Ovarian Cancer - news item 1 of 135
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Diethylstilbestrol: Ovarian cancer following in utero exposure: case report
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(Source: Reactions)
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RSS Source: Med Worm - Ovarian Cancer Sun, 6 Mar 2011 4:02:10 pm
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Ovarian Cancer - news item 2 of 135
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Milk and the risk and progression of cancer.
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Authors: Rock CL Observational evidence suggests that nutritional factors contribute to a substantial proportion of cancer cases, and milk contains numerous bioactive substances that could affect risk and progression of cancer. Cancer results from multiple genetic and epigenetic events over time, so demonstrating a specific effect of nutrients or other...
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RSS Source: Med Worm - Ovarian Cancer Sun, 6 Mar 2011 12:45:03 pm
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Ovarian Cancer - news item 3 of 135
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The use of recombinant erythropoietin for the treatment of chemotherapyâ€induced anemia in patients with ovarian cancer does not affect progressionâ€free or overall survival
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CONCLUSIONS.The current results indicated that there was no difference in cancerâ€related PFS or OS with use of ESA in this cohort of women treated for ovarian cancer. Cancer 2011. © 2010 American Cancer Society. (Source: Cancer)
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RSS Source: Med Worm - Ovarian Cancer Fri, 4 Mar 2011 2:20:00 pm
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Ovarian Cancer - news item 4 of 135
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Aiming To Make Chemotherapy More Effective Against Ovarian Cancer
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York University researchers have zeroed in on a genetic process that may allow ovarian cancer to resist chemotherapy. Researchers in the university's Faculty of Science & Engineering studied a tiny strand of our genetic makeup known as a MicroRNA, involved in the regulation of gene expression. Cancer occurs when gene...
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RSS Source: Med Worm - Ovarian Cancer Fri, 4 Mar 2011 7:00:00 am
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Ovarian Cancer - news item 5 of 135
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Immunohistochemical and ultrastructural characterization of the ovarian surface epithelium of Japanese quail (Coturnix japonica)
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ABSTRACTContrary to humans, most ovarian tumors in other species do not arise from the ovarian surface epithelium but are of follicularâ€, stromal†or germâ€cell origin. One of the few species where ovarian cancer arises from the ovarian surface epithelium (OSE) is chicken (Gallus domesticus). Little is known about the morphology...
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RSS Source: Med Worm - Ovarian Cancer Thu, 3 Mar 2011 11:00:00 pm
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Ovarian Cancer - news item 6 of 135
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Cytotoxic Effect of Hyperthermia and Chemotherapy with Platinum Salt on Ovarian Cancer Cells: Results of an in vitro Study
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Eur Surg Res 2011;46:139†147 (DOI:10.1159/000324395) (Source: Karger Publishers) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Ovarian Cancer Thu, 3 Mar 2011 2:18:18 pm
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Ovarian Cancer - news item 7 of 135
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How ovarian cancer resists chemotherapy
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Researchers have zeroed in on a genetic process that may allow ovarian cancer to resist chemotherapy. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Ovarian Cancer Thu, 3 Mar 2011 2:52:43 am
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Ovarian Cancer - news item 8 of 135
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Review: Upper extremity DVT
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Source: N Engl J Med Area: News This Clinical Practice review covers deep-vein thrombosis (DVT) affecting the upper extremities. As usual, the author presents an example patient and uses this case to discuss the management based on current published evidence. The patient presented is a middle-aged lady who presents with...
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RSS Source: Med Worm - Ovarian Cancer Wed, 2 Mar 2011 11:00:00 pm
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Ovarian Cancer - news item 9 of 135
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Reactive lymphoid hyperplasia of liver mimicking late ovarian cancer recurrence: case report and literature review
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We describe a case of hepatic RLH which developed in a patient treated for ovarian cancer 11 years previously. Radiological features on computed tomography (CT) scan and PET†CT (positron emission tomography†computed tomography) were strongly suggestive of oncological disease, in contrast to magnetic resonance imaging (MRI); the volume increment...
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RSS Source: Med Worm - Ovarian Cancer Wed, 2 Mar 2011 6:09:29 am
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Ovarian Cancer - news item 10 of 135
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York U researchers uncovering how ovarian cancer resists chemotherapy
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(York University) York University researchers have zeroed in on a genetic process that may allow ovarian cancer to resist chemotherapy. (Source: EurekAlert! - Social and Behavioral Science)
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RSS Source: Med Worm - Ovarian Cancer Wed, 2 Mar 2011 4:00:00 am
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Ovarian Cancer - news item 11 of 135
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Influence of the family cluster effect on psychosocial variables in families undergoing BRCA1/2 genetic testing for cancer susceptibility
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Conclusions: Our results suggest that the family cluster effect influences the majority of behavioral and psychosocial variables. When studying psychosocial aspects of genetic testing for cancer susceptibility, the family cluster effect should be routinely accounted for when determining sample size and statistical methods. Copyright © 2011 John Wiley & Sons,...
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RSS Source: Med Worm - Ovarian Cancer Tue, 1 Mar 2011 11:00:00 pm
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Ovarian Cancer - news item 12 of 135
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Role of Extended Chemotherapy in Advanced Ovarian Cancer Patients with High Posttreatment Serum CA-125 Levels
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Gynecol Obstet Invest (DOI:10.1159/000322438) (Source: Karger Publishers)
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RSS Source: Med Worm - Ovarian Cancer Tue, 1 Mar 2011 4:07:55 pm
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Ovarian Cancer - news item 13 of 135
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A precursor microRNA in a cancer cell nucleus: Get me out of here!
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Authors: Melo SA, Esteller M In line with their broad-based effects, microRNAs (miRNAs), small non-coding RNA molecules ~22 nucleotides long that silence target mRNAs, are thought to act as oncogenes or tumor suppressor genes based on their inhibition of tumor-suppressive and oncogenic mRNAs, respectively. We and others previously showed that...
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RSS Source: Med Worm - Ovarian Cancer Tue, 1 Mar 2011 3:17:09 am
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Ovarian Cancer - news item 14 of 135
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[Articles] Association between miR-200c and the survival of patients with stage I epithelial ovarian cancer: a retrospective study of two independent tumour tissue collections
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miR-200c has potential as a predictor of survival, and is a biomarker of relapse, in stage I EOC. (Source: The Lancet Oncology)
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RSS Source: Med Worm - Ovarian Cancer Mon, 28 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 15 of 135
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[Comment] New terminology for cytoreduction in advanced ovarian cancer
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The goal of primary cytoreductive surgery for the treatment of advanced ovarian cancer (FIGO stages II†IV) should be to achieve a reduction to microscopic disease, as cytoreduction to nodules of less than 1 cm in maximum diameter is associated with a clear benefit in terms of overall survival compared...
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RSS Source: Med Worm - Ovarian Cancer Mon, 28 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 16 of 135
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[Comment] microRNAs in stage I epithelial ovarian cancer
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One could not have missed the buzz surrounding microRNAs (miRNAs). The short (about 21 nucleotides) RNA molecules are involved in tumorigenesis, and are thought to hold great promise as diagnostic or prognostic biomarkers. miRNAs might even have therapeutic potential, either through regulating the expression of crucial genes, or by being...
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RSS Source: Med Worm - Ovarian Cancer Mon, 28 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 17 of 135
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The therapeutic potential of targeting the EGFR family in epithelial ovarian cancer
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Authors: Q Sheng & J Liu (Source: British Journal of Cancer AOP) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Ovarian Cancer Mon, 28 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 18 of 135
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Impact on mortality and cancer incidence rates of using random invitation from population registers for recruitment to trials
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Conclusions: Recruitment to screening trials through invitation from population registers does not prevent a pronounced HVE on mortality. The impact on cancer incidence is much smaller. Similar shortfalls can be expected in other screening RCTs and it maybe prudent to use the various mortality and incidence rates presented as guides...
