Ovarian Cancer - news item 1 of 48
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Amidization of doxorubicin alleviates doxorubicin-induced contractile dysfunction and reduced survival in murine cardiomyocytes.
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Related Articles Amidization of doxorubicin alleviates doxorubicin-induced contractile dysfunction and reduced survival in murine cardiomyocytes. Toxicol Lett. 2008 May 30;178(3):197-201 Authors: Turdi S, Xu P, Li Q, Shen Y, Kerram P, Ren J Doxorubicin is an effective anthracycline used for cancer therapy. However, the clinical application of doxorubicin has been...
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RSS Source: Med Worm - Ovarian Cancer Thu, 15 May 2008 10:52:48 am
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Ovarian Cancer - news item 2 of 48
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Magnetic resonance (mr) imaging of suspected ovarian cancer
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BJOG: An International Journal of Obstetrics and Gynaecology, Volume 115, Issue 7, Page 811-813, June 2008. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
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RSS Source: Med Worm - Ovarian Cancer Wed, 14 May 2008 11:02:17 am
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Ovarian Cancer - news item 3 of 48
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A statement for extensive primary cytoreductive surgery in advanced ovarian cancer
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BJOG: An International Journal of Obstetrics and Gynaecology, Volume 115, Issue 7, Page 808-810, June 2008. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
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RSS Source: Med Worm - Ovarian Cancer Wed, 14 May 2008 11:00:25 am
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Ovarian Cancer - news item 4 of 48
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The accurate staging of ovarian cancer using 3t magnetic resonance imaging – a realistic option
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BJOG: An International Journal of Obstetrics and Gynaecology, Volume 115, Issue 7, Page 894-901, June 2008. Objectives The aim of the study was to determine whether staging primary ovarian cancer using 3.0 Tesla (3T) magnetic resonance imaging (MRI) is comparable to surgical staging of the disease.Design A retrospective study consisting of a...
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RSS Source: Med Worm - Ovarian Cancer Wed, 14 May 2008 11:00:00 am
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Ovarian Cancer - news item 5 of 48
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Hoxa11 dna methylation - a novel prognostic biomarker in ovarian cancer
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Epigenetic alterations play a major role in cancer. Recently we reported that stem cell Polycomb group targets (PcGTs) are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than nontargets. To identify potential, prognostic DNA methylation markers in ovarian cancer we analyzed the DNA methylation at 71 different...
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RSS Source: Med Worm - Ovarian Cancer Tue, 13 May 2008 4:00:00 am
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Ovarian Cancer - news item 6 of 48
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[medical_sciences] the basal-like mammary carcinomas induced by brca1 or bard1 inactivation implicate the brca1/bard1 heterodimer in tumor suppression
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Women with germ-line mutations of the BRCA1 tumor suppressor gene are highly susceptible to breast and ovarian cancer. The protein... (Source: Proceedings of the National Academy of Sciences)
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RSS Source: Med Worm - Ovarian Cancer Tue, 13 May 2008 4:00:00 am
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Ovarian Cancer - news item 7 of 48
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[genetics] genomic and epigenetic alterations deregulate microrna expression in human epithelial ovarian cancer
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MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that function as negative gene regulators. miRNA deregulation is involved... (Source: Proceedings of the National Academy of Sciences)
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RSS Source: Med Worm - Ovarian Cancer Tue, 13 May 2008 4:00:00 am
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Ovarian Cancer - news item 8 of 48
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Combined biomarkers may improve referrals of women at high risk for ovarian cancer.
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Page: 27DOI: 10.1097/01.COT.0000319878.86627.b3Authors: Victorian, Brande (Source: Oncology Times - Current Table Of Contents)
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RSS Source: Med Worm - Ovarian Cancer Mon, 12 May 2008 11:46:26 pm
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Ovarian Cancer - news item 9 of 48
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Bevacizumab plus paclitaxel/carboplatin is predicted to become the clinical gold-standard for advanced ovarian cancer in 2011
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(Source: Inpharma)
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RSS Source: Med Worm - Ovarian Cancer Mon, 12 May 2008 10:31:18 pm
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Ovarian Cancer - news item 10 of 48
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Cytoreductive surgery (peritonectomy procedures) combined with hyperthermic intraperitoneal chemotherapy (hipec) in the treatment of diffuse peritoneal carcinomatosis from ovarian cancer
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Because of scarce data from larger series and nonhomogeneous selection criteria, further information is needed on peritonectomy with hyperthermic intraperitoneal chemotherapy (HIPEC) in managing patients with ovarian peritoneal carcinomatosis.In an open, prospective, single-center nonrandomized phase 2 study conducted from November 2000 to April 2007, 47 patients with primary advanced or...
