Pancreatic Cancer - news item 1 of 142
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BioSante's Pancreas Cancer Vaccine Shows Survival Increase In Newly Published Study
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BioSante Pharmaceuticals, Inc. (NASDAQ: BPAX) announced publication of results from a Phase II clinical study that show BioSante's Pancreas Cancer Vaccine increased the median survival of resected pancreatic cancer patients from 15 to 20 months, as reported in published data, to 24.8 months, an increase of more than 25 percent....
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RSS Source: Med Worm - Pancreatic Cancer Sun, 6 Mar 2011 7:00:00 am
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Pancreatic Cancer - news item 2 of 142
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Possible new treatment strategies for pancreatic cancer
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Researchers have identified a protein that can be modified to improve the effectiveness of one of the most common drugs used to treat pancreatic cancer. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Pancreatic Cancer Sat, 5 Mar 2011 12:00:00 am
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Pancreatic Cancer - news item 3 of 142
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Netting Pancreatic Cancer Genes
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Pancreatic neuroendocrine tumors (PanNETs) are aggressive human cancers that often develop silently and progress to untreatable metastatic disease prior to diagnosis. Using an exome sequencing strategy to identify recurrent somatic … [Read more] (Source: This Week in Science)
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RSS Source: Med Worm - Pancreatic Cancer Fri, 4 Mar 2011 4:59:57 am
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Pancreatic Cancer - news item 4 of 142
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[Report] DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors
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A rare but deadly form of human pancreatic cancer harbors mutations in chromatin remodeling genes.Authors: Yuchen Jiao, Chanjuan Shi, Barish H. Edil, Roeland F. de Wilde, David S. Klimstra, Anirban Maitra, Richard D. Schulick, Laura H. Tang, Christopher L. Wolfgang, Michael A. Choti, Victor E. Velculescu, Luis A. Diaz Jr.,...
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RSS Source: Med Worm - Pancreatic Cancer Fri, 4 Mar 2011 4:59:45 am
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Pancreatic Cancer - news item 5 of 142
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Transcriptional regulation of claudinâ€18 via specific protein kinase C signaling pathways and modification of DNAâ€methylation in human pancreatic cancer cells
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AbstractSince claudinâ€18 (Cldn18) is overexpressed in precursor lesion PanIN and pancreatic duct carcinoma, it serves as a diagnostic marker and a target of immunotherapy. The stomach isoform of Cldn18, Cldn18a2 is regulated via a PKC/MAPK/APâ€1â€dependent pathway in PKC activator 12â€Oâ€tetradecanoylphorbol 13â€acetate (TPA)â€stimulated gastric cancer cells. However, little is known about...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 3 Mar 2011 11:00:00 pm
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Pancreatic Cancer - news item 6 of 142
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p22phox, Nox4, and Akt in Pancreatic Cancer Cell Survival [Signal Transduction]
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We recently showed that Nox4 NADPH oxidase is highly expressed in pancreatic ductal adenocarcinoma and that it is activated by growth factors and plays a pro-survival, anti-apoptotic role. Here we investigate the mechanisms through which insulin-like growth factor I and serum (FBS) activate NADPH oxidase in pancreatic cancer (PaCa) cells....
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RSS Source: Med Worm - Pancreatic Cancer Thu, 3 Mar 2011 11:00:00 pm
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Pancreatic Cancer - news item 7 of 142
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Omeros Unlocks Orphan GPCRs Linked To Pancreatic Cancer And Cognitive Disorders
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Omeros Corporation (Nasdaq: OMER) announced that it has identified compounds that interact selectively with two orphan G protein-coupled receptors (GPCRs) linked to pancreatic cancer (GPR182) and cognitive disorders (GPR12). Together with the three previously unlocked orphans linked to squamous cell carcinoma (GPR87), obesity (GPR85) and appetite control (GPR101), Omeros has...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 3 Mar 2011 11:00:00 am
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Pancreatic Cancer - news item 8 of 142
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Researchers find possible new treatment strategies for pancreatic cancer
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(University of Georgia) New University of Georgia research has identified a protein that can be modified to improve the effectiveness of one of the most common drugs used to treat pancreatic cancer. (Source: EurekAlert! - Medicine and Health)
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RSS Source: Med Worm - Pancreatic Cancer Thu, 3 Mar 2011 4:00:00 am
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Pancreatic Cancer - news item 9 of 142
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Immunotherapy of Peritoneal Carcinomatosis with the Antibody Catumaxomab in Colon, Gastric, or Pancreatic Cancer: An Open-Label, Multicenter, Phase I/II Trial.
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Conclusions: Intraperitoneal catumaxomab is a promising option for the treatment of PC from GI cancer. PMID: 21358214 [PubMed - in process] (Source: Onkologie)
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RSS Source: Med Worm - Pancreatic Cancer Thu, 3 Mar 2011 2:45:04 am
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Pancreatic Cancer - news item 10 of 142
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This Week in Science
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Whittling Away at Graphene Layers | Netting Pancreatic Cancer Genes | Join the Queue | Hungry Horses | A Visible Sawtooth | Sizing Signals | Tangents to Vector Transmission | Space Rock History Revealed | Dissecting the Centriole | Wrap and Slide | Improving Old Memories | Exploiting Ancient Seas | Made to Move | Break It Down, Sweep It Out | A Closer...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 2 Mar 2011 11:00:00 pm
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Pancreatic Cancer - news item 11 of 142
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hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes
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Abstract Immunotherapy targeting the hTERT subunit of telomerase has been shown to induce robust immune responses in cancer patients after vaccination with single hTERT peptides. Vaccination with dendritic cells (DCs) transfected with hTERT mRNA has the potential to induce strong immune responses to multiple hTERT epitopes and is therefore an...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 2 Mar 2011 6:47:41 am
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Pancreatic Cancer - news item 12 of 142
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PALB2 mutations in familial breast and pancreatic cancer
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Abstract PALB2 (Partner And Localizer of BRCA2) binds to and co-localizes with BRCA2 in DNA repair. Germline mutations in PALB2 have been identified in approximately 1†2% of familial breast cancer and 3†4% of familial pancreatic cancer cases. The goal of this study was to evaluate the prevalence of...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 2 Mar 2011 6:00:45 am
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Pancreatic Cancer - news item 13 of 142
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Histone deacetylase inhibitor, MGCD0103, synergizes with gemcitabine in human pancreatic cells
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SummaryHistone deacetylase inhibitors are a group of recently developed compounds that modulate cell growth and survival. We evaluated effects of the HDAC inhibitor, MGCD0103, on growth of pancreatic carcinoma models following single agent treatment and in combination with gemcitabine. MGCD0103 inhibited tumor cell growth and acted synergistically with gemcitabine to...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 28 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 14 of 142
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Diabetes mellitus, other medical conditions and pancreatic cancer: a caseâ€control study
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ConclusionsDiabetes is associated with heightened risk of pancreatic cancer. The association is significant for diabetes diagnosed up to 10 years before pancreatic cancer. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Diabetes/Metabolism Research and Reviews) MedWorm Message: Watch the new MedWorm demo and find out how to get all...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 28 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 15 of 142
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TGFâ€Î²2 Gene Silencing with Trabedersen (AP 12009) in Pancreatic Cancer
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AbstractPancreatic cancer is one of the most aggressive human cancers with a 5â€yearâ€survival rate of < 5%. Overexpression of transforming growth factor beta 2 (TGFâ€Î²2) in pancreatic malignancies is suggested to be a pivotal factor for malignant progression by inducing immunosuppression, metastasis, angiogenesis, and proliferation. Trabedersen (AP 12009) is a phosphorothioate...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 28 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 16 of 142
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[Articles] Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study
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The addition of axitinib to gemcitabine does not improve overall survival in advanced pancreatic cancer. These results add to increasing evidence that targeting of VEGF signalling is an ineffective strategy in this disease. (Source: The Lancet Oncology)
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RSS Source: Med Worm - Pancreatic Cancer Mon, 28 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 17 of 142
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[Comment] Development of targeted therapies for pancreatic cancer
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Pancreatic cancer remains resistant to conventional cytotoxic therapy and several targeted agents. Targeting of angiogenesis in this disease gained momentum after the demonstration of benefit from drugs directed against the vascular endothelial growth factor (VEGF) or its receptor (VEGFR) in some cancers. However, phase 3 trials of anti-VEGF agents (bevacizumab)...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 28 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 18 of 142
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Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion
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Authors: J Y Lee, K T Lee, J K Lee, K H Lee, K-T Jang, J S Heo, S H Choi, YIl Kim & J C Rhee (Source: British Journal of Cancer AOP)
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RSS Source: Med Worm - Pancreatic Cancer Mon, 28 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 19 of 142
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Activated KrasG12D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin
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Authors: S Rachagani, S Senapati, S Chakraborty, M P Ponnusamy, S Kumar, L M Smith, M Jain & S K Batra (Source: British Journal of Cancer AOP) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Pancreatic Cancer Mon, 28 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 20 of 142
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CNT1 Expression Influences Proliferation and Chemosensitivity in Drug-Resistant Pancreatic Cancer Cells
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In this study, we discovered a role for the human concentrative nucleoside transporter-1 (hCNT1; SLC28A1), a high-affinity pyrimidine nucleoside transporter, in determining the chemosensitivity of human pancreatic cancer cells to gemcitabine, the drug used presently as a standard of care. Compared with normal pancreas and pancreatic ductal epithelial cells, hCNT1...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 28 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 21 of 142
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Long-term Use of Cholesterol-Lowering Drugs and Cancer Incidence in a Large United States Cohort
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We examined the association between long-term use of cholesterol-lowering drugs, predominantly statins, and the incidence of ten common cancers, as well as overall cancer incidence, among 133,255 participants (60,059 men and 73,196 women) in the Cancer Prevention Study II Nutrition Cohort during the period from 1997 to 2007. Multivariate Cox...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 28 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 22 of 142
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Secondary Use of EHR: Data Quality Issues and Informatics Opportunities
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Source: Botsis T et al, AMIA Summits Transl Sci Proc. 2010 Content: Given the large-scale deployment of Electronic Health Records (EHR), secondary use of EHR data will be increasingly needed in all kinds of health services or clinical research. This paper reports some data quality issues we encountered in a...
