Senile Dementia/Alzheimer's Disease - news item 1 of 131
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Improved Understanding Of Long-Term Memory Formation Has Implications For Neurodegenerative Diseases Such As Parkinson's And Alzheimer's Disease
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Star-shaped cells in our brains called astrocytes were once considered little more than structures to fill the gaps between all-important neurons. But more recent evidence has emerged to reveal that those astrocytes play more than a supporting role; they are involved in information processing and signal transmission and they help...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sat, 5 Mar 2011 7:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 2 of 131
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Scientists create cells in Alzheimer's breakthrough
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Brain cells that play a critical role in Alzheimer's disease have been created in the laboratory by scientists. (Source: Scotsman.com News - Health of the NHS)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 3 of 131
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Star-shaped brain cells feed long-term memory
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Researchers have found that lactate, a type of energy fuel in the brain, plays a critical role in the formation of long-term memory. These findings have important implications for common illnesses like Alzheimer's disease, other neurodegenerative disorders, aging-related memory impairment and diabetes. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 6:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 4 of 131
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Scientists re-grow cells that die in Alzheimer's, according to study
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For the first time scientists have been able to re-grow the brain cells that die early in Alzheimer's disease according to a study published today (Friday 4 March) in the journal Stem Cells. (Source: Alzheimers Society)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 4:26:16 pm
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Senile Dementia/Alzheimer's Disease - news item 5 of 131
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New Evidence Alzheimer's Disease Inherited From Mothers
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Investigators have identified twice as much gray matter volume reduction in people with a mother with Alzheimer's. Medscape Medical News (Source: Medscape Today Headlines)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 4:07:07 pm
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Senile Dementia/Alzheimer's Disease - news item 6 of 131
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Clinical Trials Update: March 4, 2011
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Alzheimer's Disease Opioid Induced Constipation Eczema (Source: The Doctors Lounge - Health News) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 2:50:00 pm
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Senile Dementia/Alzheimer's Disease - news item 7 of 131
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Liver may be Alzheimer's amyloid source
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LA JOLLA, Calif., March 4 (UPI) -- The liver, not the brain, may be the source of the amyloid that deposits as brain plaques associated with Alzheimer's disease, U.S. researchers suggest. (Source: Health News - UPI.com)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 1:23:26 pm
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Senile Dementia/Alzheimer's Disease - news item 8 of 131
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Lab-grown neurons might repair Alzheimer's brains
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Alzheimer's disease kills brain cells vital for memory – now we can make new ones from human embryonic stem cells, raising hopes of transplants (Source: New Scientist - Health)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 12:07:39 pm
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Senile Dementia/Alzheimer's Disease - news item 9 of 131
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Brain [Uâ€13C]glucose metabolism in mice with decreased αâ€ketoglutarate dehydrogenase complex activity
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AbstractThe activity of the αâ€ketoglutarate dehydrogenase complex (KGDHC), a mitochondrial enzyme complex that mediates the oxidative decarboxylation of αâ€ketoglutarate in the TCA cycle, is reduced in Alzheimer's disease. We investigated the metabolic effects of a partial KGDHC activity reduction on brain glucose metabolism using mice with disrupted expression of dihydrolipoyl...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 10:18:00 am
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Senile Dementia/Alzheimer's Disease - news item 10 of 131
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Scripps Research Study Points To Liver, Not Brain, As Origin Of Alzheimer's Plaques
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Unexpected results from a Scripps Research Institute and ModGene, LLC study could completely alter scientists' ideas about Alzheimer's disease pointing to the liver instead of the brain as the source of the "amyloid" that deposits as brain plaques associated with this devastating condition. The findings could offer a relatively simple...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 10:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 11 of 131
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Brain cells grown in the lab will help to identify new Alzheimer's drugs
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Embryonic stem cells can be used to create almost limitless supplies of the brain cell linked to memory loss in Alzheimer'sScientists have made dishes of human brain cells that could speed up the search for drugs and lead to new treatments for Alzheimer's disease, a devastating and incurable neurodegenerative disorder.The...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 7:22:00 am
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Senile Dementia/Alzheimer's Disease - news item 12 of 131
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U.S. team makes key memory cells in lab dish
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CHICAGO (Reuters) - U.S. researchers have coaxed stem cells into becoming a type of brain cell that dies off early in people with Alzheimer's disease. (Source: Reuters: Health)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 5:01:05 am
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Senile Dementia/Alzheimer's Disease - news item 13 of 131
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Boosting protein garbage disposal in brain cells protects mice from Alzheimer's disease
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(Georgetown University Medical Center) Gene therapy that boosts the ability of brain cells to gobble up toxic proteins prevents development of Alzheimer's disease in mice that are predestined to develop it, report researchers at Georgetown University Medical Center. They say the treatment -- which is given just once - could...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 4:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 14 of 131
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Human stem cells transformed into key neurons lost in Alzheimer's
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(Northwestern University) Northwestern Medicine researchers for the first time have transformed a human embryonic stem cell into a critical neuron that dies early in Alzheimer's disease and is a major cause of memory loss. This ability to reprogram stem cells and grow a limitless supply of the neurons will enable...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 4:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 15 of 131
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Liver, not brain, may be origin of Alzheimer’s plaques
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Unexpected results from a new study could completely alter scientists' ideas about Alzheimer's disease -- pointing to the liver instead of the brain as the source of the "amyloid" that deposits as brain plaques associated with this devastating condition. The findings could offer a relatively simple approach for Alzheimer's prevention...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 4 Mar 2011 12:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 16 of 131
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TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons
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Conclusions: These data suggest that activation of TRPM8 channels triggers the activation of Nav1.8 channels which leads to calcium influx through VGCC. We suggest that TTR-induced calcium influx into DRG neurons may contribute to the pathophysiology of FAP. Furthermore, we speculate that similar mechanisms may mediate the toxic effects of...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 3 Mar 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 17 of 131
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Brain's 'autopilot' provides insight into early development of Alzheimer's disease