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RSS Source: Med Worm - Ovarian Cancer Mon, 28 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 19 of 135
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Incidence and mortality in epithelial ovarian cancer by family history of any cancer
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CONCLUSIONS:Fatal familial risks were higher for concordant ovarian, ovarianâ€breast, and ovarianâ€prostate cancers than the corresponding incident risks. This may suggest that highly fatal subtypes exist for these cancers, calling for genetic dissection. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)
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RSS Source: Med Worm - Ovarian Cancer Mon, 28 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 20 of 135
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Apoptin Gene Transfer via Modified Wheat Histone H4 Facilitates Apoptosis of Human Ovarian Cancer Cells
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Cancer Biotherapy & Radiopharmaceuticals Feb 2011, Vol. 26, No. 1: 121-126. (Source: Cancer Biotherapy and Radiopharmaceuticals)
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RSS Source: Med Worm - Ovarian Cancer Mon, 28 Feb 2011 9:23:23 pm
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Ovarian Cancer - news item 21 of 135
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Paclitaxel plus bevacizumab extends PFS in ovarian cancer
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Adding a bi-weekly dose of bevacizumab†an angiogenesis inhibitor†to weekly paclitaxel treatment for recurrent epithelial ovarian cancer significantly improves progression-free survival compared with paclitaxel treatment alone, report US researchers. (Source: MedWire News - Oncology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the...
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RSS Source: Med Worm - Ovarian Cancer Mon, 28 Feb 2011 3:00:23 pm
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Ovarian Cancer - news item 22 of 135
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Clinical Management of Hereditary Breast Cancer Syndromes
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Abstract Over the past 15 years there has been substantial improvement in the understanding of hereditary breast cancer. Germline genetic testing for mutations in BRCA1, BRCA2, PTEN and TP53 allows for the identification of individuals at increased risk for breast, ovarian and other cancers. Advances in screening, prevention and treatment...
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RSS Source: Med Worm - Ovarian Cancer Mon, 28 Feb 2011 5:39:52 am
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Ovarian Cancer - news item 23 of 135
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HRT in difficult circumstances: are there any absolute contraindications?
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Authors: Maclennan AH Many traditional contraindications to hormone replacement therapy (HRT) are based on the theoretical potential for these hormones to worsen a disease process and are rarely based on supporting data. This review addresses the available data and lack of data that make the prescription of HRT difficult in...
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RSS Source: Med Worm - Ovarian Cancer Sun, 27 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 24 of 135
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Sphingosine-1 phosphate Receptor (S1P1), a Critical Receptor Controlling Human Lymphocyte Trafficking, is Expressed in Hen and Human Ovaries and Ovarian Tumors.
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Conclusion: The results show that S1P1 is expressed in the hen and human ovary as well as in ovarian tumors. These findings support the use of the hen in further studies of the role of S1P1 in metastasis and immune cell trafficking in ovarian tumor development. (Source: Journal of Ovarian...
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RSS Source: Med Worm - Ovarian Cancer Sun, 27 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 25 of 135
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Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals
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Conclusions: In this study, mutations in previously known breast cancer susceptibility genes can explain 13.4% of the analyzed high-risk BRCA1/2-negative HBOC individuals. CHEK2 mutations, c.470T>C and c.1100delC, make a considerable contribution (12.2%) to these high-risk individuals but further segregation analysis is needed to evaluate the clinical significance of these mutations...
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RSS Source: Med Worm - Ovarian Cancer Sun, 27 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 26 of 135
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Genomics of the NF-κB signaling pathway: hypothesized role in ovarian cancer
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Conclusions Compelling evidence suggests that NF-κB plays a critical role in ovarian cancer, yet inherited variation in these genes has not been thoroughly assessed in relation to disease risk or outcome. We present a collection of variants in key genes and suggest creation of a custom genotyping array as an...
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RSS Source: Med Worm - Ovarian Cancer Sat, 26 Feb 2011 8:42:06 pm
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Ovarian Cancer - news item 27 of 135
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99mTc-MAA/90Y-Bremsstrahlung SPECT/CT after simultaneous Tc-MAA/90Y-microsphere injection for immediate treatment monitoring and further therapy planning for radioembolization
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Conclusion Combining RE and Re-MAA is feasible in appropriately selected patients. Content Type Journal ArticlePages 1-8DOI 10.1007/s00259-011-1751-yAuthors Hojjat Ahmadzadehfar, Department of Nuclear Medicine, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, GermanyAmir Sabet, Department of Nuclear Medicine, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, GermanyMarianne Muckle, Department of Nuclear Medicine, University...
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RSS Source: Med Worm - Ovarian Cancer Sat, 26 Feb 2011 2:18:57 pm
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Ovarian Cancer - news item 28 of 135
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My ongoing battle with ovarian cancer
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On the eve of Ovarian Cancer Awareness Month, Jane Kelly describes her battle to keep hope alive while, all around, specialists pile on the bad news. (Source: Telegraph Health)
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RSS Source: Med Worm - Ovarian Cancer Fri, 25 Feb 2011 4:46:35 pm
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Ovarian Cancer - news item 29 of 135
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Contrast-Enhanced Sonography Depicts Spontaneous Ovarian Cancer at Early Stages in a Preclinical Animal Model
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Conclusions— The laying hen may be a useful animal model for determining ovarian tumor-associated vascular kinetics diagnostic of early-stage ovarian cancer using a contrast agent. This model may also be useful for testing the efficacy of different contrast agents in a preclinical setting. (Source: Journal of Ultrasound in Medicine)
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RSS Source: Med Worm - Ovarian Cancer Thu, 24 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 30 of 135
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Immunotherapy for Ovarian Cancer: What's Next? [BIOLOGY OF NEOPLASIA]
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In the past decade, we have witnessed important gains in the treatment of ovarian cancer; however, additional advances are required to reduce mortality. With compelling evidence that ovarian cancers are immunogenic tumors, immunotherapy should be further pursued and optimized. The dramatic advances in laboratory and clinical procedures in cellular immunotherapy,...
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RSS Source: Med Worm - Ovarian Cancer Thu, 24 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 31 of 135
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GPs Take More Than A Month To Record Ovarian Cancer Diagnosis In One In 10 Cases, UK
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Family doctors can take more than a month to record ovarian cancer, once diagnosed by a specialist, in one in 10 cases, indicates research published in the launch issue of the new online journal BMJ Open. Ovarian cancer was also incorrectly or prematurely classified in 11% of cases, the data...
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RSS Source: Med Worm - Ovarian Cancer Thu, 24 Feb 2011 7:00:00 am
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Ovarian Cancer - news item 32 of 135
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Groundbreaking Australian Study Examines Treatment For Women With Ovarian Cancer
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A groundbreaking national study by the Queensland Institute of Medical Research (QIMR) and National Breast and Ovarian Cancer Centre (NBOCC) will provide the first national data about the treatment received by women diagnosed with ovarian cancer in Australia. "The study reviewed the treatment received by women in Australia with ovarian...
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RSS Source: Med Worm - Ovarian Cancer Thu, 24 Feb 2011 7:00:00 am
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Ovarian Cancer - news item 33 of 135
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Early-stage ovarian cancer management: still a challenge
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Content Type Journal ArticlePages 67-68DOI 10.1007/s12094-011-0619-8Authors Antonio González MartÃn, Medical Oncology Department, Centro Oncológico MD Anderson International, C/ Arturo Soria, 270, ES-28033 Madrid, Spain Journal Clinical and Translational OncologyOnline ISSN 1699-3055Print ISSN 1699-048X Journal Volume Volume 13 Journal Issue Volume 13, Number 2 (Source: Clinical and Translational Oncology)
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RSS Source: Med Worm - Ovarian Cancer Thu, 24 Feb 2011 6:38:03 am
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Ovarian Cancer - news item 34 of 135
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Platinum-based adjuvant chemotherapy on moderate- and high-risk stage I and II epithelian ovarian cancer patients. Long-term single institution experience and literature review
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Conclusions The long-term outcome of this series is comparable to the published evidence and reflects the limited activity of platinum-based CT in the adjuvant setting. The potential survival advantage of the addition of paclitaxel to carboplatin cannot be definitively answered due to the small number of patients, the limited follow-up...