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RSS Source: Med Worm - Pancreatic Cancer Sun, 27 Feb 2011 3:14:47 pm
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Pancreatic Cancer - news item 23 of 142
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Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer
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Conclusions Familial PC patients appear to develop tumors outside of the pancreatic head more frequently than sporadic PC patients. This difference in tumor distribution may be due to a broader area of cancer susceptibility within the pancreas for familial PC patients. Content Type Journal ArticlePages 1-7DOI 10.1007/s11605-011-1417-xAuthors Joshua G. Barton,...
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RSS Source: Med Worm - Pancreatic Cancer Sat, 26 Feb 2011 2:17:01 pm
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Pancreatic Cancer - news item 24 of 142
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Bypass Surgery Versus Intentionally Incomplete Resection in Palliation of Pancreatic Cancer: Is Resection the Lesser Evil?
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Conclusions Because of the higher surgery-related morbidity and mortality and lack of survival benefit in cases of advanced adenocarcinoma of the pancreas, intentionally incomplete palliative resection is not advisable. Content Type Journal ArticlePages 1-7DOI 10.1007/s11605-011-1469-yAuthors Michael Tachezy, Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Germany, Martinistraße...
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RSS Source: Med Worm - Pancreatic Cancer Sat, 26 Feb 2011 2:16:58 pm
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Pancreatic Cancer - news item 25 of 142
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Erratum to: Staging of pancreatic cancer with multidetector CT in the setting of preoperative chemoradiation therapy
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Content Type Journal ArticlePages 1-1DOI 10.1007/s00261-011-9702-4Authors E. P. Tamm, Department of Diagnostic Radiology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 57, Houston, Texas 77070, USAE. M. Loyer, Department of Diagnostic Radiology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 57, Houston,...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 24 Feb 2011 4:25:02 pm
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Pancreatic Cancer - news item 26 of 142
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FAK and Interacting Proteins as Therapeutic Targets in Pancreatic Cancer
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(Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents))
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RSS Source: Med Worm - Pancreatic Cancer Thu, 24 Feb 2011 2:28:09 pm
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Pancreatic Cancer - news item 27 of 142
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Tumor imaging with multicolor fluorescent protein expression
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Abstract Imaging with fluorescent proteins has been revolutionary and has led to the new field of in vivo cell biology. Many new applications of this technology have been developed. Green fluorescent protein (GFP)-labeled or red fluorescent protein (RFP)-labeled HT-1080 human fibrosarcoma cells were used to determine clonality of metastasis by...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 24 Feb 2011 7:04:10 am
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Pancreatic Cancer - news item 28 of 142
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Characterization of antilytic peptide antibody: application for the detection of lyticâ€based hybrid peptide in serum samples
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AbstractWe previously reported that a novel targeted drug termed hybrid epidermal growth factor receptor (EGFR)â€lytic peptide, made by chemical conjugation of targeted binding peptide and cellâ€killing, lyticâ€peptide components, has selective cytotoxic activity that allows it to discriminate between normal and cancer cells. In addition, in vivo analysis revealed that this...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 23 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 29 of 142
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High intensity focused ultrasound ablation: A new therapeutic option for solid tumors
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Franco Orsi, Paolo Arnone, Wenzhi Chen, Lian ZhangJournal of Cancer Research and Therapeutics 2010 6(4):414-420Surgery has been the standard of care in selected cases with solid tumors. However, a majority of patients are unable to undergo surgical resection because of the tumor sites, advanced stages, or poor general condition. High...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 23 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 30 of 142
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18F-FDG PET/MRI fusion in characterizing pancreatic tumors: comparison to PET/CT
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Conclusion PET/MRI fusion, especially PET with T1-w MRI, was demonstrated to be superior to PET/CT in characterizing PTs, offering better mapping and fusion image quality. Content Type Journal ArticlePages 1-8DOI 10.1007/s10147-011-0202-xAuthors Mitsuaki Tatsumi, Department of Nuclear Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka JapanKayako Isohashi, Department...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 23 Feb 2011 10:33:40 pm
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Pancreatic Cancer - news item 31 of 142
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MicroRNA Expression as a Predictive Marker for Gemcitabine Response after Surgical Resection of Pancreatic Cancer
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Conclusions miR-142-5p is a promising predictive marker for gemcitabine response in patients with resected pancreatic cancer. Content Type Journal ArticlePages 1-7DOI 10.1245/s10434-011-1602-xAuthors Kenoki Ohuchida, Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanKazuhiro Mizumoto, Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 23 Feb 2011 10:04:40 pm
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Pancreatic Cancer - news item 32 of 142
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A Benefit-Risk Assessment of Erlotinib in Non-Small-Cell Lung Cancer and Pancreatic Cancer
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(Source: Drug Safety)
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RSS Source: Med Worm - Pancreatic Cancer Wed, 23 Feb 2011 1:06:11 am
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Pancreatic Cancer - news item 33 of 142
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Synergistic antitumor effect of interferon-ß with gemcitabine in interferon-α-non-responsive pancreatic cancer cells.
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In conclusion, our results indicated that the growth-inhibitory effect of IFN-ß with gemcitabine was synergistic not only in pancreatic cancer cells with strong expression of IFNAR2, but also in those with weak expression of IFNAR2. PMID: 21347515 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
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RSS Source: Med Worm - Pancreatic Cancer Tue, 22 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 34 of 142
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Infinity Initiates Phase 2 Portion of Trial of IPI-926 in Pancreatic Cancer
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CAMBRIDGE, Mass., Feb. 22, 2011 (GLOBE NEWSWIRE) -- Infinity Pharmaceuticals, Inc. (Nasdaq:INFI) today announced the initiation of the randomized Phase 2 portion of the trial of IPI-926 in combination with gemcitabine (also known as Gemzar(r)) in patients with previously untreated, metastatic, pancreatic cancer. The Phase 2 portion of the trial...
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RSS Source: Med Worm - Pancreatic Cancer Tue, 22 Feb 2011 12:00:00 pm
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Pancreatic Cancer - news item 35 of 142
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Discovery Of Protein That Fuels Inflammation In Pancreatic And Breast Tumors
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Separate studies published online on February 21 in the Journal of Experimental Medicine identify a protein that drives tumor-promoting inflammation in pancreatic and breast tumors. Inflammatory reactions come in several flavors - Th1 and Th2, for example - each classified according to the proteins, or cytokines, that predominate. Tumors are...
