Prostate Cancer - news item 1 of 133
|
|
Prostate cancer: Targeted therapy shrank tumors up to 74 percent in cells in mice
|
|
Researchers have identified a potential target to treat an aggressive type of prostate cancer. The target, a gene called SPINK1, could be to prostate cancer what HER2 has become for breast cancer. (Source: ScienceDaily Headlines)
|
|
RSS Source: Med Worm - Prostate Cancer Sat, 5 Mar 2011 12:00:00 pm
|
|
|
|
Prostate Cancer - news item 2 of 133
|
|
The debate over prostate cancer tests
|
|
It would seem all men should have PSA checks to detect cancer. But the medical community is divided. Some, even the scientist who discovered PSA, see more harm than good.Men of a certain age have heard the pitch many times: If they care about their health, they really should get...
|
|
RSS Source: Med Worm - Prostate Cancer Sat, 5 Mar 2011 4:37:53 am
|
|
|
|
Prostate Cancer - news item 3 of 133
|
|
[Articles] Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study
|
|
Denosumab was better than zoledronic acid for prevention of skeletal-related events, and potentially represents a novel treatment option in men with bone metastases from castration-resistant prostate cancer. (Source: LANCET)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 4 Mar 2011 5:24:38 pm
|
|
|
|
Prostate Cancer - news item 4 of 133
|
|
[Comment] Unravelling the role of denosumab in prostate cancer
|
|
Advances in cancer therapies have brought about changes in the treatment of metastatic prostate cancer. Because prostate cancer usually metastasises to the bone, strategies to target the bone are being actively developed (). Zoledronic acid was the first approved agent for retarding skeletal events in men with metastatic prostate cancer, on...
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 4 Mar 2011 5:24:31 pm
|
|
|
|
Prostate Cancer - news item 5 of 133
|
|
Annual Evidence Update on Prostate cancer: 7-11 March 2011
|
|
An update of the evidence on this topic from NHS Evidence - cancer (Source: NLH)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 4 Mar 2011 3:16:21 pm
|
|
|
|
Prostate Cancer - news item 6 of 133
|
|
PSA velocity ‘should not be included in practice guidelines’
|
|
Men with rapid increases in prostate-specific antigen velocity †the rate at which prostate-specific antigen levels change over time †should not be recommended for biopsy in the absence of other prostate cancer indicators, say US researchers. (Source: MedWire News - Prostate Cancer) MedWorm Message: Watch the new MedWorm demo...
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 4 Mar 2011 2:27:51 pm
|
|
|
|
Prostate Cancer - news item 7 of 133
|
|
Cancer Patients' Partners Become Ill Themselves
|
|
Katarina Sjövall has studied partners of individuals with colorectal cancer, lung cancer, breast cancer or prostate cancer. The study shows that the number of diagnosed diseases among partners increased by 25 per cent after the cancer diagnosis. "Having a close relative with cancer entails worry and anxiety and an increased...
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 4 Mar 2011 10:00:00 am
|
|
|
|
Prostate Cancer - news item 8 of 133
|
|
High fat diet reduces the expression of glutathione peroxidase 3 in mouse prostate
|
|
CONCLUSIONSHigh fat diet alters pathways related to many genes concerned with oxidative stress. GPx3, a gene identified by this analysis, was found to be downâ€regulated by high fat diet and appears be decreased in human prostate cancers, suggesting that GPx3 may have a possible role in modulating carcinogenesis. Prostate ©...
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 4 Mar 2011 3:53:43 am
|
|
|
|
Prostate Cancer - news item 9 of 133
|
|
VIDEO: Cause Celeb
|
|
Ex-footballer Les Ferdinand on his grandfather's prostate cancer (Source: BBC News | Health | UK Edition)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 11:54:59 pm
|
|
|
|
Prostate Cancer - news item 10 of 133
|
|
NHS Choices assessment: New prostate cancer test shows promise
|
|
Source: NHS Choices Area: News NHS Choices has carried out an assessment of press reports that a new test for prostate cancer "detects twice as many cases as the current method." This story is based on a study in 288 men with and without prostate cancer, which assessed whether a...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 11 of 133
|
|
Cyclin D1 Regulation of Androgen Signaling [Gene Regulation]
|
|
D-type cyclins regulate cellular outcomes in part through cyclin-dependent, kinase-independent mechanisms that modify transcription factor action, and recent in vivo studies showed that cyclin D1 associates with a large number of transcriptional regulators in cells of the retina and breast. Given the frequency of cyclin D1 alterations in cancer, it...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 12 of 133
|
|
Benign prostatic hyperplasia: racial differences in treatment patterns and prostate cancer prevalence
|
|
CONCLUSIONAs evidenced by this analysis of ‘realâ€world’ clinical practice, African Americans with BPH have a much greater risk of developing prostate cancer than similar Caucasian men highlighting the need for education and early detection in this population. (Source: BJU International) MedWorm Message: Watch the new MedWorm demo and find out...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 13 of 133
|
|
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells
|
|
Conclusion: SFN exerts differential effects on cell proliferation, HDAC activity and downstream targets in normal and cancer cells. (Source: Nahrung / Food)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 14 of 133
|
|
Drug appears to help slow prostate tumour growth
|
|
An already commonly used drug may help slow the growth of prostate cancer tumours in men who've been advised to take a wait-and-see approach to their disease. (Source: CTV Health)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 10:22:15 pm
|
|
|
|
Prostate Cancer - news item 15 of 133
|
|
Is Baldness an Indicator for Prostate Cancer?
|
|
Dr. Gerald Chodak reports on a new study that may be causing misunderstandings among patients. Medscape Urology (Source: Medscape Today Headlines)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 9:30:21 pm
|
|
|
|
Prostate Cancer - news item 16 of 133
|
|
PHEN Live Webcast- Prostate Cancer & Sex: Let's Talk About It
|
|
(Source: DF/HCC: Latest News) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 7:27:00 pm
|
|
|
|
Prostate Cancer - news item 17 of 133
|
|
The Wide Open (Dynamic) Range
|
|
Clinical Diagnostics: Improved immunoassay measures prostate cancer biomarker over a range of four orders of magnitude. (Source: Chemical and Engineering News)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 6:50:00 pm
|
|
|
|
Prostate Cancer - news item 18 of 133
|
|
Longer Prostate Ca Screening Intervals for Baseline PSAs < 3 ng/mL?