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Watching the brain's "autopilot" network in real time may help determine the onset of cognitive decline and potentially aid in making an early diagnosis of Alzheimer's disease, according to researchers. (Source: ScienceDaily Headlines)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 3 Mar 2011 6:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 18 of 131
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Association between metabolic syndrome and cognitive decline: a systematic review of prospective populationâ€based studies
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Conclusion: The MS may be associated with cognitive impairment and vascular dementia but not for AD, which need to be further investigated with highâ€quality studies. (Source: Acta Neuropsychiatrica)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 3 Mar 2011 5:28:10 pm
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Senile Dementia/Alzheimer's Disease - news item 19 of 131
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Comparison of language impairment in lateâ€onset depression and Alzheimer's disease
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Conclusion: Language impairment resembling AD was found in the aforementioned language subtests of the ABCD in elderly depressed patients; the mental status and episodic memory subtests were useful to discriminate between AD and depression. The ABCD has proven to be a suitable tool for language evaluation in this population and...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 3 Mar 2011 5:28:09 pm
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Senile Dementia/Alzheimer's Disease - news item 20 of 131
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Clinical Trials Update: March 3, 2011
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Type 2 Diabetes High Triglycerides Alzheimer's Disease (Ages 50-89) (Source: The Doctors Lounge - Health News) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 3 Mar 2011 3:12:00 pm
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Senile Dementia/Alzheimer's Disease - news item 21 of 131
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Alzheimer's disease: Portrait of dementia's effect on photographer's mother
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When photographer Mark Edwards' mother June from Braintree was diagnosed with Alzheimer's disease, he decided to use his art to chart the effects of the illness. (Source: the Mail online | Health)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 3 Mar 2011 3:02:48 pm
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Senile Dementia/Alzheimer's Disease - news item 22 of 131
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Memory cells killed by Alzheimer's grown in laboratory
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Brain cells that are most vulnerable to attack from Alzheimer's Disease have been grown by scientists for the first time in a breakthrough that could help reverse memory loss. (Source: Telegraph Health)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 3 Mar 2011 1:51:35 pm
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Senile Dementia/Alzheimer's Disease - news item 23 of 131
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Researchers find new mechanism behind the formation and maintenance of long-term memories
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(The Mount Sinai Hospital / Mount Sinai School of Medicine) Researchers from Mount Sinai School of Medicine have found that lactate, a type of energy fuel in the brain, plays a critical role in the formation of long-term memory. These findings have important implications for common illnesses like Alzheimer's disease, other...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 3 Mar 2011 4:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 24 of 131
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Animal models in the drug discovery pipeline for Alzheimer's disease
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SummaryWith increasing feasibility of predicting conversion of mild cognitive impairment to dementia based on biomarker profiling, the urgent need for efficacious diseaseâ€modifying compounds has become even more critical. Despite intensive research, underlying pathophysiological mechanisms remain insufficiently documented for purposeful target discovery. Translational research based on valid animal models may aid...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 2 Mar 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 25 of 131
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Peripheral reduction of βâ€amyloid is sufficient to reduce brain βâ€amyloid: Implications for Alzheimer's disease
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AbstractThree loci that modify βâ€amyloid (Aβ) accumulation and deposition in the brains of a mouse model of Alzheimer's disease have been previously described. One encompasses the Psen2 gene encoding presenilin 2, a component of the γâ€secretase activity responsible for generating Aβ by proteolysis. We show that the activity of mouse...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 2 Mar 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 26 of 131
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"Card sorting": a tool for research in ethics on treatment decision-making at the end of life in Alzheimer patients with a life threatening complication
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Discussion time, which was conducted by the head carer of the department, concerned the clinical situation of the patient based on the shared responses.DiscussionDuring team meetings, the "card sorting" method was quickly adopted by professionals as a tool to assist with discussion beyond the context of the study. The participants...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 2 Mar 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 27 of 131
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Compounding Artifacts with Uncertainty, and an Amyloid Cascade Hypothesis that is “Too Big to Failâ€
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AbstractWith each failure of antiâ€amyloidâ€Î² therapy in clinical trials, new trials are initiated with no hint of slowing down. This may be due, in part, to the fact that the amyloid cascade hypothesis has been so modified over time, that it is now impossible to confirm or deny. The hypothesis...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 2 Mar 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 28 of 131
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Differential regulation of BACE1 expression by oxidative and nitrosative signals
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In this study, we investigated redox regulation of BACE1, the rate-limiting enzyme responsible for the beta-cleavage of APP to Abeta peptides. Results: Herein, we studied events such as S-nitrosylation, a covalent modification of cysteine residues by NO, and H2O2-mediated oxidation. We found that NO and H2O2 differentiallymodulate BACE1 expression and...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 2 Mar 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 29 of 131
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Alzheimer's disease: When tough questions loom
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Alzheimer's challenges multiply near the end of life. Consider tips on how to prepare. (Source: MayoClinic.com Full Feed) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 2 Mar 2011 1:45:00 am
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Senile Dementia/Alzheimer's Disease - news item 30 of 131
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[Prenatal Infection as Driving Force of Aging-Associated Neurodegenerative Diseases.]
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Authors: Knuesel I Alzheimer's disease (AD) is the most common type of age-related dementia. Besides few genetic mutations, many non-genetic risk factors are known to significantly influence disease onset and progression. How-ever, the molecular mechanisms and their causal relationships are largely unknown. We developed a mouse model that is characterized...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 1 Mar 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 31 of 131
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We Really Do Fear Alzheimer's Disease
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On Feb. 24, the results of a Harris Interactive survey of over 1000 people done for the MetLife Foundation were released, and the results may surprise you. The telephone survey, completed in September 2010, found that 31% of Americans fear developing Alzheimer's disease, second only to cancer (41%). The next...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 1 Mar 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 32 of 131
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Change in stress and social support as predictors of cognitive decline in older adults with and without depression
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ConclusionsThese findings extend prior research on the importance of social factors in aging and depression which have largely focused on moodâ€related outcomes. Future confirmatory studies are needed. In addition, biological and other studies should be conducted to further our understanding of the relationship between stress, social support and cognition in...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 1 Mar 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 33 of 131