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RSS Source: Med Worm - Ovarian Cancer Mon, 12 May 2008 4:00:00 am
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Ovarian Cancer - news item 11 of 48
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Axillary lymph node metastasis from serous ovarian cancer: a case report and review of the literature
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Abstract Introduction The symptoms and findings of ovarian cancer are parallel with the degree of intra-abdominal expansion of the tumor. Metastases in the early stage occur by peritoneal fluid’s tracking via the circulatory system. Renal and cerebral metastases of ovarian cancer have been previously reported, but axillary lymph node metastasis is...
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RSS Source: Med Worm - Ovarian Cancer Sat, 10 May 2008 9:14:58 am
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Ovarian Cancer - news item 12 of 48
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Marshall edwards, inc.: extended accrual time and decreased sample size for ovature, a multinational phase iii clinical study for women with recurrent ovarian cancer
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SYDNEY, AUSTRALIA and LONDON and NEW CANAAN, CT (MARKET WIRE) The accrual time for the OVArian TUmor REsponse (OVATURE) clinical study, a Phase III study of the investigational chemosensitizing drug, phenoxodiol, has been extended to facilitate complete patient enrollment in the U.S., Europe, and Australia. Increasing the accrual period allowed...
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RSS Source: Med Worm - Ovarian Cancer Fri, 9 May 2008 12:28:00 pm
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Ovarian Cancer - news item 13 of 48
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Bipar sciences expands phase 2 clinical trials of bsi-201, a novel dna repair inhibitor, in ovarian cancer
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BiPar Sciences, Inc. announced the expansion of Phase 2 clinical trial programs for its lead product, BSI-201, in ovarian cancer. This is the third major clinical trial of BSI-201 that BiPar has launched in the past 6 months, expanding on on going trials in breast and brain cancer. (Source: Cancer /...
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RSS Source: Med Worm - Ovarian Cancer Fri, 9 May 2008 7:00:00 am
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Ovarian Cancer - news item 14 of 48
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Novel treatment of ovarian cancer cell lines with imatinib mesylate combined with paclitaxel and carboplatin leads to receptor-mediated antiproliferative effects
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Abstract Purpose Imatinib is a small molecule inhibiting the tyrosine kinases bcr-abl, c-kit, PDGFR-α and PDGFR-β. Investigations were performed to screen ovarian cancer cell lines and tumor samples for target receptor expression. Effects of Imatinib on cell proliferation and apoptosis induction were measured with and without additional cytotoxic agents. Methods Expression patterns...
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RSS Source: Med Worm - Ovarian Cancer Fri, 9 May 2008 6:24:16 am
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Ovarian Cancer - news item 15 of 48
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The early detection of ovarian cancer: from traditional methods to proteomics. can we really do better than serum ca-125?
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Related Articles The early detection of ovarian cancer: from traditional methods to proteomics. Can we really do better than serum CA-125? Am J Obstet Gynecol. 2008 May 9; Authors: Nossov V, Amneus M, Su F, Lang J, Janco JM, Reddy ST, Farias-Eisner R Ovarian cancer is the leading cause of...
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RSS Source: Med Worm - Ovarian Cancer Fri, 9 May 2008 4:00:00 am
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Ovarian Cancer - news item 16 of 48
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Two cases of pregnant women with ovarian endometrioma mimicking a malignant ovarian tumor
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The detection of an ovarian mass during pregnancy is often a diagnostic challenge. We describe 2 cases of ovarian endometrioma during pregnancy with marked mural nodules on the cyst wall. The sonographic and MR imaging findings mimicked ovarian cancer. Surgical intervention may still be inevitable to exclude the possibility of...