|
|
In a population-based screening study of nearly 20,000 men in Rotterdam, men with baseline prostate-specific antigen (PSA) levels < 3 ng/mL were at very low risk of developing prostate cancer. (Source: Cancer Network)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 11:00:00 am
|
|
|
|
Prostate Cancer - news item 19 of 133
|
|
Scientists Target Aggressive Prostate Cancer
|
|
Researchers at the University of Michigan Comprehensive Cancer Center have identified a potential target to treat an aggressive type of prostate cancer. The target, a gene called SPINK1, could be to prostate cancer what HER2 has become for breast cancer. Like HER2, SPINK1 occurs in only a small subset of...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 10:00:00 am
|
|
|
|
Prostate Cancer - news item 20 of 133
|
|
New bowel cancer test developed
|
|
New prostate cancer test uses urine samples to check if men have the disease (Source: Nursing in Practice) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 9:51:00 am
|
|
|
|
Prostate Cancer - news item 21 of 133
|
|
Prostate cancer urine test 'twice as good'
|
|
Scientists in the UK have developed a new prostate cancer urine test that could increase early diagnosis rates. (Source: Nursing Times Breaking News)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 8:46:00 am
|
|
|
|
Prostate Cancer - news item 22 of 133
|
|
Unneccessary Biopsies For Prostate Cancer?
|
|
(Ivanhoe Newswire) -- Prostate cancer is one of the most controversial cancers in both diagnosis and treatment; and with recommendations from several cancer organizations to men with a rapid rise in PSA to immediately have a biopsy for prostate . . . it only adds to the already heated debate. (Source: Medical Headlines...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 4:00:00 am
|
|
|
|
Prostate Cancer - news item 23 of 133
|
|
Daily, Monthly and Seasonal Variation in PSA Levels and the Association With Weather Parameters
|
|
The authors assess the correlation of PSA levels with meteorological data. Prostate Cancer and Prostatic Diseases (Source: Medscape Today Headlines)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 3 Mar 2011 3:00:00 am
|
|
|
|
Prostate Cancer - news item 24 of 133
|
|
Macrophages induce neuroendocrine differentiation of prostate cancer cells via BMP6â€IL6 Loop
|
|
CONCLUSIONSTherefore, we propose that BMPâ€6 secreted by prostate cancer cells induces ILâ€6 expression in macrophages; ILâ€6, in turn, stimulates the NED of prostate cancer cells. Prostate © 2011 Wileyâ€Liss, Inc. (Source: The Prostate) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest,...
|
|
RSS Source: Med Worm - Prostate Cancer Wed, 2 Mar 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 25 of 133
|
|
On-demand use of erectile aids in men with preoperative erectile dysfunction treated by whole gland prostate cryoablation
|
|
Authors: M Kimura, C F Donatucci, M Tsivian, J R Caso, D M Moreira, V Mouraviev, T Satoh, S Baba & T J Polascik (Source: International Journal of Impotence Research)
|
|
RSS Source: Med Worm - Prostate Cancer Wed, 2 Mar 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 26 of 133
|
|
iCAD Features Image Analysis Solutions for Breast, Prostate and Colon Cancer Detection at the ECR 2011
|
|
NASHUA, N.H.--(Healthcare Sales & Marketing Network)-- iCAD, Inc. (Nasdaq:ICAD ), an industry-leading provider of advanced image analysis, workflow solutions and radiation therapies for the early identification and treatment of cancer, announces its featur... Devices, Radiology, Oncology iCAD, computer-aided detection, breast cancer, prostate cancer, colon cancer (Source: HSMN NewsFeed)
|
|
RSS Source: Med Worm - Prostate Cancer Wed, 2 Mar 2011 7:08:02 pm
|
|
|
|
Prostate Cancer - news item 27 of 133
|
|
New prostate cancer test shows promise
|
|
Conclusion This study has identified a potential new marker for prostate cancer. This research is at an early stage, and much further research is needed. The test’s accuracy will need to be confirmed in larger samples of men from non-specialist settings to show how effective it is at screening for...
|
|
RSS Source: Med Worm - Prostate Cancer Wed, 2 Mar 2011 11:19:00 am
|
|
|
|
Prostate Cancer - news item 28 of 133
|
|
High-dose radiation techniques produced differing toxicity profiles
|
|
Patients with prostate cancer assigned to external beam radiation with HDR brachytherapy boost experienced higher rates of acute adverse effects. (Source: HemOncToday.com)
|
|
RSS Source: Med Worm - Prostate Cancer Wed, 2 Mar 2011 9:43:00 am
|
|
|
|
Prostate Cancer - news item 29 of 133
|
|
Are ‘Self-Referrals’ Proper?
|
|
When Kenneth Baker found out he had prostate cancer, his urologist detailed his options: The 84-year-old was too old for surgery, but he could pick from two forms of radiation or simply wait to see if he really needed treatment. (Source: RWJF News Digest - Quality/Equality)
|
|
RSS Source: Med Worm - Prostate Cancer Wed, 2 Mar 2011 8:40:29 am
|
|
|
|
Prostate Cancer - news item 30 of 133
|
|
Use of Testosterone Replacement Therapy in Patients with Prostate Cancer
|
|
Abstract Prostate cancer is among the more common and less lethal malignancies, yielding a large population of survivors. The incidence of hypogonadism increases in the same elderly population of men who most frequently develop prostate cancer, and the risk of becoming hypogonadal is increased further by prostate cancer therapy. The...
|
|
RSS Source: Med Worm - Prostate Cancer Wed, 2 Mar 2011 6:45:11 am
|
|
|
|
Prostate Cancer - news item 31 of 133
|
|
Quality of Evidence to Compare Outcomes of Open and Robot-Assisted Laparoscopic Prostatectomy
|
|
Abstract Robot-assisted laparoscopic radical prostatectomy (RALP) has gained widespread acceptance in the treatment of prostate cancer. While it increasingly is becoming the surgical approach of choice in many centers, limited data exist directly comparing it to radical retropubic prostatectomy (RRP). This review examines the evidence comparing RALP to RRP. The...
|
|
RSS Source: Med Worm - Prostate Cancer Wed, 2 Mar 2011 6:45:11 am
|
|
|
|
Prostate Cancer - news item 32 of 133
|
|
Phase II trial of cisplatin plus prednisone in docetaxel-refractory castration-resistant prostate cancer patients
|
|
Conclusions Cisplatin plus prednisone appears to represent an active regimen in docetaxel-refractory CRPC with an acceptable toxicity profile. Further investigations in this setting are warranted to confirm these early encouraging findings. Content Type Journal ArticlePages 1-7DOI 10.1007/s00280-011-1594-zAuthors Carlo Buonerba, Department of Endocrinology and Medical Oncology, Genitourinary Cancer Section, University Federico...
|
|
RSS Source: Med Worm - Prostate Cancer Wed, 2 Mar 2011 6:44:54 am
|
|
|
|
Prostate Cancer - news item 33 of 133
|
|
Imaging in Prostate Cancer Diagnosis: Present Role and Future Perspectives
|
|
Urol Int (DOI:10.1159/000324515) (Source: Urologia Internationalis : Last 20 articles)
|
|
RSS Source: Med Worm - Prostate Cancer Tue, 1 Mar 2011 10:00:00 pm
|
|
|
|
Prostate Cancer - news item 34 of 133
|
|
Sports-themed campaign educates public about prostate cancer
|
|
A new health education campaign is harnessing the power of sports and celebrities to bring prostate cancer to the forefront as a critical men's health issue and to challenge men to take charge of their health. (Source: Modern Medicine) MedWorm Message: Watch the new MedWorm demo and find out how...