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RSS Source: Med Worm - Pancreatic Cancer Tue, 22 Feb 2011 10:00:00 am
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Pancreatic Cancer - news item 36 of 142
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p8 expression controls pancreatic cancer cell migration, invasion, adhesion and tumorigenesis
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In conclusion, p8 expression controls pancreatic cancer cell migration, invasion and adhesion, three processes required for metastasis, at least in part, through CDC42, a major regulator of cytoskeleton organization. J. Cell. Physiol. © 2011 Wileyâ€Liss, Inc. (Source: Journal of Cellular Physiology)
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RSS Source: Med Worm - Pancreatic Cancer Mon, 21 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 37 of 142
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Stereotactic body radiation therapy for abdominal targets using volumetric intensity modulated arc therapy with RapidArc: Feasibility and clinical preliminary results.
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Conclusions. SBRT for abdominal targets delivered by means of RA resulted to be feasible with good early clinical results in terms of local control rate and acute toxicity profile. RA allowed to achieve required target coverage as well as to keep within normal tissue dose/volume constraints. PMID: 21338272 [PubMed -...
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RSS Source: Med Worm - Pancreatic Cancer Sun, 20 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 38 of 142
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Angiographic Intervention in Patients With a Suspected Visceral Artery Pseudoaneurysm Complicating Pancreatitis and Pancreatic Surgery [Original Article]
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Conclusion Embolization was highly effective in treating a pseudoaneurysm complicating pancreatitis and pancreatic surgery. The hemodynamic status at the time of angiography determines overall survival. (Source: Archives of Surgery)
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RSS Source: Med Worm - Pancreatic Cancer Sun, 20 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 39 of 142
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Tumor Angiogenic Marker Expression Levels during Tumor Growth: Longitudinal Assessment with Molecularly Targeted Microbubbles and US Imaging [Molecular Imaging]
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Conclusion: Targeted contrast-enhanced US imaging allows noninvasive in vivo assessment of the expression levels of αvβ3 integrin, endoglin, and VEGFR2, which vary during tumor growth in subcutaneous cancer xenografts. © RSNA, 2011 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10101079/-/DC1 (Source: Radiology) MedWorm Message: Watch the new MedWorm demo and find out how to get...
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RSS Source: Med Worm - Pancreatic Cancer Sun, 20 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 40 of 142
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TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression
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Authors: M Seux, S Peuget, M P Montero, C Siret, V Rigot, P Clerc, V Gigoux, E Pellegrino, L Pouyet, P N'Guessan, S Garcia, M Dufresne, J L Iovanna, A Carrier, F André & N J Dusetti (Source: Oncogene)
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RSS Source: Med Worm - Pancreatic Cancer Sun, 20 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 41 of 142
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Hypoxia activates the hedgehog signaling pathway in a ligandâ€independent manner by upregulation of Smo transcription in pancreatic cancer
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SummaryThe hedgehog (Hh) signaling pathway is activated in various types of cancer including pancreatic ductal adenocarcinoma. It has been shown that extremely low oxygen tension (below 1% O2) is found in tumor tissue including pancreatic ductal adenocarcinoma cells (PDAC) and increases the invasiveness of PDAC. To investigate the contribution of...
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RSS Source: Med Worm - Pancreatic Cancer Sun, 20 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 42 of 142
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The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer
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Authors: Chuhan Chung, Christopher C Mader, John C Schmitz, Jorunn Atladottir, Phillip Fitchev, Mona L Cornwell, Anthony J Koleske, Susan E Crawford & Fred Gorelick (Source: Laboratory Investigation AOP)
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RSS Source: Med Worm - Pancreatic Cancer Sun, 20 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 43 of 142
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Dr. Charles Epstein dies at 77; geneticist survived attack by Unabomber
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UC San Francisco scientist helped unlock the secrets of Down syndrome. Dr. Charles Epstein, a UC San Francisco medical geneticist who studied Down syndrome and pioneered genetic counseling for families with affected children, but whose career was temporarily interrupted by a vicious 1993 attack by the notorious Unabomber, died Feb....
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RSS Source: Med Worm - Pancreatic Cancer Sat, 19 Feb 2011 11:22:41 pm
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Pancreatic Cancer - news item 44 of 142
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WITHDRAWN: Pancreaticoduodenectomy (classic Whipple) versus pylorus-preserving pancreaticoduodenectomy (pp Whipple) for surgical treatment of periampullary and pancreatic carcinoma.
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Authors: Diener MK, Heukaeufer C, Schwarzer G, Seiler CM, Antes G, Knaebel HP, Büchler MW Pancreatic cancer is the fourth leading cause of cancer death for men and the fifth for women. The standard treatment for resectable tumours is either a classic Whipple operation or a pylorus-preserving pancreaticoduodenectomy. It is...
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RSS Source: Med Worm - Pancreatic Cancer Sat, 19 Feb 2011 1:00:09 pm
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Pancreatic Cancer - news item 45 of 142
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Behind the headlines: Pancreas cancer develops over years
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“Lethal pancreatic cancer grows for decades,†according to the BBC. The cancer may “lurk in the body for many years before patients fall illâ€, it said. The news is based on a study that has estimated the way pancreatic cancer progresses by examining tumours taken from seven patients killed by...
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RSS Source: Med Worm - Pancreatic Cancer Fri, 18 Feb 2011 4:09:11 pm
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Pancreatic Cancer - news item 46 of 142
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Oncolytics Biotech(R) Inc. Announces Start Of Enrollment In Randomized Phase II Pancreatic Cancer Study
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Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today that enrollment has begun in a 2-Arm randomized Phase II study of carboplatin, paclitaxel plus REOLYSIN® versus carboplatin and paclitaxel alone in the first line treatment of patients with recurrent or metastatic pancreatic cancer. The Principal Investigator is Dr. Tanios Bekaii-Saab, Medical...
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RSS Source: Med Worm - Pancreatic Cancer Fri, 18 Feb 2011 7:00:00 am
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Pancreatic Cancer - news item 47 of 142
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Urgent Need for Pancreatic Cancer Legislation
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Federal Research Funding Analysis Highlights Urgent Need for Pancreatic Cancer Legislation - Senator Sheldon Whitehouse (D-RI) and Representatives Anna Eshoo (D-CA) and Leonard Lance (R-NJ) Re-introduce the Pancreatic Cancer Research & Education Act. (Source: Disabled World)
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RSS Source: Med Worm - Pancreatic Cancer Fri, 18 Feb 2011 1:08:50 am
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Pancreatic Cancer - news item 48 of 142
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Pancreas organogenesis: From bud to plexus to gland
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AbstractPancreas oganogenesis comprises a coordinated and highly complex interplay of signaling events and transcriptional networks that guide a stepâ€wise process of organ development from early bud specification all the way to the final mature organ state. Extensive research on pancreas development over the last few years, largely driven by a...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 17 Feb 2011 11:57:40 pm
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Pancreatic Cancer - news item 49 of 142
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ATP assay-guided chemosensitivity testing for gemcitabine with biopsy specimens obtained from unresectable pancreatic cancer using endoscopic ultrasonography-guided fine-needle aspiration
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Conclusion Chemosensitivity testing by use of EUS-FNA samples in patients with unresectable pancreatic cancer is feasible. This definition emphasizes the possibility of selecting patients for whom favorable results from gemcitabine treatment can be expected. Content Type Journal ArticlePages 1-8DOI 10.1007/s10147-011-0197-3Authors Takeru Wakatsuki, Department of Gastroenterology and Rheumatology, Fukushima Medical University,...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 17 Feb 2011 4:03:48 pm
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Pancreatic Cancer - news item 50 of 142
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Transient silencing of galectin-3 expression promotes both in vitro and in vivo drug-induced apoptosis of human pancreatic carcinoma cells
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Abstract Pancreatic cancer demonstrates a strong resistance to anticancer drugs, presumably due to its resistance to drug induced apoptosis. Although gemcitabine (GEM) might be partially effective for treating advanced pancreatic cancer, its efficacy is still less than satisfactory. Galectin-3 (gal-3), a member of the β-galactoside-binding protein family, is a multifunctional...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 17 Feb 2011 4:01:32 pm
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Pancreatic Cancer - news item 51 of 142
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Patrick Swayze's widow calls for more research into pancreatic cancer
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Patrick Swayze's widow, Lisa Niemi Swayze, spoke in Washington this week about a bill that would make pancreatic cancer a federal research priority, according to a CNN report. Swayze died nearly a year and a half ago from the disease, nearly 22 months... (Source: OrlandoSentinel: Medical Research)
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RSS Source: Med Worm - Pancreatic Cancer Thu, 17 Feb 2011 3:00:00 pm
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Pancreatic Cancer - news item 52 of 142
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Recurrence Pattern and Prognosis of Pancreatic Cancer After Pancreatic Fistula
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Conclusions PF was statistically significantly related to peritoneal recurrence, and patients with PF developed peritoneal recurrence earlier than those without PF. With regard to the development of peritoneal recurrence, PF may be considered to be a negative prognostic factor. Content Type Journal ArticlePages 1-9DOI 10.1245/s10434-011-1604-8Authors Shunji Nagai, Department of Surgery...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 17 Feb 2011 7:09:24 am
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Pancreatic Cancer - news item 53 of 142
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Whole Genome Sequencing Used To Help Inform Deadly Pancreatic Tumor Therapy
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Whole genome sequencing - spelling out a person's entire DNA genetic code - has moved one step closer to being a medical option for direct patient care. Physicians and researchers at Mayo Clinic in Arizona and the Translational Genomics Research Institute (TGen) successfully completed sequencing both a single patients normal...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 17 Feb 2011 7:00:00 am
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Pancreatic Cancer - news item 54 of 142
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Efficacy of infusional 5-fluorouracil, doxorubicin, and mitomycin-C (iFAM) in the treatment of patients with gemcitabine-pretreated pancreatic cancer and analysis of prognostic factors in a salvage setting
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Conclusions iFAM is an effective and well-tolerated in patients with gemcitabine-pretreated pancreatic cancer, even patients with an ECOG PS of 2. ECOG PS and CA 19-9 were shown to be significant prognostic factors in this salvage setting. Content Type Journal ArticlePages 1-10DOI 10.1007/s00280-011-1584-1Authors Kyu-Hyoung Lim, Department of Internal Medicine, Seoul...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 17 Feb 2011 6:06:56 am
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Pancreatic Cancer - news item 55 of 142
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Pro-survival Role of Heat Shock Factor 1 (HSF1) in the Pathogenesis of PancreatoBiliary Tumors.
