Psoriasis - news item 1 of 134
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Comorbidities significantly increase economic burden of psoriasis
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Patients with psoriasis and comorbidities incur significantly more health costs, mostly as a result of greater utilization of medical services, compared with psoriasis patients without comorbidities, research results show. (Source: MedWire News - Psoriasis)
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RSS Source: Med Worm - Psoriasis Sat, 5 Mar 2011 3:55:12 pm
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Psoriasis - news item 2 of 134
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Anti-Tumor Necrosis Factor-α Therapy in the Management of Psoriasis and B-Chronic Lymphocytic Leukemia
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Case Rep Dermatol 2011;3:60†63 (DOI:10.1159/000324344) (Source: Karger Publishers)
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RSS Source: Med Worm - Psoriasis Fri, 4 Mar 2011 2:17:41 pm
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Psoriasis - news item 3 of 134
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Psoriasis and multiple sclerosis - is there a link
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Objectives: To investigate the potential relationship between psoriasis and MS based on a systematic review of the literature. (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - Psoriasis Fri, 4 Mar 2011 11:00:38 am
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Psoriasis - news item 4 of 134
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Basophil recruitment and activation in inflammatory skin diseases
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Conclusions:  Basophils infiltrate into skin lesions more commonly than previously thought, and thus they may play important roles in a variety of inflammatory skin diseases. (Source: Allergy)
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RSS Source: Med Worm - Psoriasis Thu, 3 Mar 2011 11:00:00 pm
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Psoriasis - news item 5 of 134
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An Illustrative Case of Subcutaneous Panniculitis-Like T-Cell Lymphoma
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Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a very rare form of skin lymphoma that is localized primarily to the subcutaneous adipose tissue without palpable involvement of the lymph nodes. Diagnosis of SPTCL is a challenge, especially during its early phases when symptoms mimic other, more common conditions, such as benign...
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RSS Source: Med Worm - Psoriasis Thu, 3 Mar 2011 1:56:13 pm
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Psoriasis - news item 6 of 134
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Recalcitrant Palmoplantar Pustular Psoriasis Treated with Etanercept
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We report a 10â€yearâ€old boy presenting with palmoplantar pustular psoriasis, resistant to topical and systemic treatments, who was successfully treated with subcutaneous etanercept (0.4 mg/kg) twice a week for 1 month. Maintenance therapy was extended for 18 months in combination with near ultraviolet light therapy without any adverse effect. Etanercept may be a...
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RSS Source: Med Worm - Psoriasis Wed, 2 Mar 2011 11:00:00 pm
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Psoriasis - news item 7 of 134
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Contemporary epidemiology of gout in the UK general population
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Conclusions: The contemporary incidence of gout in UK remains substantial. In this general population cohort, associations with previously purported risk factors were evident including psoriasis, heart failure, hypertriglyceridemia, and cyclosporine therapy. Use of gout-specific treatment has remained relatively constant in recent years except for an increase of colchicine. (Source: Arthritis...
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RSS Source: Med Worm - Psoriasis Wed, 2 Mar 2011 11:00:00 pm
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Psoriasis - news item 8 of 134
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High resolution mapping in the major histocompatibility complex region identifies multiple independent novel loci for psoriatic arthritis
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Conclusion Four new loci for either psoriasis or PsA in the MHC region that are independent of known HLA alleles have been identified. The effect size of these variants is modest. Replication of these variants in multiple larger populations is necessary. (Source: Annals of the Rheumatic Diseases)
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RSS Source: Med Worm - Psoriasis Wed, 2 Mar 2011 11:00:00 pm
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Psoriasis - news item 9 of 134
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Drug-specific risk of non-tuberculosis opportunistic infections in patients receiving anti-TNF therapy reported to the 3-year prospective French RATIO registry
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Conclusion Various and severe OIs, especially those with intracellular micro-organisms, may develop in patients receiving anti-TNF treatment. Monoclonal anti-TNF antibody rather than soluble TNF receptor therapy and steroid use >10 mg/day are independently associated with OI. (Source: Annals of the Rheumatic Diseases)
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RSS Source: Med Worm - Psoriasis Wed, 2 Mar 2011 11:00:00 pm
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Psoriasis - news item 10 of 134
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Tanning Bed Exposure Can Be Deadly When Complicated By Medication Reactions
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Tanning bed exposure can produce more than some tanners may bargain for, especially when they self-diagnose and use the radiation to treat skin eruptions, according to research conducted by the Indiana University School of Medicine Department of Dermatology. "There are many reasons to be cautious of tanning bed radiation but...
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RSS Source: Med Worm - Psoriasis Wed, 2 Mar 2011 8:00:00 am
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Psoriasis - news item 11 of 134
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Tanning bed exposure can be deadly
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Tanning bed exposure can produce more than some tanners may bargain for, particularly when they self-diagnose and use the radiation to treat skin eruptions, as per research conducted by the Indiana University School of Medicine Department of Dermatology. "There are a number of reasons to be cautious of tanning bed...
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RSS Source: Med Worm - Psoriasis Wed, 2 Mar 2011 3:23:46 am
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Psoriasis - news item 12 of 134
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Plasma and tissue osteopontin in relation to plasma selenium in patients with psoriasis
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Conclusions  High plasma OPN and low plasma Se levels are predictable factors for occurrence of psoriasis. Further studies examining the effects of Se supplementations on the levels of plasma OPN, together with their effects on psoriasis outcome and cardiovascular risk factors in these patients, are needed. (Source: Journal of the...
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RSS Source: Med Worm - Psoriasis Tue, 1 Mar 2011 11:00:00 pm
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Psoriasis - news item 13 of 134
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VESTALCARE SPOT FREE PSORIASIS (Calcarea Silicata, Lithium Carbonicum, Natrum Muriaticum, Phytolacca Decandra, Sarsaparilla, Sulphur Iodatum, Thyroidinum,) Tablet [Apotheca Company]
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Updated Date: Mar 1, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
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RSS Source: Med Worm - Psoriasis Tue, 1 Mar 2011 4:00:00 am
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Psoriasis - news item 14 of 134
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Prognosis Following Firstâ€time Myocardial Infarction in Patients with Psoriasis: a Danish Nationwide Cohort Study
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Conclusion:  This first study of the impact of psoriasis on prognosis after firstâ€time MI indicated a significantly impaired prognosis in patients with psoriasis. Further studies of this novel association are warranted. (Source: Journal of Internal Medicine)
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RSS Source: Med Worm - Psoriasis Mon, 28 Feb 2011 11:00:00 pm
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Psoriasis - news item 15 of 134
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Tobacco smoke is related to Th17 generation with clinical implications for psoriasis patients
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Abstract:  Environmental factors contribute to the increased prevalence of autoimmune diseases via T helper typeâ€17 cell (Th17) activation. Tobacco smoking increases the risk of psoriasis, but the mechanisms are not clear. We evaluated the percentage of circulating Th17 among CD3+ cells in peripheral blood mononuclear cells (PBMC) obtained from 27...
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RSS Source: Med Worm - Psoriasis Sun, 27 Feb 2011 11:00:00 pm
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Psoriasis - news item 16 of 134
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Inhibition of keratin 17 expression with antisense and RNAi strategies: exploring novel therapy for psoriasis
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Abstract:  Psoriasis is now considered to be a chronic, immuneâ€mediated and inflammatory skin disease. As the precise cause of psoriasis remains unknown, its treatment is challenging for dermatologists. Keratin 17 (K17), an intermediate filament protein, is highly expressed in psoriatic lesions, while not normally expressed in healthy epidermis. Studies have...