|
|
RSS Source: Med Worm - Prostate Cancer Tue, 1 Mar 2011 8:56:31 pm
|
|
|
|
Prostate Cancer - news item 35 of 133
|
|
Cryotherapy for prostate cancer
|
|
— Overview covers risks, what to expect, results of this cancer treatment. (Source: MayoClinic.com Full Feed)
|
|
RSS Source: Med Worm - Prostate Cancer Tue, 1 Mar 2011 4:11:00 pm
|
|
|
|
Prostate Cancer - news item 36 of 133
|
|
New prostate test 'twice as good'
|
|
A urine test for prostate cancer may be more reliable and accurate, claim researchers. (Source: BBC News | Health | UK Edition)
|
|
RSS Source: Med Worm - Prostate Cancer Tue, 1 Mar 2011 3:34:45 pm
|
|
|
|
Prostate Cancer - news item 37 of 133
|
|
Urine test for prostate cancer 'in 18 months'
|
|
GPs could offer men at risk of prostate cancer a simple urine test for the disease in as little as 18 months, say British scientists behind the breakthrough. (Source: Telegraph Health)
|
|
RSS Source: Med Worm - Prostate Cancer Tue, 1 Mar 2011 1:54:48 pm
|
|
|
|
Prostate Cancer - news item 38 of 133
|
|
Bavarian Nordic Announces Start Of Randomized Phase 2 Study Comparing PROSTVAC(R) And Chemotherapy Versus Chemotherapy
|
|
Bavarian Nordic A/S (OMX: BAVA) announced the initiation of a new multicenter, randomized Phase 2 study of patients with metastatic castration-resistant prostate cancer (mCRPC) treated with PROSTVAC(R). The study will compare PROSTVAC® followed by docetaxel (chemotherapy) versus docetaxel alone. Patients in the PROSTVAC® arm will receive an accelerated treatment with...
|
|
RSS Source: Med Worm - Prostate Cancer Tue, 1 Mar 2011 7:00:00 am
|
|
|
|
Prostate Cancer - news item 39 of 133
|
|
Complementary Medicine Use by Men With Prostate Cancer
|
|
How are men using alternative medicine to treat prostate cancer? Prostate Cancer and Prostatic Diseases (Source: Medscape Today Headlines) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
|
|
RSS Source: Med Worm - Prostate Cancer Tue, 1 Mar 2011 3:00:00 am
|
|
|
|
Prostate Cancer - news item 40 of 133
|
|
Doctor-owned centers spark criticism, scrutiny
|
|
The Maryland Board of Physicians is set to announce that radiation therapies such as IMRT for prostate cancer are covered by the state's "self-referral" law, which restricts doctors from referring patients to facilities in which they have a financial interest. (Source: Wash Post Health)
|
|
RSS Source: Med Worm - Prostate Cancer Tue, 1 Mar 2011 12:59:04 am
|
|
|
|
Prostate Cancer - news item 41 of 133
|
|
Mutational analysis of NCOA2 gene in prostate cancer and other common cancers
|
|
(Source: APMIS)
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 42 of 133
|
|
The Mechanism of Sertralineâ€induced [Ca2+]i Rise in Human PC3 Prostate Cancer Cells
|
|
This study examined if sertraline altered basal [Ca2+]i levels in suspended PC3 human prostate cancer cells by using furaâ€2 as a Ca2+â€sensitive fluorescent probe. At concentrations of 10â€150 μM, sertraline induced a [Ca2+]i rise in a concentrationâ€dependent fashion. The Ca2+ signal was reduced partly by removing extracellular Ca2+ indicating that...
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 43 of 133
|
|
Steroid 5-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders.
|
|
Authors: Paba S, Frau R, Godar SC, Devoto P, Marrosu F, Bortolato M The enzyme steroid 5 reductase (S5 R) catalyzes the conversion of 4-3-ketosteroid precursors - such as testosterone, progesterone and androstenedione - into their 5 -reduced metabolites. Although the current nomenclature assigns five enzymes to the S5 R...
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 44 of 133
|
|
[Articles] Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study
|
|
The results of this study provide strong evidence that the CCP score is a robust prognostic marker, which, after additional validation, could have an essential role in determining the appropriate treatment for patients with prostate cancer. (Source: The Lancet Oncology)
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 45 of 133
|
|
[News] Where next for research and development in oncology?
|
|
Pfizer are closing their main European research and development (R&D) headquarters and making cuts to their US sites. They are slicing US$2 billion from their 2012 R&D budget, and have their $330 million settlements due for Prempro's risks of breast cancer. MannKind are cutting 41% of their workforce. Patents for...
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 46 of 133
|
|
[Comment] Show us a sign: the search for “game changing†prostate cancer biomarkers
|
|
Prostate cancer is a heterogeneous disease. Encouraging results were obtained in many single tissue-based biomarker studies that were undertaken in the quest to define heterogeneity and designed to provide more useful information for prognosis than do clinical variables (eg, cancer stage, Gleason score, and concentrations of serum prostate-specific antigen [PSA])....
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 47 of 133
|
|
Antagonists of growth hormone-releasing hormone (GHRH) reduce prostate size in experimental benign prostatic hyperplasia [Medical Sciences]
|
|
This study sheds light on the mechanism of action of GHRH antagonists in BPH and suggests that GHRH antagonists should be considered for further development as therapy for BPH. (Source: Proceedings of the National Academy of Sciences)
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 48 of 133
|
|
Prostate Guideline Causes Many Needless Biopsies, Study Says
|
|
Current guidelines for the early detection of prostate cancer recommend a biopsy for men whose P.S.A. rises rapidly, no matter what the initial level. (Source: RWJF News Digest - Quality/Equality)
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 49 of 133
|
|
Presence of tumoural C-reactive protein correlates with progressive prostate cancer
|
|
Authors: B Elsberger, L Lankston, D C McMillan, M A Underwood & J Edwards (Source: Prostate Cancer and Prostatic Diseases)
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 50 of 133
|
|
Predicting prostate cancer at rebiopsies in patients with high-grade prostatic intraepithelial neoplasia: a study on 546 patients
|
|
Authors: A Antonelli, R Tardanico, L Giovanessi, N Pesenti, L Gatti, T Zambolin, D Zani, S C Cunico & C Simeone (Source: Prostate Cancer and Prostatic Diseases) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 51 of 133
|
|
Identification of a Clinically Relevant Androgen-Dependent Gene Signature in Prostate Cancer
|
|
The androgen receptor (AR) is the principal target for treatment of non–organ-confined prostate cancer (PCa). Androgen deprivation therapies (ADT) directed against the AR ligand–binding domain do not fully inhibit androgen-dependent signaling critical for PCa progression. Thus, information that could direct the development of more effective ADTs is desired. Systems and...