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Conclusion: HSF1 plays a pro-survival role in the pathogenesis of pancreatobiliary tumors. Modulation of HSF1 activity could therefore emerge as a novel therapeutic strategy for cancer treatment. PMID: 21330448 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
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RSS Source: Med Worm - Pancreatic Cancer Wed, 16 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 56 of 142
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mTOR Inhibitor Treatment of Pancreatic Cancer in a Patient With Peutz-Jeghers Syndrome [CORRESPONDENCE]
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(Source: Journal of Clinical Oncology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Pancreatic Cancer Wed, 16 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 57 of 142
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CXCR2-Dependent Endothelial Progenitor Cell Mobilization in Pancreatic Cancer Growth.
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Authors: Li A, Cheng XJ, Moro A, Singh RK, Hines OJ, Eibl G Neovascularization is essential for tumor growth. We have previously reported that the chemokine receptor CXCR2 is an important regulator in tumor angiogenesis. Here we report that the mobilization of bone marrow (BM)-derived endothelial progenitor cells (EPCs) is...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 16 Feb 2011 8:00:16 am
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Pancreatic Cancer - news item 58 of 142
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Medically Managed Hypercholesterolemia and Insulin-Dependent Diabetes Mellitus Preoperatively Predicts Poor Survival after Surgery for Pancreatic Cancer
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Conclusions Patients with PDAC being treated for pre-existing diabetes or hypercholesterolemia with either insulin or statin-based therapy have an increased risk of early postoperative mortality. A simple scoring system based on preoperative medications can be used to predict early and overall survival following resection. Content Type Journal ArticlePages 1-7DOI 10.1007/s11605-011-1448-3Authors...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 16 Feb 2011 6:04:00 am
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Pancreatic Cancer - news item 59 of 142
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Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer.
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This study indicates that HDAC1 is required for pancreatic epithelial proliferation in development and cancer. We hypothesize that aberrant expression of HDAC1 modulates the developmental and signaling pathways in exocrine pancreatic epithelia and consequently the genes required for cellular proliferation during development and progression of pancreatic neoplasia. PMID: 21301206 [PubMed...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 16 Feb 2011 5:46:54 am
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Pancreatic Cancer - news item 60 of 142
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Apoptosis mediated cytotoxicity of citrus obacunone in human pancreatic cancer cells.
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Authors: Murthy KN, Jayaprakasha GK, Patil BS Obacunone is one of the oxygenated triterpenoids found in rutaceae family. It has been demonstarcted for various biological activites including inhibition of cancer cells proliferation and tumor. The current study is an attempt to understand the mode of cytotoxicity of obacunone using cultured...
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RSS Source: Med Worm - Pancreatic Cancer Tue, 15 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 61 of 142
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Kenneth Mars, Co-Star in Mel Brooks Comedies, Dies at 75
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Brooks Collaborator Who Appeared in "The Producers" and "Young Frankenstein" Dies of Pancreatic Cancer at 75 (Source: Health News: CBSNews.com)
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RSS Source: Med Worm - Pancreatic Cancer Tue, 15 Feb 2011 7:09:29 pm
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Pancreatic Cancer - news item 62 of 142
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Oncolytics Biotech® Inc. Meets Primary Endpoint For First Part Of U.S. Phase 2 Pancreatic Cancer Clinical Trial
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Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ: ONCY) announced preliminary results from a U.S. Phase 2 clinical trial (REO 017) using intravenous administration of REOLYSIN® in combination with gemcitabine (Gemzar®) in patients with advanced pancreatic cancer. The trial is being conducted at the Cancer Therapy & Research Center at The University...
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RSS Source: Med Worm - Pancreatic Cancer Tue, 15 Feb 2011 8:00:00 am
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Pancreatic Cancer - news item 63 of 142
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Serum Biomarker Panels for the Detection of Pancreatic Cancer.
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CONCLUSIONS: The PDAC-specific biomarker panels identified in this investigation warrant additional clinical validation to determine their role in screening targeted high-risk populations. Clin Cancer Res; 17(4); 805-16. ©2010 AACR. PMID: 21325298 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
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RSS Source: Med Worm - Pancreatic Cancer Mon, 14 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 64 of 142
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Intake of vegetables, fruits, carotenoids, and vitamins C and E and pancreatic cancer risk in the Netherlands Cohort Study
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In conclusion, we observed no association between a high consumption of vegetables and fruits and pancreatic cancer risk in this large cohort study, which is in agreement with previous prospective studies. Furthermore, we observed no association between the intake of carotenoids, vitamins and vitamin supplements and pancreatic cancer risk. (Source:...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 14 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 65 of 142
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Therapeutic Potential of Poly(ADP-ribose) Polymerase Inhibitor AG014699 in Human Cancers With Mutated or Methylated BRCA1 or BRCA2
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Conclusion Human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2 were sensitive to AG014699 monotherapy, indicating a potential role for PARP inhibitors in sporadic human cancers. (Source: JNCI)
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RSS Source: Med Worm - Pancreatic Cancer Mon, 14 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 66 of 142
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Physician knowledge and appropriate utilization of computed tomographic colonography in colorectal cancer screening
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Conclusions Most physicians have limited experience with CTC and are unaware of recent recommendations concerning CTC in CRC screening. Content Type Journal ArticlePages 1-8DOI 10.1007/s00261-011-9698-9Authors Matthew S. Chang, Muzzi Mirza Pancreatic Cancer Prevention and Genetics Program, and Division of Digestive and Liver Diseases, Department of Medicine, Columbia University College of...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 14 Feb 2011 5:58:07 am
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Pancreatic Cancer - news item 67 of 142
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Everolimus shows promising results in pancreatic cancer patients
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Results from the RADIANT-3 trial show that patients with low-grade or intermediate-advanced pancreatic neuroendocrine tumors have a significantly reduced risk for disease progression or death after treatment with everolimus versus placebo. (Source: MedWire News - Oncology)
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RSS Source: Med Worm - Pancreatic Cancer Sun, 13 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 68 of 142
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Genexol inhibits primary tumour growth and metastases in gemcitabineâ€resistant pancreatic ductal adenocarcinoma
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Discussion:  Genexol proved to be an effective treatment for gemcitabineâ€resistant PDA. These data combined with the successful clinical use of genexol in Phase II trials of other malignancies suggests it maybe an effective treatment for pancreatic cancer, specifically for those patients resistant to gemcitabine. (Source: HPB: official journal of the...