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RSS Source: Med Worm - Psoriasis Sun, 27 Feb 2011 11:00:00 pm
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Psoriasis - news item 17 of 134
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Inverse Psoriasis: Case Presentation and Review
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(Source: American Journal of Clinical Dermatology)
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RSS Source: Med Worm - Psoriasis Sun, 27 Feb 2011 5:01:18 pm
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Psoriasis - news item 18 of 134
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Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin
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Conclusions: Our studies consolidate the properties of lentiviral vectors as a tool for potent gene delivery and for evaluation of mRNA targets for anti-inflammatory therapy. However, in contrast to local anti-TNFalpha treatment, the therapeutic potential of targeting IL-12B at the RNA level in psoriasis is questioned. (Source: BMC Dermatology)
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RSS Source: Med Worm - Psoriasis Sat, 26 Feb 2011 11:00:00 pm
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Psoriasis - news item 19 of 134
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Start dose for UV-B psoriasis treatment important for tolerance, not efficacy
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Determining the appropriate dose of narrowband ultraviolet-B treatment for psoriasis patients by first working out their minimal erythemal dose does not affect treatment efficacy, but is important for identifying adverse effects, say researchers. (Source: MedWire News - Psoriasis)
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RSS Source: Med Worm - Psoriasis Sat, 26 Feb 2011 3:32:19 pm
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Psoriasis - news item 20 of 134
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Clinical Trials Update: Feb. 25, 2011
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Opioid Induced Constipation Psoriasis Bipolar Depression (Source: The Doctors Lounge - Health News) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Psoriasis Fri, 25 Feb 2011 3:21:00 pm
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Psoriasis - news item 21 of 134
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HOME HEALTH PSORIASIS (Salicylic Acid) Cream [Home Health]
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Updated Date: Feb 24, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
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RSS Source: Med Worm - Psoriasis Thu, 24 Feb 2011 4:00:00 am
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Psoriasis - news item 22 of 134
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Effect of narrowband ultraviolet B phototherapy on serum folic acid levels in patients with psoriasis
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Abstract Narrowband ultraviolet B phototherapy (NB-UVB) is a widely used modality in the treatment of psoriasis and is generally accepted as safe in pregnancy. Previous studies have described photodegradation of serum folate after exposure to UVA radiation but the effect of UVB is not known. We studied the effect of...
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RSS Source: Med Worm - Psoriasis Wed, 23 Feb 2011 11:11:03 pm
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Psoriasis - news item 23 of 134
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Survival in cancer patients hospitalised for psoriasis: a populationâ€based cohort study in Sweden
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Conclusions:  A previously diagnosed psoriasis worsens the prognosis of many cancers. Worse prognosis was more pronounced in psoriatic cancer patients diagnosed at earlier age, previously hospitalised for alcoholâ€related diseases, or with severe symptoms. Our study provided clinicians and patients with information about mortality risk and prognostic factors for psoriatic cancer...
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RSS Source: Med Worm - Psoriasis Wed, 23 Feb 2011 11:00:00 pm
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Psoriasis - news item 24 of 134
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Efficacious and safe management of moderateâ€toâ€severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0.05% combined with ketoconazole shampoo 2%: a randomised, controlled study
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Conclusion:  The combination therapy of twice weekly clobetasol shampoo alternating with twice weekly ketoconazole shampoo provided significantly greater efficacy than ketoconazole alone and a sustained effect in the treatment of moderateâ€toâ€severe scalp SD. (Source: British Journal of Dermatology) MedWorm Message: Watch the new MedWorm demo and find out how to...
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RSS Source: Med Worm - Psoriasis Wed, 23 Feb 2011 11:00:00 pm
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Psoriasis - news item 25 of 134
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Psoriasis and melanocytic naevi: does the first confer a protective role against melanocyte progression to naevi?
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Conclusions  People with psoriasis had fewer melanocytic naevi. It suggests that the proinflammatory cytokine network in psoriasis skin might inhibit melanogenesis, melanocyte growth and/or progression to naevi. (Source: British Journal of Dermatology)
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RSS Source: Med Worm - Psoriasis Wed, 23 Feb 2011 11:00:00 pm
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Psoriasis - news item 26 of 134
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Possible association of Henoch†Schönlein purpura in adults with odontogenic focal infection
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Conclusions  Latent OFI is an important infectious focus that is involved in the pathogenesis of HSP and influences its disease activity. (Source: International Journal of Dermatology)
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RSS Source: Med Worm - Psoriasis Wed, 23 Feb 2011 3:30:19 pm
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Psoriasis - news item 27 of 134
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HOME HEALTH PSORIASIS MEDICATED SCALP AND BODY WASH (Salicylic Acid) Liquid [Home Health]
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Updated Date: Feb 23, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
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RSS Source: Med Worm - Psoriasis Wed, 23 Feb 2011 4:00:00 am
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Psoriasis - news item 28 of 134
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Chemical Constituents and Pharmacological Properties of Poria cocos
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Planta MedDOI: 10.1055/s-0030-1270823AbstractPoria cocos (Polyporaceae) is a saprophytic fungus that grows in diverse species of Pinus. Its sclerotium, called fu-ling or hoelen, is used in traditional Chinese and Japanese medicine for its diuretic, sedative, and tonic effects. Various studies of this fungus have demonstrated its marked anti-inflammatory activity in different...
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RSS Source: Med Worm - Psoriasis Tue, 22 Feb 2011 11:00:00 pm
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Psoriasis - news item 29 of 134
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Lipid levels in patients with lichen planus: a case†control study
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Conclusion  The results obtained in this study indicate an association between LP and dyslipidaemia. Lipid levels screening in men or women with LP may be useful to detect individuals at risk and start preventive treatment against the development of cardiovascular disease. (Source: Journal of the European Academy of Dermatology and...
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RSS Source: Med Worm - Psoriasis Tue, 22 Feb 2011 11:00:00 pm
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Psoriasis - news item 30 of 134
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Treatment of palmoplantar psoriasis with infliximab: a randomized, doubleâ€blind placeboâ€controlled study
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Conclusions  This pilot study did not reach its primary endpoint of mâ€PPPASI 75 at week 14. However, infliximab was observed to be more efficacious than placebo in improving PPSA and with respect to the percentage of patients reaching mâ€PPPASI 50 at week 14. Larger and longer term studies are needed...
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RSS Source: Med Worm - Psoriasis Tue, 22 Feb 2011 11:00:00 pm
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Psoriasis - news item 31 of 134
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Prevalence and characteristics of psoriatic arthritis in Chinese patients with psoriasis
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Conclusion  The findings are consistent with a low prevalence of PsA among patients with psoriasis in Asia and confirm a high percentage of undiagnosed cases with active arthritis among PsA patients in dermatologist’s office. Dermatologists should screen for PsA in their patients, especially those with risk characteristics and early signs. (...
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RSS Source: Med Worm - Psoriasis Tue, 22 Feb 2011 11:00:00 pm
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Psoriasis - news item 32 of 134
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The levels of adiponectin and leptin and their relation to other markers of cardiovascular risk in patients with psoriasis
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Conclusion  The data suggest that in addition to the strong effect of inflammation and LDL oxidation, adipokine level may be one of the mechanisms behind the close association between psoriasis and CVD. Given the significant relations of several markers with BMI, health consequences of excessive weight should be better communicated...
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RSS Source: Med Worm - Psoriasis Tue, 22 Feb 2011 11:00:00 pm
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Psoriasis - news item 33 of 134
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AAD Develops Guidelines for Psoriasis and Psoriatic Arthritis
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The American Academy of Dermatology has issued guidelines for the treatment of psoriasis and psoriatic arthritis, presented in a 6-part series.n Medscape Medical News (Source: Medscape Rheumatology Headlines)
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RSS Source: Med Worm - Psoriasis Tue, 22 Feb 2011 7:59:38 pm
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Psoriasis - news item 34 of 134
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Psoriasis Guidelines Call for Tailored Treatment
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Title: Psoriasis Guidelines Call for Tailored TreatmentCategory: Health NewsCreated: 2/19/2011 11:00:00 AMLast Editorial Review: 2/22/2011 (Source: MedicineNet Chronic Pain General) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Psoriasis Tue, 22 Feb 2011 6:00:00 am
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Psoriasis - news item 35 of 134
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Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression
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Conclusion Our results indicate that the specific inhibitory effects of DMF on RSK1 and MSK1 activation together with the induction of p-c-Jun (S63) and p-p53 (S15) lead to the inhibition of keratinocyte proliferation, partly explaining the anti-psoriatic effect of DMF. Content Type Journal ArticlePages 1-11DOI 10.1007/s00011-011-0316-7Authors B. Gesser, Department of...