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 52 of 133
|
|
Systematic Analysis of MicroRNAs Targeting the Androgen Receptor in Prostate Cancer Cells
|
|
Androgen receptor (AR) is expressed in all stages of prostate cancer progression, including in castration-resistant tumors. Eliminating AR function continues to represent a focus of therapeutic investigation, but AR regulatory mechanisms remain poorly understood. To systematically characterize mechanisms involving microRNAs (miRNAs), we conducted a gain-of function screen of 1129 miRNA...
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 53 of 133
|
|
Peroxiredoxin 1 Controls Prostate Cancer Growth through Toll-Like Receptor 4-Dependent Regulation of Tumor Vasculature
|
|
In recent years a number of studies have implicated chronic inflammation in prostate carcinogenesis. However, mitigating factors of inflammation in the prostate are virtually unknown. Toll-like receptor 4 (TLR4) activity is associated with inflammation and is correlated with progression risk in prostate cancer (CaP). TLR4 ligands include bacterial cell wall...
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 54 of 133
|
|
Steps in prostate cancer progression that lead to bone metastasis
|
|
AbstractProstate cancer is a complex disease in which metastasis to the bone is the main cause of death. Initial stages of metastasis are generally similar to those for most solid tumors; however, the mechanisms that underlie the homing of prostate tumor cells to the bone remain incompletely understood. Prostate cancer...
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 55 of 133
|
|
The impact of amyloid precursor protein signalling and histone deacetylase inhibition on neprilysin expression in human prostate cells
|
|
AbstractThe zinc metallopeptidase, neprilysin (NEP), is an endothelinâ€1 degrading enzyme whose expression is extensively downâ€regulated in prostate cancer. The expression of NEP in neuronal cells is regulated by intramembrane proteolysis of the amyloid precursor protein (APP) through its intracellular domain (AICD) facilitating histone acetylation of the NEP promoter and gene...
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 56 of 133
|
|
The association between radiographic response and overall survival in men with metastatic castrationâ€resistant prostate cancer receiving chemotherapy
|
|
CONCLUSIONS:In men with metastatic CRPC and measurable disease receiving chemotherapy, objective tumor response was prognostic for OS and appeared to complement PSA assessment. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 57 of 133
|
|
Incidence and mortality in epithelial ovarian cancer by family history of any cancer
|
|
CONCLUSIONS:Fatal familial risks were higher for concordant ovarian, ovarianâ€breast, and ovarianâ€prostate cancers than the corresponding incident risks. This may suggest that highly fatal subtypes exist for these cancers, calling for genetic dissection. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 58 of 133
|
|
Assessing the impact of comorbid illnesses on death within 10 years in prostate cancer treatment candidates
|
|
Groome et al use the caseâ€cohort design to study the contribution of comorbidity to death from causes other than prostate cancer in a large group of men treated for cure. They modify an existing comorbidity instrument, the CIRSâ€G, for use to predict risk of dying from nonprostate cancer causes. (Source:...
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 59 of 133
|
|
Preoperative hypogonadism is not an independent predictor of highâ€risk disease in patients undergoing radical prostatectomy
|
|
CONCLUSIONS:In contrast with previous reports, preoperative circulating TT levels were not associated with highâ€risk PCa. Likewise, hypogonadism did not achieve independent predictor status for highâ€risk PCa. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer)
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 60 of 133
|
|
Turning conventional wisdom upsideâ€down
|
|
A revolution in traditional oncological concepts has shifted our gaze from high serum testosterone to low testosterone as a potential predictor of highâ€risk prostate cancer. The results of a study by Salonia et al add to a growing literature indicating that preoperative low serum T increases the likelihood of highâ€risk...
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 61 of 133
|
|
Efficacy and Safety of Dutasteride on Prostate Cancer Risk Reduction in Asian Men: The Results from the REDUCE Study
|
|
Conclusions The incidence of prostate cancer in the dutasteride group was lower than that in the placebo group, although the difference was not significant. These results paralleled those for the overall population and support the value of dutasteride for prostate cancer risk reduction in Asian men with an increased risk...
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 62 of 133
|
|
Serum Testosterone Level to Predict the Efficacy of Sequential Use of Antiandrogens as Second-line Treatment Following Androgen Deprivation Monotherapy in Patients with Castration-resistant Prostate Cancer
|
|
Conclusions Serum testosterone could play an important role when delayed maximal androgen blockade is indicated as the second-line treatment in patients with castration-resistant prostate cancer. Delayed maximal androgen blockade might be more beneficial in patients with a serum testosterone level of ≥5 ng/dl. (Source: Japanese Journal of Clinical Oncology)
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 63 of 133
|
|
GPs slated over cancer
|
|
A LACK of knowledge and scepticism amongst some GPs prevent men in Edinburgh from receiving a prostate cancer check, a charity has said. (Source: Scotsman.com News - Health)
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 64 of 133
|
|
Most men 'unaware of prostate cancer test'
|
|
Two-thirds of men at a raised risk of prostate cancer do not know about a blood test described as the "first line of defence" against the disease, says a charity. (Source: Telegraph Health) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest,...
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 5:12:00 pm
|
|
|
|
Prostate Cancer - news item 65 of 133
|
|
Live Longer: New Chemo in Progressive Prostate Cancer
|
|
Commentary on this F1000 practice-changing study discusses the impact of cabazitaxel on advanced prostate cancer. Faculty of 1000 Medicine (Source: Medscape Urology Headlines)
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 4:00:00 pm
|
|
|
|
Prostate Cancer - news item 66 of 133
|
|
Live Longer: New 1st-Line Chemo in Advanced Prostate Cancer
|
|
Commentary on this F1000 practice-changing study discusses the impact of cabazitaxel on advanced prostate cancer. Faculty of 1000 Medicine (Source: Medscape Pharmacist Headlines)
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 4:00:00 pm
|
|
|
|
Prostate Cancer - news item 67 of 133
|
|
Genes may predict severity of prostate cancer
|
|
Researchers identify a four-gene signature that could help spot aggressive versus indolent forms of the disease and reduce harmful overtreatment. (Source: American Medical News - HEALTH)
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 11:00:00 am
|
|
|
|
Prostate Cancer - news item 68 of 133
|
|
Mouse Models of Prostate Cancer
|
|
The development and optimization of high-throughput screening methods has identified a multitude of genetic changes associated with human disease. The use of immunodeficient and genetically engineered mouse models that mimic the human disease has been crucial in validating the importance of these genetic pathways in prostate cancer. These models provide...