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RSS Source: Med Worm - Pancreatic Cancer Fri, 11 Feb 2011 4:14:20 pm
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Pancreatic Cancer - news item 69 of 142
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EGFR Targeted PLGA Nanoparticles Using Gemcitabine for Treatment of Pancreatic Cancer
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(Source: Journal of Biomedical Nanotechnology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Pancreatic Cancer Fri, 11 Feb 2011 1:27:49 am
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Pancreatic Cancer - news item 70 of 142
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Gastrointestinal cancer and brain metastasis
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AbstractMetastatic brain tumors represent 20% to 40% of all intracranial neoplasms and are found most frequently in association with lung cancer (50%) and breast cancer (12%). Although brain metastases occur in <4% of all tumors of the gastrointestinal (GI) tract, the incidence of GI brain metastasis is rising in part...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 10 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 71 of 142
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Physician attitudes and treatment patterns for pancreatic cancer
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Conclusion: Most physicians were insightfully aware of both the survival benefit and potential risks of surgical resection. However, some did overestimate the surgical mortality and underestimate the associated survival benefit. Although advanced age may justly account for some of the patients not receiving a referral, it is reasonable to assume...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 10 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 72 of 142
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Novartis' Afinitor May Help Steve Job's Rare Pancreatic Cancer
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Apple's leader, Steve Jobs, announced to his employees in 2004 that he had been diagnosed with a cancerous tumor in his pancreas. The prognosis for pancreatic cancer is usually very grim, however he stated that he had a rare, far less aggressive type known as islet cell neuroendocrine tumor. This...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 10 Feb 2011 7:00:00 pm
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Pancreatic Cancer - news item 73 of 142
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RET-protooncogene variants in patients with sporadic neoplasms of the digestive tract and the central nervous system
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Conclusions Although our data did not reach significance in our small cohorts, we cannot rule out the involvement of the âˆ'5G promoter allele and the c.2372A>T mutation in the development of the aforementioned tumours. Content Type Journal ArticlePages 1-6DOI 10.1007/s00384-011-1150-7Authors Felix Rückert, Department of Visceral, Thoracic and Vascular Surgery, University...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 10 Feb 2011 6:55:48 pm
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Pancreatic Cancer - news item 74 of 142
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Lehigh's Stabler Arena to be a Pink Zone on Saturday
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Two drugs already used to treat kidney cancer doubled survival in a rare form of pancreatic cancer known as neuroendocrine cancer or islet cell tumors, researchers reported Wednesday. The tumors account for only about 1.4% of the 40,000 people who... (Source: OrlandoSentinel: Medical Research) MedWorm Message: Watch the new MedWorm...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 10 Feb 2011 3:24:25 pm
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Pancreatic Cancer - news item 75 of 142
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New cancer drugs increase survival in rare form of pancreatic cancer suffered by Steve Jobs
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Two drugs already used to treat kidney cancer doubled survival in a rare form of pancreatic cancer known as neuroendocrine cancer or islet cell tumors, researchers reported Wednesday. The tumors account for only about 1.4% of the 40,000 people who... (Source: OrlandoSentinel: Medical Research)
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RSS Source: Med Worm - Pancreatic Cancer Thu, 10 Feb 2011 9:49:00 am
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Pancreatic Cancer - news item 76 of 142
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Everolimus Improves Progression-Free Survival For Patients With Rare Pancreatic Cancer
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In an international Phase III randomized study, everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), has shown to dramatically improve progression-free survival for patients with advanced pancreatic neuroendocrine tumors (pNET), according to researchers from The University of Texas MD Anderson Cancer Center. The findings were published in the...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 10 Feb 2011 8:00:00 am
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Pancreatic Cancer - news item 77 of 142
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2 Experimental Drugs Show Promise for Rare Pancreatic Cancer
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Title: 2 Experimental Drugs Show Promise for Rare Pancreatic CancerCategory: Health NewsCreated: 2/9/2011 8:05:00 PMLast Editorial Review: 2/10/2011 (Source: MedicineNet Crohn's Disease General)
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RSS Source: Med Worm - Pancreatic Cancer Thu, 10 Feb 2011 6:00:00 am
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Pancreatic Cancer - news item 78 of 142
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[Diffusion-weighted imaging of the pancreas.]
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Authors: Grünberg K, Grenacher L, Klauß M Diffusion-weighted imaging (DWI) has increasingly gained in importance over the last 10 years especially in cancer imaging for differentiation of malignant and benign lesions. Through development of fast magnetic resonance imaging (MRI) sequences DWI is not only applicable in neuroradiology but also in...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 9 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 79 of 142
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Studies on mechanisms of interferon-gamma action in pancreatic cancer using a data-driven and model-based approach
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Conclusions: IFNgamma is equally effective in DSL-6A/C1 tumors with and without stellate cells. While its action in the presence of PSC may be explained by inhibition of fibrogenesis, its efficiency in PSC-free tumors is unlikely to be caused by direct effects on the tumor cells alone but may involve inhibitory...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 9 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 80 of 142
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2 Drugs Look Promising for Rare Pancreatic Cancer
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Two kidney cancer drugs show great promise for the treatment of the rare type of pancreatic cancer that Steve Jobs was diagnosed with in 2004. (Source: WebMD Health)
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RSS Source: Med Worm - Pancreatic Cancer Wed, 9 Feb 2011 9:02:11 pm
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Pancreatic Cancer - news item 81 of 142
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Two cancer drugs keep rare pancreatic tumors in check
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The new pills offer hope to the small number of Americans, including Apple CEO Steve Jobs, who have a rare form of pancreatic cancer. (Source: USATODAY.com Health) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Pancreatic Cancer Wed, 9 Feb 2011 8:49:32 pm
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Pancreatic Cancer - news item 82 of 142
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Incidence of Pancreatic Cancer in Chinese Patients with Chronic Pancreatitis
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Pancreatology 2011;11:16†23 (DOI:10.1159/000322982) (Source: Karger Publishers)
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RSS Source: Med Worm - Pancreatic Cancer Wed, 9 Feb 2011 2:20:00 pm
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Pancreatic Cancer - news item 83 of 142
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Europe cancer deaths 'may fall in 2011'
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Conclusion These predictions come from a well-conducted study, which used the most recent data on cancer mortality trends, While the findings are estimates, they’re likely to be accurate. Overall, cancer rates in Europe are falling, but lung cancer rates among women are rising. In the UK, despite levelling off, lung...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 9 Feb 2011 10:07:00 am
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Pancreatic Cancer - news item 84 of 142
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Everolimus improves progression-free survival for patients with rare pancreatic cancer, study finds
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In an international Phase III randomized study, everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), has shown to dramatically improve progression-free survival for patients with advanced pancreatic neuroendocrine tumors (pNET), according to researchers. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Pancreatic Cancer Wed, 9 Feb 2011 4:00:00 am
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Pancreatic Cancer - news item 85 of 142
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[Locally advanced unresectable pancreatic cancer: Induction chemoradiotherapy followed by maintenance gemcitabine versus gemcitabine alone: Definitive results of the 2000-2001 FFCD/SFRO phase III trial.]
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CONCLUSION: This intensive induction schedule of chemoradiation was more toxic and less effective than gemcitabine alone. PMID: 21315644 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
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RSS Source: Med Worm - Pancreatic Cancer Tue, 8 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 86 of 142
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ABO blood group alleles and the risk of pancreatic cancer in Japanese population
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In conclusion, this caseâ€control study showed a statistically significant association between ABO blood group and PC risk in a Japanese population. Further studies are necessary to define the mechanisms by which the ABO gene or closely linked genetic variants influence PC risk. (Source: Cancer Science) MedWorm Message: Watch the new...
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RSS Source: Med Worm - Pancreatic Cancer Tue, 8 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 87 of 142
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Doubling Survival Rate of Pancreatic Cancer Patients by 2020
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Pancreatic Cancer Action Network Announces New Initiative to Double the Survival Rate for Pancreatic Cancer Patients by 2020. (Source: Disabled World)
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RSS Source: Med Worm - Pancreatic Cancer Tue, 8 Feb 2011 6:14:30 pm
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Pancreatic Cancer - news item 88 of 142
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Markers of Pancreatic Cancer: Working Toward Early Detection.