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RSS Source: Med Worm - Psoriasis Tue, 22 Feb 2011 5:58:34 am
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Psoriasis - news item 36 of 134
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A Case-control Study on Family Dysfunction in Patients with Alopecia Areata, Psoriasis and Atopic Dermatitis.
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In conclusion, family dysfunction may play an important role in the onset or the exacerbation of psoriasis, alopecia, and atopic dermatitis. PMID: 21336474 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
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RSS Source: Med Worm - Psoriasis Sun, 20 Feb 2011 11:00:00 pm
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Psoriasis - news item 37 of 134
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A Randomized Comparison of Methods of Selecting Narrowband UV-B Starting Dose to Treat Chronic Psoriasis [Study]
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Conclusions The methods of determining the starting dose in this predominantly skin phototype I and II population, treated 3 times weekly, with a 20% followed by 10% incremental reduction in dose, did not significantly influence the effectiveness of treatment. Had there been a clinically important difference in efficacy, we would...
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RSS Source: Med Worm - Psoriasis Sun, 20 Feb 2011 11:00:00 pm
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Psoriasis - news item 38 of 134
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Adalimumbab effective for psoriasis previously treated with anti-TNF therapy
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Patients with chronic plaque psoriasis can be treated effectively with adalimumab even if treatment with other anti-tumor necrosis factor agents has failed, shows a subanalysis of the BELIEVE study. (Source: MedWire News - Psoriasis)
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RSS Source: Med Worm - Psoriasis Sat, 19 Feb 2011 4:13:10 pm
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Psoriasis - news item 39 of 134
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CalciMedica Initiates Phase I Clinical Trial Of First CRAC Channel Inhibitor (CCI) For Psoriasis
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CalciMedica, a biotechnology company developing small molecules to treat inflammatory and autoimmune diseases, announced that it has dosed the first cohort in a Phase 1 clinical trial of CM2489. CM2489 is a first-in-class calcium-release activated calcium (CRAC) channel inhibitor being studied as a once-daily oral therapeutic for patients with moderate-to-severe...
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RSS Source: Med Worm - Psoriasis Fri, 18 Feb 2011 10:00:00 am
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Psoriasis - news item 40 of 134
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Development and characterization of eucalyptol microemulsions for topic delivery of curcumin.
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In conclusion, microemulsions were successfully developed for transdermal curcumin delivery after screening various components and adjusting the oil/water ratios. The curcumin permeation rate of the microemulsion developed was 15.7-fold higher than that of the control (eucalyptol only). These results indicate that an eucalyptol microemulsion system is a promising tool for...
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RSS Source: Med Worm - Psoriasis Fri, 18 Feb 2011 3:45:09 am
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Psoriasis - news item 41 of 134
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Increased cysteinyldopa plasma levels hint to melanocyte as stress sensor in psoriasis
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Abstract:  The possible role of melanocyte as a modulator of the inflammation and keratinocyte hyperproliferation in psoriasis has been hypothesised but never demonstrated on experimental basis. Aim of the present study was to assess whether plasma levels of 5â€Sâ€cysteinyldopa (CD), a metabolite reflecting melanocyte activity, undergo changes in association with...
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RSS Source: Med Worm - Psoriasis Thu, 17 Feb 2011 3:38:32 pm
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Psoriasis - news item 42 of 134
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In vivo response of GsdmA3Dfl/+ mice to topically applied antiâ€psoriatic agents: effects on epidermal thickness, as determined by optical coherence tomography and H&E staining
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This study evaluated in vivo the potential of optical coherence tomography (OCT) to determine changes in thickness of the epidermis in response to the topically applied antiâ€psoriatics betamethasone dipropionate (BD), salicylic acid (SA) and also fish oil (FO). GsdmA3Dfl/+ mice have an inflammatory hair loss phenotype that includes hyperproliferation and...
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RSS Source: Med Worm - Psoriasis Thu, 17 Feb 2011 3:38:28 pm
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Psoriasis - news item 43 of 134
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Antigens from Leishmania amastigotes inducing clinical remission of psoriatic arthritis
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Abstract A first generation vaccine (AS100-1) was manufactured with protein from four cultured Leishmania species, which proved to be effective in the treatment of psoriasis. A single blind trial on 3,132 psoriasis patients revealed 508 (16.2%) subjects with psoriatic arthritis (PsA) that received AS100-1 antigens. The study group was distributed...
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RSS Source: Med Worm - Psoriasis Thu, 17 Feb 2011 7:01:31 am
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Psoriasis - news item 44 of 134
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Evaluation of soluble CD163 as a marker of inflammation in psoriasis
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This study investigated whether serum levels of soluble (s)CD163 correlated with psoriasis activity as assessed by the Psoriasis Area and Severity Index (PASI). CD163, a glycoprotein molecule expressed on macrophages and dendritic cells, is cleaved from the surface of these cells in some inflammatory diseases, and sCD163 levels have been...
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RSS Source: Med Worm - Psoriasis Thu, 17 Feb 2011 7:00:12 am
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Psoriasis - news item 45 of 134
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Physician and Patient Perception of Disease Severity, Quality of Life, and Treatment Satisfaction in Psoriasis: An Observational Study in Spain.
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CONCLUSIONS: Our results highlight the substantial impact of psoriasis on patient quality of life and the consequent need for systematic quality-of-life assessment in affected patients. Patients reported a high level of satisfaction with the care provided by dermatologists and the treatment received. There was good agreement between patients and dermatologists...
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RSS Source: Med Worm - Psoriasis Wed, 16 Feb 2011 11:00:00 pm
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Psoriasis - news item 46 of 134
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Elevated levels of TNF-α, IL-1β and IL-10 in hidradenitis suppurativa skin; a rationale for targeting TNF-α and IL-1β
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Conclusions:  This study shows for the first time that IL-1β, TNF-α and IL-10 levels are elevated in HS skin. These data provide a rationale for therapies with biologics targeting cytokines such as TNF-α and IL-1. PMID: 21332464 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology) MedWorm...
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RSS Source: Med Worm - Psoriasis Wed, 16 Feb 2011 11:00:00 pm
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Psoriasis - news item 47 of 134
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Cardiovascular safety of ustekinumab in patients with moderate-to-severe psoriasis: Results of integrated analyses of data from phase II and III clinical studies.
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Conclusion:  The totality of available clinical data suggests neither a detrimental nor a beneficial effect of ustekinumab on serious CV events. Additional data are needed to define the net effect of ustekinumab on CV events. PMID: 21332467 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
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RSS Source: Med Worm - Psoriasis Wed, 16 Feb 2011 11:00:00 pm
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Psoriasis - news item 48 of 134
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Quality of life and sexual health in patients with genital psoriasis
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Conclusions:  In addition to quality of life, sexual health is diminished in a considerable number of psoriatic patients and particularly women with genital lesions have on average high levels of sexual distress. We underscore the need for physicians to implement attention for the impact of psoriasis on psychosocial and sexual...
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RSS Source: Med Worm - Psoriasis Wed, 16 Feb 2011 11:00:00 pm
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Psoriasis - news item 49 of 134
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Elevated levels of TNFâ€Î±, ILâ€1β and ILâ€10 in hidradenitis suppurativa skin; a rationale for targeting TNFâ€Î± and ILâ€1β
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Conclusions:  This study shows for the first time that ILâ€1β, TNFâ€Î± and ILâ€10 levels are elevated in HS skin. These data provide a rationale for therapies with biologics targeting cytokines such as TNFâ€Î± and ILâ€1. (Source: British Journal of Dermatology)
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RSS Source: Med Worm - Psoriasis Wed, 16 Feb 2011 11:00:00 pm
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Psoriasis - news item 50 of 134
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Eczema In Children Not Improved By Ion-Exchange Water Softeners
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Water softeners provide no additional clinical benefit to usual care in children with eczema, so the use of ion-exchange water softeners for the treatment of moderate to severe eczema in children should not be recommended. However, it is up to each family to decide whether or not the wider benefits...