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RSS Source: Med Worm - Ovarian Cancer Thu, 24 Feb 2011 6:37:56 am
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Ovarian Cancer - news item 35 of 135
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GPs take more than a month to record ovarian cancer diagnosis in one in 10 cases
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(BMJ-British Medical Journal) Family doctors can take more than a month to record ovarian cancer, once diagnosed by a specialist, in one in 10 cases, indicates research published in the launch issue of the new online journal BMJ Open. (Source: EurekAlert! - Medicine and Health)
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RSS Source: Med Worm - Ovarian Cancer Thu, 24 Feb 2011 4:00:00 am
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Ovarian Cancer - news item 36 of 135
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Prognostic and predictive relevance of CA-125 at primary surgery of ovarian cancer
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Conclusions Although CA-125 serum levels differ significantly before and after surgery in early and advanced-stage ovarian cancer and preoperative CA-125 values correlate with surgical outcome in advanced-stage disease, we could not determine a preoperative cutoff value for prediction of the surgical result. A prognostic relevance was only observed for postoperative...
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RSS Source: Med Worm - Ovarian Cancer Wed, 23 Feb 2011 11:07:34 pm
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Ovarian Cancer - news item 37 of 135
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GPs delay recording ovarian cancer diagnosis
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Study finds month long delays in GPs recording diagnosesRelated items from OnMedicaSymptoms don’t reliably predict ovarian cancerCancer drug fund announcedScotland reduces cancer waiting times but still misses target Smoking may worsen cancer painGuideline to help GPs spot cervical cancer early (Source: OnMedica Latest News)
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RSS Source: Med Worm - Ovarian Cancer Wed, 23 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 38 of 135
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A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice
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Abstract An N-ethyl-N-nitrosourea random mutation screen was used to identify recessive modifiers of gene silencing in the mouse using an epigenetically sensitive reporter transgene. One of the mutant lines, MommeR1, was identified as a suppressor of variegation and it showed female-specific age-associated infertility in homozygotes. Linkage analysis identified a region...
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RSS Source: Med Worm - Ovarian Cancer Wed, 23 Feb 2011 10:37:31 pm
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Ovarian Cancer - news item 39 of 135
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Usefulness of computed tomography in predicting cytoreductive surgical outcomes for ovarian cancer
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Conclusion Using specific CT findings from patients with ovarian cancer, we have devised two predictive models that have an accuracy of greater than 90% for predicting whether cytoreductive surgery will completely remove all tumor tissue, which should greatly aid in the differential decision-making as to whether to attempt cytoreductive surgery...
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RSS Source: Med Worm - Ovarian Cancer Wed, 23 Feb 2011 10:37:26 pm
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Ovarian Cancer - news item 40 of 135
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Identification of the Coexisting HER2 Gene Amplification and Novel Mutations in the HER2 Protein-Overexpressed Mucinous Epithelial Ovarian Cancer
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Conclusions HER2 protein overexpression correlated significantly with HER2 gene amplification in EOC (P = 0.027). It is surprising that all 4 cases of mucinous EOC showed HER2 gene amplification confirmed by FISH testing. However, we suppose that increasing the number of cases would possibly modify the results. This study also showed...
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RSS Source: Med Worm - Ovarian Cancer Wed, 23 Feb 2011 10:03:45 pm
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Ovarian Cancer - news item 41 of 135
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Wildâ€type p53 enhances Annexin IV gene expression in ovarian clear cell adenocarcinoma
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SummaryThe protein annexin IV (ANX4) is elevated specifically and characteristically in ovarian clear cell adenocarcinoma (CCA), a highly malignant histological subtype of epithelial ovarian cancer. Based on the hypothesis that the expression of ANX4 in CCA is regulated by a unique transcription mechanism, we explored the cisâ€elements involved in CCAâ€specific...
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RSS Source: Med Worm - Ovarian Cancer Wed, 23 Feb 2011 7:58:25 pm
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Ovarian Cancer - news item 42 of 135
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Onions and Garlic Prevent Kidney Cancer?
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In a study, participants consuming the most garlic had a 39 per cent reduced risk for cancer of the oral cavity and pharynx, 57 percent reduced risk for esophageal cancer, 26 per cent reduced risk for colorectal cancer, 44 per cent reduced risk for laryngeal cancer, 10 per cent reduced...
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RSS Source: Med Worm - Ovarian Cancer Wed, 23 Feb 2011 3:59:57 pm
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Ovarian Cancer - news item 43 of 135
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Ovarian cancer symptoms: What you need to know
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Ovarian cancer kills more than any other reproductive cancer but often goes undetected (Source: Health News: CBSNews.com)
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RSS Source: Med Worm - Ovarian Cancer Wed, 23 Feb 2011 1:38:27 pm
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Ovarian Cancer - news item 44 of 135
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Bevacizumab Ups PFS in Phase III OCEANS Ovarian Cancer Trial
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The Swiss pharmaceutical company Roche and Roche Group member Genentech have announced that addition of bevacizumab (Avastin) to chemotherapy improved progression-free survival over chemotherapy alone in the phase III OCEANS ovarian cancer study, meeting the study’s primary endpoint. (Source: Cancer Network) MedWorm Message: Watch the new MedWorm demo and find...
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RSS Source: Med Worm - Ovarian Cancer Wed, 23 Feb 2011 11:00:00 am
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Ovarian Cancer - news item 45 of 135
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Breastfeeding and Diabetes.
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In conclusion, breastfeeding could be considered a modifiable risk factor for the development of diabetes and even a potential protective lifestyle measure from future cardio-metabolic and malignant diseases. Therefore, health care professionals should encourage both women with and without diabetes to breastfeed their children. PMID: 21348815 [PubMed - as supplied...
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RSS Source: Med Worm - Ovarian Cancer Tue, 22 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 46 of 135
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Serum antiâ€glycan antibody detection of nonâ€mucinous ovarian cancers by using a printed glycan array
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AbstractEpithelial Ovarian cancer has the highest mortality rate among gynaecological cancers. Altered glycosylation is associated with oncogenic transformation producing tumorâ€associated carbohydrate antigens. We investigated the potential of natural occurring antiâ€glycan antibodies in the diagnosis of ovarian cancer by using printed glycan array.Antiâ€glycan antibodies bound to 203 chemically synthesized printed glycans...
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RSS Source: Med Worm - Ovarian Cancer Tue, 22 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 47 of 135
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Akt3 controls VEGF secretion and angiogenesis in ovarian cancer cells
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AbstractThe PI3 kinase/Akt pathway is commonly deregulated in human cancers, functioning in such processes as proliferation, glucose metabolism, survival and motility. We have previously described a novel function for one of the Akt isoforms (Akt3) in primary endothelial cells: the control of VEGFâ€induced mitochondrial biogenesis. We sought to determine if...
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RSS Source: Med Worm - Ovarian Cancer Tue, 22 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 48 of 135
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Ovarian cancer arising in endometrioid cysts: ultrasound findings
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ConclusionsBorderline tumors and carcinomas arising in endometrioid cysts show a vascularised solid component at ultrasound examination, and this figure was present in all malignant transformation. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. (Source: Ultrasound in Obstetrics and Gynecology)
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RSS Source: Med Worm - Ovarian Cancer Tue, 22 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 49 of 135
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Cancer predisposing BARD1 mutations in breast†ovarian cancer families
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Abstract The breast cancer susceptibility gene BARD1 (BRCA1-associated RING domain protein, MIM# 601593) acts with BRCA1 in DNA double-strand break (DSB) repair and also in apoptosis initiation. We screened 109 BRCA1/2 negative high-risk breast and/or ovarian cancer patients from North-Eastern Poland for BARD1 germline mutations using a combination of denaturing...
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RSS Source: Med Worm - Ovarian Cancer Tue, 22 Feb 2011 4:07:52 pm
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Ovarian Cancer - news item 50 of 135
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Red and processed meat consumption and risk of ovarian cancer: a dose-response meta-analysis of prospective studies
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Authors: A Wallin, N Orsini & A Wolk (Source: British Journal of Cancer AOP)
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RSS Source: Med Worm - Ovarian Cancer Mon, 21 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 51 of 135
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A genistein derivative, ITB-301, induces microtubule depolymerization and mitotic arrest in multidrug-resistant ovarian cancer
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Conclusion These results identify ITB-301 as a novel anti-tubulin agent that could be used in cancers that are multidrug resistant. We propose a structural model for the binding of ITB-301 to α- and β-tubulin dimers on the basis of molecular docking simulations. This model provides a rationale for future work...