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RSS Source: Med Worm - Ovarian Cancer Fri, 9 May 2008 4:00:00 am
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Ovarian Cancer - news item 17 of 48
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[mechanisms of signal transduction] activation of klf8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells
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KLF8 (Krüppel-like factor 8) is a transcription factor downstream of focal adhesion kinase (FAK) important in the regulation of the cell cycle and also plays a critical role in oncogenic transformation and epithelial to mesenchymal transition. Here we report the mechanisms by which FAK regulates KLF8 expression in human ovarian...
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RSS Source: Med Worm - Ovarian Cancer Fri, 9 May 2008 4:00:00 am
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Ovarian Cancer - news item 18 of 48
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Optimal chemotherapy negates obesity effect on ovarian cancer survival
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Determining the impact of obesity on ovarian cancer overall survival and progression-free survival in the context of optimal chemotherapy dosage. (Source: MedWire News - Ob/Gyn)
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RSS Source: Med Worm - Ovarian Cancer Fri, 9 May 2008 12:00:00 am
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Ovarian Cancer - news item 19 of 48
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A pilot study evaluating the efficacy and toxicity of biweekly gemcitabine and pegylated liposomal doxorubicin in recurrent platinum-resistant epithelial ovarian cancer
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Abstract Background Both gemcitabine and pegylated liposomal doxorubicin (PLD) are antineoplastic drugs with clinical activity in patients with platinum-resistant ovarian cancer. The present study was designed to assess the efficacy and safety of biweekly scheduled gemcitabine and PLD combination therapy in such patients. Methods Eighteen women with ovarian cancer that had recurred...
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RSS Source: Med Worm - Ovarian Cancer Thu, 8 May 2008 5:45:54 am
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Ovarian Cancer - news item 20 of 48
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Mortality benefits of smoking cessation - vascular risk drops early, most excess risk gone by 20 years
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There is a significant reduction in the risk of early death within a few years of stopping smoking, according to a long-term analysis of a large epidemiological study, and after 20 years most of the excess risk has disappeared. Smoking is the greatest preventable cause of early death and disability...
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RSS Source: Med Worm - Ovarian Cancer Thu, 8 May 2008 12:00:00 am
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Ovarian Cancer - news item 21 of 48
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Fertility drugs and risk of ovarian cancer: dispelling the myth.
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Page: 313DOI: 10.1097/GCO.0b013e3282fdc6c3Authors: Zreik, Tony G a,b; Ayoub, Chakib M c; Hannoun, Antoine a; Karam, Cynthia J a; Munkarah, Adnan R d (Source: Current Opinion in Obstetrics and Gynecology)
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RSS Source: Med Worm - Ovarian Cancer Wed, 7 May 2008 9:26:02 pm
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Ovarian Cancer - news item 22 of 48
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Coexisting endometrial and ovarian carcinomas: a retrospective clinicopathological study.
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Related Articles Coexisting endometrial and ovarian carcinomas: A retrospective clinicopathological study. Pathol Res Pract. 2008 May 7; Authors: Caldarella A, Crocetti E, Taddei GL, Paci E The purpose of this study was to characterize patients diagnosed with synchronous primary carcinomas of the endometrium and ovary. Between 1985 and 2002, 46...
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RSS Source: Med Worm - Ovarian Cancer Wed, 7 May 2008 4:00:00 am
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Ovarian Cancer - news item 23 of 48
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A possible link between the pubertal growth of girls and ovarian cancer in their daughters
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At puberty, the distance between the iliac crests of the female pelvis, measured by the intercristal and interspinous diameters, increases rapidly. This is mainly controlled by estrogens. We have followed up 6,370 women who were born in Helsinki during 1934-1944, and whose mothers' pelvic bones were measured during routine antenatal...
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RSS Source: Med Worm - Ovarian Cancer Tue, 6 May 2008 4:00:00 am
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Ovarian Cancer - news item 24 of 48
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Original contribution: smoking and smoking cessation in relation to mortality in women
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Context Smoking is associated with an increased risk of total and cause-specific death, but the rate of mortality risk reduction after quitting compared with continuing to smoke is uncertain. There is inadequate or insufficient evidence to infer the presence or absence of a causal relationship between smoking and ovarian cancer...