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RSS Source: Med Worm - Psoriasis Wed, 16 Feb 2011 10:00:00 am
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Psoriasis - news item 51 of 134
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New Psoriasis Guidelines Stress Importance Of Individualized Treatment Plans
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Building on the evidence-based findings of five previously published guidelines of care that examine the use of a variety of medical therapies for the management and treatment of psoriasis and psoriatic arthritis, the American Academy of Dermatology (Academy) has released its sixth and final guidelines of care for psoriasis. The...
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RSS Source: Med Worm - Psoriasis Wed, 16 Feb 2011 8:00:00 am
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Psoriasis - news item 52 of 134
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A case of psoriasis with ANCA-negative pauci-immune crescentic glomerulonephritis in children
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Content Type Journal ArticlePages 1-2DOI 10.1007/s00467-011-1794-0Authors Narayan Prasad, Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014 IndiaNitin Agarwal, Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014 IndiaDharmender Bhaduria, Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014 IndiaAmit Gupta,...
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RSS Source: Med Worm - Psoriasis Mon, 14 Feb 2011 6:13:44 am
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Psoriasis - news item 53 of 134
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Law of unintended consequences
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To the Editor: Colchicine has been used for more than 200 years as an inexpensive treatment for gout. The tablet form has been widely available in the United States since the 19th century. Colchicine is also first-line treatment for a number of dermatologic disorders, including Behçet’s disease and leukocytoclastic vasculitis...
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RSS Source: Med Worm - Psoriasis Sat, 12 Feb 2011 3:30:11 pm
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Psoriasis - news item 54 of 134
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Systemic therapy could reduce CV risk in psoriasis patients
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Patients with severe plaque-type psoriasis who respond well to continuous systemic therapy experience a simultaneous reduction in levels of biomarkers that indicate cardiovascular risk, show study findings. (Source: MedWire News - Dermatology)
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RSS Source: Med Worm - Psoriasis Sat, 12 Feb 2011 3:30:01 pm
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Psoriasis - news item 55 of 134
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Expression of antimicrobial peptides and proteins in etanercept-treated psoriasis patients.
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Authors: Gambichler T, Kobus S, Kobus A, Tigges C, Scola N, Altmeyer P, Kreuter A, Bechara FG, Skrygan M Recent papers highlight the role of dysregulated expression of antimicrobial peptides and proteins (AMPs) in the pathogenesis of psoriasis. The pro-inflammatory cytokine tumour necrosis-α factor (TNF-α) is effective in the treatment...
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RSS Source: Med Worm - Psoriasis Fri, 11 Feb 2011 11:00:00 pm
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Psoriasis - news item 56 of 134
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Effective Treatments Improve Appearance but Do Not Cure Psoriasis
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Clinically effective treatments with ustekinumab or etanercept, which normalize the appearance of the skin, do not cure the underlying disease process in psoriasis. Medscape Medical News (Source: Medscape Today Headlines) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information...
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RSS Source: Med Worm - Psoriasis Fri, 11 Feb 2011 10:34:26 pm
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Psoriasis - news item 57 of 134
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Clinical Trials Update: Feb. 11, 2011
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Psoriasis Multiple Sclerosis Systemic Lupus Erythematosus (SLE) (Source: The Doctors Lounge - Health News)
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RSS Source: Med Worm - Psoriasis Fri, 11 Feb 2011 3:55:00 pm
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Psoriasis - news item 58 of 134
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Tumor Necrosis Factor Inhibitors May Decrease MI Risk in Psoriasis
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Tumor necrosis factor inhibitors might decrease the risk for myocardial infarction (MI) in patients with psoriasis. Medscape Medical News (Source: Medscape Today Headlines)
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RSS Source: Med Worm - Psoriasis Fri, 11 Feb 2011 11:56:20 am
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Psoriasis - news item 59 of 134
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Circassia Acquires Worldwide Rights to Novel Psoriasis and Atopic Dermatitis Treatment From Airmid Inc
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OXFORD, England, February 9, 2011 (HSMN NewsFeed) -- Circassia Ltd, a specialty biopharmaceutical company focused on allergy, today announced that it has acquired the worldwide development and commercialization rights to the novel topical therapeutic for... Biopharmaceuticals, Dermatology, AcquisitionsCircassia, Airmid, PAP-1, psoriasis, dermatitis (Source: HSMN NewsFeed)
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RSS Source: Med Worm - Psoriasis Wed, 9 Feb 2011 12:04:43 pm
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Psoriasis - news item 60 of 134
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Border patrol: Immune cells protect body from invaders
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Barrier sites -- the skin, gut, lung -- limit the inner body's exposure to allergens, pollutants, viruses, bacteria, and parasites. Understanding how the immune system works in these external surfaces has implications for understanding such inflammatory diseases as asthma, psoriasis, IBD, and food allergies, all of which occur at the...
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RSS Source: Med Worm - Psoriasis Wed, 9 Feb 2011 9:00:00 am
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Psoriasis - news item 61 of 134
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Usefulness of Ultrasound Imaging in Detecting Psoriatic Arthritis of Fingers and Toes in Patients with Psoriasis
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Conclusion. US proved valuable in detecting joint and/or tendon abnormalities in the fingers and toes of patients with suspicious changes. The dermatologist should consider US to obtain an accurate assessment of suspicious findings. (Source: Clinical and Developmental Immunology) MedWorm Message: Watch the new MedWorm demo and find out how to...
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RSS Source: Med Worm - Psoriasis Tue, 8 Feb 2011 1:56:03 pm
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Psoriasis - news item 62 of 134
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Immune Cells Border Patrol Protect Body From Invaders
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So-called barrier sites - the skin, gut, lung - limit the inner body's exposure to allergens, pollutants, viruses, bacteria, and parasites. Understanding how the immune system works in these external surfaces has implications for understanding such inflammatory diseases as asthma, psoriasis, IBD, and food allergies, all of which occur at...
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RSS Source: Med Worm - Psoriasis Tue, 8 Feb 2011 11:00:00 am
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Psoriasis - news item 63 of 134
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Anacor Pharmaceuticals Announces First Patient Dosed In A Phase 2b Trial Of AN2728 For Psoriasis
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Anacor Pharmaceuticals (NASDAQ:ANAC) announced that the first patient has been dosed in a Phase 2b trial of AN2728, a topical anti-inflammatory product candidate for the treatment of psoriasis. Psoriasis is a chronic inflammatory skin disease that affects approximately 7.5 million people in the United States and over 100 million people...
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RSS Source: Med Worm - Psoriasis Tue, 8 Feb 2011 7:00:00 am
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Psoriasis - news item 64 of 134
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Narrowband UV-B, Monochromatic Excimer Laser, and Photodynamic Therapy in Psoriasis: A Consensus Statement of the Spanish Psoriasis Group.
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Authors: Carrascosa JM, López-Estebaranz JL, Carretero G, Daudén E, Ferrándiz C, Vidal D, Belinchón I, Sánchez-Regaña M, Puig L, Novel treatment strategies and new information concerning the management of moderate to severe psoriasis justify a reassessment of the role of the classic therapies in this setting. This consensus statement evaluates...
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RSS Source: Med Worm - Psoriasis Mon, 7 Feb 2011 11:00:00 pm
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Psoriasis - news item 65 of 134
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Border patrol: Immune cells protect body from invaders, according to Penn study
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(University of Pennsylvania School of Medicine) Barrier sites -- the skin, gut, lung -- limit the inner body's exposure to allergens, pollutants, viruses, bacteria, and parasites. Understanding how the immune system works in these external surfaces has implications for understanding such inflammatory diseases as asthma, psoriasis, IBD, and food allergies,...