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RSS Source: Med Worm - Ovarian Cancer Mon, 21 Feb 2011 3:57:24 pm
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Ovarian Cancer - news item 52 of 135
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Pleural Effusion Detected at CT prior to Primary Cytoreduction for Stage III or IV Ovarian Carcinoma: Effect on Survival [Genitourinary Imaging]
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Conclusion: Moderate-to-large pleural effusion on preoperative CT images in patients with stage III or IV epithelial ovarian cancer was independently associated with poorer overall survival after controlling for age, preoperative CA-125 level, surgical stage, ascites, and cytoreductive status. © RSNA, 2011 (Source: Radiology)
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RSS Source: Med Worm - Ovarian Cancer Sun, 20 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 53 of 135
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Anti-proliferative and pro-apoptotic actions of a novel human and mouse ovarian tumor-associated gene OTAG-12: downregulation, alternative splicing and drug sensitization
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Authors: X Chen, H Zhang, J P Aravindakshan, W H Gotlieb & M R Sairam (Source: Oncogene)
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RSS Source: Med Worm - Ovarian Cancer Sun, 20 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 54 of 135
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PhD Thesis On Two Genes Involved In Hereditary Breast And Ovary Cancer Cases Treated In The Basque Country
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Between 5 % and 10 % of breast cancer cases are hereditary, arising because the patient inherits from the father or mother a mutation in a gene that is susceptible to causing the illness. BRCA1 and BRCA2 have already been identified as two of the genes to be monitored. It is estimated...
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RSS Source: Med Worm - Ovarian Cancer Sat, 19 Feb 2011 8:00:00 am
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Ovarian Cancer - news item 55 of 135
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Sun Pharmaceutical Industries Europe B.V. Withdraws Its Marketing Authorisation Application For Topotecan SUN (Topotecan)
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The European Medicines Agency has been formally notified by Sun Pharmaceutical Industries B.V. of its decision to withdraw its application for a centralised marketing authorisation for the medicinal product Topotecan SUN (topotecan) 1 mg and 4 mg powder for concentrate for solution for infusion. The medicine was developed as a...
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RSS Source: Med Worm - Ovarian Cancer Fri, 18 Feb 2011 9:00:00 am
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Ovarian Cancer - news item 56 of 135
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Studying Therapy Response and Resistance in Mouse Models for BRCA1-Deficient Breast Cancer
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Abstract Worldwide, more than one million women are diagnosed with breast cancer every year, making it the most common malignancy of females in the developed world. Germline mutations in the breast cancer susceptibility genes BRCA1 and BRCA2 account for 4†6% of all breast cancer cases, and mutation carriers have...
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RSS Source: Med Worm - Ovarian Cancer Thu, 17 Feb 2011 4:02:59 pm
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Ovarian Cancer - news item 57 of 135
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In vitro antitumor mechanism of a novel cyclin-dependent kinase inhibitor CDKI-83
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In this study, we report the cellular mechanistic investigation of CDKI-83, a K i-nanomolar CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 μM, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determined by the activated caspase-3, Annexin...
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RSS Source: Med Worm - Ovarian Cancer Thu, 17 Feb 2011 4:00:53 pm
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Ovarian Cancer - news item 58 of 135
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Cancer Drug Better Than Laser Surgery For Baby Blindness
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Bevacizumab is becoming quite popular these days. Aside from treating ovarian cancer, it has been published this week that it also benefits premature infants suffering from blindness or retinopathy of prematurity and is less of a risk than laser surgery. Retinopathy of prematurity (ROP) is abnormal blood vessel development in...
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RSS Source: Med Worm - Ovarian Cancer Thu, 17 Feb 2011 3:00:00 pm
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Ovarian Cancer - news item 59 of 135
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Bevacizumab and its use in epithelial ovarian cancer
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Future Oncology , Ahead of Print, Pages 1-15. (Source: Future Oncology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Ovarian Cancer Thu, 17 Feb 2011 3:00:26 am
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Ovarian Cancer - news item 60 of 135
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[Non-Curable Tumours of the Female Genital Tract: Therapeutic Options in Bowel Stenosis and Bleeding.]
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CONCLUSION: In particular the dictum of "primum nihil nocere" has to be followed in consideration of the patient's declared intention, the patient's prognosis, general condition, psychological strain as well as the expected complications. PMID: 21332030 [PubMed - as supplied by publisher] (Source: Zentralblatt fur Chirurgie)
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RSS Source: Med Worm - Ovarian Cancer Wed, 16 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 61 of 135
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Prohibitin as a novel target protein of luteinizing hormone in ovarian epithelial carcinogenesis.
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Authors: Jia L, Yi XF, Zhang ZB, Zhuang ZP, Li J, Chambers SK, Kong BH, Zheng W <p>The exact role of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in ovarian epithelial carcinoma (OEC) development has not been yet characterized. This prompted us to identify particular proteins to better understand the...
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RSS Source: Med Worm - Ovarian Cancer Wed, 16 Feb 2011 5:15:03 pm
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Ovarian Cancer - news item 62 of 135
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Potential role of coregistered photoacoustic and ultrasound imaging in ovarian cancer detection and characterization.
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Authors: Aguirre A, Ardeshirpour Y, Sanders MM, Brewer M, Zhu Q Currently, there is no adequate technology to detect early stage ovarian cancers. Most of the cancers in the ovary are detected when the cancer has already metastasized to other parts of the body. As a result, ovarian cancer has...
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RSS Source: Med Worm - Ovarian Cancer Wed, 16 Feb 2011 8:00:16 am
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Ovarian Cancer - news item 63 of 135
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Targeting granzyme B to tumor cells using a yoked human chorionic gonadotropin
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Conclusions These results validate LHR as a therapeutic target and indicate that delivery of the human pro-apoptotic enzyme GrB to tumor cells by yoked hCG has substantial selectivity and therapeutic potential for human tumors that express high levels of LHR such as ovarian carcinomas. Content Type Journal ArticlePages 1-12DOI 10.1007/s00280-011-1573-4Authors...
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RSS Source: Med Worm - Ovarian Cancer Wed, 16 Feb 2011 6:01:40 am
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Ovarian Cancer - news item 64 of 135
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Genomic rearrangements of the BRCA1 gene in Chilean breast cancer families: an MLPA analysis
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Abstract Point mutations and small deletions and insertions in BRCA1 and BRCA2 genes are responsible of about 20% of hereditary breast cancer cases in Chilean population. Studies in other populations have identified the amplification and/or deletion of one or more exons in these genes as the cause of the disease....
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RSS Source: Med Worm - Ovarian Cancer Wed, 16 Feb 2011 5:55:05 am
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Ovarian Cancer - news item 65 of 135
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Retrospective study of the impact of pharmacogenetic variants on paclitaxel toxicity and survival in patients with ovarian cancer
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Conclusion CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correlated to overall survival, sensoric neuropathy, and neutropenia in 119 patients treated for ovarian cancer with paclitaxel/carboplatin. Content Type Journal ArticlePages 1-8DOI 10.1007/s00228-011-1007-6Authors Troels K. Bergmann, Clinical Pharmacology, Institute of Public Health, University of Southern Denmark,...
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RSS Source: Med Worm - Ovarian Cancer Wed, 16 Feb 2011 5:54:05 am
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Ovarian Cancer - news item 66 of 135
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Ovarian cancer stem cells and inflammation.
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Authors: Mor G, Yin G, Chefetz I, Yang Y, Alvero A Epithelial ovarian cancer (EOC) is the fourth leading cause of cancer-related deaths in women in the United States and the leading cause of gynecologic cancer deaths. The major limiting factor in the treatment of ovarian cancer is recurrence and...
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RSS Source: Med Worm - Ovarian Cancer Wed, 16 Feb 2011 5:45:10 am
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Ovarian Cancer - news item 67 of 135
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Longâ€term clinical and immunological effects of p53â€SLP® vaccine in ovarian cancer patients
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AbstractVaccineâ€induced p53â€specific immune responses were previously reported to be associated with improved response to secondary chemotherapy in small cell lung cancer patients. We investigated longterm clinical and immunological effects of the p53â€SLP® vaccine in recurrent ovarian cancer patients. Twenty patients were immunized with the p53â€SLP® vaccine between July 2006 and...