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 10:50:44 am
|
|
|
|
Prostate Cancer - news item 69 of 133
|
|
External beam radiation for prostate cancer
|
|
— Overview covers risks, what to expect and results. (Source: MayoClinic.com Full Feed) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
|
|
RSS Source: Med Worm - Prostate Cancer Mon, 28 Feb 2011 1:45:00 am
|
|
|
|
Prostate Cancer - news item 70 of 133
|
|
Man with Prostate, Lung, and Thyroid Cancer to Embark on 2600 Mile Trek
|
|
A man with three types of diagnosed cancer including stage 4 lung cancer says he will embark on a 2600 mile trek along the entire length of the Pacific Coast Trail which stretches from Mexico into Canada....Read Full Post (Source: About.com Prostate Cancer)
|
|
RSS Source: Med Worm - Prostate Cancer Sun, 27 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 71 of 133
|
|
Trial Results May Have Influenced PSA Testing Trend
|
|
Prostate-specific antigen (PSA) testing of men for prostate cancer appears to have declined slightly since the 2009 publication of trials with conflicting findings on the effect of PSA testing on mortality, according to research published online Feb. 28 in the Journal of the National Cancer Institute. (Source: Modern Medicine)
|
|
RSS Source: Med Worm - Prostate Cancer Sun, 27 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 72 of 133
|
|
CADTH Rapid Response Report: Antibiotic prophylaxis for patients undergoing transrectal ultrasound biopsy
|
|
Source: Canadian Agency for Drugs and Technologies in Health (CADTH) Area: News The purpose of this Rapid Response Report from the Canadian Agency for Drugs and technologies in Health (CADTH) was to determine the clinical effectiveness of antibiotic prophylaxis for the prevention of bacteraemia and septicaemia in patients undergoing transrectal...
|
|
RSS Source: Med Worm - Prostate Cancer Sun, 27 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 73 of 133
|
|
Rising PSA Leads To Too Many Unnecessary Prostate Biopsies
|
|
If a male's PSA (prostate specific antigen) has risen rapidly in recent years, he should not have a biopsy if his clinical exam is normal and the total PSA level is not yet high, researchers from Memorial Sloan-Kettering Cancer Center wrote in the Journal of the National Cancer Institute. They...
|
|
RSS Source: Med Worm - Prostate Cancer Sat, 26 Feb 2011 10:00:00 pm
|
|
|
|
Prostate Cancer - news item 74 of 133
|
|
PSA Screening Drops Since Two Large Trial Results Were Published
|
|
One large American health care network reports that PSA screening has gone down since a set of new guidelines were issued, as well as the publication of two large trials, says an article in the Journal of the National Cancer Institute. PSA screening should not occur for males older than...
|
|
RSS Source: Med Worm - Prostate Cancer Sat, 26 Feb 2011 7:00:00 am
|
|
|
|
Prostate Cancer - news item 75 of 133
|
|
Regulation of the androgen receptor by SET9-mediated methylation
|
|
The androgen receptor (AR) is a member of the nuclear hormone receptor family of transcription factors that plays a critical role in regulating expression of genes involved in prostate development and transformation. Upon hormone binding, the AR associates with numerous co-regulator proteins that regulate the activation status of target genes...
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 76 of 133
|
|
Prostate cancer biopsies questioned
|
|
SAN ANTONIO, Feb. 25 (UPI) -- A rapid rise in PSA levels often leads doctors to suggest biopsies, but U.S. researchers say a study shows the rise is not a good predictor of prostate cancer. (Source: Health News - UPI.com)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 10:55:08 pm
|
|
|
|
Prostate Cancer - news item 77 of 133
|
|
Denosumab Slows Bone Events in Prostate CA (CME/CE)
|
|
(MedPage Today) -- The monoclonal antibody denosumab (Xgeva) was better than zoledronic acid (Zometa) -- the standard of care -- at delaying skeletal-related events in men with bone metastases from castration-resistant prostate cancer, a phase III trial showed. (Source: MedPage Today State Required CME)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 10:13:12 pm
|
|
|
|
Prostate Cancer - news item 78 of 133
|
|
Metabolic syndrome is associated with high grade gleason score when prostate cancer is diagnosed on biopsy
|
|
CONCLUSIONSIn our single center study, MS is associated with an increased risk of high grade Gleason score when prostate cancer is diagnosed on biopsy. However, these results should be confirmed in a larger multicenter study. Prostate © 2011 Wileyâ€Liss, Inc. (Source: The Prostate)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 9:40:51 pm
|
|
|
|
Prostate Cancer - news item 79 of 133
|
|
PSA Level Change Not a Prefictor for Prostate Cancer
|
|
Change in PSA level does not predict prostate cancer - Screening for PSA velocity leads to many unnecessary biopsies and should be removed from screening guidelines... (Source: Disabled World) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!...
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 7:53:55 pm
|
|
|
|
Prostate Cancer - news item 80 of 133
|
|
[Department of Error] Department of Error
|
|
de Bono JS, Oudard S, Ozguroglu M, et al, for the TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet 2010; 376: 1147†54†In figure 2B of this Article (Oct 2), the data shown for patients with...
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 5:05:17 pm
|
|
|
|
Prostate Cancer - news item 81 of 133
|
|
Early male baldness linked to prostate cancer risk
|
|
Men with prostate cancer are twice as likely to have started losing their hair by the age of 20 years compared with men without the disease, reports a French research team. (Source: MedWire News - Prostate Cancer)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 2:27:17 pm
|
|
|
|
Prostate Cancer - news item 82 of 133
|
|
HY251, a novel decahydrocyclopenta[a]indene analog, from Aralia continentalis induces apoptosis via down-regulation of AR expression in human prostate cancer LNCaP cells.
|
|
Authors: Oh HL, Lee CH In the course of screening for a novel anticancer drug candidate, we previously isolated HY251 with the molecular structure of 3-propyl-2-vinyl-1,2,3,3a,3b,6,7,7a,8,8a-decahydrocyclopenta[a]indene-3,3a,7a,8a-tetraol from the roots of Aralia continentalis. The current study was designed to evaluate the detailed mechanisms of apoptotic induction of HY251 in androgen-sensitive prostate...
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 1:30:22 pm
|
|
|
|
Prostate Cancer - news item 83 of 133
|
|
Change In PSA Level Does Not Predict Prostate Cancer
|
|
Researchers at Memorial Sloan-Kettering Cancer Center have found that change in PSA levels over time known as PSA velocity is a poor predictor of prostate cancer and may lead to many unnecessary biopsies. The new study of more than 5,000 men was published online February 24 in the Journal of...
