI, Omdal R, Torbergsen T, Aasly J Background. Highly purified IgG administered intravenously (IVIG) is used to treat many neurological diseases. Material and methods. This review is based on articles identified through a search in PubMed and the authors' knowledge and experience within the field. Results....
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RSS Source: Med Worm - Myasthenia Gravis Wed, 8 Sep 2010 10:00:00 pm
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Myasthenia Gravis - news item 105 of 139
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P2.40 Infantile onset anti-MUSK positive myasthenia gravis: report of two cases
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Discussion: Anti-MUSK positive myasthenia gravis also evident in early infancy. Ptosis without ophthalmoparesis, proximal weakness were the characteristic findings in our patients. (Source: Neuromuscular Disorders)
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RSS Source: Med Worm - Myasthenia Gravis Wed, 8 Sep 2010 5:54:44 am
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Myasthenia Gravis - news item 106 of 139
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Desperate for a Cure, One Physician Heals Himself
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Frustrated by lack of interest from drug companies, a Belgian doctor pursues own research to help cure his myasthenia gravis, a rare neurological condition. (Source: WSJ.com: Health)
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RSS Source: Med Worm - Myasthenia Gravis Wed, 1 Sep 2010 9:58:26 pm
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Myasthenia Gravis - news item 107 of 139
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Confusion and controversies in diagnosis and treatment of myasthenia
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Abstract (Source: Acta Ophthalmologica) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Myasthenia Gravis Tue, 31 Aug 2010 10:00:00 pm
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Myasthenia Gravis - news item 108 of 139
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CASE STUDY: Diagnostic challenge: Myasthenia gravis in the emergency department
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Abstract (Source: Journal of the American Academy of Nurse Practitioners)
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RSS Source: Med Worm - Myasthenia Gravis Tue, 31 Aug 2010 10:00:00 pm
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Myasthenia Gravis - news item 109 of 139
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Thoracoscopic Thymectomy
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Our experience with video-assisted thoracoscopic (VATS) thymectomy began in the late 1990s. This has evolved from our larger VATS experience with a wide array of other thoracic procedures. We are primarily utilizing the thoracoscopic approach in those patients with myasthenia gravis. Although there are a number of approaches (the classic...
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RSS Source: Med Worm - Myasthenia Gravis Tue, 31 Aug 2010 4:10:09 am
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Myasthenia Gravis - news item 110 of 139
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Gigantomastia and vulvar lactating adenoma in a patient with myasthenia during pregnancy
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We report the association of gigantomastia during pregnancy and a lactating adenoma in ectopic breast tissue of the vulva in a context of myasthenia in a 27-year-old primigravid woman. We discuss the pathophysiologic condition and management of gigantomastia that involves ectopic breast tissue during pregnancy. (Source: American Journal of Obstetrics...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 26 Aug 2010 10:00:00 pm
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Myasthenia Gravis - news item 111 of 139
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Hypomorphic Rag mutations can cause destructive midline granulomatous disease
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This study was registered at www.clinicaltrials.gov as #NCT00128973. (Source: Blood)
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RSS Source: Med Worm - Myasthenia Gravis Thu, 26 Aug 2010 3:02:32 pm
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Myasthenia Gravis - news item 112 of 139
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Coexistent of muscle specific tyrosine kinase and acetylcholine receptor antibodies in a myasthenia gravis patient
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Hamid Suhail, Subbiah Vivekanandhan, Sumit Singh, Madhuri BehariNeurology India 2010 58(4):668-669 (Source: Neurology India)
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RSS Source: Med Worm - Myasthenia Gravis Wed, 25 Aug 2010 5:51:58 am
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Myasthenia Gravis - news item 113 of 139
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Noninvasive Positive Airway Pressure in Hypercapnic Respiratory Failure in Noncardiac Medical Disorders
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This article discusses NIPPV in chronic obstructive pulmonary disease, cystic fibrosis, kyphoscoliosis, and neuromuscular disorders, including amyotrophic lateral sclerosis, Duchenne muscular dystrophy, myasthenia gravis, and postpolio syndrome. NIPPV is typically delivered by bilevel positive airway pressure (BPAP) or, in some cases, ventilatory support other than BPAP. (Source: Sleep Medicine Clinics)...