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Authors: Goggins M Because early detection of pancreatic cancer is the best way to cure this disease, investigators continue to try to identify accurate markers of early pancreatic cancer. Because early-stage pancreatic cancer is generally asymptomatic, the only reliable way to detect it is by targeting individuals at increased risk...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 7 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 89 of 142
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Horizon scanning: Axitinib not effective in pancreatic cancer
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Source: Lancet Oncology Area: News A controlled trial showed that axitinib plus gemcitabine did not improve outcomes in pancreatic cancer compared to gemcitabine alone. Axitinib is a new inhibitor of vascular endothelial growth factor (VEGF) receptors that is in late-stage development. This trial investigated whether it was effective in the...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 7 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 90 of 142
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Tumour cryoablation combined with palliative bypass surgery in the treatment of unresectable pancreatic cancer: a retrospective study of 142 patients
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Conclusions Cryosurgery combined with palliative bypass surgery can be considered a safe and effective treatment for unresectable pancreatic cancer. Though this technique remains only palliative, it may be further employed to improve advanced stage pancreatic cancer. (Source: Postgraduate Medical Journal)
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RSS Source: Med Worm - Pancreatic Cancer Mon, 7 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 91 of 142
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Autoimmune Pancreatitis: Current Diagnostic Criteria Are Suboptimal
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CONCLUSIONS: When applied to a highly selected single center referral population in the United States, current Japanese guidelines for the diagnosis of autoimmune pancreatitis have suboptimal sensitivity. (Source: Journal of Gastroenterology and Hepatology)
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RSS Source: Med Worm - Pancreatic Cancer Mon, 7 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 92 of 142
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Laparoscopic modified anterior RAMPS in well-selected left-sided pancreatic cancer: technical feasibility and interim results
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Conclusion Laparoscopic modified anterior RAMPS is thought to be technically feasible for curative resection in well-selected pancreatic cancer. The oncologic feasibility of this technique needs to be investigated based on long-term follow-up. More careful study is necessary. Content Type Journal ArticlePages 1-2DOI 10.1007/s00464-010-1556-2Authors Sung Hoon Choi, Division of Biliopancreas, Department...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 7 Feb 2011 5:46:05 am
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Pancreatic Cancer - news item 93 of 142
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Phase I trial of hedgehog pathway inhibitor GDC-0449 in patients with refractory, locally-advanced or metastatic solid tumors.
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ConclusionsGDC-0449 has an acceptable safety profile and encouraging anti-tumor activity in advanced BCC and medulloblastoma. Further study in these and other cancer types is warranted. PMID: 21300762 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
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RSS Source: Med Worm - Pancreatic Cancer Sun, 6 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 94 of 142
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Diagnostic value of confocal laser endomicroscopy for gastric superficial cancerous lesions
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Conclusions CLE can be used to identify gastric superficial cancer/HGIN lesions with high validity and reliability. (Source: Gut)
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RSS Source: Med Worm - Pancreatic Cancer Thu, 3 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 95 of 142
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Body mass index and body size in early adulthood and risk of pancreatic cancer in a central European multicenter caseâ€control study
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AbstractThe relationship between two measures of excess body weight, body mass index (BMI) and body size score, and risk of pancreatic cancer was examined among 574 pancreatic cancer cases and 596 frequencyâ€matched controls from the Czech Republic and Slovakia enrolled between 2004 and 2009. Analyses using multivariable logistic regression showed...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 2 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 96 of 142
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Acetylâ€11â€ketoâ€Î²â€boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression
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In this report, we demonstrate that acetylâ€11â€ketoâ€Î²â€ boswellic acid (AKBA), a component of the therapeutic plant Boswellia serrata, can downregulate CXCR4 expression in pancreatic cancer cells. The reduction in CXCR4 induced by this terpenoid was found to be cellâ€type specific, as its expression was also abrogated in leukemia, myeloma, and...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 2 Feb 2011 11:00:00 pm
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Pancreatic Cancer - news item 97 of 142
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You can reduce your risk of pancreatic cancer
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Q: Every time I open a newspaper, I seem to read about another VIP with cancer of the pancreas. Is there some way I can be tested to see if I'm at risk? A: Cancer of the pancreas is relatively uncommon. Only about 43,000 cases are diagnosed in the United... (...
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RSS Source: Med Worm - Pancreatic Cancer Tue, 1 Feb 2011 7:09:35 am
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Pancreatic Cancer - news item 98 of 142
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EUS visualization and direct celiac ganglia neurolysis predicts better pain relief in patients with pancreatic malignancy (with video)
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Conclusions: Visualization of celiac ganglia with direct injection is the best predictor of response to EUS-CPN in patients with pancreatic malignancy. (Source: Gastrointestinal Endoscopy)
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RSS Source: Med Worm - Pancreatic Cancer Mon, 31 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 99 of 142
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Cover Picture: Electrophoresis 3†4'2011
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AbstractDouble Issue no. 3†4 is “packed†with very important contributions to the field, assembling one FAST TRACK article and 17 solid and original research articles distributed over 6 distinct parts. The FAST TRACK article advances a fully integrated PDMS/SUâ€8/quartz microfluidic chip with a novel macroporous PDMS membrane for isoelectric...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 31 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 100 of 142
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Re: "Circulating 25-Hydroxyvitamin D and Risk of Pancreatic Cancer"
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(Source: American Journal of Epidemiology)
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RSS Source: Med Worm - Pancreatic Cancer Mon, 31 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 101 of 142
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Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP-Mediated Expression of HMGA2
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One of the hallmarks of human pancreatic ductal adenocarcinoma (PDAC) is its pronounced type I collagen-rich fibrotic reaction. Although recent reports have shown that the fibrotic reaction can limit the efficacy of gemcitabine chemotherapy, the underlying mechanisms remain poorly understood. In this article, we show that the type I collagen...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 31 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 102 of 142
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Intracellular CD24 Inhibits Cell Invasion by Posttranscriptional Regulation of BART through Interaction with G3BP
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We report a novel function for the CD24 molecule in pancreatic cancer cells. Intracellular CD24 is associated with stress granules that contain specific mRNAs and RNA-binding proteins that regulate mRNA stability and translation. Intracellular CD24 in stress granules is associated with G3BP, a phosphorylation-dependent endoribonuclease. The vesicles in which the...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 31 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 103 of 142
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14-3-3{sigma} Exerts Tumor-Suppressor Activity Mediated by Regulation of COP1 Stability
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Constitutive photomorphogenic 1 (COP1) is a p53-targeting E3 ubiquitin ligase that is downregulated by DNA damage through mechanisms that remain obscure. Here, we report that COP1 is not downregulated following DNA damage in 14-3-3 null cells, implicating 14-3-3 as a critical regulator in the response of COP1 to DNA damage....
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RSS Source: Med Worm - Pancreatic Cancer Mon, 31 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 104 of 142
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Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53
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The ability to observe changes in molecular behavior during cancer cell invasion in vivo remains a major challenge to our understanding of the metastatic process. Here, we demonstrate for the first time, an analysis of RhoA activity at a subcellular level using FLIM-FRET (fluorescence lifetime imaging microscopy-fluorescence resonance energy transfer)...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 31 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 105 of 142
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Covered Stent Placement for Duodenal Obstruction in Pancreatic Cancer
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Digestion 2011;83:296 (DOI:10.1159/000313695) (Source: Karger Publishers) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Pancreatic Cancer Mon, 31 Jan 2011 1:17:53 pm
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Pancreatic Cancer - news item 106 of 142
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Slug enhances invasion ability of pancreatic cancer cells through upregulation of matrix metalloproteinase-9 and actin cytoskeleton remodeling
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Authors: Kejun Zhang, Dong Chen, Xuelong Jiao, Shaoyan Zhang, Xiangping Liu, Jingyu Cao, Liqun Wu & Dongsheng Wang (Source: Laboratory Investigation AOP)
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RSS Source: Med Worm - Pancreatic Cancer Sun, 30 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 107 of 142
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GI cancers in 2010: New standards and a predictive biomarker for adjuvant therapy
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Authors: Manish R. Sharma & Richard L. Schilsky Randomized phase III trials have established new standards of care for advanced biliary cancer, HER2-positive advanced gastric or gastro-esophageal junction cancer, and preliminarily, for metastatic pancreatic cancer. There is now a validated predictive biomarker to guide use of adjuvant chemotherapy in patients...