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 12:00:00 pm
|
|
|
|
Prostate Cancer - news item 84 of 133
|
|
PSA velocity may not contribute to prostate cancer screening process
|
|
(Source: HemOncToday.com)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 11:31:00 am
|
|
|
|
Prostate Cancer - news item 85 of 133
|
|
PSA rise not good prostate cancer predictor: study
|
|
A rising PSA level isn't such a good predictor of prostate cancer after all and can lead to many unnecessary biopsies, says a large new study. (Source: CTV Health)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 11:02:28 am
|
|
|
|
Prostate Cancer - news item 86 of 133
|
|
Protein surge 'not cancer sign'
|
|
Further concerns have been raised over the reliability of protein testing as an indicator of prostate cancer. (Source: BBC News | Health | UK Edition)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 10:29:33 am
|
|
|
|
Prostate Cancer - news item 87 of 133
|
|
Change in PSA level does not predict prostate cancer, study finds
|
|
Researchers have found that change in PSA levels over time -- known as PSA velocity -- is a poor predictor of prostate cancer and may lead to many unnecessary biopsies. (Source: ScienceDaily Headlines)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 9:00:00 am
|
|
|
|
Prostate Cancer - news item 88 of 133
|
|
Denosumab Better Than Current Gold Standard Of Zoledronic Acid For Preventing Bone Events In Men With Hormone-Resistant Prostate Cancer
|
|
Prostate cancer in men usually becomes resistant to initial hormone treatment within a few years of diagnosis (and is thereafter called castration-resistant prostate cancer) and tumours begin to grow again and spread to other parts of the body (metastasis), including bones. This increases the risk of bone breakages and other...
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 7:00:00 am
|
|
|
|
Prostate Cancer - news item 89 of 133
|
|
Design, synthesis and validation of integrin α2β1-targeted probe for microPET imaging of prostate cancer
|
|
Conclusion The sarcophagine-conjugated DGEA peptide allows noninvasive imaging of tumor-associated α2β1 expression, which may be a useful PET probe for evaluating the metastatic potential of prostate cancer. Content Type Journal ArticlePages 1-10DOI 10.1007/s00259-011-1752-xAuthors Chiun-Wei Huang, Department of Radiology, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033,...
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 6:17:50 am
|
|
|
|
Prostate Cancer - news item 90 of 133
|
|
Study: PSA Rise Not Good Prostate Cancer Predictor
|
|
A rising PSA level isn't such a good predictor of prostate cancer after all and can lead to many unnecessary biopsies, says a large new study. (Source: WDSU.com - Health)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 6:09:28 am
|
|
|
|
Prostate Cancer - news item 91 of 133
|
|
Newer Drug May Help Prevent Fracture in Men With Prostate Cancer
|
|
Title: Newer Drug May Help Prevent Fracture in Men With Prostate CancerCategory: Health NewsCreated: 2/24/2011 10:05:00 PMLast Editorial Review: 2/25/2011 (Source: MedicineNet Cancer General)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 6:00:00 am
|
|
|
|
Prostate Cancer - news item 92 of 133
|
|
Rapid Rise in PSA Levels a Poor Predictor of Prostate Cancer: Study
|
|
Title: Rapid Rise in PSA Levels a Poor Predictor of Prostate Cancer: StudyCategory: Health NewsCreated: 2/24/2011 8:05:00 PMLast Editorial Review: 2/25/2011 (Source: MedicineNet Cancer General) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 6:00:00 am
|
|
|
|
Prostate Cancer - news item 93 of 133
|
|
PSA Screening for Prostate Cancer Dips in Large U.S. Health Network
|
|
Title: PSA Screening for Prostate Cancer Dips in Large U.S. Health NetworkCategory: Health NewsCreated: 2/24/2011 8:05:00 PMLast Editorial Review: 2/25/2011 (Source: MedicineNet Cancer General)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 6:00:00 am
|
|
|
|
Prostate Cancer - news item 94 of 133
|
|
New data show worrisome use of imaging for prostate cancer
|
|
New research presented at this month's Genitourinary Cancers Symposium in Orlando, (more) (Source: AuntMinnie.com Headlines)
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 6:00:00 am
|
|
|
|
Prostate Cancer - news item 95 of 133
|
|
Update in Testosterone Therapy for Men (CME)
|
|
Conclusions.  T deficiency is highly prevalent in the aging male and represents a sign of physical and sexual frailty. The significance of low T in elderly men has yet to be completely clarified. Large, prospective intervention trials will help solve this dilemma. Corona G, Rastrelli G, Forti G, and Maggi...
|
|
RSS Source: Med Worm - Prostate Cancer Fri, 25 Feb 2011 1:17:02 am
|
|
|
|
Prostate Cancer - news item 96 of 133
|
|
New Treatment for Bone Metastases Shows Dramatic Preliminary Results
|
|
Preliminary results from a trial examining the effects of cabozantinib, one of a family of drugs known as wide-spectrum tyrosine kinase inhibitors, showed dramatic improvement for many men with prostate cancer metastases to the bones....Read Full Post (Source: About.com Prostate Cancer)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 97 of 133
|
|
PSA test results: It isn’t how fast they go up
|
|
A study of 5,519 men conducted by Dr. Andrew Vickers of Memorial Sloan-Kettering Cancer Center in New York showed that rising levels of prostate specific antigen (PSA) were not an indicator of an increased risk of prostate cancer. Dr. Vickers’ team found that only high absolute levels of PSA were...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 98 of 133
|
|
Prostate Cancer Ablation with Transrectal High-Intensity Focused Ultrasound: Assessment of Tissue Destruction with Contrast-enhanced US [Vascular and Interventional Radiology]
|
|
Conclusion: Contrast-enhanced US is a promising tool for distinguishing between ablated (devascularized) and viable (enhancing) tissue immediately after HIFU treatment. © RSNA, 2011 (Source: Continuous Publishing articles)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 99 of 133
|
|
Prostate-Specific Antigen Velocity No Indication for Biopsy
|
|
A current guideline on early detection of prostate cancer, which recommends biopsy based on high prostate-specific antigen velocity even without other indications, may lead to many unnecessary biopsies, according to a study published online Feb. 24 in the Journal of the National Cancer Institute. (Source: Modern Medicine) MedWorm Message: Watch...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 100 of 133
|
|
Denosumab May Delay Skeletal-Related Events
|
|
Denosumab prevents skeletal-related events for longer than zoledronic acid in patients with castration-resistant prostate cancer with bone metastases, according to research published online Feb. 25 in The Lancet. (Source: Modern Medicine)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 101 of 133
|
|
Androgenic Alopecia Tied to Prostate Cancer Risk
|
|
Early-onset androgenic alopecia is associated with the development of prostate cancer later in life, according to a study published online Feb. 15 in the Annals of Oncology. (Source: Modern Medicine)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 102 of 133
|
|
Annual Evidence Updates planned for March 2011
|
|
Source: NHS Evidence Area: News The NHS Evidence Specialist Collections are web-based collections containing clinical and non-clinical information on the major health priority areas. Each specialist collection identifies and provides access to quality assessed information of relevance to the community that it serves. An aspect of this involves the production...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 103 of 133