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Review: Alzheimer's disease
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Source: Lancet Area: News The Lancet has featured a review on recent evidence regarding the epidemiology, pathogenesis, diagnosis, and treatment of Alzheimer's disease, and discusses potential ways to reduce the risk of developing the disease. (Source: NeLM - News)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 1 Mar 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 34 of 131
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AAN in the News: Alzheimer's Risk Looks Higher if Mom Had the Disease
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(MSN) A new study adds more weight to research showing the risk of developing Alzheimer's disease is greater if your mother, rather than your father, had the disorder. (Source: American Academy of Neurology) MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest,...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 1 Mar 2011 3:16:00 pm
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Senile Dementia/Alzheimer's Disease - news item 35 of 131
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New Hope For Alzheimer's And Stroke Victims
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One in eight Americans will fall prey to Alzheimer's disease at some point in their life, current statistics say. Because Alzheimer's is associated with vascular damage in the brain, many of them will succumb through a painful and potentially fatal stroke. But researchers led by Dr. Dan Frenkel of Tel...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 1 Mar 2011 10:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 36 of 131
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More Evidence That Alzheimer's Disease May Be Inherited From Your Mother
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Results from a new study contribute to growing evidence that if one of your parents has Alzheimer's disease, the chances of inheriting it from your mother are higher than from your father. The study is published in the March 1, 2011, print issue of Neurology®, the medical journal of the...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 1 Mar 2011 8:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 37 of 131
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Semiparametric Estimation of the Covariateâ€Specific ROC Curve in Presence of Ignorable Verification Bias
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Summary Covariateâ€specific receiver operating characteristic (ROC) curves are often used to evaluate the classification accuracy of a medical diagnostic test or a biomarker, when the accuracy of the test is associated with certain covariates. In many largeâ€scale screening tests, the gold standard is subject to missingness due to high cost...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 28 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 38 of 131
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Interactome mapping suggests new mechanistic details underlying Alzheimer's disease [RESEARCH]
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Recent advances toward the characterization of Alzheimer's disease (AD) have permitted the identification of a dozen of genetic risk factors, although many more remain undiscovered. In parallel, works in the field of network biology have shown a strong link between protein connectivity and disease. In this manuscript, we demonstrate that...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 28 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 39 of 131
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Maternal History of Alzheimer's Tied to Brain Atrophy
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Cognitively intact older people with a maternal family history of Alzheimer's disease show progressive brain atrophy in areas associated with the condition, according to a study published in the March 1 issue of Neurology. (Source: Modern Medicine)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 28 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 40 of 131
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Vital Signs: Maternal Link to Alzheimer’s Makes a Gain
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A new study contributes to growing evidence that the chances of inheriting Alzheimer’s from your mother are higher than from your father. (Source: NYT Health)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 28 Feb 2011 10:30:15 pm
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Senile Dementia/Alzheimer's Disease - news item 41 of 131
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Mother's Alzheimer's Disease May Boost Your Risk
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Having a mother with Alzheimer's disease may boost your risk of getting it more than having a father who suffers from the degenerative brain disorder, new research suggests. (Source: WebMD Health)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 28 Feb 2011 10:10:10 pm
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Senile Dementia/Alzheimer's Disease - news item 42 of 131
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The New Old Age: When Dementia Drains the Pocketbook
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Faced with the possibility that their parents have grown too confused to manage their own finances, many adult children turn to physicians. But often they are ill equipped to help cope with an elderly patient's financial problems. (Source: NYT Health)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 28 Feb 2011 9:42:57 pm
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Senile Dementia/Alzheimer's Disease - news item 43 of 131
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Vital Signs: Patterns: Maternal Link to Alzheimer’s Makes a Gain
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A new study contributes to growing evidence that the chances of inheriting Alzheimer’s from your mother are higher than from your father. (Source: NYT Health)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 28 Feb 2011 8:29:18 pm
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Senile Dementia/Alzheimer's Disease - news item 44 of 131
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Alzheimer's Risk Looks Higher if Mom Had the Disease
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Brain scans of dementia-free adults revealed more atrophy in those whose mothers had the disorder Source: HealthDay Related MedlinePlus Pages: Alzheimer's Disease, Family History (Source: MedlinePlus Health News)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 28 Feb 2011 8:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 45 of 131
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The New Old Age: Cost of Dementia
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Faced with the possibility that their parents have grown too confused to manage their own finances, many adult children turn to physicians. But often they are ill equipped to help cope with an elderly patient's financial problems. (Source: NYT Health)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 28 Feb 2011 6:28:48 pm
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Senile Dementia/Alzheimer's Disease - news item 46 of 131
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Antidepressants for agitation and psychosis in dementia
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Objectives: To assess the safety and efficacy of antidepressants in treating psychosis and agitation in older adults with Alzheimer's disease, vascular, or mixed dementia. (Source: Neurological Conditions Specialist Library)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 28 Feb 2011 10:15:38 am
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Senile Dementia/Alzheimer's Disease - news item 47 of 131
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Storytelling Program Improves Lives Of People With Alzheimer's
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Nearly 16 million Americans will be diagnosed with Alzheimer's disease or another type of dementia by 2050, according to the Alzheimer's Association. Symptoms include mood and behavior changes, disorientation, memory loss and difficulty walking and speaking. The effects of anti-dementia drugs on patients' emotions and behaviors are inconsistent. Now, University...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 28 Feb 2011 10:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 48 of 131
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AFFiRiS Announces An Extension Of Its Existing Alzheimer's Disease Vaccine Development Collaboration With GlaxoSmithKline Triggering A Euro 3.5M Payment To AFFiRiS
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AFFiRiS AG announced today significant progress in their collaboration with GlaxoSmithKline Biologicals (GSK) for the development of an active vaccination programme against Alzheimer's disease. (Source: Pharmaceutical Online News)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 28 Feb 2011 9:54:00 am
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Senile Dementia/Alzheimer's Disease - news item 49 of 131
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Genome-Wide Association Studies: Is there a Genotype for Cognitive Decline in Older Persons with Type 2 Diabetes?