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RSS Source: Med Worm - Pancreatic Cancer Sun, 30 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 108 of 142
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An Apple A Day is Not Working for Steve Jobs
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As you've probably heard by now Steve Jobs, Apple's CEO, has taken another medical leave of absence, this will be his third in just over 6 years. The first leave of absence was in 2004 when Jobs was diagnosed with Pancreatic cancer. (Source: Health WorldNet)
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RSS Source: Med Worm - Pancreatic Cancer Sat, 29 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 109 of 142
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Exposure to environmental tobacco smoke in childhood and incidence of cancer in adulthood in never smokers in the European prospective investigation into cancer and nutrition
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In conclusion, childhood ETS exposure might not be a major risk factor for common cancers in adulthood. Content Type Journal ArticlePages 1-8DOI 10.1007/s10552-010-9723-2Authors Shu-Chun Chuang, School of Public Health, Imperial College London, St Mary’s Campus, Norfolk Place, W2 1PG London, UKValentina Gallo, School of Public Health, Imperial College London, St...
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RSS Source: Med Worm - Pancreatic Cancer Sat, 29 Jan 2011 4:18:58 pm
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Pancreatic Cancer - news item 110 of 142
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Early Detection Of Pancreatic Cancer: Medicine's Next Big Thing?
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(Ivanhoe Newswire) -- You don’t hear nearly as much about it as other kinds of cancers like lung cancer or breast cancer. (Source: Medical Headlines From Ivanhoe.com) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Pancreatic Cancer Fri, 28 Jan 2011 4:00:00 am
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Pancreatic Cancer - news item 111 of 142
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Nestin in gastrointestinal and other cancers: Effects on cells and tumor angiogenesis.
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Authors: Ishiwata T, Matsuda Y, Naito Z Nestin is a class VI intermediate filament protein that was originally described as a neuronal stem cell marker during central nervous system (CNS) development, and is currently widely used in that capacity. Nestin is also expressed in non-neuronal immature or progenitor cells in...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 27 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 112 of 142
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Serum DJâ€1 as a Diagnostic Marker and Prognostic Factor for Pancreatic Cancer
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CONCLUSIONS: These findings indicate the potential clinical significance for serum DJâ€1 level to be used for the diagnosis and prognosis prediction of patients with PC. (Source: Chinese Journal of Digestive Diseases)
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RSS Source: Med Worm - Pancreatic Cancer Thu, 27 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 113 of 142
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In vivo imaging of pancreatic tumours and liver metastases using 7 Tesla MRI in a murine orthotopic pancreatic cancer model and a liver metastases model
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Background: Pancreatic cancer is the fourth leading cause of tumour death in the western world. However, appropriate tumour models are scarce. Here we present a syngeneic murine pancreatic cancer model using 7 Tesla MRI and evaluate its clinical relevance and applicability. Methods: 6606PDA murine pancreatic cancer cells were orthotopically injected...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 27 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 114 of 142
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Correlation of basal EGFR expression with pancreatic cancer grading but not with clinical outcome after gemcitabine-based treatment
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(Source: Annals of Oncology)
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RSS Source: Med Worm - Pancreatic Cancer Thu, 27 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 115 of 142
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Multicenter phase II trial of adjuvant therapy for resected pancreatic cancer using cisplatin, 5-fluorouracil, and interferon-alfa-2b-based chemoradiation: ACOSOG Trial Z05031
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Conclusions: Notwithstanding promising multi-institutional efficacy results, further development of this regimen will require additional modifications to mitigate toxic effects. (Source: Annals of Oncology)
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RSS Source: Med Worm - Pancreatic Cancer Thu, 27 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 116 of 142
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Ets-1 expression and gemcitabine chemoresistance in pancreatic cancer cells.
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This study examines a hypothesis that implicates Ets-1 in the development of gemcitabine-resistance in pancreatic cancer cells. Ets-1 protein expression was assessed in parental pancreatic cancer cells and their gemcitabine-resistant clones. Western blot analysis revealed elevated levels of Ets-1 protein expression in gemcitabine-resistant PANC1(GemRes) (4.8-fold increase; P < 0.05), MIA...
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RSS Source: Med Worm - Pancreatic Cancer Thu, 27 Jan 2011 12:15:19 pm
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Pancreatic Cancer - news item 117 of 142
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Cigarette Smoking and Other Lifestyle Factors in Relation to the Risk of Pancreatic Cancer Death: A Prospective Cohort Study in Japan
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Conclusions These data suggested that smoking increases the risk of death from pancreatic cancer in Japanese women. (Source: Japanese Journal of Clinical Oncology)
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RSS Source: Med Worm - Pancreatic Cancer Wed, 26 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 118 of 142
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Pancreatic Cancer: surgery is a feasible therapeutic option for elderly patients
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Background: Compromised physiological reserve, comorbidities, and the natural history of pancreatic cancer may deny pancreatic resection from elderly patients. We evaluated outcomes of elderly patients amenable to pancreatic surgery. Methods: The medical records of all patients who underwent pancreatic resection at our institution (1995-2007) were retrospectively reviewed. Patient, tumor, and...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 26 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 119 of 142
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ASCO GI: IMRT Boosts Resectability in Pancreatic Cancer
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SAN FRANCISCO (MedPage Today) -- Resectability increased almost fourfold in patients with pancreatic cancer after neoadjuvant therapy that included intensity-modulated radiation therapy (IMRT), results of three small trials showed. (Source: MedPage Today Gastroenterology)
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RSS Source: Med Worm - Pancreatic Cancer Wed, 26 Jan 2011 6:00:00 pm
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Pancreatic Cancer - news item 120 of 142
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ASCO GI: Agent Shows Promise in Pancreatic Cancer
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SAN FRANCISCO (MedPage Today) -- A liposomal formulation of irinotecan (CPT-11) passed an early clinical test in metastatic pancreatic cancer, meeting survival and safety endpoints for continued evaluation. (Source: MedPage Today Gastroenterology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant,...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 26 Jan 2011 5:45:13 pm
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Pancreatic Cancer - news item 121 of 142
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Green Tea Epigallocatechin Gallate Exhibits Anticancer Effect in Human Pancreatic Carcinoma Cells via the Inhibition of Both Focal Adhesion Kinase and Insulin-Like Growth Factor-I Receptor
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The exact molecular mechanism by which epigallocatechin gallate (EGCG) suppresses human pancreatic cancer cell proliferation is unclear. We show here that EGCG-treated pancreatic cancer cells AsPC-1 and BxPC-3 decrease cell adhesion ability on micro-pattern dots, accompanied by dephosphorylations of both focal adhesion kinase (FAK) and insulin-like growth factor-1 receptor (IGF-1R)...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 26 Jan 2011 3:42:06 pm
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Pancreatic Cancer - news item 122 of 142
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Ohio State University To Lead New Pancreatic Cancer Trial
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Dr. Tanios Bekaii-Saab, medical director of gastrointestinal oncology at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James), is leading a new, two-arm, randomized phase II pancreatic cancer clinical trial that will study a formulation of the human reovirus...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 26 Jan 2011 8:00:00 am
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Pancreatic Cancer - news item 123 of 142
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PharmaEngine Reports That PEP02 Met The Primary Endpoints In Phase II Studies In Gastric Cancer And Pancreatic Cancer
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PharmaEngine, Inc. announced that two phase II studies of PEP02 (liposome irinotecan) in gastric and pancreatic cancer studies were presented at the 2011 Gastrointestinal Cancers Symposium of the American Society of Clinical Oncology (ASCO) in San Francisco, CA, USA. PharmaEngine completed a multi-national (Europe and Asia) randomized non-comparative phase II...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 26 Jan 2011 8:00:00 am
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Pancreatic Cancer - news item 124 of 142
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Morphological and cytoskeletal changes of pancreatic cancer cells in three-dimensional spheroidal culture
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In conclusion, PDAC cells showed morphological changes, spheroid formation, and alterations of cytoskeletal proteins in 3D culture. E-cadherin might be one of the key molecules involved in spheroid formation of PDAC cells. The 3D spheroidal culture system was a useful method for cell imaging with contrast-phase microscopy and confocal microscopy....
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RSS Source: Med Worm - Pancreatic Cancer Wed, 26 Jan 2011 1:57:55 am
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Pancreatic Cancer - news item 125 of 142
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Open-label trial on efficacy and security of treatment with gemcitabine and oral modulation with tegafur and levofolinic acid (GEMTG) in patients with advanced pancreatic cancer
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Conclusions The administration of gemcitabine, associated with oral tegafur and leucovorin, has activity against advanced pancreatic cancer, with an adequate toxicity profile. Content Type Journal ArticlePages 61-66DOI 10.1007/s12094-011-0618-9Authors Carles Pericay Pijaume, Oncology Department, Corporació Sanità ria Parc TaulÃ, Parc TaulÃ, s/n, ES-08208 Sabadell, Barcelona, SpainPilar Escudero Emperador, Oncology Department, Hospital ClÃnico...