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RSS Source: Med Worm - Ovarian Cancer Tue, 15 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 68 of 135
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My tumour grew SIX centimetres in just SIX days
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Ovarian cancer is scarily easy to miss. But, as Sophie found, acting fast can be the difference between life and death. (Source: the Mail online | Health)
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RSS Source: Med Worm - Ovarian Cancer Tue, 15 Feb 2011 8:41:15 am
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Ovarian Cancer - news item 69 of 135
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Enhanced internalization of ErbB2 in SK-BR-3 cells with multivalent forms of an artificial ligand.
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In this report, we designed divalent and multivalent forms of EC-1 peptide with the Fc portion of the human IgG and bionanocapsule modified with ZZ-tag on its surface in order to improve the interaction with ErbB2. These forms showed higher affinity to ErbB2 than that of EC-1 monomer. Furthermore, prominent...
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RSS Source: Med Worm - Ovarian Cancer Mon, 14 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 70 of 135
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Spectrin αII and βII tetramers contribute to platinum anticancer drug resistance in ovarian serous adenocarcinoma
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AbstractTo overcome drug resistance in ovarian carcinoma, novel resistance mechanisms must be elucidated for clinical application. We purified 2 proteins in the 300 kDa range from cisplatinâ€resistant cells (NOS2CR2) by affinity chromatography with cisplatinâ€exposed Glutathione Sepharose 4B. The purified proteins were identified as spectrin αII and βII by peptide mass...
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RSS Source: Med Worm - Ovarian Cancer Mon, 14 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 71 of 135
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Sugars in diet and risk of cancer in the NIHâ€AARP diet and health study
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In this report, we investigated the association of total sugars, sucrose, fructose, added sugars, added sucrose and added fructose in the diet with risk of 24 malignancies. Participants (n = 435,674) aged 50†71 years from the NIHâ€AARP Diet and Health Study were followed for 7.2 years. The intake of individual...
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RSS Source: Med Worm - Ovarian Cancer Mon, 14 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 72 of 135
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Downregulation of cell surface CA125/MUC16 induces epithelial-to-mesenchymal transition and restores EGFR signalling in NIH:OVCAR3 ovarian carcinoma cells
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Downregulation of cell surface CA125/MUC16 induces epithelial-to-mesenchymal transition and restores EGFR signalling in NIH:OVCAR3 ovarian carcinoma cells British Journal of Cancer advance online publication, February 15, 2011. doi:10.1038/bjc.2011.34 Authors: M Comamala, M Pinard, C Thériault, I Matte, A Albert, M Boivin, J Beaudin, A Piché & C Rancourt (Source: British...
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RSS Source: Med Worm - Ovarian Cancer Mon, 14 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 73 of 135
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Randomized Phase III Clinical Trial Evaluating Weekly Cisplatin for Advanced Epithelial Ovarian Cancer
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This randomized, open label, phase III clinical trial (1988–1992) compared the efficacy and safety of a dose-dense regimen of single-agent cisplatin with a standard 3-weekly schedule in first-line chemotherapy for advanced epithelial ovarian cancer. Two hundred eighty-five patients were randomly assigned to the experimental dose-dense arm (cisplatin 50 mg/m2 weekly...
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RSS Source: Med Worm - Ovarian Cancer Mon, 14 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 74 of 135
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Identifying hypermethylated CpG islands using a quantile regression model
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Conclusions: In this paper, we propose to use a quantile regression model to identify hypermethylated CGIs by incorporating probe effects to account for noise due to unmeasurable factors. Our model can efficiently identify hypermethylated CGIs in both breast and ovarian cancer data. (Source: BMC Bioinformatics - Latest articles)
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RSS Source: Med Worm - Ovarian Cancer Mon, 14 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 75 of 135
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Enhanced internalization of ErbB2 in SKâ€BRâ€3 cells with multivalent forms of an artificial ligand
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In this report, we designed divalent and multivalent forms of ECâ€1 peptide with the Fc portion of the human IgG and bionanocapsule modified with ZZâ€tag on its surface in order to improve the interaction with ErbB2. These forms showed higher affinity to ErbB2 than that of ECâ€1 monomer. Furthermore, prominent...
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RSS Source: Med Worm - Ovarian Cancer Mon, 14 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 76 of 135
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Increased ovarian cancer risk associated with menopausal estrogen therapy is reduced by adding a progestin
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Source: DARE Area: Evidence > Medication Safety CRD Summary: The authors concluded that oestrogen therapy use increased ovarian cancer in a duration-dependent manner; adding progestins appeared to reduce this effect to some extent. The conclusions appeared to be supported by the evidence but the limited search, lack of reporting of review...
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RSS Source: Med Worm - Ovarian Cancer Mon, 14 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 77 of 135
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The MDM2 Promoter SNP285C/309G Haplotype Diminishes Sp1 Transcription Factor Binding and Reduces Risk for Breast and Ovarian Cancer in Caucasians
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Stian Knappskog, Merete Bjørnslett, Line M. Myklebust, Petra E.A. Huijts, Maaike P. Vreeswijk, Hege Edvardsen, Yongli Guo, Xuemei Zhang, Ming Yang, Sanna K. Ylisaukko-oja, Pia Alhopuro, Johanna Arola, Rob A.E.M. Tollenaar, Christi J. van Asperen, Caroline Seynaeve, Vidar Staalesen, Ranjan Chrisanthar, Erik Løkkevik, Helga B. Salvesen, D. Gareth Evans, William...
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RSS Source: Med Worm - Ovarian Cancer Mon, 14 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 78 of 135
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Ovarian cancer mortality linked to early adulthood BMI and weight gain
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High body mass index and weight gain during early adulthood are associated with increased mortality in ovarian cancer patients, say researchers. (Source: MedWire News - Ob/Gyn)
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RSS Source: Med Worm - Ovarian Cancer Mon, 14 Feb 2011 10:49:43 pm
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Ovarian Cancer - news item 79 of 135
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OXiGENE to Collaborate With NCI/CTEP, GOG on Phase 2 Study of ZYBRESTAT in Patients With Relapsed Ovarian Cancer
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SOUTH SAN FRANCISCO, Calif., Feb. 14, 2011 (GLOBE NEWSWIRE) -- OXiGENE, Inc. (Nasdaq:OXGN), a clinical-stage, biopharmaceutical company developing novel therapeutics to treat cancer and eye diseases, announced today that it has entered into a Cooperative Research and Development Agreement with the National Cancer Institute's (NCI) Cancer Therapy Evaluation Program (CTEP)...
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RSS Source: Med Worm - Ovarian Cancer Mon, 14 Feb 2011 12:00:00 pm
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Ovarian Cancer - news item 80 of 135
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Genetic counseling for patients and families with hereditary breast and ovarian cancer in a developing Asian country: an observational descriptive study
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Abstract Genetic counseling (GC) and genetic testing are vital risk management strategies in hereditary breast and ovarian cancer (HBOC) syndromes. Hitherto, cancer genetic testing amongst Asians has been described only in developed and high-income Asian countries. We studied the uptake and acceptance of GC and genetic testing services to Asian...
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RSS Source: Med Worm - Ovarian Cancer Mon, 14 Feb 2011 5:58:18 am
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Ovarian Cancer - news item 81 of 135
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Screening of 1331 Danish breast and/or ovarian cancer families identified 40 novel BRCA1 and BRCA2 mutations
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In conclusion, the mutation screening identified 40 novel variants in the BRCA1 and BRCA2 genes and thereby extends the knowledge of the BRCA1/BRCA2 mutation spectrum. Nineteen of the mutations were interpreted as pathogenic, 3 missense mutations were suggested to be pathogenic based on in silico analysis, 6 mutations were suggested...
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RSS Source: Med Worm - Ovarian Cancer Mon, 14 Feb 2011 5:58:17 am
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Ovarian Cancer - news item 82 of 135
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Assessing the information desire of patients with advanced cancer by providing information with a decision aid, which is evaluated in a randomized trial: a study protocol
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This study is a randomized controlled trial of patients with advanced colorectal, breast, or ovarian cancer who have started treatment with first-line palliative chemotherapy. The trial will consist of 100 patients in the decision aid group and 70 patients in the usual care group. To collect complete data of 170...