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Authors: Abbatecola AM, Oliveri F, Corsonello A, Antonicelli R, Corica F, Lattanzio F There is a dramatic increase in the number of elderly persons on a worldwide scale with an increase in chronic comorbidities, especially type 2 diabetes (T2DM) and dementia. Although cognitive faculties commonly deteriorate in non-diabetic persons as...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sun, 27 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 50 of 131
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Proton pump inhibitors reduce interferonâ€Î³â€induced neurotoxicity and STAT3 phosphorylation of human astrocytes
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AbstractProton pump inhibitors (PPIs) are known to possess antiâ€inflammatory properties. Inflammatory processes, including astrocytic activation, are implicated in the pathogenesis of different neurodegenerative diseases. Our recent study has indicated that interferon (IFN)â€Î³â€induced astrocytic neurotoxicity is mediated, at least in part, by phosphorylation of signal transducer and activator of transcription (STAT)...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sun, 27 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 51 of 131
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Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease
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Conclusions: We conclude that FHm individuals without dementia have progressive gray matter volume reductions in select AD-vulnerable brain regions, specifically the precuneus and parahippocampal gyrus. These data complement and extend reports of regional cerebral metabolic differences and increases in amyloid-β burden in FHm subjects, which may be related to a...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sun, 27 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 52 of 131
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Retinal vascular caliber and risk of dementia: The Rotterdam Study
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Conclusions: Retinal venular widening is associated with an increased risk of vascular dementia. Our findings are in line with previous observations in stroke and cerebral small-vessel disease and suggest that the association between larger retinal venular calibers and dementia may reflect cerebral hypoperfusion and subsequent ischemia. (Source: Neurology)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sun, 27 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 53 of 131
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Bilingualism good for the brain, researchers say
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The skill helps improve multitasking and prioritizing, and helps ward off early symptoms of Alzheimer's disease, experts say.Does being bilingual give young children a mental edge, or does it delay their learning? (Source: Los Angeles Times - Science)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sun, 27 Feb 2011 3:02:00 am
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Senile Dementia/Alzheimer's Disease - news item 54 of 131
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Awards for Research in Alzheimer's Disease
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MetLife Foundation Announces Major Awards to Scientists for Research in Alzheimer's Disease. (Source: Disabled World)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sun, 27 Feb 2011 12:14:11 am
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Senile Dementia/Alzheimer's Disease - news item 55 of 131
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Britain is bottom of Euro league table at diagnosing Alzheimer's
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Britons with symptoms of Alzheimer's disease take twice as long to be diagnosed as sufferers living in other European countries, research has found. (Source: Telegraph Health)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sat, 26 Feb 2011 9:57:53 am
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Senile Dementia/Alzheimer's Disease - news item 56 of 131
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Frequent Misdiagnosis of Alzheimer's
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During my fellowship training in geriatric psychiatry back in the mid-90's, we were taught repeatedly that as long as you were thorough and followed the rules, it was fairly easily to make a diagnosis of Alzheimer's disease (AD) and have reasonable confidence you were right. In fact, I recall specifically...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 25 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 57 of 131
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Alzheimer's Disease May Be Easily Misdiagnosed
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New research shows that Alzheimer's disease and other dementing illnesses may be easily misdiagnosed in the elderly, according to early results of a study of people in Hawaii who had their brains autopsied after death. The research is being released today and will be presented as part of a plenary...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 25 Feb 2011 6:22:13 pm
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Senile Dementia/Alzheimer's Disease - news item 58 of 131
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Report Launched Today Reveals That The Dementia Research Agenda In Most EU Countries Remains Critically Under-Funded And Under-Valued
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A report launched today by the leading Think Tank, International Longevity Centre - UK (ILC-UK) reveals that the dementia research agenda in most EU countries remains critically under-funded and under-valued. The report, 'The European Dementia Research Agenda' finds there is widespread disparity in the diagnosis, treatment and care of people...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 25 Feb 2011 10:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 59 of 131
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Alzheimer's breakthrough: scientists discover omega-3s override the bad gene causing Alzheimer's
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We present these findings in protest of the way in which they were acquired.For more information: http://www.aftau.org/site/News2?page=NewsArticle&id=13946 http://www.naturalnews.com/Alzheimers.html (Source: NaturalNews.com)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 25 Feb 2011 6:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 60 of 131
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Application of immunosignatures to the assessment of Alzheimer's disease
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AbstractObjectives:Accurate assessment of Alzheimer's disease (AD), both preâ€symptomatically and at different disease stages, will become increasingly important with the expanding elderly population. There are a number of indications that the immune system is engaged in AD. Here we explore the ability of an antibodyâ€profiling technology to characterize AD and screen...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 24 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 61 of 131
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Touch Panelâ€type Dementia Assessment Scale: a new computerâ€based rating scale for Alzheimer's disease
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Conclusions:  The TDAS appears to be a sensitive and comprehensive assessment battery for rating the symptoms of Alzheimer's disease, and can be substituted for the ADASâ€cog. (Source: Psychogeriatrics)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 24 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 62 of 131
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Except for cancer, Alzheimer's most feared
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ROCHESTER, N.Y., Feb. 24 (UPI) -- Except for the fear of cancer, U.S. adults most fear getting Alzheimer's disease, but few make preparations for the onset of the disease, a survey indicates. (Source: Health News - UPI.com)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 24 Feb 2011 9:36:54 pm
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Senile Dementia/Alzheimer's Disease - news item 63 of 131
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AAN Press Release: Alzheimer's Disease May Be Easily Misdiagnosed
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New research shows that Alzheimer's disease and other dementing illnesses may be easily misdiagnosed in the elderly, according to early results of a study of people in Hawaii who had their brains autopsied after death. (Source: American Academy of Neurology)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 24 Feb 2011 5:31:04 pm
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Senile Dementia/Alzheimer's Disease - news item 64 of 131
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Depressive symptoms predict longitudinal change in executive control but not memory
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ConclusionsDepressive symptoms are associated with longitudinal decline in cognition. However, this association selectively involves executive control, not memory, and possibly only a subset of ‘executive’ functions. Although depressive symptoms may hasten conversion from mild cognitive impairment (MCI) to dementia, depressionâ€related conversion is not likely to be mediated by evolution of...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 24 Feb 2011 4:21:23 pm
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Senile Dementia/Alzheimer's Disease - news item 65 of 131
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Alzheimer's Misdiagnosis, Accuracy Is Important
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Brain autopsies in Hawaii are revealing that some cases of severe dementia and Alzheimer's have been misdiagnosed before death. Misdiagnoses increased with older age and also reflected non-specific manifestations of dementia, a very high prevalence of mixed brain lesions, and the ambiguity of most neuroimaging measures. Four hundred twenty six...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 24 Feb 2011 8:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 66 of 131
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Alzheimer's Disease May Be Misdiagnosed
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(Source: eMedicineHealth.com)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 24 Feb 2011 6:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 67 of 131
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Molecular signaling how do axons die?
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Authors: Coleman M Axons depend critically on axonal transport both for supplying materials and for communicating with cell bodies. This chapter looks at each activity, asking what aspects are essential for axon survival. Axonal transport declines in neurodegenerative disorders, such as Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis, and...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 24 Feb 2011 2:36:26 am
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Senile Dementia/Alzheimer's Disease - news item 68 of 131
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Matter of Life and Death: the Pharmacological Approaches Targeting Apoptosis in Brain Diseases.
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Authors: Cavallucci V, D'Amelio M Neurodegenerative diseases that include amyotrophic lateral sclerosis, Huntington's disease, Alzheimer's disease, Parkinson's disease, stroke, brain trauma and spinal cord injury, are associated with the inappropriate activation of a neuronal cell-suicide program called apoptosis. Given that central nervous system tissue has very limited regenerative capacity it...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 23 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 69 of 131
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Antiapoptotic Drugs: A Therapautic Strategy for the Prevention of Neurodegenerative Diseases.