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RSS Source: Med Worm - Myasthenia Gravis Tue, 24 Aug 2010 8:32:09 am
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Myasthenia Gravis - news item 114 of 139
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A novel galectin-1 and interleukin 2 receptor β haplotype is associated with autoimmune myasthenia gravis
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Abstract: Galectin-1 (LGALS1) and interleukin receptor 2β (IL2Rβ) are regulators of T-cell activation. Here we evaluated the association of regulatory region polymorphisms of the LGALS1 (rs4820293, rs4820294) and IL2Rβ (rs743777, rs228941) genes in 146 Caucasian myasthenia gravis patients compared to 291 ethnically matched controls. A significant difference was found in...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 22 Aug 2010 11:00:00 pm
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Myasthenia Gravis - news item 115 of 139
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An increase in non-toxigenic Corynebacterium diphtheriae infections in Poland †molecular epidemiology and antimicrobial susceptibility of strains isolated from past outbreaks and those currently circulating in Poland
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Conclusions: The genetic similarity of non-toxigenic C. diphtheriae strains causing infection suggests that the strains represent a single clone. They may possess additional virulence genes in a chromosome, related with higher pathogenicity and invasiveness. The genetic changes have not been followed by resistance to antibiotics. (Source: International Journal of Infectious...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 22 Aug 2010 10:00:00 pm
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Myasthenia Gravis - news item 116 of 139
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Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis
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Conclusion: Thymoma cells of patients with and without MG express AQP4. AQP4 autoantibodies from serum of NMO patients bound to AQP4 expressed on thymoma cell membrane. (Source: Journal of Neuroimmunology)
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RSS Source: Med Worm - Myasthenia Gravis Sun, 22 Aug 2010 10:00:00 pm
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Myasthenia Gravis - news item 117 of 139
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Selective recognition and elimination of nicotinic acetylcholine receptor-reactive B cells by a recombinant fusion protein AChR-Fc in myasthenia gravis in vitro
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Abstract: AChR-reactive B cells play a key role in the pathogenesis of myasthenia gravis (MG) by producing autoantibodies. Selective elimination of AChR-reactive B cells will be a promising way to treat MG. Thus, we generated a fusion protein (referred to as AChR-Fc) composed of the human extracellular domain of AChR...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 19 Aug 2010 10:00:00 pm
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Myasthenia Gravis - news item 118 of 139
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Bilateral video-assisted thoracoscopic thymectomy has a surgical extent similar to that of transsternal extended thymectomy with more favorable early surgical outcomes for myasthenia gravis patients
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Conclusions The BVT was a safe procedure with a surgical extent and amount similar to those of T-3b thymectomy and less invasive for patients with MG. Long-term follow-up assessment and more extensive data are mandatory to verify the early surgical outcomes. Content Type Journal ArticleDOI 10.1007/s00464-010-1280-yAuthors Chang Young Lee, Department...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 19 Aug 2010 5:24:22 am
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Myasthenia Gravis - news item 119 of 139
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Twenty-one-year survival in an invasive thymoma successfully treated with seven-fold iterative surgery [Case report - Thoracic oncologic]
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We report a case of a 48-year-old patient with an initial diagnosis of myasthenia gravis who underwent radical thymectomy and adjuvant radiotherapy in 1988 for an invasive thymoma. Six years after the first operation the patient was submitted to re-iterative surgery (pleural recurrence) and, as of the period from 1994...
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RSS Source: Med Worm - Myasthenia Gravis Wed, 18 Aug 2010 3:18:25 pm
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Myasthenia Gravis - news item 120 of 139
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A Comparison of EMG and Muscle Biopsy in ICU Weakness
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Conclusions EMG and MB are complementary investigations. They agreed completely in four cases but in the rest of the cases there was uncertainty as to the primary process based on the results of electrophysiological studies. In only one case was there a clear discordance between electrophysiological studies and muscle biopsy....