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RSS Source: Med Worm - Pancreatic Cancer Wed, 26 Jan 2011 1:23:01 am
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Pancreatic Cancer - news item 126 of 142
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FibroGen Reports Interim Results Of A Phase 1 / 2 Trial Of FG-3019 In Locally Advanced Or Metastatic Pancreatic Cancer
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FibroGen, Inc. announced interim results of a phase 1 / 2 trial of FG-3019, a therapeutic antibody against connective tissue growth factor (CTGF), in combination with gemcitabine and erlotinib in individuals with unresectable pancreatic cancer. FG-3019 has been well-tolerated, no dose-limiting toxicities have been observed, and dose escalation continues. The interim...
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RSS Source: Med Worm - Pancreatic Cancer Tue, 25 Jan 2011 7:00:00 am
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Pancreatic Cancer - news item 127 of 142
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Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth.
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CONCLUSIONS: These results provide evidence that combined targeted biological therapy in addition to cytotoxic chemotherapy can overcome treatment resistance. Such treatment strategies may be used to tailor therapy based on identified biomarkers of resistance to targeted monotherapy. Clin Cancer Res; 17(3); 483-93. ©2011 AACR. PMID: 21266529 [PubMed - as supplied...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 24 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 128 of 142
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Micronuclei levels in peripheral blood lymphocytes as a potential biomarker for pancreatic cancer risk
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To find biomarkers for risk prediction of pancreatic cancer (PC), we evaluated the frequency of micronuclei (MN) in peripheral lymphocytes of 346 patients with PC and 449 healthy controls. The levels of baseline MN (mean ± standard error of micronucleated cells per 1000 binucleated cells) were significantly higher in patients (...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 24 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 129 of 142
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CacyBP/SIP protein promotes proliferation and G1/S transition of human pancreatic cancer cells
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AbstractCalcyclinâ€binding protein or Siahâ€1â€interacting protein (CacyBP/SIP), a component of the ubiquitinâ€mediated proteolysis, could participate in betaâ€catenin degradation, which was found to be related to the malignant phenotypes of pancreatic cancer previously. However, the role of CacyBP/SIP itself in pancreatic cancer has not been investigated. In the present study, CacyBP/SIP expression...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 24 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 130 of 142
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Genes Map Study Finds Clues to Pancreatic Cancer
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Experts in the genetics of cancer said on Thursday they have found out why some people can live for years with the same kind of rare pancreatic cancer that affects Apple CEO Steve Jobs. Reuters Health Information (Source: Medscape Pathology Headlines)
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RSS Source: Med Worm - Pancreatic Cancer Mon, 24 Jan 2011 9:00:20 pm
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Pancreatic Cancer - news item 131 of 142
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Immunomedics touts pancreatic drug studies
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Antibody-directed drug and radionuclide therapeutics for pancreatic cancer (more) (Source: AuntMinnie.com Headlines)
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RSS Source: Med Worm - Pancreatic Cancer Mon, 24 Jan 2011 6:51:07 pm
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Pancreatic Cancer - news item 132 of 142
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Fatal interstitial lung disease associated with gemcitabine and erlotinib therapy for lung cancer
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Abstract Gemcitabine in combination with the oral epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib, is a treatment option for patients with advanced pancreatic cancer. Lung toxicity has been described for each of these drugs. A 59-year-old man with advanced non-small-cell lung cancer developed acute respiratory failure with bilateral interstitial...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 24 Jan 2011 5:04:02 pm
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Pancreatic Cancer - news item 133 of 142
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Cell membrane and cytoplasmic epidermal growth factor receptor expression in pancreatic ductal adenocarcinoma
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Abstract The significance of over-expression of epidermal growth factor receptor (EGFR) in pancreatic carcinoma is unclear. In this study, we examined the association between EGFR over-expression (membranous and cytoplasmic), the associated histopathologic features and clinical outcomes in post-resection pancreatic cancer patients. EGFR expression was determined immunohistochemically in 90 patients who...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 24 Jan 2011 5:03:59 pm
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Pancreatic Cancer - news item 134 of 142
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Threshold Pharmaceuticals' TH-302 Continues to Demonstrate Promising Activity in Pancreatic Cancer Phase 1/2 Clinical Trial
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REDWOOD CITY, Calif., Jan. 24, 2011 (GLOBE NEWSWIRE) -- Threshold Pharmaceuticals, Inc. (Nasdaq:THLD) today announced updated Phase 1/2 clinical trial results related to the Company's clinical stage hypoxia-activated prodrug, TH-302. The results were presented at the ASCO Gastro Intestinal Cancers Symposium that took place in San Francisco from January 20-22,...
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RSS Source: Med Worm - Pancreatic Cancer Mon, 24 Jan 2011 12:25:00 pm
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Pancreatic Cancer - news item 135 of 142
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Prognostic roles of human equilibrative transporter 1 (hENTâ€1) and ribonucleoside reductase subunit M1 (RRM1) in resected pancreatic cancer
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CONCLUSIONS:Low expression of hENTâ€1 was associated with worse OS and PFS in patients with resected pancreatic adenocarcinoma independent of gemcitabine therapy. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)
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RSS Source: Med Worm - Pancreatic Cancer Sun, 23 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 136 of 142
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Expression of heparan sulfate in gastric carcinoma and its correlation with clinicopathological features and patient survival
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Conclusion The data suggest that heparan sulfate may play an important role in regulating the biology of gastric cancer, and that it may be a useful prognostic marker of this tumour. (Source: Journal of Clinical Pathology)
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RSS Source: Med Worm - Pancreatic Cancer Sun, 23 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 137 of 142
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Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells
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Authors: J Merlin, L Stechly, S de Beaucé, D Monté, E Leteurtre, I van Seuningen, G Huet & P Pigny (Source: Oncogene)
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RSS Source: Med Worm - Pancreatic Cancer Sun, 23 Jan 2011 11:00:00 pm
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Pancreatic Cancer - news item 138 of 142
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Online Physician Education Program Outlines Treatment Strategies For Pancreatic Cancer
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The American Society of Clinical Oncology (ASCO) and the Pancreatic Cancer Action Network announced a partnered effort to educate physicians about treatment strategies for pancreatic cancer. From a joint collaboration between ASCO University®, the Pancreatic Cancer Action Network, and The ASCO Cancer Foundation®, the 2011 ASCO Tumor Board: Pancreatic Cancer...
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RSS Source: Med Worm - Pancreatic Cancer Sun, 23 Jan 2011 7:00:00 am
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Pancreatic Cancer - news item 139 of 142
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Genetic Code for Form of Pancreatic Cancer Cracked
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Johns Hopkins scientists crack genetic code for form of pancreatic cancer. (Source: Disabled World) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Pancreatic Cancer Sat, 22 Jan 2011 10:26:02 pm
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Pancreatic Cancer - news item 140 of 142
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NewLink Genetics To Present Phase 2 Data Of Its HyperAcute® Pancreas Immunotherapy At ASCO 2011 Gastrointestinal Cancers Symposium
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NewLink Genetics Corporation announced that additional data from its Phase 2 clinical trial of the company's investigational HyperAcute® Pancreas cancer immunotherapy will be presented during a poster session at the American Society of Clinical Oncology 2011 Gastrointestinal Cancers Symposium in San Francisco, California. A summary of the poster is below... (...
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RSS Source: Med Worm - Pancreatic Cancer Sat, 22 Jan 2011 8:00:00 am
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Pancreatic Cancer - news item 141 of 142
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Genetic code for form of pancreatic cancer
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Researchers at Johns Hopkins have deciphered the genetic code for a type of pancreas cancer, called neuroendocrine or islet cell tumors. The work, described online in the Jan. 20 issue of Science Express, shows that patients whose tumors have certain coding "mistakes" live twice as long as those without them........ (...
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RSS Source: Med Worm - Pancreatic Cancer Sat, 22 Jan 2011 3:31:51 am
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Pancreatic Cancer - news item 142 of 142
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New Developments in Pancreatic Cancer
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Abstract Pancreatic adenocarcinoma presents in an advanced stage and has a dismal prognosis. Extensive recent research efforts have provided us with greater insight into the etiology of pancreatic cancer and have also improved our means of prognostication. Molecular analysis demonstrated that specific pathways involved in pancreatic carcinogenesis are perhaps more...
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RSS Source: Med Worm - Pancreatic Cancer Fri, 21 Jan 2011 7:32:56 pm
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