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RSS Source: Med Worm - Ovarian Cancer Tue, 6 May 2008 4:00:00 am
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Ovarian Cancer - news item 25 of 48
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Continuing prognosis improvement encouraging in ovarian cancer
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Determining how the chances of survival among ovarian cancer patients changes after treatment. (Source: MedWire News - Ob/Gyn)
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RSS Source: Med Worm - Ovarian Cancer Tue, 6 May 2008 12:00:00 am
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Ovarian Cancer - news item 26 of 48
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Phase i toxicity and pharmacology study of trimethylcolchicinic acid in patients with advanced malignancies
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Summary A phase I study of trimethylcolchicinic acid (TMCA) given orally once daily for 5 days every 3rd week was performed in 19 patients with advanced malignancies. Myelosuppression and mucositis were the major toxicities observed. Serum TMCA levels were monitored and appear to be useful in predicting toxicities. A partial response...
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RSS Source: Med Worm - Ovarian Cancer Mon, 5 May 2008 7:55:41 pm
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Ovarian Cancer - news item 27 of 48
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Mitomycin c cross-resistance induced by adriamycin in human ovarian cancer cells in vitro
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Summary We prepared Adriamycin-resistant cancer cells by exposing an ovarian serous cystadenocarcinoma cell line to the drug. The resistant cells also showed cross-resistance to a wide variety of other compounds, including vincristine, vinblastine, actinomycin D, daunorubicin, mitomycin C and carboquone. Against vincristine, the cells showed a >5,000-fold increase in resistance, far...
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RSS Source: Med Worm - Ovarian Cancer Mon, 5 May 2008 7:55:28 pm
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Ovarian Cancer - news item 28 of 48
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Proteolix initiates phase 2 clinical trial of carfilzomib in patients with relapsed solid tumors
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SOUTH SAN FRANCISCO, Calif. -- Proteolix, Inc. today announced that patient dosing has commenced in a Phase 2 clinical trial of carfilzomib (PR-171), a selective blocker of proteasome activity, in relapsed solid tumors. A Phase 1b dose-escalation trial of carfilzomib in patients with advanced solid tumors has recently been completed....
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RSS Source: Med Worm - Ovarian Cancer Fri, 2 May 2008 5:00:00 am
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Ovarian Cancer - news item 29 of 48
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New ovarian cancer quality of care study findings have been reported by scientists at national cancer institute
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A report, 'A prospective study of risk-reducing salpingo-oophorectomy and longitudinal CA-125 screening among women at increased genetic risk of ovarian cancer: design and baseline characteristics: a gynecologic oncology group study,' is newly published data in Cancer Epidemiology, Biomarkers & Prevention. According to a study from the United States, "Women who...
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RSS Source: Med Worm - Ovarian Cancer Fri, 2 May 2008 5:00:00 am
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Ovarian Cancer - news item 30 of 48
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Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy.
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Related Articles Dihydroartemisinin Induces Apoptosis and Sensitizes Human Ovarian Cancer Cells to Carboplatin Therapy. J Cell Mol Med. 2008 May 2; Authors: Chen T, Li M, Zhang R, Wang H The present study was designed to determine the effects of artemisinin and its derivatives on human ovarian cancer cells, to...
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RSS Source: Med Worm - Ovarian Cancer Fri, 2 May 2008 4:00:00 am
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Ovarian Cancer - news item 31 of 48
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Dna repair gene ercc2 polymorphisms and associations with breast and ovarian cancer risk
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Breast and ovarian cancers increased in the last decades. Except rare cases with a genetic predisposition and high penetrance, these pathologies are viewed as a polygenic disease. In this concept, association studies look for genetic variations such as polymorphisms in low penetrance genes, i.e. genes in interaction with environmental factors....
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RSS Source: Med Worm - Ovarian Cancer Fri, 2 May 2008 4:00:00 am
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Ovarian Cancer - news item 32 of 48
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Clear cell ovarian cancer 'portends poorer survival'
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Determining how the prognosis of clear cell ovarian cancer differs to that of other cell types. (Source: MedWire News - Ob/Gyn)
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RSS Source: Med Worm - Ovarian Cancer Fri, 2 May 2008 12:00:00 am
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Ovarian Cancer - news item 33 of 48
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Cathepsin b mediates the ph-dependent proinvasive activity of tumor-shed microvesicles.