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RSS Source: Med Worm - Psoriasis Mon, 7 Feb 2011 4:00:00 am
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Psoriasis - news item 66 of 134
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Data on etanercept in plaque psoriasis with scalp involvement to be presented at conference
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Source: BioSpace Area: News BioSpace has reported on data from a Phase IV study evaluating etanercept in the treatment of psoriasis with scalp involvement, to be presented at the 69th Annual American Academy of Dermatology (AAD) meeting. The double-blind study included 124 adults with moderate to severe plaque psoriasis with...
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RSS Source: Med Worm - Psoriasis Sun, 6 Feb 2011 11:00:00 pm
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Psoriasis - news item 67 of 134
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Bone mineral density and body composition in postmenopausal women with psoriasis and psoriatic arthritis
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Conclusions: Ps and PsA patients did not present lower BMD. However, they had a higher prevalence of osteoporotic fractures and higher risk of metabolic syndrome. Patients with a longer duration of disease, disability and recurrent falls need preventive measures. (Source: Arthritis Research and Therapy)
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RSS Source: Med Worm - Psoriasis Sun, 6 Feb 2011 11:00:00 pm
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Psoriasis - news item 68 of 134
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Tissue Solutions Granted Ethical Approval to Collect Psoriasis Skin Biopsies
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Psoriasis is one of the most prevalent of all autoimmune diseases and the second most common skin diseases, the first being acne. 125 million people worldwide (2% to 3% of the total population) have psoriasis. Psoriasis is not a cosmetic problem. Nearly 60% of sufferers report their disease to be...
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RSS Source: Med Worm - Psoriasis Sun, 6 Feb 2011 11:00:00 pm
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Psoriasis - news item 69 of 134
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Expression of tachykinins and their receptors in plaque psoriasis with pruritus
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Conclusions  Tachykinins may play a role for psoriasis disease per se, in addition to pruritus in this disease. Targeting the combined NKâ€1 and NKâ€2 receptors might be a possible treatment. (Source: British Journal of Dermatology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the...
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RSS Source: Med Worm - Psoriasis Sun, 6 Feb 2011 11:00:00 pm
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Psoriasis - news item 70 of 134
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Childhood pustular psoriasis: case report
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A psorÃase pustulosa generalizada é tipo raro de psorÃase descrita pela primeira vez, em 1910, por Von Zumbusch. A psorÃase pustulosa generalizada na criança tende a ter um curso mais benigno que no adulto, entretanto, em sua forma grave, pode por em risco a vida do paciente. Talvez, pela raridade...
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RSS Source: Med Worm - Psoriasis Sat, 5 Feb 2011 3:27:02 pm
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Psoriasis - news item 71 of 134
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Etanercept effective with favorable safety profile for psoriasis over 4 years
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Pooled results from four studies show that etanercept is an effective treatment for psoriasis for up to 4 years, with low rates of serious adverse events. (Source: MedWire News - Psoriasis)
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RSS Source: Med Worm - Psoriasis Sat, 5 Feb 2011 3:27:00 pm
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Psoriasis - news item 72 of 134
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Influence of endothelial nitric oxide synthase polymorphisms in psoriasis risk
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In conclusion, NOS3 gene polymorphism would be risk factors for developing Ps. Content Type Journal ArticlePages 1-5DOI 10.1007/s00403-011-1129-9Authors Pablo Coto-Segura, Dermatology II Department, University Hospital Central of Asturias (HUCA), 33007 Oviedo, SpainEliecer Coto, Molecular Genetics Department, University Hospital Central of Asturias (HUCA), Oviedo, SpainAlbert Mas-Vidal, Dermatology II Department, University Hospital...
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RSS Source: Med Worm - Psoriasis Fri, 4 Feb 2011 2:33:44 am
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Psoriasis - news item 73 of 134
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Anti-cytokine therapies for psoriasis.
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Authors: Nograles KE, Krueger JG Current approaches for the treatment of psoriasis with anti-cytokine therapies involve the blockade of TNF-ï¡ï€¬ï€ PMID: 21300061 [PubMed - as supplied by publisher] (Source: Experimental Cell Research) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant,...
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RSS Source: Med Worm - Psoriasis Thu, 3 Feb 2011 11:00:00 pm
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Psoriasis - news item 74 of 134
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The Importance of Stereochemistry on the Actions of Vitamin D.
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Authors: Chiellini G, Deluca HF The seco-steroid hormone 1α,25-dihydroxyvitamin D(3) [1α,25(OH)(2)D(3)] is the most potent natural metabolite of vitamin D(3) and regulates primarily calcium and phosphate homeostasis, but also as a regulator of specific differentiation and of the immune system. Most, if not all, of the biological actions of 1α,25(OH) (...
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RSS Source: Med Worm - Psoriasis Thu, 3 Feb 2011 11:00:00 pm
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Psoriasis - news item 75 of 134
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Resolution of adalimumab-induced psoriasis after vitamin D deficiency treatment
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Abstract Tumoral necrosis factor alpha blockers are very efficient in the treatment of many inflammatory systemic diseases, including rheumatoid arthritis and psoriasis. However, a paradoxical arouse of psoriasiform lesions may occur in a few patients taking anti-TNFα. The etiology of this rare side effect is still a mystery, and its...
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RSS Source: Med Worm - Psoriasis Thu, 3 Feb 2011 7:47:03 pm
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Psoriasis - news item 76 of 134
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Prevalence of patient-reported comorbidities in early and established psoriatic arthritis cohorts
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Abstract The aim of this study is to describe the comorbidity profile in patients with early and established psoriatic arthritis (PsA). Patients with PsA were selected from a registry of patients with psoriasis in Newfoundland. Patients with a diagnosis of psoriasis according to the CASPAR classification criteria are entered in...
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RSS Source: Med Worm - Psoriasis Thu, 3 Feb 2011 6:23:49 am
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Psoriasis - news item 77 of 134
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Human neutrophils interact with both 6-sulfo LacNAc+ DC and NK cells to amplify NK-derived IFN{gamma}: role of CD18, ICAM-1, and ICAM-3
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We report that human neutrophils establish a network with both natural killer (NK) cells and 6-sulfo LacNAc+ dendritic cells (slanDCs), which ultimately serves to up-regulate NK-derived interferon (IFN). This network involves direct reciprocal interactions and positive amplification loops mediated by cell-derived cytokines. Accordingly, we show that after lipopolysaccharide + interleukin-2 (IL-2)...
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RSS Source: Med Worm - Psoriasis Wed, 2 Feb 2011 11:00:00 pm
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Psoriasis - news item 78 of 134
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A systematic investigation of confirmed autoimmune loci in earlyâ€onset psoriasis reveals an association with IL2/IL21
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Conclusion  The findings, although requiring replication, suggest that IL2/IL21 may play a key role in the pathogenesis of psoriasis as well as in other diverse autoimmune diseases. (Source: British Journal of Dermatology)
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RSS Source: Med Worm - Psoriasis Wed, 2 Feb 2011 11:00:00 pm
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Psoriasis - news item 79 of 134
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Calcipotriol plus Betamethasone Dipropionate Gel Compared with Tacalcitol Ointment and the Gel Vehicle Alone in Patients with Psoriasis Vulgaris: A Randomized, Controlled Clinical Trial
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Dermatology (DOI:10.1159/000323408) (Source: Karger Publishers) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Psoriasis Wed, 2 Feb 2011 1:10:46 pm
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Psoriasis - news item 80 of 134
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On the missing link between inflammation and cancer.
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Authors: Alexandrescu DT, Riordan NH, Ichim TE, Kauffman CL, Kabigting F, Dutton CT, Dasanu CA A various array of cutaneous granulomatous disorders have been found to be associated with internal malignancy. Among them, sarcoidosis, granuloma anulare (GA), psoriasis, pyoderma gangrenosum (PG), or other neutrophilic dermatoses such as the Sweet syndrome...