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RSS Source: Med Worm - Ovarian Cancer Sun, 13 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 83 of 135
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The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene
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Authors: X Zhang, J George, S Deb, J L Degoutin, E A Takano, S B Fox, D D L Bowtell & K F Harvey (Source: Oncogene) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Ovarian Cancer Sun, 13 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 84 of 135
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P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin
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Authors: L W T Cheung, A S C Mak, A N Y Cheung, H Y S Ngan, P C K Leung & A S T Wong (Source: Oncogene)
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RSS Source: Med Worm - Ovarian Cancer Sun, 13 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 85 of 135
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Role of Hypoxia and Glycolysis in the Development of Multi-Drug Resistance in Human Tumor Cells and the Establishment of an Orthotopic Multi-Drug Resistant Tumor Model in Nude Mice using Hypoxic Pre-Conditioning
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Conclusion: Hypoxic pre-conditiong and xenografting may be used to develop a multitude of orthotopic models for MDR cancer aiding in the study and treatment of the disease. (Source: Cancer Cell International)
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RSS Source: Med Worm - Ovarian Cancer Sun, 13 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 86 of 135
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Recreational Physical Activity and Ovarian Cancer Risk and Survival
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Conclusions: Our data provide weak evidence in support of beneficial effects of physical activity on ovarian cancer risk and survival, but results should be interpreted cautiously because of the lack of a clear dose response relation with higher levels of exercise and the likely misclassification of self-reported activity. (Source: Annals...
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RSS Source: Med Worm - Ovarian Cancer Sat, 12 Feb 2011 10:22:34 pm
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Ovarian Cancer - news item 87 of 135
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My Father's Heart: AÂ Son's Journey
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“i carry your heart (i carry it in my heart)†e. e. cummings In the ranks of “defining moments†in any life, the death of a parent is high on the list. The younger the child is when a parent dies, the larger the effect on the rest of life. I...
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RSS Source: Med Worm - Ovarian Cancer Sat, 12 Feb 2011 7:54:16 pm
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Ovarian Cancer - news item 88 of 135
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Nearly 25% of women with early ovarian cancer not given recommended biopsies
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More than one-quarter of women with apparent early-stage ovarian cancer don't receive recommended lymph node biopsies to check for cancer spread, ... (Source: USATODAY.com Health) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Ovarian Cancer Sat, 12 Feb 2011 5:00:02 pm
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Ovarian Cancer - news item 89 of 135
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Discovery may lead to turning back the clock on ovarian cancer
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Cancer researchers have discovered that a type of regulatory RNA may be effective in fighting ovarian cancer. This new discovery may allow physicians to turn back the clock of the tumor's life cycle to a phase where traditional chemotherapy can better do its job. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Ovarian Cancer Fri, 11 Feb 2011 9:00:00 am
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Ovarian Cancer - news item 90 of 135
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A patient presenting nasal septum perforation during bevacizumab-containing chemotherapy for advanced breast cancer.
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Authors: Petrelli F, Cabiddu M, Barbara C, Barni S Nasal septum perforation is a rare but described complication of the anti-angiogenetic agent bevacizumab. This is the case of a 48-year-old female breast cancer patient, who developed a nasal septum perforation during treatment with paclitaxel and bevacizumab for advanced disease. After...
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RSS Source: Med Worm - Ovarian Cancer Thu, 10 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 91 of 135
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Crk and CrkL present with different expression and significance in epithelial ovarian carcinoma
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In conclusion, these two highly homologous proteins hold features that allow for the differential association with each binding molecules, thereby activating different signaling pathways and being involved in diverse roles in ovarian cancer. Mol. Carcinog. © 2011 Wileyâ€Liss, Inc. (Source: Molecular Carcinogenesis)
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RSS Source: Med Worm - Ovarian Cancer Thu, 10 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 92 of 135
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Retrospective analysis on coexisting ovarian cancer in 976 patients with clinical stage I endometrial carcinoma
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Conclusion:  The incidence of coexisting ovarian cancer in clinical stage I endometrial carcinoma is low, but the decision for ovary preservation at the time of operation still needs to be made with caution because of occult ovarian metastasis, especially for patients with highâ€risk factors. (Source: Journal of Obstetrics and Gynaecology...
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RSS Source: Med Worm - Ovarian Cancer Thu, 10 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 93 of 135
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Lymphangioleiomyomatosis suspected to be a gynecologic disease
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We present a case of a 30â€yearâ€old Japanese female with abdominal pain during menstrual periods was suspected of having ovarian cancer due to exaggerated ascites observed at a local clinic. Subsequently, she was transferred to our hospital for further investigations, and was diagnosed with LAM. Three years after diagnosis, she...
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RSS Source: Med Worm - Ovarian Cancer Thu, 10 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 94 of 135
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miR-200 family microRNAs involved in ovarian cancer metastasis
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Chen J. Gynecol Oncol. 2011;doi:10.1016/j.ygyno.2010.12.339. (Source: HemOncToday.com)
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RSS Source: Med Worm - Ovarian Cancer Thu, 10 Feb 2011 4:49:00 pm
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Ovarian Cancer - news item 95 of 135
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A response to the forgotten fallopian tube
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Authors: David D. L. Bowtell, Michael Friedlander, Michael Quinn & Gillian Mitchell We thank Johannes Dietl and Jörg Wischhusen for their correspondence on the recent Opinion article (The genesis and evolution of high-grade serous ovarian cancer. Nature Rev. Cancer10, 803†808 (2010)) and agree with the authors (The forgotten (Source:...
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RSS Source: Med Worm - Ovarian Cancer Wed, 9 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 96 of 135
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The forgotten fallopian tube
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Authors: Johannes Dietl & Jörg Wischhusen In David D. L. Bowtell's recent Opinion article (The genesis and evolution of high-grade serous ovarian cancer. Nature Rev. Cancer10, 803†808 (2010)), a considerable body of evidence is presented which further supports the central role of (Source: Nature Reviews Cancer)
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RSS Source: Med Worm - Ovarian Cancer Wed, 9 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 97 of 135
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Avastin Extends Progression-Free Survival in Ovarian Cancer
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Roche has announced that its top-selling drug Avastin (bevacizumab) helps women with recurrent ovarian cancer live significantly longer without their disease getting worse, a late-stage trial showed, giving the troubled drug a much needed boost. Reuters Health Information (Source: Medscape ObGyn and Womens Health Headlines) MedWorm Message: Watch the new...
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RSS Source: Med Worm - Ovarian Cancer Wed, 9 Feb 2011 10:41:18 pm
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Ovarian Cancer - news item 98 of 135
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Third Phase III Study Of Avastin-Based Regimen Met Primary Endpoint In Ovarian Cancer
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Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), announced that OCEANS, a Phase III study evaluating Avastin® (bevacizumab) in combination with chemotherapy (carboplatin and gemcitabine) followed by continued use of Avastin alone until disease progression in women with previously treated (recurrent), platinum-sensitive ovarian cancer, met its...
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RSS Source: Med Worm - Ovarian Cancer Wed, 9 Feb 2011 7:00:00 am
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Ovarian Cancer - news item 99 of 135
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Ovarian Cancer Biomarkers for Molecular Biosensors and Translational Medicine
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This article presents a review of selected biomarkers from the past 20 years of ovarian cancer research which provide both diagnostic and prognostic promise. Expert Review of Molecular Diagnostics (Source: Medscape Today Headlines)
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RSS Source: Med Worm - Ovarian Cancer Wed, 9 Feb 2011 3:00:00 am
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Ovarian Cancer - news item 100 of 135
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Addition of bevacizumab to weekly paclitaxel significantly improves progression-free survival in heavily pretreated recurrent epithelial ovarian cancer.
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CONCLUSION: A significant increase in PFS with a trend towards improved OS was demonstrated in this heavily pretreated population treated with paclitaxel/bevacizumab as compared to weekly paclitaxel alone. This data should be helpful in guiding future trials to determine the optimal care for women with recurrent EOC. PMID: 21315428 [PubMed...