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RSS Source: Med Worm - Myasthenia Gravis Wed, 18 Aug 2010 5:49:30 am
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Myasthenia Gravis - news item 121 of 139
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10th King's College Neuromuscular Disease Symposium (2010-11-26)
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This successful annual event continues, with an educational programme on clinical management of neuromuscular disease, including two talks each on Paediatric and Adult Muscle Disease, Neurophysiology, and Motor Neuron Disease. There will be talks on · Congenital myasthenia (<?xml:namespace prefix = st1 ns = "urn:schemas-microsoft-com:office:smarttags" /?><st1:place w:st=&q (Source: Institute of Psychiatry | Events)
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RSS Source: Med Worm - Myasthenia Gravis Tue, 17 Aug 2010 8:42:09 am
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Myasthenia Gravis - news item 122 of 139
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Gabapentin: Exacerbation of myasthenia gravis in an elderly patient: case report
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(Source: Reactions) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Myasthenia Gravis Mon, 16 Aug 2010 6:07:41 am
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Myasthenia Gravis - news item 123 of 139
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Unusual association of seronegative, nonparaneoplastic limbic encephalitis and relapsing polychondritis in a patient with history of thymectomy for myasthenia: a case study
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Content Type Journal ArticleDOI 10.1007/s00415-010-5691-4Authors KateÅ™ina Storey, Department of Neurology, Thomayer Teaching Hospital and Institute for Postgraduate Education in Medicine, VÃdeňská 800, 14059 Prague 4, Czech RepublicRadoslav MatÄ›j, Department of Pathology and Molecular Medicine, Thomayer Teaching Hospital, Prague, Czech RepublicRobert Rusina, Department of Neurology, Thomayer Teaching Hospital and Institute for...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 12 Aug 2010 5:33:56 pm
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Myasthenia Gravis - news item 124 of 139
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Myasthenia and related disorders of the neuromuscular junction
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Our understanding of transmission at the neuromuscular junction has increased greatly in recent years. We now recognise a wide variety of autoimmune and genetic diseases that affect this specialised synapse, causing muscle weakness and fatigue. These disorders greatly affect quality of life and rarely can be fatal. Myasthenia gravis is...
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RSS Source: Med Worm - Myasthenia Gravis Tue, 3 Aug 2010 1:31:24 pm
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Myasthenia Gravis - news item 125 of 139
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Visual and Systemic Outcomes in Pediatric Ocular Myasthenia Gravis
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Conclusions: In our series, 24% of patients had disease resolution and 23% had generalized symptoms. Our larger cohort confirms previous findings that treated and untreated pediatric patients with OMG have a relatively low risk of developing generalized symptoms and that related amblyopia is readily reversible. Although our treatments were more...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 1 Aug 2010 10:00:00 pm
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Myasthenia Gravis - news item 126 of 139
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Myasthenia Gravis†An Unexpected Cause of Respiratory Failure and Reversible Left Ventricular Dysfunction after Cardiac Surgery
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(Source: Journal of Cardiac Surgery)
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RSS Source: Med Worm - Myasthenia Gravis Sat, 31 Jul 2010 10:00:00 pm
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Myasthenia Gravis - news item 127 of 139
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Comment on myasthenia gravis associated with TNFâ€Î± receptor blockers: A multifaceted issue
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(Source: Muscle and Nerve) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Myasthenia Gravis Sat, 31 Jul 2010 10:00:00 pm
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Myasthenia Gravis - news item 128 of 139
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Pre†and postsynaptic neuromuscular junction abnormalities in musk myasthenia
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Abstract (Source: Muscle and Nerve)
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RSS Source: Med Worm - Myasthenia Gravis Sat, 31 Jul 2010 10:00:00 pm
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Myasthenia Gravis - news item 129 of 139
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IgG Fc N-Glycosylation Changes in Lambert-Eaton Myasthenic Syndrome and Myasthenia Gravis
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Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research)
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RSS Source: Med Worm - Myasthenia Gravis Sat, 31 Jul 2010 10:34:36 am
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Myasthenia Gravis - news item 130 of 139
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Flotros 20mg film-coated tablets (Trospium chloride) - New SPC
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Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Indicated for symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency as may occur in patients with overactive bladder (e.g. idiopathic or neurologic detrusor overactivity). In patients with severe kidney dysfunction (creatinine clearance between 10 and 30...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 29 Jul 2010 10:00:00 pm
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Myasthenia Gravis - news item 131 of 139
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---
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Myasthenia Gravis, and related disorders affecting transmission across the neuromuscular junction, represent diagnostic and treatment challenges. Recent epidemiological studies have shown that disease prevalence has increased since the 1950s in the US (NIH, The National Women's Health Centre, 2004). This is partly due to heightened awareness, better diagnostic methods and...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 25 Jul 2010 10:00:00 pm
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Myasthenia Gravis - news item 132 of 139
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Atorvastatin/simvastatin: Muscle weakness in a patient with myasthenia gravis: case report
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(Source: Reactions)
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RSS Source: Med Worm - Myasthenia Gravis Fri, 23 Jul 2010 4:32:26 am
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Myasthenia Gravis - news item 133 of 139
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On the frontline: What an optometrist needs to know about myasthenia gravis
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Conclusions: Because patients with undiagnosed myasthenia gravis may present initially with ocular signs or symptoms, it is important for the optometrist to be familiar with the condition and the simple “in-office†tests that can be performed to establish a tentative diagnosis and management plan. The optometrist can also participate in...