|
|
Denosumab vs. zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: RCT
|
|
Source: Lancet Area: News Denosumab is a human monoclonal antibody against the receptor activator of nuclear factor ?-B ligand (RANKL), which is responsible for osteoclast formation, differentiation, and survival. In the Lancet, researchers present the findings of a RCT of denosumab vs. zoledronic acid to treat bone metastases in men...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 104 of 133
|
|
Prostate cancerâ€derived angiogenin stimulates the invasion of prostate fibroblasts
|
|
AbstractProstate fibroblasts promote prostate cancer progression by secreting factors that enhance tumor growth and induce the migration and invasion of prostate cancer cells. Considering the role of fibroblasts in cancer progression, we hypothesized that prostate cancer cells recruit these cells to their vicinity, where they are most directly available to...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 105 of 133
|
|
The potential utility of telomereâ€related markers for cancer diagnosis
|
|
ABSTRACTThe role telomeres and telomerase play in the initiation and progression of human cancers has been extensively evaluated. Telomeres are nucleoprotein complexes comprised of the hexanucleotide DNA repeat sequence, TTAGGG, and numerous telomereâ€associated proteins, including the six member Shelterin complex. The main function of the telomere is to stabilize the...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 106 of 133
|
|
Genetic variation in RNASEL and risk for prostate cancer in a populationâ€based case†control study
|
|
CONCLUSIONSThis study identified three RNASEL variants that are associated with risk for prostate cancer. Further research is required to confirm these results and to better understand the potential role RNASEL variants may play in the etiology of sporadic prostate cancer. Prostate © 2011 Wileyâ€Liss, Inc. (Source: The Prostate)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 107 of 133
|
|
SWAP70, actinâ€binding protein, function as an oncogene targeting tumorâ€suppressive miRâ€145 in prostate cancer
|
|
CONCLUSIONSDownâ€regulation of miRâ€145 was a frequent event in CaP, and it may have a tumor suppressive function. SWAP70 may be a target of miRâ€145, and it might have a potential oncogenic function. The novel molecular networks though which miRâ€145 acts, may provide new insights into the underlying molecular mechanisms of...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 108 of 133
|
|
Gene expression pathways of high grade localized prostate cancer
|
|
CONCLUSIONSIn addition to androgen receptor signaling, growth factor, and cytokine mediated pathways are active in clinically localized high grade prostate cancer. The availability of therapeutics that selectively target these pathways encourages the development of clinical trials for their selective use in the neoadjuvant or adjuvant setting in men at high...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 109 of 133
|
|
Docosahexaenoic acid selectively induces human prostate cancer cell sensitivity to oxidative stress through modulation of NFâ€ÎºB
|
|
CONCLUSIONSNFâ€ÎºB is heavily implicated in promoting prosurvival signaling and may be critical for resistance to the chronic oxidative stress observed in the pathogenesis of prostate cancer. Our studies indicate that exposure of cells to physiologically achievable levels of DHA prior to treatment with H2O2 results in decreased cancer cell survival...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 110 of 133
|
|
Lobeâ€specific lineages of carcinogenesis in the transgenic adenocarcinoma of mouse prostate and their responses to chemopreventive selenium
|
|
CONCLUSIONThe C57BL/6J TRAMP mouse represents at least two lineages of prostate carcinogenesis. Chemoprevention studies should incorporate this knowledge for efficacy assessment and molecular target validations. Prostate © 2011 Wileyâ€Liss, Inc. (Source: The Prostate)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 111 of 133
|
|
hZIP1 zinc transporter downâ€regulation in prostate cancer involves the overexpression of ras responsive element binding proteinâ€1 (RREBâ€1)
|
|
CONCLUSIONSRREBâ€1 overexpression results in downâ€regulation of hZIP1 and contributes to the loss of hZIP1 expression and zinc in prostate cancer. This is an early event in prostate carcinogenesis. Prostate © 2011 Wileyâ€Liss, Inc. (Source: The Prostate)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 112 of 133
|
|
Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection
|
|
XMRV is a gammaretrovirus associated in some studies with human prostate cancer and chronic fatigue syndrome. Central to the hypothesis of XMRV as a human pathogen is the description of integration sites in DNA from prostate tumour tissues. Here we demonstrate that 2 of 14 patient-derived sites are identical to...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 113 of 133
|
|
Hormone therapy for prostate cancer
|
|
— Overview covers risks, what to expect and results. (Source: MayoClinic.com Full Feed) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 9:08:00 pm
|
|
|
|
Prostate Cancer - news item 114 of 133
|
|
Monitoring Bone Metastases With Diffusion-Weighted Imaging
|
|
Could DWI be a reasonable alternative to PSA in patients with advanced prostate cancer? Medscape Radiology (Source: Medscape Today Headlines)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 8:55:52 pm
|
|
|
|
Prostate Cancer - news item 115 of 133
|
|
American Cancer Society announces Cancer Facts & Figures for African Americans, 2011-2012 available
|
|
The report finds:Death rates among African Americans for all cancers combined have been decreasing since the early 1990s. The decline has been larger in men (2.5% per year since 1995) than in women (1.5% per year since 1999). A similar decline in death rates has been observed among whites since...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 8:55:00 pm
|
|
|
|
Prostate Cancer - news item 116 of 133
|
|
Amide proton transfer MR imaging of prostate cancer: A preliminary study
|
|
Conclusion:APTâ€MR imaging is feasible in prostate cancer detection and has the potential to discriminate between cancer and noncancer tissues. J. Magn. Reson. Imaging 2011;33:647†654. © 2011 Wileyâ€Liss, Inc. (Source: Journal of Magnetic Resonance Imaging)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 8:18:02 pm
|
|
|
|
Prostate Cancer - news item 117 of 133
|
|
PSA Testing Declines, a Bit
|
|
After results from 2 landmark prostate cancer screening trials were published, a mild change of mind about screening might have occurred, according to a new study. Medscape Medical News (Source: Medscape Today Headlines)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 8:03:39 pm
|
|
|
|
Prostate Cancer - news item 118 of 133
|
|
Spikes in PSA a poor predictor of prostate cancer
|
|
CHICAGO (Reuters) - A sudden spike in blood levels of prostate specific antigen, or PSA, is not an accurate way to predict prostate cancer, and testing for such changes can lead to overtreatment, U.S. researchers said on Thursday. (Source: Reuters: Health) MedWorm Message: Watch the new MedWorm demo and find...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 8:02:11 pm
|
|
|
|
Prostate Cancer - news item 119 of 133
|
|
Rapid Rise in PSA Levels a Poor Predictor of Prostate Cancer
|
|