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RSS Source: Med Worm - Ovarian Cancer Tue, 8 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 101 of 135
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Evaluation of combined bevacizumab and intraperitoneal carboplatin or paclitaxel therapy in a mouse model of ovarian cancer
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Conclusions Following IP administration to mice, bevacizumab demonstrates rapid and near complete absorption. Bevacizumab therapy, initiated prior to IP carboplatin or paclitaxel administration, increased survival time significantly in mice, and results were not dependent on the route of bevacizumab administration (IV vs. IP). Content Type Journal ArticlePages 1-8DOI 10.1007/s00280-011-1566-3Authors Dhaval...
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RSS Source: Med Worm - Ovarian Cancer Tue, 8 Feb 2011 9:04:26 pm
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Ovarian Cancer - news item 102 of 135
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Avastin Proven To Battle Ovarian Cancer With Some Success
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A new Avastin study in recurrent, platinum-sensitive ovarian cancer showed women lived significantly longer without their disease getting worse. Bevacizumab (trade name Avastin) is a humanized monoclonal antibody that recognizes and blocks vascular endothelial growth factor A. VEGF-A is a chemical signal that stimulates the growth of new blood vessels (...
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RSS Source: Med Worm - Ovarian Cancer Tue, 8 Feb 2011 8:00:00 pm
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Ovarian Cancer - news item 103 of 135
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Avastin Maker Claims Ovarian Cancer Benefit
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(MedPage Today) -- The biological agent bevacizumab (Avastin) reduced the risk of ovarian cancer progression in women with one form of the disease, the drug's maker said. (Source: MedPage Today OB/GYN)
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RSS Source: Med Worm - Ovarian Cancer Tue, 8 Feb 2011 5:13:12 pm
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Ovarian Cancer - news item 104 of 135
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Roche's Avastin Gets a Trial Boost
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Roche said its cancer drug Avastin helped women suffering from ovarian cancer live longer without their disease worsening, raising the odds the medicine will win approval. (Source: WSJ.com: Health)
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RSS Source: Med Worm - Ovarian Cancer Tue, 8 Feb 2011 11:16:31 am
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Ovarian Cancer - news item 105 of 135
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Trial shows Avastin helps ovarian cancer patients live longer
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(Source: bizjournals.com Health Care:Physician Practices headlines)
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RSS Source: Med Worm - Ovarian Cancer Tue, 8 Feb 2011 4:00:00 am
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Ovarian Cancer - news item 106 of 135
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Overexpression of Pregnancy-Associated Plasma Protein-A in Ovarian Cancer Cells Promotes Tumor Growth in Vivo.
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In conclusion, our data show that PAPP-A proteolytic activity enhances the tumorigenic potential of ovarian cancer cells and establish a novel tumor growth-promoting role of PAPP-A. PMID: 21303951 [PubMed - as supplied by publisher] (Source: Endocrinology)
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RSS Source: Med Worm - Ovarian Cancer Mon, 7 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 107 of 135
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HE4 and CA125 as a diagnostic test in ovarian cancer: prospective validation of the Risk of Ovarian Malignancy Algorithm
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Authors: T Van Gorp, I Cadron, E Despierre, A Daemen, K Leunen, F Amant, D Timmerman, B De Moor & I Vergote (Source: British Journal of Cancer AOP)
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RSS Source: Med Worm - Ovarian Cancer Mon, 7 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 108 of 135
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Solitary Internal Mammary Lymph Node Metastases Detected by18F-FDG-PET/CT in Ovarian Cancer
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Case Rep Oncol 2011;4:60†67 (DOI:10.1159/000324486) (Source: Karger Publishers) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Ovarian Cancer Mon, 7 Feb 2011 2:16:33 pm
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Ovarian Cancer - news item 109 of 135
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Tumor immune surveillance and ovarian cancer
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Abstract In the past few years, cancer immunotherapies have produced promising results. Although traditionally considered unresponsive to immune therapy, increasing evidence indicates that ovarian cancers are, in fact, immunogenic tumors. This evidence comes from diverse epidemiologic and clinical data comprising evidence of spontaneous antitumor immune response and its association with...
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RSS Source: Med Worm - Ovarian Cancer Mon, 7 Feb 2011 5:39:46 am
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Ovarian Cancer - news item 110 of 135
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Hormone replacement therapy and some risk factors for breast cancer among Slovenian postmenopausal women.
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Conclusions?Our analysis revealed some differences from the previously published literature, which might reflect underlying demographic changes. Comprehensive medical care in HRT users without pre-existing breast abnormalities probably reduces the incidence of new breast cancer cases in Slovenia. PMID: 21294673 [PubMed - as supplied by publisher] (Source: Climacteric)
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RSS Source: Med Worm - Ovarian Cancer Sun, 6 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 111 of 135
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Functional roles of Src and Fgr in ovarian carcinoma.
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CONCLUSIONS: This study demonstrates that, in addition to Src, Fgr plays a biologically significant role in cancer growth and might represent an important target. PMID: 21300758 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research) MedWorm Message: Watch the new MedWorm demo and find out how to get all...
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RSS Source: Med Worm - Ovarian Cancer Sun, 6 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 112 of 135
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MHC class I-presented tumor antigens identified in ovarian cancer by immunoproteomic analysis are targets for T cell responses against breast and ovarian cancer.
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CONCLUSIONS: Mixtures of specific peptides identified as naturally presented on cancer cells and capable of activating tumor specific T cells in vitro also initiate or augment immune responses toward solid tumors in cancer patients. PMID: 21300761 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
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RSS Source: Med Worm - Ovarian Cancer Sun, 6 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 113 of 135
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Enhancive Effects of Lewis y Antigen on CD44-mediated Adhesion and Spreading of Human Ovarian Cancer Cell Line RMG-I.
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This study aimed to investigate the molecular structural relationship between cell adhesive molecule CD44 and Lewis y antigen, and determine the effects of Lewis y antigen on CD44-mediated adhesion and spreading of ovarian cancer cell line RMG-I and the Lewis y antigen-overexpressed cell line RMG-I-H. Methods: The expression of CD44...
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RSS Source: Med Worm - Ovarian Cancer Sun, 6 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 114 of 135
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E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression
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E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression Oncogene advance online publication, February 7, 2011. doi:10.1038/onc.2011.6 Authors: M-T Lau, C Klausen & P C K Leung (Source: Oncogene)
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RSS Source: Med Worm - Ovarian Cancer Sun, 6 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 115 of 135
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CA125 surveillance increases optimal resectability at secondary cytoreductive surgery for recurrent epithelial ovarian cancer.
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CONCLUSIONS: Each week delay after first CA125 elevation correlated with a 3% increased chance of suboptimal resection at SCS. Serial CA125 surveillance for early detection of recurrence may increase rates of optimal SCS and potentially influence overall survival. PMID: 21300398 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
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RSS Source: Med Worm - Ovarian Cancer Fri, 4 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 116 of 135
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'One in eight' will get breast cancer
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Breast cancer is now the UK’s most common form of cancer, according to new figures released by Cancer Research UK. The charity has chosen to highlight the scale of the disease in the UK to coincide with World Cancer Day, and it estimates that one in eight women will be...
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RSS Source: Med Worm - Ovarian Cancer Fri, 4 Feb 2011 3:55:00 pm
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Ovarian Cancer - news item 117 of 135
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Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with BORIS/CTCF expression ratio and advanced stage.
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CONCLUSIONS: DNA hypomethylation coordinately affects CG antigen gene promoters and specific repetitive DNA elements in EOC, and correlates with advanced stage disease. The BORIS/CTCF mRNA expression ratio is closely associated with DNA hypomethylation and confers poor prognosis in EOC. PMID: 21296871 [PubMed - as supplied by publisher] (Source: Clinical Cancer...
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RSS Source: Med Worm - Ovarian Cancer Thu, 3 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 118 of 135
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OCRF Research Finds Antibody Inhibits Development of Ovarian Cancer
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 OCRF Research Finds Antibody Inhibits Development of Ovarian Cancer OCRF Grantee Dr. Ernst LengyelThe purpose of this study was to understand the functional and preclinical efficacy of targeting the urokinase plasminogen activator receptor (u-PAR) in ovarian cancer.  U-Par is a protein that’s part of the plasminogen activation system, components of which have...