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Authors: Sureda FX, Junyent F, Verdaguer E, Auladell C, Pelegri C, Vilaplana J, Folch J, Canudas AM, Zarate CB, Pallès M, Camins A The purpose of this review is to discuss potential pathways involved in the pathogenesis of neurodegenerative diseases, highlighting current pharmacological drug targets in neuronal apoptosis prevention. The...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 23 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 70 of 131
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Independent contribution of temporal {beta}-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease
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The relationship between β-amyloid deposition and memory deficits in early Alzheimer’s disease is unresolved, as past studies show conflicting findings. The present study aims to determine the relative contribution of regional β-amyloid deposition, hippocampal atrophy and white matter integrity to episodic memory deficits in non-demented older individuals harbouring one of...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 23 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 71 of 131
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Alois Alzheimer (1864-1915) and the Alzheimer syndrome
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Alois Alzheimer is known for his seminal work in recognizing a form of presenile dementia. His early interests were natural history and botany. He started his medical education in Berlin and attended the universities of Wurzburg and Tübingen. Nissl and Alzheimer worked together on extensive investigation of the pathology of...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 23 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 72 of 131
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Alternative Theory of Alzheimer's
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While most researchers studying Alzheimer's disease still believe in the amyloid hypothesis, the disappointments of proposed treatments and other setbacks in the past few years have rekindled interest in other theories of what causes Alzheimer's. One such theory, the mitochondrial cascade theory of Alzheimer's disease, argues that a person's genes...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 23 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 73 of 131
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Guidelines for the biological treatment of Alzheimer's disease and other dementias have been released
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(Source: PharmacoEconomics and Outcomes News)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 23 Feb 2011 10:05:03 pm
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Senile Dementia/Alzheimer's Disease - news item 74 of 131
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Effect of Memantine on Resting State Default Mode Network Activity in Alzheimers Disease
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(Source: Drugs)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 23 Feb 2011 4:17:46 pm
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Senile Dementia/Alzheimer's Disease - news item 75 of 131
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Atorvastatin improved scopolamine-induced impairment in memory acquisition in mice: Involvement of nitric oxide.
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In this study, effects of atorvastatin on acquisition of spatial recognition memory and the involvement of nitric oxide (NO) have been determined in a two-trial recognition Y-maze test and passive avoidance. Atorvastatin (1, 5mg/kg, p.o.) was administered prior to acquisition phase, either in presence or in absence of a non-specific...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 76 of 131
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Neuroprotective Effect of Neuropeptide Y against Beta-Amyloid 25-35 Toxicity in SH-SY5Y Neuroblastoma Cells Is Associated with Increased Neurotrophin Production.
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Conclusion: In conclusion, this study demonstrates that NPY increases the survival of SH-SY5Y neuroblastoma cells and counteracts the toxic effect of Aβ. In addition, NPY restores the neurotrophin levels in these cells. Although preliminary, these observations might be useful to understand the pathology of Alzheimer's and/or develop new therapeutic strategies....
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 77 of 131
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Characterization of the Brain β-Amyloid Isoform Pattern at Different Ages of Tg2576 Mice.
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Conclusions: This study provides new information about age-dependent Aβ isoforms and oligomers as well as their effect on site-specific tau phosphorylation in this transgenic mouse model. Our observations suggest that the different human Aβ isoforms do not directly cause increased tau phosphorylation and that the cognitive deficits seen in this...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 78 of 131
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How to Get from Here to There: Macrophage Recruitment in Alzheimer's Disease.
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Authors: Rezai-Zadeh K, Gate D, Gowing G, Town T Alzheimer's disease (AD) is pathologically defined by presence of intracellular neurofibrillary tangles and extracellular amyloid plaques comprised of amyoid-β (Aβ) peptides. Despite local recruitment of brain microglia to sites of amyloid deposition, these mononuclear phagocytes ultimately fail at restricting β-amyloid plaque...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 79 of 131
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The Early Involvement of the Innate Immunity in the Pathogenesis of Alzheimer's Disease: Neuropathological, Epidemiological and Genetic Evidence.
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Authors: Eikelenboom P, Veerhuis R, Exel EV, Hoozemans JJ, Rozemuller AJ, van Gool WA The idea that an inflammatory process is involved in Alzheimer's disease (AD) was proposed already hundred years ago but only the past twenty years inflammation-related proteins have been identified within plaques. A number of acute-phase proteins...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 80 of 131
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Molecular Mechanisms and Therapeutic Application of NSAIDs and Derived Compounds in Alzheimer's Diseas.
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This article reviews the current knowledge and views on the above mechanisms and critically discusses current obstacles and the potential as future AD therapeutics. PMID: 21345168 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research) MedWorm Message: Watch the new MedWorm demo and find out how to get all...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 81 of 131
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Inflammatory Risk Factors and Pathologies Associated with Alzheimer's Disease.
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Authors: Sastre M, Richardson JC, Gentleman SM, Brooks DJ The importance of inflammatory processes in Alzheimer's disease (AD) progression has been confirmed during the past decade by the intensive investigation of inflammatory mediators in the brain of AD patients as well as by the genetic and drug manipulation of animal...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 82 of 131
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Does a Pro-Inflammatory Process Precede Alzheimer's Disease and Mild Cognitive Impairment?
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Authors: Ferretti MT, Cuello AC The occurrence of a plaque-dependent inflammation in Alzheimer's disease has been extensively documented in both human specimens and transgenic models of the disease. Since insoluble plaques are present in AD patients from early preclinical stages of the pathology, the point at which neuroinflammation first occurs...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 83 of 131
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Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia.