Measuring changes over time leads to unnecessary biopsies, researchers say Source: HealthDay Related MedlinePlus Page: Prostate Cancer (Source: MedlinePlus Health News)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 8:00:00 pm
|
|
|
|
Prostate Cancer - news item 120 of 133
|
|
When PSA Is Not High, Velocity Can Mislead
|
|
Prostate-specific antigen (PSA) velocity is a poor predictor of prostate cancer, and its use might lead to a large number of unnecessary biopsies. Medscape Medical News (Source: Medscape Today Headlines)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 7:35:15 pm
|
|
|
|
Prostate Cancer - news item 121 of 133
|
|
Urological cancer care pathways: development and use in the context of systematic reviews and clinical practice guidelines
|
|
Conclusion The process provides a useful framework for improving urological cancer care through evidence synthesis, research prioritisation, stakeholder involvement and international collaboration. Although the focus of this work is urological cancers, the methodology can be applied to all aspects of urology and is transferable to other clinical specialties. Content Type...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 4:36:54 pm
|
|
|
|
Prostate Cancer - news item 122 of 133
|
|
CD8+ T cells specific for the androgen receptor are common in patients with prostate cancer and are able to lyse prostate tumor cells
|
|
Abstract The androgen receptor (AR) is a hormone receptor that plays a critical role in prostate cancer, and depletion of its ligand has long been the cornerstone of treatment for metastatic disease. Here, we evaluate the AR ligand-binding domain (LBD) as an immunological target, seeking to identify HLA-A2-restricted epitopes recognized...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 4:33:31 pm
|
|
|
|
Prostate Cancer - news item 123 of 133
|
|
Methods for Evaluation of Structural and Biological Properties of Antiinvasive Natural Products
|
|
Prostate cancer is considered the most common cancer form among males in Western countries. Very limited options are available for the treatment of advanced metastatic prostate cancer. More than 50% of today’s anticancer drugs are natural products or derived from a natural origin. To discover new entities with potential to...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 3:43:14 pm
|
|
|
|
Prostate Cancer - news item 124 of 133
|
|
Mounting Evidence That Agent Orange Exposure Ups Prostate Cancer Risk
|
|
A study of nearly 3000 veterans showed that men exposed to Agent Orange in Vietnam were 49% more likely to be diagnosed with prostate cancer than men who were not exposed to the defoliate. Medscape Medical News (Source: Medscape Today Headlines)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 2:40:37 pm
|
|
|
|
Prostate Cancer - news item 125 of 133
|
|
Too many men having prostate cancer biopsies, warn scientists
|
|
Many men are undergoing unnecessary biopsy operations to test for prostate cancer because a widely-used indicator for the disease is flawed, researchers have warned. (Source: Telegraph Health)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 2:24:07 pm
|
|
|
|
Prostate Cancer - news item 126 of 133
|
|
Q Chip Successfully Reports Preclinical Studies With Therapeutic Cancer Peptides Using Innovative Drug Delivery Platform
|
|
Q Chip Ltd, an emerging biopharmaceutical company developing innovative sustained-release drug formulations, announces it has successfully completed preclinical studies with formulations of two leading therapeutic cancer peptides. The peptides, Q-Leuprolide and Q-Octreotide for prostate cancer and acromegaly respectively, were formulated using Q Chip's innovative drug delivery platform, Q-SpheraTM... (Source: Health...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 9:00:00 am
|
|
|
|
Prostate Cancer - news item 127 of 133
|
|
Radiotherapy in rectal cancer: development, adequacy and radiotherapy utilisation rate. A comparative analysis with the most frequent tumour sites
|
|
Conclusions The “radiotherapy utilisation rate†for rectal cancer was equivalent to the estimated optimum rate as defined on the basis of reference groups. The therapy utilised developed chronologically in parallel with the available scientific evidence. The radiotherapy utilisation rates for breast and prostate cancer gradually increased, with a tendency to...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 6:38:02 am
|
|
|
|
Prostate Cancer - news item 128 of 133
|
|
PSA velocity screening for prostate cancer may lead to unnecessary biopsies
|
|
(Journal of the National Cancer Institute) Guidelines of several cancer organizations have recommended that men with a rapid rise in PSA have a biopsy for prostate cancer, even if there is no other indication and the PSA is within the "normal" range. But change in PSA -- known as PSA...
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 4:00:00 am
|
|
|
|
Prostate Cancer - news item 129 of 133
|
|
Comorbidity Severity and Quality of Life After Treatment for Early-stage Prostate Cancer
|
|
How does the severity of comorbidities affect patients' quality of life following radical prostatectomy or radiation therapy for prostate cancer? Prostate Cancer and Prostatic Diseases (Source: Medscape Today Headlines)
|
|
RSS Source: Med Worm - Prostate Cancer Thu, 24 Feb 2011 3:00:00 am
|
|
|
|
Prostate Cancer - news item 130 of 133
|
|
Fatigue in prostate cancer patients treated with external beam radiotherapy: A prospective 5-year long-term patient-reported evaluation
|
|
Conclusions: Fatigue is a common symptom among patients with PC. A large percentage of patients reported pre-treatment fatigue. Fatigue increased over time, with the highest level seen at the end of EBRT. Severe fatigue was reported by 4% 5-year post-treatment. More work is needed in order to identify which patients...
|
|
RSS Source: Med Worm - Prostate Cancer Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 131 of 133
|
|
Dosimetric risk estimates of radiation-induced malignancies after intensity modulated radiotherapy
|
|
Conclusions: The estimated risk of radiation-induced malignancies in the thyroid and rectum was similar to the available literature, while the risk for bladder carcinomas was lower than that reported. However, the calculated risk of radiation-induced tumors of the brain was more than that reported with conventional radiation therapy. We propose...
|
|
RSS Source: Med Worm - Prostate Cancer Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 132 of 133
|
|
The integrin signalling adaptor p130CAS is also a key player in prostate cancer
|
|
Authors: Gaelle Fromont & Olivier Cussenot In a recent Review article (Integrin signalling adaptors: not only figurants in the cancer story. Nature Rev. Cancer10, 858†870 (2010)), Sara Cabodi and colleagues discussed the influence of integrin adaptors, including the p130 Crk-associated substrate (p130CAS; (Source: Nature Reviews Cancer)
|
|
RSS Source: Med Worm - Prostate Cancer Wed, 23 Feb 2011 11:00:00 pm
|
|
|
|
Prostate Cancer - news item 133 of 133
|
|
FGFR4 Gly388Arg polymorphism contributes to prostate cancer development and progression: A meta-analysis of 2618 cases and 2305 controls
|
|
Conclusion: This meta-analysis showed the evidence that FGFR4 Gly388Arg polymorphism was associated with an increased risk of prostate cancer development and progression, suggesting that FGFR4 Gly388Arg polymorphism could be a marker for prostate cancer development and progression. (Source: BMC Cancer) MedWorm Message: Watch the new MedWorm demo and find out...
|
|
RSS Source: Med Worm - Prostate Cancer Wed, 23 Feb 2011 11:00:00 pm
|
|
|