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RSS Source: Med Worm - Ovarian Cancer Thu, 3 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 119 of 135
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N-Glycosylation of total cellular glycoproteins from the human ovarian carcinoma SKOV3 cell line and of recombinantly expressed human erythropoietin
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In this study, a detailed structure analysis of the N-linked glycans from total glycoproteins from the SKOV3 ovarian carcinoma cell line and from a recombinantly expressed secretory glycoprotein, erythropoietin (EPO), produced from the same cells has been performed using high-performance anion exchange chromatography with pulsed amperometric detection and matrix-assisted laser...
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RSS Source: Med Worm - Ovarian Cancer Thu, 3 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 120 of 135
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The perils of a vanishing cohort: a study of social comparisons by women with advanced ovarian cancer
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Conclusions: We suggest that social comparisons made by women with ovarian cancer are influenced by specific clinical factors associated with their diagnosis†in particular, their status as a member of a ‘vanishing cohort’†and argue for further research examining the specific comparison needs and preferences of patients with advanced disease...
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RSS Source: Med Worm - Ovarian Cancer Thu, 3 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 121 of 135
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Ovarian Cancer Risks In African-American Women To Be Determined In New Clinical Trial
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University Hospitals Case Medical Center and Case Western Reserve University School of Medicine are conducting an important new study addressing the lack of knowledge about causes and risk factors for ovarian cancer in African American women. The five-year study is funded by the National Cancer Institute through Case Western Reserve...
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RSS Source: Med Worm - Ovarian Cancer Thu, 3 Feb 2011 9:00:00 am
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Ovarian Cancer - news item 122 of 135
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RNAi-mediated downregulation of NOB1 suppresses the growth and colony-formation ability of human ovarian cancer cells
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Abstract Nin one binding protein (NOB1p), encoded by the NOB1 gene, is a crucial molecule in the maturation of the 20S proteasome and protein degradation. The present study evaluates whether NOB1 is an appropriate molecular target for cancer gene therapy. In two ovarian cancer cell lines, SKOV3 and HEY, NOB1...
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RSS Source: Med Worm - Ovarian Cancer Thu, 3 Feb 2011 6:08:12 am
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Ovarian Cancer - news item 123 of 135
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OCRF Research Identifies New Therapeutic Target
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OCRF research illuminates role of protein in ovarian cancer, identifies new therapeutic target OCRF Grantee Dr. Rugang ZhangResearch funded in part by OCRF has illuminated the role protein EZH2 plays in ovarian cancer, and has identified the protein as a potential therapeutic target.  Drs. Andrew Godwin and Rugang Zhang, both recipients of...
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RSS Source: Med Worm - Ovarian Cancer Wed, 2 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 124 of 135
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The activated TGFâ€beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer
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AbstractPeritoneal dissemination including omental metastasis is the most frequent route of metastasis and an important prognostic factor in advanced ovarian cancer. We analyzed the publicly available microarray dataset (GSE2109) using binary regression and found that the TGFâ€beta signaling pathway was activated in omental metastases as compared to primary sites of...
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RSS Source: Med Worm - Ovarian Cancer Wed, 2 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 125 of 135
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Expression of ALDH and CD133 defines ovarian cancer stem cells
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AbstractIdentification of cancer stem cells is crucial for advancing cancer biology and therapy. Several markers including CD24, CD44, CD117, CD133, ABCG, ESA and ALDH are utilized to identify and investigate human epithelial cancer stem cells in the literature. We have now systemically analyzed and compared the expression of these markers...
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RSS Source: Med Worm - Ovarian Cancer Wed, 2 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 126 of 135
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Clinical Trials Update: Feb. 2, 2011
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Emphysema/COPD Alzheimer's Disease (Ages 50-89) Ovarian Cancer (Source: The Doctors Lounge - Health News) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Ovarian Cancer Wed, 2 Feb 2011 2:30:00 pm
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Ovarian Cancer - news item 127 of 135
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MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer [Research Communications]
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Post-transcriptional regulators have emerged as robust effectors of metastasis and display deregulated expression through unknown mechanisms. Here, we reveal that the human microRNA-335 locus undergoes genetic deletion and epigenetic promoter hypermethylation in every metastatic derivative obtained from independent patients’ malignant cell populations. Genetic deletion of miR-335 is a common event...
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RSS Source: Med Worm - Ovarian Cancer Tue, 1 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 128 of 135
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H.O.W. 'Time is of the Essence Luncheon' featured guest speakers Fran Drescher and Dr. Andrew Berchuck
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Recently, more than 270 supporters of Hearing the Ovarian Cancer Whisper (H.O.W.) attended the H.O.W. "Time is of the Essence Luncheon" at The Flagler Museum Pavilion in Palm Beach. Actress and activist Fran Drescher along with ovarian cancer expert Dr.... (Source: OrlandoSentinel: Medical Research)
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RSS Source: Med Worm - Ovarian Cancer Tue, 1 Feb 2011 11:00:00 pm
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Ovarian Cancer - news item 129 of 135
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Dog that can 'sniff out bowel cancer'
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Conclusion This small study showed that a trained dog could accurately differentiate between people with bowel cancer and healthy volunteers from stool and breath samples. There are various practical and methodological limitations to this technique that indicate it may be unfeasible to use dogs to screen for cancer. The researchers...
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RSS Source: Med Worm - Ovarian Cancer Tue, 1 Feb 2011 3:56:00 pm
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Ovarian Cancer - news item 130 of 135
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Healthy eating index and ovarian cancer risk
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This study investigates the association between the Healthy Eating Index (HEI), which reflects adherence to the current USDA Dietary Guidelines for Americans and ovarian cancer risk in a population-based case†control study in New Jersey. A total of 205 cases and 390 controls completed the Block 98.2 food frequency questionnaire (...
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RSS Source: Med Worm - Ovarian Cancer Tue, 1 Feb 2011 7:47:12 am
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Ovarian Cancer - news item 131 of 135
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New clinical trial to determine ovarian cancer risks in African-American women
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(University Hospitals Case Medical Center) University Hospitals Case Medical Center and Case Western Reserve University School of Medicine are conducting a new study addressing lack of knowledge about causes and risk factors for ovarian cancer in African-American women. Ovarian cancer is the most lethal of all gynecologic cancers. African-American women...
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RSS Source: Med Worm - Ovarian Cancer Tue, 1 Feb 2011 4:00:00 am
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Ovarian Cancer - news item 132 of 135
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T-Oligos Inhibit Growth and Induce Apoptosis in Human Ovarian Cancer Cells
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Oligonucleotides , Vol. 0, No. 0. (Source: Oligonucleotides)
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RSS Source: Med Worm - Ovarian Cancer Tue, 1 Feb 2011 3:02:23 am
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Ovarian Cancer - news item 133 of 135
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The Molecular Basis of Synergism between Carboplatin and ABT-737 Therapy Targeting Ovarian Carcinomas
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Resistance to standard chemotherapy (carboplatin + paclitaxel) is one of the leading causes of therapeutic failure in ovarian carcinomas. Emergence of chemoresistance has been shown to be mediated in part by members of the Bcl family of proteins including the antiapoptotic protein Bcl-xL, whose expression is correlated with shorter disease-free intervals...
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RSS Source: Med Worm - Ovarian Cancer Mon, 31 Jan 2011 11:00:00 pm
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Ovarian Cancer - news item 134 of 135
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Measuring success in ovarian cancer risk reducing strategies
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Success in ovarian cancer riskâ€reducing strategies is based in outcome data and on patient satisfaction. Despite increased estrogen deficiency symptoms, satisfaction rates were higher with riskâ€reducing bilateral salpingoâ€oophorectomy. Reduced satisfaction was due to uncertainty in decision making. (Source: Cancer)
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RSS Source: Med Worm - Ovarian Cancer Mon, 31 Jan 2011 11:00:00 pm
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Ovarian Cancer - news item 135 of 135
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New players in ovarian cancer
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AbstractOvarian cancer is the leading cause of gynecologic cancer mortality worldwide. The aim of this review is to highlight the most recent studies regarding ovarian cancer pathogenesis and the new therapeutic approaches against this insidious disease. We focus on the relevance of some cell cycle genes, transcription factors and microRNAs...
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RSS Source: Med Worm - Ovarian Cancer Mon, 31 Jan 2011 11:00:00 pm
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