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RSS Source: Med Worm - Myasthenia Gravis Thu, 22 Jul 2010 10:00:00 pm
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Myasthenia Gravis - news item 134 of 139
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Predictors for good functional outcome after neurocritical care
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Conclusions: This investigation revealed that age, length of ventilation and TISS-28 on day one were strongly predictive for outcome. The diagnoses of hemorrhagic stroke and cerebral neoplasm leading to neurocritical care predispose for functional dependence or death, whereas patients with GBS and MG are more likely to recover after neurocritical...
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RSS Source: Med Worm - Myasthenia Gravis Mon, 19 Jul 2010 10:00:00 pm
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Myasthenia Gravis - news item 135 of 139
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Airway limitation and exercise intolerance in well-regulated myasthenia gravis patients.
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CONCLUSION: Well-regulated MG patients, especially those using pyridostigmine, tend to have an airway obstruction. The modest airway limitation might be a contributing factor to their fatigue. Patients who are not using acetylcholinesterase inhibitor seem to have diminished exercise endurance in spite of their clinically complete remission. PMID: 20586729 [PubMed -...
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RSS Source: Med Worm - Myasthenia Gravis Sun, 18 Jul 2010 7:15:03 am
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Myasthenia Gravis - news item 136 of 139
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Apolipoprotein-E genotypes and myasthenia gravis
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Hamid Suhail, Christhunesa C Soundararajan, Subbiah Vivekanandhan, Sumit Singh, Madhuri BehariNeurology India 2010 58(3):443-445Autoimmune myasthenia gravis (MG) is a disorder of neuromuscular junction. Possible role of multiple genes in the development of the MG has been documented. This case-control study, studied the association of apolipoprotein E (Apo-E) alleles with MG....
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RSS Source: Med Worm - Myasthenia Gravis Sun, 18 Jul 2010 5:05:06 am
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Myasthenia Gravis - news item 137 of 139
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Paralytic Strabismus: Third, Fourth, and Sixth Nerve Palsy
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This article reviews the key anatomic concepts, clinical presentation, differential diagnosis, and management of ocular motor nerve palsies. Dysfunction of an ocular motor nerve must be distinguished from other causes of abnormal eye movements, such as myasthenia gravis or thyroid eye disease, which are outside the scope of this article. (...
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RSS Source: Med Worm - Myasthenia Gravis Sat, 17 Jul 2010 5:04:10 am
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Myasthenia Gravis - news item 138 of 139
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Pyridostigmineâ€induced dystonic blepharospasm in a patient with ocular myasthenia gravis
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(Source: Movement Disorders)
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RSS Source: Med Worm - Myasthenia Gravis Wed, 14 Jul 2010 10:00:00 pm
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Myasthenia Gravis - news item 139 of 139
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In vivo adsorption of autoantibodies in myasthenia gravis using Nanodisc-incorporated acetylcholine receptor.
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In this study, we have successfully incorporated the AChR protein purified from Torpedo Californicus into a Nanodisc (ND) membrane scaffold protein/phospholipid structure. We go on to demonstrate the effectiveness of this ND-AChR complex, administered intravenously, in the in vivo down-modulation of anti-AChR antibodies and subsequent amelioration of clinical disease in...
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RSS Source: Med Worm - Myasthenia Gravis Tue, 13 Jul 2010 10:00:00 pm
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