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The objective of this study was to determine the neuropathological correlates of regional medial temporal lobe volume measures on magnetic resonance imaging (MRI) in subjects with Lewy body dementia (LBD). Twenty-three autopsy-confirmed LBD cases with an MRI scan close to death (mean 1.5 years) were studied. MRI-based volumetric measures were...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 84 of 131
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Body mass index in midlife and lateâ€life as a risk factor for dementia: a metaâ€analysis of prospective studies
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SummaryThe relationship between body mass index (BMI) (in midlife and lateâ€life) and dementia was investigated in metaâ€analyses of 16 articles reporting on 15 prospective studies. Followâ€ups ranged from 3.2 to 36.0 years. Metaâ€analyses were conducted on samples including 25 624 participants evaluated for Alzheimer's disease (AD), 15 435 participants evaluated for vascular...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 85 of 131
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Spinal Fluid Donation for Alzheimers Research
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Every 70 seconds, someone in the United States develops Alzheimers disease. At this time, there is no cure for Alzheimers - but researchers and clinicians at the University of Kentucky Sanders-Brown Center on Aging are working diligently to change that fact, even when it means putting their own bodies on...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 8:51:43 pm
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Senile Dementia/Alzheimer's Disease - news item 86 of 131
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Intellect Neurosciences Issues Shareholder Update
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NEW YORK, Feb. 22, 2011 (GLOBE NEWSWIRE) -- Intellect Neurosciences, Inc. (OTCBB:ILNS), a biopharmaceutical company engaged in the discovery and development of disease-modifying therapeutic agents for the treatment and prevention of Alzheimer's disease with an internal diversified pipeline and licenses with major pharmaceutical companies covering products in late-stage clinical trials,...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 6:15:00 pm
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Senile Dementia/Alzheimer's Disease - news item 87 of 131
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[Personal View] Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ɛ4 allele
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Some patients with early-onset Alzheimer's disease (AD) present with a distinct phenotype. Typically, the first and most salient characteristic of AD is episodic memory impairment. A few patients, however, present with focal cortical, non-memory symptoms, such as difficulties with language, visuospatial, or executive functions. These presentations are associated with specific...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 5:51:34 pm
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Senile Dementia/Alzheimer's Disease - news item 88 of 131
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[Rapid Review] The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations
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Advances in gerontology have yielded crucial insights into the molecular and biochemical aspects of the ageing process. The sirtuin pathway, which is most notable for its association with the anti-ageing effects of calorie restriction, has received particular attention, and pharmacological or transgenic upregulation of the sirtuin pathway has shown promising...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 5:51:34 pm
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Senile Dementia/Alzheimer's Disease - news item 89 of 131
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[Review] Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
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Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) are characterised by the appearance of reactive microglial and astroglial cells, a process referred to as neuroinflammation. In transgenic mouse models of mutant SOD1-associated familial ALS, reactive microglial cells and astrocytes actively contribute to the death of...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 5:51:34 pm
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Senile Dementia/Alzheimer's Disease - news item 90 of 131
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[Review] Apolipoprotein E in Alzheimer's disease and other neurological disorders
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Apolipoprotein E (APOE) is a 299-aminoacid protein encoded by the APOE gene. Three common polymorphisms in the APOE gene, ɛ2, ɛ3, and ɛ4, result in a single aminoacid change in the APOE protein. APOE ɛ2, ɛ3, and ɛ4 alleles strongly alter, in a dose-dependent manner, the likelihood of developing Alzheimer's...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 5:51:34 pm
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Senile Dementia/Alzheimer's Disease - news item 91 of 131
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[Articles] Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer's disease: a retrospective cohort study
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Clinical deterioration can be detected as measurable cognitive impairment around two decades before dementia onset in PSEN1 E280A carriers. Onset and progression of pre-dementia stages should be considered in the investigation and use of therapeutic interventions for familial AD. (Source: Lancet Neurology) MedWorm Message: Watch the new MedWorm demo and...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 5:51:33 pm
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Senile Dementia/Alzheimer's Disease - news item 92 of 131
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[In Context] Michael Schlossmacher
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Michael Schlossmacher was raised in Vienna, Austria. After medical school, he moved to Boston, MA, USA, and joined Dennis Selkoe's laboratory at Harvard University to study Alzheimer's disease. After residency training (medicine and neurology), he focused on Parkinson's disease. Since 2007, he has been directing a laboratory at the University...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 5:51:33 pm
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Senile Dementia/Alzheimer's Disease - news item 93 of 131
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[In Context] Philip Scheltens: friendly face of Alzheimer's disease research
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Philip Scheltens, professor of cognitive neurology and director of the Alzheimer's Center at Vrije Universiteit Medical Center in Amsterdam, Netherlands, is a born networker†in the nicest possible sense. (Source: Lancet Neurology)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 5:51:33 pm
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Senile Dementia/Alzheimer's Disease - news item 94 of 131
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[In Context] Big science for a big problem: ADNI enters its second phase
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An initiative to find biomarkers of Alzheimer's disease progression that researchers and industry describe as “a new way to do science†is entering its second 5-year phase. But what makes it so special? Adrian Burton investigates. (Source: Lancet Neurology)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 5:51:33 pm
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Senile Dementia/Alzheimer's Disease - news item 95 of 131
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[Comment] Setting the stage for prevention of familial Alzheimer's disease
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Alzheimer's disease (AD) is a large worldwide public-health challenge, and the problem is increasing as populations age. Once a patient has developed AD, progression of the disease is difficult to influence; thus, increasing focus is being put on prevention. Studies of preventive interventions for late-onset AD are arduous endeavours, in...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 5:51:32 pm
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Senile Dementia/Alzheimer's Disease - news item 96 of 131
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[Editorial] Dementia policy: will finances follow aspirations?
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On both sides of the Atlantic, politicians have voted overwhelmingly to adopt measures to make dementia a health priority: in January the European Initiative on Alzheimer's Disease and Other Dementias was approved by the European Parliament and the US National Alzheimer's Project Act (NAPA) was signed into law. Both initiatives...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 5:51:32 pm
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Senile Dementia/Alzheimer's Disease - news item 97 of 131
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Granulovacuolar degeneration (GVD) bodies of Alzheimer's disease (AD) resemble lateâ€stage autophagic organelles
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Conclusions: The resultant immunohistochemical signature suggests that granulovacuolar degeneration bodies (GVBs) do contain lateâ€stage autophagic markers, and accumulate at the nexus of autophagic and endocytic pathways. The data further suggest that failure to complete autolysosome formation may be an important correlate of GVB accumulation. (Source: Neuropathology and Applied Neurobiology)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 5:36:12 pm
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Senile Dementia/Alzheimer's Disease - news item 98 of 131
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Studying Aging, and Fearing Budget Cuts
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Dr. Richard J. Hodes, the director of the National Institute on Aging, weighs the research his lab is doing in a time of fiscal pressure. (Source: NYT)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 4:45:12 am
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Senile Dementia/Alzheimer's Disease - news item 99 of 131
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Obesity gene may up dementia risk
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STOCKHOLM, Sweden, Feb. 21 (UPI) -- People with the FTO genotype linked to overweight and increased diabetes risk have three times the risk for Alzheimer's disease, researchers in Sweden say. (Source: Health News - UPI.com) MedWorm Message: Watch the new MedWorm demo and find out how to get all the...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Tue, 22 Feb 2011 2:19:56 am
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Senile Dementia/Alzheimer's Disease - news item 100 of 131
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Curcumin Activates Wnt/β-catenin Signaling Pathway through Inhibiting the Activity of GSK-3β in APPswe transfected SY5Y cells.