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RSS Source: Med Worm - Psoriasis Tue, 1 Feb 2011 5:15:03 am
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Psoriasis - news item 81 of 134
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Autoimmune thyroiditis and delayed onset psoriasis in association with combination therapy for chronic hepatitis C infection.
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We report a case of a 46-year-old indigen woman who was positive for multiple autoantibodies, and developed autoimmune thyroiditis that manifested as hypothyroidism during pegylated interferon and ribavarin therapy for chronic hepatitis C infection. She also developed plaque psoriasis after the completion of therapy. In our case, the association with...
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RSS Source: Med Worm - Psoriasis Mon, 31 Jan 2011 11:00:00 pm
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Psoriasis - news item 82 of 134
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Use of complementary and alternative medicine among dermatology outpatients in Singapore.
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Conclusions:  Prevalence of CAM use in dermatology patients was high. Many doctors were unaware of patients' CAM use despite most patients being willing to declare it. Patients generally expected dermatologists to provide CAM advice. Dermatologists should make a concerted effort to identify likely CAM users and consider openly discussing CAM...
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RSS Source: Med Worm - Psoriasis Mon, 31 Jan 2011 11:00:00 pm
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Psoriasis - news item 83 of 134
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Psoriasis induced by cetuximab: A paradoxical adverse effect.
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We report a case of psoriasis induced by cetuximab, which was a surprising adverse effect. PMID: 21332695 [PubMed - in process] (Source: The Australasian Journal of Dermatology)
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RSS Source: Med Worm - Psoriasis Mon, 31 Jan 2011 11:00:00 pm
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Psoriasis - news item 84 of 134
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Classification of Papuloâ€Squamous skin diseases using image analysis
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Conclusion: Rough sets approach proves its superiority for both the segmentation and the classification processes of papuloâ€squamous skin diseases compared with the other used segmentation and classification techniques. (Source: Skin Research and Technology)
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RSS Source: Med Worm - Psoriasis Mon, 31 Jan 2011 11:00:00 pm
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Psoriasis - news item 85 of 134
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Cardiovascular safety of ustekinumab in patients with moderateâ€toâ€severe psoriasis: Results of integrated analyses of data from phase II and III clinical studies
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Conclusion:  The totality of available clinical data suggests neither a detrimental nor a beneficial effect of ustekinumab on serious CV events. Additional data are needed to define the net effect of ustekinumab on CV events. (Source: British Journal of Dermatology) MedWorm Message: Watch the new MedWorm demo and find out...
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RSS Source: Med Worm - Psoriasis Mon, 31 Jan 2011 11:00:00 pm
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Psoriasis - news item 86 of 134
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Platelet-Activating Factor Blockade Inhibits the T-Helper Type 17 Cell Pathway and Suppresses Psoriasis-Like Skin Disease in K5.hTGF-β1 Transgenic Mice.
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Authors: Singh TP, Huettner B, Koefeler H, Mayer G, Bambach I, Wallbrecht K, Schön MP, Wolf P Platelet-activating factor (PAF), a potent biolipid mediator, is involved in a variety of cellular transduction pathways and plays a prominent role in inducing inflammation in different organs. We used K5.hTGF-β1 transgenic mice, which...
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RSS Source: Med Worm - Psoriasis Mon, 31 Jan 2011 11:00:00 pm
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Psoriasis - news item 87 of 134
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[Adverse events during biological therapy - focusing on dermatological side-effects.]
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Conclusion: The use of TNF-α blockers may provoke a broad spectrum of dermatological side effects. Our results suggest that the majority of these are infectious and inflammatory disorders, the latter may relatively often appear as drug induced psoriasis. The occurrence of malignancies was very low in our series. Orv. Hetil.,...
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RSS Source: Med Worm - Psoriasis Mon, 31 Jan 2011 11:00:00 pm
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Psoriasis - news item 88 of 134
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HAXâ€1: A family of apoptotic regulators in health and disease
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This study aims to summarize our current knowledge on the physiological implications of the expression profile of the HAXâ€1 subfamily in health and disease, and provide new information on the differential expression and activities of HAXâ€1 members in three distinct types of cancer. © 2011 Wileyâ€Liss, Inc. (Source: Journal of...
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RSS Source: Med Worm - Psoriasis Mon, 31 Jan 2011 11:00:00 pm
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Psoriasis - news item 89 of 134
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Filgrastim/peginterferon--2a/ribavirin: Haematological disorders, psoriasis: case report
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(Source: Reactions) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Psoriasis Mon, 31 Jan 2011 2:44:00 pm
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Psoriasis - news item 90 of 134
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Therapiekombinationen bei der Behandlung der Psoriasis
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(Source: JDDG)
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RSS Source: Med Worm - Psoriasis Mon, 31 Jan 2011 2:29:30 pm
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Psoriasis - news item 91 of 134
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Sun exposure induces rapid immunological changes in skin and peripheral blood in patients with psoriasis.
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Conclusions  Our data show that clinical improvement of psoriasis following sun exposure is preceded by a rapid reduction in local and systemic inflammatory markers, strongly suggesting that immune modulation mediated the observed clinical effect. We cannot completely rule out that other mechanisms, such as stress reduction, may contribute, but it...
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RSS Source: Med Worm - Psoriasis Mon, 31 Jan 2011 12:15:15 pm
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Psoriasis - news item 92 of 134
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Exposure To Worm Infection In The Womb May Protect Against Eczema, Study Suggests
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Exposure to worm infections in the womb may protect a newborn infant from developing eczema, a study funded by the Wellcome Trust suggests. A large trial in Uganda showed that treating a pregnant woman for worm infections increased her child's chances of developing the allergic skin disease. Published this week...
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RSS Source: Med Worm - Psoriasis Mon, 31 Jan 2011 8:00:00 am
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Psoriasis - news item 93 of 134
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Percutaneous penetration of 5-methoxypsoralen in rhesus monkeys.
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CONCLUSION: A high percentage of the administered 5-methoxypsoralen was absorbed. This provides a foundation of methodology to evaluate the efficacy of other delivery vehicles for 5-methoxypsoralen and serves as part of its dermatotoxic profile. PMID: 21281688 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
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RSS Source: Med Worm - Psoriasis Sun, 30 Jan 2011 11:00:00 pm
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Psoriasis - news item 94 of 134
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Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis
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Conclusions: We present evidence for subtype specific association of the ERAP1 gene with ERA JIA and the IL23R gene with juvenile-onset PsA. The findings will require validation in independent JIA datasets. These results suggest distinct pathogenic pathways in these subtypes. (Source: Arthritis Research and Therapy) MedWorm Message: Watch the new...
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RSS Source: Med Worm - Psoriasis Sun, 30 Jan 2011 11:00:00 pm
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Psoriasis - news item 95 of 134
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Clinical Trials Update: Jan. 31, 2011
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Endometriosis Hepatitis C Psoriasis (Source: The Doctors Lounge - Health News)
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RSS Source: Med Worm - Psoriasis Sun, 30 Jan 2011 11:00:00 pm
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Psoriasis - news item 96 of 134
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Presence of arthritis does not affect osteoporosis in psoriasis patients
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Psoriasis patients are at increased risk for osteoporosis, based on serum osteoprotegrin elevations, regardless of whether they have psoriatic arthritis, say Egyptian researchers. (Source: MedWire News - Psoriasis)
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RSS Source: Med Worm - Psoriasis Sat, 29 Jan 2011 2:19:17 pm
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Psoriasis - news item 97 of 134
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Increased expression of TRAIL and its death receptors DR4 and DR5 in plaque psoriasis
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Abstract TNF-related apoptosis-inducing ligand (TRAIL) is recognized as an important regulator of immune responses during infections and various autoimmune-mediated pathologies. Its role in inflammatory dermatoses is largely unknown. We aimed to investigate the expression of TRAIL and its receptors DR4 and DR5 in psoriasis vulgaris. Immunohistochemistry for TRAIL, DR4 and...