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Related Articles Cathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles. Neoplasia. 2008 May;10(5):481-8 Authors: Giusti I, D'Ascenzo S, Millimaggi D, Taraboletti G, Carta G, Franceschini N, Pavan A, Dolo V Vesicles shed by cancer cells are known to mediate several tumor-host interactions. Tumor microenvironment may, in turn, influence...
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RSS Source: Med Worm - Ovarian Cancer Thu, 1 May 2008 4:00:00 am
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Ovarian Cancer - news item 34 of 48
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Rules of tumor cell development and their application to biomarkers for ovarian cancer.
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Related Articles Rules of tumor cell development and their application to biomarkers for ovarian cancer. Oncol Nurs Forum. 2008 May;35(3):403-9 Authors: McLemore MR, Miaskowski C, Aouizerat BE, Chen LM, Dodd M Purpose/Objectives: To apply the Hanahan and Weinberg conceptual framework for tumor development to the specific biomarkers observed or expressed...
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RSS Source: Med Worm - Ovarian Cancer Thu, 1 May 2008 4:00:00 am
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Ovarian Cancer - news item 35 of 48
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Dietary patterns and risk of ovarian cancer in the california teachers study cohort.
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Related Articles Dietary patterns and risk of ovarian cancer in the california teachers study cohort. Nutr Cancer. 2008 May-Jun;60(3):285-91 Authors: Chang ET, Lee VS, Canchola AJ, Dalvi TB, Clarke CA, Reynolds P, Purdie DM, Stram DO, West DW, Ziogas A, Bernstein L, Horn-Ross PL Previous studies have examined the association...
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RSS Source: Med Worm - Ovarian Cancer Wed, 30 Apr 2008 10:10:38 pm
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Ovarian Cancer - news item 36 of 48
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Distribution of p53 expression in tissue from 774 danish ovarian tumour patients and its prognostic significance in ovarian carcinomas . from the danish "malova" ovarian cancer study
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APMIS, Volume 116, Issue 5, Page 400-9, May 2008. Høgdall EVS, Christensen L, Høgdall CK, Frederiksen K, Gayther S, Blaakaer J, Jacobs IJ, Kjaer SK. Distribution of p53 expression in 774 Danish ovarian tumour patients and its prognostic significance in ovarian carcinomas. APMIS 2008;116:400–9.The ... (Source: APMIS)
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RSS Source: Med Worm - Ovarian Cancer Wed, 30 Apr 2008 3:23:01 pm
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Ovarian Cancer - news item 37 of 48
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Breast cancer in women suffering from serious mental illness.
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Breast cancer in women suffering from serious mental illness. Schizophr Res. 2008 Apr 30; Authors: Barak Y, Levy T, Achiron A, Aizenberg D BACKGROUND: Breast cancer is a major public health concern and the most common cause of cancer-related mortality among women. Compared with the general population, schizophrenia patients have...
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RSS Source: Med Worm - Ovarian Cancer Wed, 30 Apr 2008 4:00:00 am
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Ovarian Cancer - news item 38 of 48
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Body size and risk of epithelial ovarian and related cancers: a population-based case-control study
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Different subtypes of ovarian cancer appear to have different causes; however, the association between body mass index (BMI) and the different subtypes is unclear. We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study...
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RSS Source: Med Worm - Ovarian Cancer Wed, 30 Apr 2008 4:00:00 am
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Ovarian Cancer - news item 39 of 48
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Receiving inconclusive genetic test results: an interpretive description of the brca1/2 experience
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We examined the experience of 21 women diagnosed with breast or ovarian cancer who received inconclusive BRCA1/2 genetic test results. Although these women received similar information on the technical meaning of an inconclusive result, their interpretations of personal risk for a probable, inherited cancer mutation differed. Their interpretations ranged from...
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RSS Source: Med Worm - Ovarian Cancer Wed, 30 Apr 2008 4:00:00 am
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Ovarian Cancer - news item 40 of 48
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Complementary and alternative medicine use among women at increased genetic risk of breast and ovarian cancer
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Background: Complementary and alternative medicine (CAM) use is well documented among breast cancer patients and survivors, but little evidence is available to describe rates and patterns of use among women at increased genetic risk of breast cancer. Methods: A pre-visit telephone interview was conducted to ascertain CAM use among the...