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Authors: Zhang X, Yin WK, Shi XD, Li Y Wnt/β-catenin signaling pathway plays an important role in the genesis and development of Alzheimer's disease. The study aims to investigate the effect of Curcumin on the expression of GSK-3β, β-catenin and CyclinD1 in vitro, which are tightly correlated with Wnt/β-catenin signaling...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 21 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 101 of 131
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Parkinson's Disease Dementia
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Recently an astute reader of our Alzheimer's site here at About.com pointed out that an article published a few years ago called Parkinsons Disease Dementia was actually about Parkinson's disease itself as opposed to the dementia that often accompanies it. It turns out the reader was absolutely right, so I...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 21 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 102 of 131
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The Doctor’s World: When Alzheimer’s Waited Outside the Oval Office
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“My Father at 100,†Ron Reagan’s memoir, is a reminder of the difficulty of distinguishing the initial symptoms of Alzheimer’s from, say, simple forgetfulness. (Source: NYT Health)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 21 Feb 2011 7:00:19 pm
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Senile Dementia/Alzheimer's Disease - news item 103 of 131
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Smoking Increases Alzheimer's Risk
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We all know smoking cigarettes is bad for your health. Now there is an added risk. Smoking may be associated with an increased risk of Alzheimer's disease and other types of dementia, such as vascular dementia. Heavy smoking, meaning a pack or more a day, in mid-life may double the...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 21 Feb 2011 7:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 104 of 131
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DTI studies in patients with Alzheimer's disease, mild cognitive impairment, or normal cognition with evaluation of the intrinsic background gradients
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Conclusion Background gradients affect the DT-MRI measurements in AD patients. Geometric average diffusion measures can be useful to minimize the intrinsic local magnetic susceptibility variations in brain tissue. Content Type Journal ArticlePages 1-14DOI 10.1007/s00234-011-0845-3Authors Geon-Ho Jahng, Department of Radiology, Kyung Hee University Hospital-Gangdong, School of Medicine, Kyung Hee University, 149...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Mon, 21 Feb 2011 4:05:38 pm
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Senile Dementia/Alzheimer's Disease - news item 105 of 131
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Comparison of four neuropathological scales for Alzheimer's disease.
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Conclusion: The correlation between the neuropathological staging systems was suboptimal, and we conclude that the choice of staging system affects the evaluation of Alzheimer pathology, and hence the final diagnosis. PMID: 21329614 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sun, 20 Feb 2011 11:00:40 pm
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Senile Dementia/Alzheimer's Disease - news item 106 of 131
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Novel High-Affinity Aβ-Binding Peptides Identified by an Advanced In vitro Evolution, Progressive Library Method.
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Authors: Tsuji-Ueno S, Komatsu M, Iguchi K, Takahashi M, Yoshino S, Suzuki M, Nemoto N, Nishigaki K Recent studies have been supporting that the generation of Aβ42 oligomers is responsible for Alzheimer's disease. Therefore, those peptides which bind to Aβ42 are scientifically interesting and can be possible candidates for the...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sun, 20 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 107 of 131
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Apolipoprotein E and Gray Matter Volume Loss in Patients with Mild Cognitive Impairment and Alzheimer Disease [Neuroradiology]
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Conclusion: APOE4 carriers with cognitive decline undergo faster GM atrophy than do noncarriers. The involvement of APOE4 in the progression of hippocampal atrophy, neocortical atrophy, or both has potential important implications for diagnosis and therapeutic approaches in patients with AD and should be considered in clinical trials. The present results...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sun, 20 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 108 of 131
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Local amygdala structural differences with 3T MRI in patients with Alzheimer disease
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Conclusions: We found in vivo local structural differences in the amygdala of patients with AD. The nuclei involved have known connections to the hippocampus (BLVM, La) and olfactory system (medial nucleus) and with cholinergic pathways (central nucleus). This pattern is consistent with the known pathophysiology of neural systems affected by...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sun, 20 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 109 of 131
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TDP-43 in aging and Alzheimer's disease - a review.
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Authors: Wilson AC, Dugger BN, Dickson DW, Wang DS Transactive response DNA-binding protein of 43 kDa (TDP-43), an RNA and DNA binding protein involved in transcriptional repression, RNA splicing and RNA metabolism during the stress response, is the major component of neuronal inclusions in amyotrophic lateral sclerosis (ALS) and frontotemporal...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sun, 20 Feb 2011 3:45:03 pm
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Senile Dementia/Alzheimer's Disease - news item 110 of 131
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5-HT(4) receptors, a place in the sun: act two.
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Authors: Bockaert J, Claeysen S, Compan V, Dumuis A 5-HT(4) receptors control brain physiological functions such as learning and memory, feeding and mood behaviour as well as gastro-intestinal transit. 5-HT(4) receptors are one of the 5-HT receptors for which the available drugs and signalling knowledge are the most advanced. Several...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sat, 19 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 111 of 131
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Speaking 2 languages may delay getting Alzheimer's
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Mastering a second language can pump up your brain in ways that seem to delay getting Alzheimer's disease later on, according to a Canadian research team. (Source: CTV Health)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Sat, 19 Feb 2011 1:47:21 pm
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Senile Dementia/Alzheimer's Disease - news item 112 of 131
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Speaking a second language can delay dementia onset for years
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Speaking a second language may slow the rate at which the brain declines with age, showing that bilingual people are better protected against Alzheimer's disease than people who use only one language. (Source: The Independent - Science) MedWorm Message: Watch the new MedWorm demo and find out how to get...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 18 Feb 2011 11:00:01 pm
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Senile Dementia/Alzheimer's Disease - news item 113 of 131
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Spatial Frequency Domain Imaging of Intrinsic Optical Property Contrast in a Mouse Model of Alzheimer's Disease.
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Authors: Lin AJ, Koike MA, Green KN, Kim JG, Mazhar A, Rice TB, Laferla FM, Tromberg BJ Extensive changes in neural tissue structure and function accompanying Alzheimer's disease (AD) suggest that intrinsic signal optical imaging can provide new contrast mechanisms and insight for assessing AD appearance and progression. In this...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 18 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 114 of 131
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Nicotine Decreases Beta-Amyloid Through Regulating BACE1 Transcription in SH-EP1-α4β2 nAChR-APP695 Cells.