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RSS Source: Med Worm - Psoriasis Fri, 28 Jan 2011 7:31:10 pm
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Psoriasis - news item 98 of 134
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Antinuclear antibodies associate with loss of response to antitumour necrosis factorâ€Î± therapy in psoriasis but do not necessarily predict treatment failure
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(Source: British Journal of Dermatology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Psoriasis Fri, 28 Jan 2011 2:29:22 pm
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Psoriasis - news item 99 of 134
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Patients’ views of nurse prescribing: effects on care, concordance and medicine taking
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Conclusions  Nurse prescribing can increase the efficiency of dermatology services. Patients experienced active involvement in decisions about their treatment which in turn contributed to concordance and adherence to treatment regimens. This study has important implications for maximizing resource use and improving access to and quality of care in dermatology specialist...
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RSS Source: Med Worm - Psoriasis Fri, 28 Jan 2011 2:29:09 pm
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Psoriasis - news item 100 of 134
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Prototype Drug Targets Metabolism, Halts Disease That Limits Bone Marrow Transplantation
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A prototype drug already shown to hold promise for treating autoimmune disorders like lupus, arthritis and psoriasis halts established graft-versus-host disease (GVHD) in mouse models of bone marrow transplantation, research at the University of Michigan and the University of Florida shows. The research, published in the Jan. 26 issue of...
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RSS Source: Med Worm - Psoriasis Fri, 28 Jan 2011 11:00:00 am
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Psoriasis - news item 101 of 134
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DMP1 protein inhibits angiogenesis, could lead to new treatments against cancer and other diseases
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Researchers in Belgium have demonstrated that the DMP1 protein has previously unsuspected anti-angiogenic activities which could be used for the development of new treatments against cancer, but also against diseases in which angiogenesis (the formation of new blood vessels) plays a major role, such as psoriasis, rheumatoid arthritis or diabetic...
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RSS Source: Med Worm - Psoriasis Thu, 27 Jan 2011 9:00:00 am
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Psoriasis - news item 102 of 134
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Periorbital edema and erythema: An unusual localization of DLE in a patient with psoriasis
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We report the case of a 33â€yearâ€old woman with psoriasis localized on the trunk and extremities who developed prominent periorbital edema and erythema diagnosed as DLE. (Source: The Journal of Dermatology)
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RSS Source: Med Worm - Psoriasis Wed, 26 Jan 2011 11:00:00 pm
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Psoriasis - news item 103 of 134
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Clinical Trials Update: Jan. 27, 2011
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Psoriasis Schizophrenia Type 2 Diabetes (Source: The Doctors Lounge - Health News) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Psoriasis Wed, 26 Jan 2011 11:00:00 pm
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Psoriasis - news item 104 of 134
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I became a surrogate mother to ease my ailments
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Mum-of-five NICOLE SMITH, 36, from New Milton, Hampshire explains how pregnancy helped ease her crippling psoriasis and arthritis and why it inspired her to become a surrogate when her family was complete (Source: Daily Express - Health)
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RSS Source: Med Worm - Psoriasis Mon, 24 Jan 2011 11:00:00 pm
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Psoriasis - news item 105 of 134
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Psoriatic triad in a patient presenting with oligodontia
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P Rai, G Kumar, M ChaudharyJournal of Indian Society of Pedodontics and Preventive Dentistry 2010 28(4):297-301Psoriasis is a common dermatological disease. It can occur at any age but usually develops between 15 and 35 years of age and may persist throughout a person's lifetime with periods of exacerbation and remission....
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RSS Source: Med Worm - Psoriasis Mon, 24 Jan 2011 11:00:00 pm
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Psoriasis - news item 106 of 134
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Adalimumab/infliximab: Angioedema and psoriasis: case report
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(Source: Reactions) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Psoriasis Mon, 24 Jan 2011 4:42:36 pm
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Psoriasis - news item 107 of 134
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Abatacept: Reactivation of cutaneous psoriasis: case report
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(Source: Reactions)
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RSS Source: Med Worm - Psoriasis Mon, 24 Jan 2011 4:42:36 pm
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Psoriasis - news item 108 of 134
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Piercing a 500-Year Veil
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Dear Health Conscious Reader, I steered my little Nissan rental car higher… deeper into Jamaica’s John Crow Mountains. S-curves and switchbacks emerged suddenly out of the sheets of blinding rain. As the storm finally began to clear, I spotted a cluster of tin-roofed houses and tiny shops. I had reached...
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RSS Source: Med Worm - Psoriasis Mon, 24 Jan 2011 1:18:14 pm
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Psoriasis - news item 109 of 134
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New insights into HIV-1-primary skin disorders
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Since the first reports of AIDS, skin involvement has become a burdensome stigma for seropositive patients and a challenging task for dermatologist and infectious disease specialists due to the severe and recalcitrant nature of the conditions. Dermatologic manifestations in AIDS patients act as markers of disease progression, a fact that...
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RSS Source: Med Worm - Psoriasis Sun, 23 Jan 2011 11:00:00 pm
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Psoriasis - news item 110 of 134
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Nonlight beer intake associated with psoriasis risk in women
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Women who drink five or more nonlight beers per week have an increased risk for developing psoriasis compared with women who do not drink alcohol, study findings indicate. (Source: MedWire News - Psoriasis)
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RSS Source: Med Worm - Psoriasis Sat, 22 Jan 2011 2:31:43 pm
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Psoriasis - news item 111 of 134
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Ustekinumab and Herpes Zoster.
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Conclusion: Ustekinumab is probably a risk factor for developing HZ. Anti-HZ vaccination prior to ustekinumab treatment should be considered. PMID: 21266799 [PubMed - as supplied by publisher] (Source: Herpes) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!...
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RSS Source: Med Worm - Psoriasis Fri, 21 Jan 2011 11:00:00 pm
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Psoriasis - news item 112 of 134
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Psoriasis in Pregnancy
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Does the most common autoimmune disorder lead to any adverse pregnancy outcomes? Medscape Dermatology (Source: Medscape Today Headlines)
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RSS Source: Med Worm - Psoriasis Fri, 21 Jan 2011 9:00:30 pm
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Psoriasis - news item 113 of 134
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Microdialysis documents changes in the micromilieu of psoriatic plaques under continuous systemic therapy
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Abstract:  Microdialysis is a novel technique suitable to analyse soluble mediators in the skin compartment. We applied this methodical approach to monitor changes in the micromilieu of psoriatic plaques under therapy. Tissue fluid was collected from lesional and nonâ€lesional skin of three patients with severe plaqueâ€type psoriasis prior to as...
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RSS Source: Med Worm - Psoriasis Fri, 21 Jan 2011 2:25:27 pm
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Psoriasis - news item 114 of 134
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Adipokines and psoriasis
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Abstract:  Adipose tissue is an active endocrine organ contributing to the regulation of multiple metabolic pathways via selfâ€produced bioactive products called adipokines. These adipokines are key players in the pathogenesis of metabolic syndrome and cardiovascular diseases. Coâ€occurrence of obesity and psoriasis could lead to interactions of both diseases in which...
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RSS Source: Med Worm - Psoriasis Fri, 21 Jan 2011 2:25:22 pm
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Psoriasis - news item 115 of 134
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Capillaroscopic pattern in paraneoplastic Raynaud’s phenomenon
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Abstract The capillaroscopic pattern in paraneoplastic Raynaud’s phenomenon (RP) has not been investigated systematically and is not well-defined. Here, we present three case reports of patients with paraneoplastic rheumatic conditions, manifested with severe secondary RP with emphasis upon capillaroscopic findings. The first patient is a 58-year-old male with known psoriasis...
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RSS Source: Med Worm - Psoriasis Fri, 21 Jan 2011 2:19:42 pm
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Psoriasis - news item 116 of 134
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Linear Psoriasis †A Case Report
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Case Rep Dermatol 2011;3:8†12 (DOI:10.1159/000324190) (Source: Karger Publishers) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Psoriasis Fri, 21 Jan 2011 1:12:40 pm
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Psoriasis - news item 117 of 134
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Research in practice: ILâ€22 and ILâ€20: significance for epithelial homeostasis and psoriasis pathogenesis
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SummaryPsoriasis vulgaris is a frequent, chronically relapsing, immuneâ€mediated, systemic disease with characteristic skin changes. Despite the importance of this disease there are currently limited therapeutic options indicating a need for effective, longâ€lasting treatment strategies with few side effects. The most recent discoveries regarding psoriasis pathogenesis, particularly our results regarding two...