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RSS Source: Med Worm - Ovarian Cancer Wed, 30 Apr 2008 4:00:00 am
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Ovarian Cancer - news item 41 of 48
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Ovarian cancer chemotherapy suboptimal in the elderly
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Examining whether elderly women with advanced ovarian cancer in the USA receive prompt and adequate chemotherapy. (Source: MedWire News - Ob/Gyn)
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RSS Source: Med Worm - Ovarian Cancer Wed, 30 Apr 2008 12:00:00 am
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Ovarian Cancer - news item 42 of 48
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Metastatic ovarian cancer to the palate: the first reported case.
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Related Articles Metastatic ovarian cancer to the palate: The first reported case. Otolaryngol Head Neck Surg. 2008 May;138(5):692-3 Authors: Yu K, Reisacher W PMID: 18439484 [PubMed - in process] (Source: Otolaryngology - Head and Neck Surgery)
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RSS Source: Med Worm - Ovarian Cancer Tue, 29 Apr 2008 8:46:05 pm
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Ovarian Cancer - news item 43 of 48
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Protein nanoparticles as drug carriers in clinical medicine.
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Related Articles Protein nanoparticles as drug carriers in clinical medicine. Adv Drug Deliv Rev. 2008 May 22;60(8):876-85 Authors: Hawkins MJ, Soon-Shiong P, Desai N Solvent-based delivery vehicles for chemotherapy agents have been instrumental in providing a means for hydrophobic agents to be administered intravenously. These solvents, however, have been associated...
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RSS Source: Med Worm - Ovarian Cancer Tue, 29 Apr 2008 9:02:31 am
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Ovarian Cancer - news item 44 of 48
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Risk of breast cancer and gynecologic cancers in a large population of nearly 50,000 infertile danish women.
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Risk of Breast Cancer and Gynecologic Cancers in a Large Population of Nearly 50,000 Infertile Danish Women. Am J Epidemiol. 2008 Apr 29; Authors: Jensen A, Sharif H, Olsen JH, Kjær SK Infertility is considered to influence the risk of breast cancer and gynecologic cancers. To assess this association, the...
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RSS Source: Med Worm - Ovarian Cancer Tue, 29 Apr 2008 4:00:00 am
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Ovarian Cancer - news item 45 of 48
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Rise in lymphadenectomy for ovarian cancer 'only marginally affected survival'
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Examining changes in the use of lymphadenectomy for the treatment of early-stage ovarian cancer over time and the impact on survival. (Source: MedWire News - Ob/Gyn)
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RSS Source: Med Worm - Ovarian Cancer Tue, 29 Apr 2008 12:00:00 am
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Ovarian Cancer - news item 46 of 48
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Black tea linked to reduced ovarian cancer
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Women drinking two or more cups of black tea a day has a 30% reduction in risk of ovarian cancer (Source: Nursing in Practice)
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RSS Source: Med Worm - Ovarian Cancer Mon, 28 Apr 2008 8:41:51 am
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Ovarian Cancer - news item 47 of 48
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Does body mass index affect progression-free or overall survival in patients with ovarian cancer? results from scotroc i trial
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Background: Previous studies have indicated an association between obesity and poor survival in several tumour types, including ovarian cancer. We sought to test the hypothesis that obesity reduces survival in a large, well-characterised and relatively homogeneous cohort of ovarian cancer patients. Patients and methods: The relationship between body mass index (...
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RSS Source: Med Worm - Ovarian Cancer Mon, 28 Apr 2008 4:00:00 am
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Ovarian Cancer - news item 48 of 48
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Potential role of mir-9 and mir-223 in recurrent ovarian cancer
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Background: MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression by binding to target mRNAs. miRNAs have not been comprehensively studied in recurrent ovarian cancer, yet an incurable disease. Results: Using real-time RT-PCR, we obtained distinct miRNA expression profiles between primary and recurrent serous papillary ovarian adenocarcinomas (n=6)...
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RSS Source: Med Worm - Ovarian Cancer Mon, 28 Apr 2008 4:00:00 am
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