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Authors: Nie HZ, Li ZQ, Yan QX, Wang ZJ, Zhao WJ, Guo LC, Yin M Alzheimer's disease (AD) is a neurodegenerative disorder that affects the elderly population. Deposition of beta-amyloid (Aβ) in the brain is a hallmark of AD pathology. In our previous study, we have constructed a cell line...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 18 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 115 of 131
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Keep Sharp, Master More Languages, Delay Alzheimer's
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A new study shows that bilingual patients did not contract Alzheimer's, the worst phase of dementia until five years later than their monolingual compadres. Mastering a second language can pump up your brain in ways that seem to delay getting Alzheimer's disease later on. Ellen Bialystok, a psychology professor at...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 18 Feb 2011 10:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 116 of 131
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Being bilingual may delay Alzheimer's and boost brain power
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Research suggests that bilingual people can hold Alzheimer's disease at bay for longer, and that bilingual children are better at prioritising tasks and multitaskingLearning a second language and speaking it regularly can improve your cognitive skills and delay the onset of dementia, according to researchers who compared bilingual individuals with...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 18 Feb 2011 1:06:56 pm
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Senile Dementia/Alzheimer's Disease - news item 117 of 131
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Study finds learning a second language may boost brain to delay the beginning of Alzheimer's
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WASHINGTON (AP) — Mastering a second language can pump up your brain in ways that seem to delay getting Alzheimer's disease later on, scientists said Friday. Never learned to habla or parlez? While the new research focuses mostly on the truly long-... (Source: OrlandoSentinel: Medical Research)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Fri, 18 Feb 2011 11:45:00 am
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Senile Dementia/Alzheimer's Disease - news item 118 of 131
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Finding a Way to Prevent Alzheimer's Disease
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Two Studies Alzheimer's Studies Launch on Two Continents in Search of Ways to Fight the Severely Debilitating Illness (Source: Health News: CBSNews.com)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 17 Feb 2011 11:27:21 pm
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Senile Dementia/Alzheimer's Disease - news item 119 of 131
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Caregiving Styles: A Cognitive and Behavioral Typology Associated With Dementia Family Caregiving.
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Authors: Corcoran MA PURPOSE: An increasing number of elderly individuals are diagnosed with Alzheimer's disease and related disorders (ADRD), many of whom receive daily caregiving from spouse or adult child. Caregiving is a "cultural activity," and as such it is strongly influenced by sociocultural beliefs about caregiving and how it...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 17 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 120 of 131
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Protecting Against Vascular Disease in Brain.
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Authors: Faraci FM Endothelial cells exert an enormous influence on blood vessels throughout the circulation but their impact is particularly pronounced in the brain. New concepts have emerged recently regarding the role of this cell type and mechanisms that contribute to endothelial dysfunction and vascular disease. Activation of the renin-angiotensin...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 17 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 121 of 131
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Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients
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Zhi-Ping Liu, Yong Wang, Xiang-Sun Zhang, Weiming Xia, Luonan Chen (Paper from Mol. BioSyst.) Zhi-Ping Liu, Mol. BioSyst., 2011, DOI: 10.1039/c0mb00325e To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source:...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 17 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 122 of 131
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Video: Reducing Alzheimer's Risk in the "Brain Shop"
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Dr. Kenneth Kosik, Professor of Neuroscience at UCSB, says some lifestyle changes can reduce the risk of Alzheimer's disease. Dr. Kosik give's Digital Journalist Megan Kelty an inside look at what he calls his "Brain Shop." (Source: Health News: CBSNews.com)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 17 Feb 2011 10:56:46 pm
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Senile Dementia/Alzheimer's Disease - news item 123 of 131
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Video: What is Alzheimer's Disease?
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Dr. Kenneth Kosik, Professor of Neuroscience at UCSB, explains the characteristics of Alzheimer's to Digital Journalist Megan Kelty and what preventative steps you can start taking today to fight this incurable disease. (Source: Health News: CBSNews.com) MedWorm Message: Watch the new MedWorm demo and find out how to get all...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 17 Feb 2011 10:56:45 pm
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Senile Dementia/Alzheimer's Disease - news item 124 of 131
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Impaired Adaptive Cellular Responses to Oxidative Stress and the Pathogenesis of Alzheimer's Disease
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Antioxidants & Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 17 Feb 2011 8:15:31 pm
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Senile Dementia/Alzheimer's Disease - news item 125 of 131
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AAN Press Release: Three Researchers Awarded $100,000 Potamkin Prize from AAN
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The Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases honors researchers for their work in helping to advance the understanding of Alzheimer's disease and related disorders. (Source: American Academy of Neurology)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 17 Feb 2011 5:28:45 pm
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Senile Dementia/Alzheimer's Disease - news item 126 of 131
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Increasing brain enzyme may slow Alzheimer's disease
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Increasing puromycin-sensitive aminopeptidase, the most abundant brain peptidase in mammals, slowed the damaging accumulation of tau proteins that are toxic to nerve cells and eventually lead to the neurofibrillary tangles, a major pathological hallmark of Alzheimer's disease and other forms of dementia, as per a research studypublished online in the...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 17 Feb 2011 11:31:38 am
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Senile Dementia/Alzheimer's Disease - news item 127 of 131
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Study Finds Increasing Brain Enzyme Can Slow Damaging Accumulation Of Tau Protein In Alzheimer's Disease
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Increasing puromycin-sensitive aminopeptidase, the most abundant brain peptidase in mammals, slowed the damaging accumulation of tau proteins that are toxic to nerve cells and eventually lead to the neurofibrillary tangles, a major pathological hallmark of Alzheimer's disease and other forms of dementia, according to a study published online in the...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Thu, 17 Feb 2011 8:00:00 am
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Senile Dementia/Alzheimer's Disease - news item 128 of 131
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Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE
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Author Summary Genetic factors are well-established to play a role in risk of Alzheimer's disease (AD). However, it has been difficult to find genes that are involved in AD susceptibility, other than a small number of genes that play a role in early-onset, high-penetrant disease risk, and the APOE ε4...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 16 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 129 of 131
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Cerebrospinal fluid and blood flow in mild cognitive impairment and Alzheimer's disease: a differential diagnosis from idiopathic normal pressure hydrocephalus
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Conclusion: Our preliminary data show that a-MCI patients present with high systolic arterial peak flows, which are associated with higher mean total cerebral arterial flows.Aqueductal CSF oscillations are within normal range in AD and higher than normal in NPH.This study provides an original dynamic vision of cerebral neurodegenerative diseases, consistent...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 16 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 130 of 131
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Cognitive activity for the treatment of older adults with mild Alzheimer's Disease (AD) - PACE AD: study protocol for a randomised controlled trial
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DiscussionThe proposed project will provide evidence as to whether CST for people with AD and their companions is more beneficial than when used for companions alone. Outcomes sought include a reduction of further cognitive decline and improved quality of life amongst older adults with mild AD. We anticipate that the...
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 16 Feb 2011 11:00:00 pm
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Senile Dementia/Alzheimer's Disease - news item 131 of 131
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Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study
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Conclusions: Major biomarker changes precede clinical AD and index cognitive impairment in AD poorly, if at all. (Source: BioMed Central)
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RSS Source: Med Worm - Seniile Dementia and Alzheimer's Disease Wed, 16 Feb 2011 11:00:00 pm
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