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RSS Source: Med Worm - Psoriasis Thu, 20 Jan 2011 11:00:00 pm
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Psoriasis - news item 118 of 134
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Erectile Dysfunction in Patients With Psoriasis
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Should an assessment of sexual function be routine for patients with psoriasis? The authors posit a link between psoriasis, atherosclerosis, and erectile dysfunction. The British Journal of Dermatology (Source: Medscape Dermatology Headlines)
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RSS Source: Med Worm - Psoriasis Thu, 20 Jan 2011 3:00:00 am
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Psoriasis - news item 119 of 134
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Erectile Dysfunction in Patients With Psoriasis: Increased Prevalence, an Unmet Need, and a Chance to Intervene
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Should an assessment of sexual function be routine for patients with psoriasis? The authors posit a link between psoriasis, atherosclerosis, and erectile dysfunction. The British Journal of Dermatology (Source: Medscape Today Headlines)
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RSS Source: Med Worm - Psoriasis Thu, 20 Jan 2011 3:00:00 am
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Psoriasis - news item 120 of 134
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Homeodomain-only protein HOP is a novel modulator of late differentiation in keratinocytes.
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Authors: Obarzanek-Fojt M, Favre B, Kypriotou M, Ryser S, Huber M, Hohl D The homeodomain-only protein (HOP) contains an atypical homeodomain which is unable to bind to DNA due to mutations in residues important for DNA binding. Recently, HOP was reported to regulate proliferation/differentiation homeostasis in different cell types. In...
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RSS Source: Med Worm - Psoriasis Wed, 19 Jan 2011 11:00:00 pm
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Psoriasis - news item 121 of 134
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Overview of dermatological adverse events of etanercept
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Source: Arch Dermatol Area: News In this article, the authors present an overview of dermatological adverse events of etanercept described in the literature and information on the occurrence, severity, treatment, and course of these reactions. MEDLINE and EMBASE were searched for reports on individual patients who developed a dermatological adverse...
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RSS Source: Med Worm - Psoriasis Wed, 19 Jan 2011 11:00:00 pm
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Psoriasis - news item 122 of 134
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Does HLA-G prevent tissue destruction in psoriasis? Comment on 'Expression of human leucocyte antigen-G primarily targets affected skin of patients with psoriasis'
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Authors: Sweeney C, Kirby B PMID: 21250964 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
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RSS Source: Med Worm - Psoriasis Tue, 18 Jan 2011 11:00:00 pm
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Psoriasis - news item 123 of 134
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Does HLAâ€G prevent tissue destruction in psoriasis? Comment on ‘Expression of human leucocyte antigenâ€G primarily targets affected skin of patients with psoriasis’
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(Source: British Journal of Dermatology)
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RSS Source: Med Worm - Psoriasis Tue, 18 Jan 2011 11:00:00 pm
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Psoriasis - news item 124 of 134
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Targeted 307 nm UVBâ€excimer light vs. topical dithranol in psoriasis
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(Source: Journal of the European Academy of Dermatology and Venereology)
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RSS Source: Med Worm - Psoriasis Tue, 18 Jan 2011 11:00:00 pm
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Psoriasis - news item 125 of 134
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BR-squared: a practical solution to the winner’s curse in genome-wide scans
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Abstract The detrimental effects of the winner’s curse, including overestimation of the genetic effects of associated variants and underestimation of sufficient sample sizes for replication studies are well-recognized in genome-wide association studies (GWAS). These effects can be expected to worsen as the field moves from GWAS into whole genome sequencing....
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RSS Source: Med Worm - Psoriasis Tue, 18 Jan 2011 5:38:23 pm
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Psoriasis - news item 126 of 134
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Getting under your skin
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A lack of knowledge about the condition means many people with psoriasis suffer unneccessarily, writes MICHELLE McDONAGH (Source: The Irish Times - Health) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Psoriasis Tue, 18 Jan 2011 2:01:49 pm
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Psoriasis - news item 127 of 134
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Severe Maternal Psoriasis Linked to Low Birth Weight
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Women with severe psoriasis are 1.4 times more likely to have a low birth weight infant, but mild psoriasis is not related to an increased risk of adverse birth outcomes, according to a study published in the January issue of the Journal of the American Academy of Dermatology. (Source: Modern...
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RSS Source: Med Worm - Psoriasis Mon, 17 Jan 2011 11:00:00 pm
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Psoriasis - news item 128 of 134
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Abbott Laboratories Limited Withdraws Its Marketing Authorisation Application For Ozespa (briakinumab)
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The European Medicines Agency has been formally notified by Abbott Laboratories Limited of its decision to withdraw its application for a centralised marketing authorisation for the medicine Ozespa (briakinumab), 100 mg solution for injection. This medicine was intended to be used for the treatment of moderate to severe chronic plaque...
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RSS Source: Med Worm - Psoriasis Mon, 17 Jan 2011 12:00:00 pm
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Psoriasis - news item 129 of 134
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Insulinâ€like growth factorâ€1 in psoriatic plaques treated with PUVA and methotrexate
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Conclusion  Both methotrexate and PUVA therapy for psoriasis are associated with a decrease in PASI score and IGFâ€1. The IGFâ€1 downâ€regulation may possibly be a consequence of the decrease in cytokines and inflammatory cellular infiltrate that occur following treatment with either modalities or due to their effect on local fibroblast...
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RSS Source: Med Worm - Psoriasis Sun, 16 Jan 2011 11:00:00 pm
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Psoriasis - news item 130 of 134
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Effective continuous systemic therapy of severe plaqueâ€type psoriasis is accompanied by amelioration of biomarkers of cardiovascular risk: results of a prospective longitudinal observational study
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Conclusions  We document an amelioration of biomarkers of cardiovascular risk in patients with severe plaqueâ€type psoriasis responding to continuous systemic therapy. The impact on the patients’metabolic state was found to be better if the psoriatic inflammation was controlled for longer. Future studies need to compare the cardioprotective effects of different...
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RSS Source: Med Worm - Psoriasis Sun, 16 Jan 2011 11:00:00 pm
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Psoriasis - news item 131 of 134
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Psoriasis: is it the tip of the iceberg for the quality of life of patients and their families?
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Conclusions  Psoriasis is a chronic disease that affects in a cumulative way the quality of life of both patients and their close relatives. (Source: Journal of the European Academy of Dermatology and Venereology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest,...
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RSS Source: Med Worm - Psoriasis Sun, 16 Jan 2011 11:00:00 pm
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Psoriasis - news item 132 of 134
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Validation of Psoriasis Clinical Severity and Outcome Measures: Searching for a Gold Standard [Evidence-Based Dermatology: Research Commentary]
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(Source: Archives of Dermatology)
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RSS Source: Med Worm - Psoriasis Sun, 16 Jan 2011 11:00:00 pm
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Psoriasis - news item 133 of 134
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Marketing authorisation application for briakinumab (Ozespa®) withdrawn
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Source: EMA Area: News Abbott Laboratories Limited has withdrawn its application for a centralised marketing authorisation for briakinumab (Ozespa), as the additional new data and analyses thought to be required for a favourable opinion could not be generated within the timeframe allowed in the centralised procedure. This medicine was intended...
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RSS Source: Med Worm - Psoriasis Sun, 16 Jan 2011 11:00:00 pm
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Psoriasis - news item 134 of 134
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Metabolic syndrome risk increased in psoriasis patients
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Patients with psoriasis are almost twice as likely to have the metabolic syndrome as people in the general population, study findings indicate. (Source: MedWire News - Dermatology)
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RSS Source: Med Worm - Psoriasis Sat, 15 Jan 2011 2:47:24 pm
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